KR20060129276A - Ａ２ｂ 길항제로서의 티아졸 유도체 - Google Patents
Ａ２ｂ 길항제로서의 티아졸 유도체 Download PDFInfo
- Publication number
- KR20060129276A KR20060129276A KR1020067014629A KR20067014629A KR20060129276A KR 20060129276 A KR20060129276 A KR 20060129276A KR 1020067014629 A KR1020067014629 A KR 1020067014629A KR 20067014629 A KR20067014629 A KR 20067014629A KR 20060129276 A KR20060129276 A KR 20060129276A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- alkyl
- compound
- alkoxy
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0401336.3A GB0401336D0 (en) | 2004-01-21 | 2004-01-21 | Organic compounds |
| GB0401336.3 | 2004-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20060129276A true KR20060129276A (ko) | 2006-12-15 |
Family
ID=31971241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020067014629A Ceased KR20060129276A (ko) | 2004-01-21 | 2005-01-20 | Ａ２ｂ 길항제로서의 티아졸 유도체 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090233938A1 (https=) |
| EP (1) | EP1709036B1 (https=) |
| JP (1) | JP2007518767A (https=) |
| KR (1) | KR20060129276A (https=) |
| CN (1) | CN1910178B (https=) |
| AT (1) | ATE388147T1 (https=) |
| AU (1) | AU2005206290B2 (https=) |
| BR (1) | BRPI0506927A (https=) |
| CA (1) | CA2553010A1 (https=) |
| DE (1) | DE602005005161T2 (https=) |
| ES (1) | ES2300985T3 (https=) |
| GB (1) | GB0401336D0 (https=) |
| PL (1) | PL1709036T3 (https=) |
| PT (1) | PT1709036E (https=) |
| RU (1) | RU2374242C2 (https=) |
| WO (1) | WO2005070926A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2270715B1 (es) | 2005-07-29 | 2008-04-01 | Laboratorios Almirall S.A. | Nuevos derivados de pirazina. |
| NZ566036A (en) | 2005-09-13 | 2010-06-25 | Janssen Pharmaceutica Nv | 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor |
| ES2274712B1 (es) | 2005-10-06 | 2008-03-01 | Laboratorios Almirall S.A. | Nuevos derivados imidazopiridina. |
| AU2007227021B2 (en) | 2006-03-17 | 2012-12-20 | Gilead Sciences, Inc. | Method of preventing and treating hepatic disease using A2B adenosine receptor antagonists |
| JP5026511B2 (ja) | 2006-05-18 | 2012-09-12 | エフ．ホフマン−ラ ロシュ アーゲー | アデノシンａ２ｂレセプターアンタゴニストとしてのチアゾロ−ピラミジン／ピリジン尿素誘導体 |
| JP2011500625A (ja) | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された１，２，４−トリアゾール |
| JO2784B1 (en) | 2007-10-18 | 2014-03-15 | شركة جانسين فارماسوتيكا ان. في | 5,3,1 - Triazole substitute derivative |
| AR070936A1 (es) | 2008-03-19 | 2010-05-12 | Janssen Pharmaceutica Nv | 1,2,4 -triazoles trisustituidos |
| JP5486591B2 (ja) | 2008-05-09 | 2014-05-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アセチルコリン受容体モジュレーターとしての三置換ピラゾール |
| US9453002B2 (en) | 2013-08-16 | 2016-09-27 | Janssen Pharmaceutica Nv | Substituted imidazoles as N-type calcium channel blockers |
| ES2580702B1 (es) | 2015-02-25 | 2017-06-08 | Palobiofarma, S.L. | Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina |
| CN109293652B (zh) * | 2017-07-24 | 2021-10-22 | 四川科伦博泰生物医药股份有限公司 | 一种取代的噻唑衍生物及其用途 |
| WO2019072143A1 (zh) * | 2017-10-11 | 2019-04-18 | 上海迪诺医药科技有限公司 | 4-氨基吡啶衍生物、其药物组合物、制备方法及应用 |
| CN112955441B (zh) | 2018-10-24 | 2024-06-18 | 里德埃克斯普洛股份公司 | 官能化氨基三嗪 |
| US20200345725A1 (en) | 2019-01-11 | 2020-11-05 | Omeros Corporation | Methods and Compositions for Treating Cancer |
| AU2023208887A1 (en) * | 2022-01-19 | 2024-06-13 | Leadxpro Ag | Functionalized aminothiazoles |
| GB2615307A (en) * | 2022-01-28 | 2023-08-09 | Adorx Therapeutics Ltd | Antagonist compounds |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2677356B1 (fr) * | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
| AU4506399A (en) * | 1998-06-05 | 1999-12-30 | Novartis Ag | Aryl pyridinyl thiazoles |
| JP2000281685A (ja) * | 1999-01-28 | 2000-10-10 | Takeda Chem Ind Ltd | チアゾロピリミジン化合物、その製造法および用途 |
| ATE311385T1 (de) * | 1999-10-27 | 2005-12-15 | Novartis Pharma Gmbh | Thiazol und imidazo(4,5-b)pyridin verbindungen und ihre verwendung als pharmazeutika |
| GB0028383D0 (en) * | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
| JP2002302445A (ja) * | 2001-02-02 | 2002-10-18 | Takeda Chem Ind Ltd | Ｊｎｋ阻害剤 |
| GB0123589D0 (en) * | 2001-10-01 | 2001-11-21 | Syngenta Participations Ag | Organic compounds |
| US20050004134A1 (en) * | 2001-11-08 | 2005-01-06 | Hideo Tsutsumi | Thiazole derivative and pharmaceutical use thereof |
-
2004
- 2004-01-21 GB GBGB0401336.3A patent/GB0401336D0/en not_active Ceased
-
2005
- 2005-01-20 AU AU2005206290A patent/AU2005206290B2/en not_active Ceased
- 2005-01-20 DE DE602005005161T patent/DE602005005161T2/de not_active Expired - Lifetime
- 2005-01-20 KR KR1020067014629A patent/KR20060129276A/ko not_active Ceased
- 2005-01-20 US US10/585,614 patent/US20090233938A1/en not_active Abandoned
- 2005-01-20 WO PCT/EP2005/000542 patent/WO2005070926A1/en not_active Ceased
- 2005-01-20 PL PL05706936T patent/PL1709036T3/pl unknown
- 2005-01-20 RU RU2006130002/04A patent/RU2374242C2/ru not_active IP Right Cessation
- 2005-01-20 PT PT05706936T patent/PT1709036E/pt unknown
- 2005-01-20 EP EP05706936A patent/EP1709036B1/en not_active Expired - Lifetime
- 2005-01-20 AT AT05706936T patent/ATE388147T1/de not_active IP Right Cessation
- 2005-01-20 CA CA002553010A patent/CA2553010A1/en not_active Abandoned
- 2005-01-20 ES ES05706936T patent/ES2300985T3/es not_active Expired - Lifetime
- 2005-01-20 JP JP2006550041A patent/JP2007518767A/ja active Pending
- 2005-01-20 CN CN2005800026886A patent/CN1910178B/zh not_active Expired - Fee Related
- 2005-01-20 BR BRPI0506927-0A patent/BRPI0506927A/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP1709036A1 (en) | 2006-10-11 |
| DE602005005161T2 (de) | 2009-03-19 |
| RU2374242C2 (ru) | 2009-11-27 |
| PT1709036E (pt) | 2008-05-28 |
| CN1910178A (zh) | 2007-02-07 |
| US20090233938A1 (en) | 2009-09-17 |
| GB0401336D0 (en) | 2004-02-25 |
| ATE388147T1 (de) | 2008-03-15 |
| AU2005206290B2 (en) | 2008-12-04 |
| BRPI0506927A (pt) | 2007-06-05 |
| PL1709036T3 (pl) | 2008-08-29 |
| EP1709036B1 (en) | 2008-03-05 |
| CA2553010A1 (en) | 2005-08-04 |
| AU2005206290A1 (en) | 2005-08-04 |
| DE602005005161D1 (de) | 2008-04-17 |
| CN1910178B (zh) | 2010-06-02 |
| RU2006130002A (ru) | 2008-02-27 |
| ES2300985T3 (es) | 2008-06-16 |
| JP2007518767A (ja) | 2007-07-12 |
| WO2005070926A1 (en) | 2005-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20060720 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20100120 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20110721 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20111130 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20110721 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |