KR20060064617A - 개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드 - Google Patents

개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드 Download PDF

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KR20060064617A
KR20060064617A KR1020067002876A KR20067002876A KR20060064617A KR 20060064617 A KR20060064617 A KR 20060064617A KR 1020067002876 A KR1020067002876 A KR 1020067002876A KR 20067002876 A KR20067002876 A KR 20067002876A KR 20060064617 A KR20060064617 A KR 20060064617A
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gly
leu
pro
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에스 크리스토퍼 데이비스
리챠드 존 폭스
베스나 가브릴로빅
갈트 더블유 휘스만
리사 마리 뉴먼
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코덱시스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
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  • Wood Science & Technology (AREA)
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  • Molecular Biology (AREA)
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  • Biotechnology (AREA)
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  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020067002876A 2003-08-11 2004-08-11 개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드 Ceased KR20060064617A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US49438203P 2003-08-11 2003-08-11
US60/494,382 2003-08-11
US54603304P 2004-02-18 2004-02-18
US60/546,033 2004-02-18

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KR20060064617A true KR20060064617A (ko) 2006-06-13

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KR1020067002876A Ceased KR20060064617A (ko) 2003-08-11 2004-08-11 개량된 할로히드린 디할로게나제 및 관련 폴리뉴클레오티드

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US (3) US7824898B2 (https=)
EP (1) EP1654356A1 (https=)
JP (1) JP2007502123A (https=)
KR (1) KR20060064617A (https=)
AU (1) AU2004265693A1 (https=)
BR (1) BRPI0413501A (https=)
CA (1) CA2535255A1 (https=)
IL (1) IL173261A0 (https=)
MX (1) MXPA06001725A (https=)
NO (1) NO20060405L (https=)
SG (1) SG148180A1 (https=)
WO (1) WO2005017141A1 (https=)

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EP3023494B1 (en) 2008-06-13 2018-11-28 Codexis, Inc. Method of synthesizing polynucleotide variants
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EP3301208B1 (en) 2009-09-18 2020-11-04 Codexis, Inc. Reduced codon mutagenesis
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
CN102884178B (zh) 2009-12-08 2014-12-03 科德克希思公司 拉唑化合物的合成
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US9102963B2 (en) 2011-04-13 2015-08-11 Codexis, Inc. Biocatalytic process for preparing eslicarbazepine and analogs thereof
EP2780448B1 (en) 2011-11-18 2019-09-11 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
EP2847214B1 (en) 2012-05-11 2017-12-27 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
CN104372038A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法
JP6643987B2 (ja) 2013-11-13 2020-02-12 コデクシス， インコーポレイテッド ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法
DK3224354T3 (da) 2014-11-25 2021-03-01 Codexis Inc Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser
WO2016130412A1 (en) 2015-02-10 2016-08-18 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN104745557B (zh) * 2015-03-05 2017-09-22 浙江工业大学 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用
EP3093337A3 (en) 2015-05-13 2017-03-15 Samsung Electronics Co., Ltd. Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same
US10358632B2 (en) 2015-12-07 2019-07-23 Samsung Electronics Co., Ltd. Bacterial cytochrome P450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
CN109295044A (zh) * 2018-10-26 2019-02-01 浙江大学 一种卤醇脱卤酶突变体及其应用
JP2022509042A (ja) * 2018-11-07 2022-01-20 ザ ロイヤル インスティテューション フォー ザ アドバンスメント オブ ラーニング／マクギル ユニバーシティ テストステロン誘導ペプチド化合物及び関連する組合せ
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Publication number Publication date
US8101395B2 (en) 2012-01-24
US7824898B2 (en) 2010-11-02
US20100167345A1 (en) 2010-07-01
AU2004265693A1 (en) 2005-02-24
US20120208259A1 (en) 2012-08-16
NO20060405L (no) 2006-03-10
IL173261A0 (en) 2006-06-11
WO2005017141A1 (en) 2005-02-24
MXPA06001725A (es) 2006-04-27
SG148180A1 (en) 2008-12-31
EP1654356A1 (en) 2006-05-10
US8535910B2 (en) 2013-09-17
JP2007502123A (ja) 2007-02-08
US20050153417A1 (en) 2005-07-14
BRPI0413501A (pt) 2006-10-10
CA2535255A1 (en) 2005-02-24

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