MXPA06001725A - Halohidrina deshalogenasas mejoradas y polinucleotidos relacionados. - Google Patents
Halohidrina deshalogenasas mejoradas y polinucleotidos relacionados.Info
- Publication number
- MXPA06001725A MXPA06001725A MXPA06001725A MXPA06001725A MXPA06001725A MX PA06001725 A MXPA06001725 A MX PA06001725A MX PA06001725 A MXPA06001725 A MX PA06001725A MX PA06001725 A MXPA06001725 A MX PA06001725A MX PA06001725 A MXPA06001725 A MX PA06001725A
- Authority
- MX
- Mexico
- Prior art keywords
- polypeptide
- seq
- amino acid
- hhdh
- acid sequence
- Prior art date
Links
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
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- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
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| US49438203P | 2003-08-11 | 2003-08-11 | |
| US54603304P | 2004-02-18 | 2004-02-18 | |
| PCT/US2004/026654 WO2005017141A1 (en) | 2003-08-11 | 2004-08-11 | Improved halohydrin dehalogenases and related polynucleotides |
Publications (1)
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| MXPA06001725A true MXPA06001725A (es) | 2006-04-27 |
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| MXPA06001725A MXPA06001725A (es) | 2003-08-11 | 2004-08-11 | Halohidrina deshalogenasas mejoradas y polinucleotidos relacionados. |
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| EP (1) | EP1654356A1 (https=) |
| JP (1) | JP2007502123A (https=) |
| KR (1) | KR20060064617A (https=) |
| AU (1) | AU2004265693A1 (https=) |
| BR (1) | BRPI0413501A (https=) |
| CA (1) | CA2535255A1 (https=) |
| IL (1) | IL173261A0 (https=) |
| MX (1) | MXPA06001725A (https=) |
| NO (1) | NO20060405L (https=) |
| SG (1) | SG148180A1 (https=) |
| WO (1) | WO2005017141A1 (https=) |
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| JP4578240B2 (ja) * | 2002-08-09 | 2010-11-10 | コデクシス， インコーポレイテッド | ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス |
| JP2007502111A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | ４−置換３−ヒドロキシ酪酸誘導体およびビシナルなシアノ，ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
| US7824898B2 (en) * | 2003-08-11 | 2010-11-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| US7541171B2 (en) | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| ATE556141T1 (de) * | 2005-12-21 | 2012-05-15 | Basf Se | Verfahren zur herstellung eines optisch angereicherten tertiären alkohols |
| ES2328183T3 (es) | 2006-03-03 | 2009-11-10 | Basf Se | Procedimiento para la preparacion de 2-oxazolidinonas sustituidas en 5 opticamente activas a partir de epoxidos racemicos y cianato empleando una halohidrina deshalogenasa. |
| US7879585B2 (en) * | 2006-10-02 | 2011-02-01 | Codexis, Inc. | Ketoreductase enzymes and uses thereof |
| JP5226509B2 (ja) * | 2007-03-07 | 2013-07-03 | 三菱レイヨン株式会社 | 改良型ハロヒドリンエポキシダーゼ |
| CN101784669B (zh) | 2007-08-24 | 2015-02-18 | 科德克希思公司 | 用于(r)-3-羟基四氢噻吩的立体选择性制备的改善的酮还原酶多肽 |
| US20090312196A1 (en) | 2008-06-13 | 2009-12-17 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| EP3023494B1 (en) | 2008-06-13 | 2018-11-28 | Codexis, Inc. | Method of synthesizing polynucleotide variants |
| HUE026181T2 (en) | 2008-08-27 | 2016-05-30 | Codexis Inc | Ketoreductase polypeptide for the preparation of 3-aryl-3-hydroxypropanamine from 3-aryl-3-ketopropanamine |
| WO2010027710A2 (en) | 2008-08-27 | 2010-03-11 | Codexis, Inc. | Ketoreductase polypeptides and uses thereof |
| EP2379713A4 (en) | 2008-12-18 | 2013-07-10 | Codexis Inc | RECOMBINANT HALOHYDRIN DEHALOGENASE POLYPEPTIDES |
| EP2401366B1 (en) | 2009-02-26 | 2013-12-18 | Codexis, Inc. | Transaminase biocatalysts |
| ES2644992T3 (es) | 2009-06-22 | 2017-12-01 | Codexis, Inc. | Reacciones de transaminasa |
| CN102482648B (zh) | 2009-06-22 | 2014-12-10 | 科德克希思公司 | 酮还原酶介导的产生α氯代醇的立体选择性途径 |
| EP3301208B1 (en) | 2009-09-18 | 2020-11-04 | Codexis, Inc. | Reduced codon mutagenesis |
| US20110082055A1 (en) * | 2009-09-18 | 2011-04-07 | Codexis, Inc. | Reduced codon mutagenesis |
| CN102884178B (zh) | 2009-12-08 | 2014-12-03 | 科德克希思公司 | 拉唑化合物的合成 |
| WO2011140219A1 (en) | 2010-05-04 | 2011-11-10 | Codexis, Inc. | Biocatalysts for ezetimibe synthesis |
| US8932836B2 (en) | 2010-08-16 | 2015-01-13 | Codexis, Inc. | Biocatalysts and methods for the synthesis of (1R,2R)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine |
| HUE037616T2 (hu) | 2010-12-08 | 2018-09-28 | Codexis Inc | Biokatalizátorok és eljárások armodafinil szintéziséhez |
| US9102963B2 (en) | 2011-04-13 | 2015-08-11 | Codexis, Inc. | Biocatalytic process for preparing eslicarbazepine and analogs thereof |
| EP2780448B1 (en) | 2011-11-18 | 2019-09-11 | Codexis, Inc. | Biocatalysts for the preparation of hydroxy substituted carbamates |
| EP2847214B1 (en) | 2012-05-11 | 2017-12-27 | Codexis, Inc. | Engineered imine reductases and methods for the reductive amination of ketone and amine compounds |
| CN104372038A (zh) * | 2013-08-12 | 2015-02-25 | 南京朗恩生物科技有限公司 | 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法 |
| JP6643987B2 (ja) | 2013-11-13 | 2020-02-12 | コデクシス， インコーポレイテッド | ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法 |
| DK3224354T3 (da) | 2014-11-25 | 2021-03-01 | Codexis Inc | Manipulerede iminreductaser og fremgangsmåder til den reduktive aminering af keton- og aminforbindelser |
| WO2016130412A1 (en) | 2015-02-10 | 2016-08-18 | Codexis, Inc. | Ketoreductase polypeptides for the synthesis of chiral compounds |
| CN104745557B (zh) * | 2015-03-05 | 2017-09-22 | 浙江工业大学 | 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用 |
| EP3093337A3 (en) | 2015-05-13 | 2017-03-15 | Samsung Electronics Co., Ltd. | Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same |
| US10358632B2 (en) | 2015-12-07 | 2019-07-23 | Samsung Electronics Co., Ltd. | Bacterial cytochrome P450 protein variant and method of reducing concentration of fluorinated methane in sample using the same |
| ES2975412T3 (es) | 2018-06-21 | 2024-07-05 | Fis Fabbrica Italiana Sintetici Spa | Proceso enzimático para la preparación de droxidopa |
| CN109295044A (zh) * | 2018-10-26 | 2019-02-01 | 浙江大学 | 一种卤醇脱卤酶突变体及其应用 |
| JP2022509042A (ja) * | 2018-11-07 | 2022-01-20 | ザ ロイヤル インスティテューション フォー ザ アドバンスメント オブ ラーニング／マクギル ユニバーシティ | テストステロン誘導ペプチド化合物及び関連する組合せ |
| IL322082A (en) | 2023-01-12 | 2025-09-01 | Novartis Ag | Engineered ketoreductase polypeptides |
| CN119530210B (zh) * | 2024-11-12 | 2025-10-03 | 南京师范大学 | 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用 |
Family Cites Families (19)
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| JP2840722B2 (ja) * | 1989-07-20 | 1998-12-24 | 日東化学工業株式会社 | ４‐ハロ‐３‐ヒドロキシブチロニトリルの製造法 |
| US5210031A (en) * | 1989-07-20 | 1993-05-11 | Nitto Chemical Industry Co., Ltd. | Process for the production of R(-)-4-halo-3-hydroxybutyronitrile |
| JP3073037B2 (ja) | 1991-03-04 | 2000-08-07 | 三菱レイヨン株式会社 | ハロヒドリンエポキシダ−ゼ遺伝子を有する組換え体プラスミドおよび該プラスミドにより形質転換された微生物 |
| JP3171931B2 (ja) * | 1992-06-02 | 2001-06-04 | 高砂香料工業株式会社 | （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法 |
| GB9512837D0 (en) * | 1995-06-23 | 1995-08-23 | Zeneca Ltd | reduction of ketone groups |
| US5908953A (en) * | 1996-12-18 | 1999-06-01 | Mitsubishi Chemical Corporation | Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester |
| JP3728045B2 (ja) | 1997-01-31 | 2005-12-21 | 三菱レイヨン株式会社 | ハロヒドリンより光学活性ジオールへの変換を触媒する新規なタンパク質 |
| EP0879890A1 (en) | 1997-05-21 | 1998-11-25 | Rijksuniversiteit te Groningen | Enantioselective epoxide hydrolases and genes encoding these |
| ES2284219T3 (es) * | 1997-12-19 | 2007-11-01 | Pfizer Ireland Pharmaceuticals | Procedimiento de sintesis de 1,3-dioles. |
| ES2207202T3 (es) * | 1998-04-30 | 2004-05-16 | Kaneka Corporation | Procedimiento para producir derivados de acido 6-cianometil-1, 3-dioxano-4-acetico. |
| EP1024139B1 (en) * | 1998-08-05 | 2004-05-12 | Kaneka Corporation | Process for the preparation of optically active 2-(6-(hydroxymethyl)-1,3-dioxan-4-yl) acetic acid derivatives |
| EP1194582A1 (de) * | 1999-07-09 | 2002-04-10 | Forschungszentrum Jülich Gmbh | Verfahren zur reduktion von keto-carbonsäuren und deren estern |
| DE60018909T2 (de) * | 1999-12-03 | 2006-03-30 | Kaneka Corp. | Neue carbonyl-reduktase, gen davon und verfahren der anwendung derselben |
| EP1158054A1 (en) | 2000-05-25 | 2001-11-28 | Rijksuniversiteit te Groningen | Enzymatic conversion of epoxides |
| JP4578240B2 (ja) * | 2002-08-09 | 2010-11-10 | コデクシス， インコーポレイテッド | ４−置換３−ヒドロキシ酪酸誘導体の生成のための酵素的プロセス |
| JP2007502111A (ja) * | 2003-08-11 | 2007-02-08 | コデクシス， インコーポレイテッド | ４−置換３−ヒドロキシ酪酸誘導体およびビシナルなシアノ，ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス |
| US7824898B2 (en) | 2003-08-11 | 2010-11-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| US7588928B2 (en) | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
| US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
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- 2004-08-11 US US10/917,179 patent/US7824898B2/en active Active
- 2004-08-11 MX MXPA06001725A patent/MXPA06001725A/es unknown
- 2004-08-11 EP EP04781364A patent/EP1654356A1/en not_active Withdrawn
- 2004-08-11 WO PCT/US2004/026654 patent/WO2005017141A1/en not_active Ceased
- 2004-08-11 CA CA002535255A patent/CA2535255A1/en not_active Abandoned
- 2004-08-11 BR BRPI0413501-6A patent/BRPI0413501A/pt not_active IP Right Cessation
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- 2004-08-11 AU AU2004265693A patent/AU2004265693A1/en not_active Abandoned
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| US8101395B2 (en) | 2012-01-24 |
| US7824898B2 (en) | 2010-11-02 |
| US20100167345A1 (en) | 2010-07-01 |
| AU2004265693A1 (en) | 2005-02-24 |
| US20120208259A1 (en) | 2012-08-16 |
| NO20060405L (no) | 2006-03-10 |
| IL173261A0 (en) | 2006-06-11 |
| WO2005017141A1 (en) | 2005-02-24 |
| SG148180A1 (en) | 2008-12-31 |
| EP1654356A1 (en) | 2006-05-10 |
| US8535910B2 (en) | 2013-09-17 |
| JP2007502123A (ja) | 2007-02-08 |
| US20050153417A1 (en) | 2005-07-14 |
| BRPI0413501A (pt) | 2006-10-10 |
| CA2535255A1 (en) | 2005-02-24 |
| KR20060064617A (ko) | 2006-06-13 |
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