SG148180A1 - Improved halohydrin dehalogenases and related polynucleotides - Google Patents

Improved halohydrin dehalogenases and related polynucleotides

Info

Publication number
SG148180A1
SG148180A1 SG200808477-4A SG2008084774A SG148180A1 SG 148180 A1 SG148180 A1 SG 148180A1 SG 2008084774 A SG2008084774 A SG 2008084774A SG 148180 A1 SG148180 A1 SG 148180A1
Authority
SG
Singapore
Prior art keywords
related polynucleotides
polynucleotides
improved halohydrin
polypeptides
halohydrin dehalogenases
Prior art date
Application number
SG200808477-4A
Other languages
English (en)
Inventor
S Christopher Davis
Richard John Fox
Vesna Gavrilovic
Gjalt W Huisman
Lisa Marie Newman
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of SG148180A1 publication Critical patent/SG148180A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG200808477-4A 2003-08-11 2004-08-11 Improved halohydrin dehalogenases and related polynucleotides SG148180A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49438203P 2003-08-11 2003-08-11
US54603304P 2004-02-18 2004-02-18

Publications (1)

Publication Number Publication Date
SG148180A1 true SG148180A1 (en) 2008-12-31

Family

ID=34197997

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200808477-4A SG148180A1 (en) 2003-08-11 2004-08-11 Improved halohydrin dehalogenases and related polynucleotides

Country Status (12)

Country Link
US (3) US7824898B2 (https=)
EP (1) EP1654356A1 (https=)
JP (1) JP2007502123A (https=)
KR (1) KR20060064617A (https=)
AU (1) AU2004265693A1 (https=)
BR (1) BRPI0413501A (https=)
CA (1) CA2535255A1 (https=)
IL (1) IL173261A0 (https=)
MX (1) MXPA06001725A (https=)
NO (1) NO20060405L (https=)
SG (1) SG148180A1 (https=)
WO (1) WO2005017141A1 (https=)

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US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
CA2535255A1 (en) 2003-08-11 2005-02-24 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
WO2007071599A2 (en) * 2005-12-21 2007-06-28 Basf Se A process for the production of an optically enriched tertiary alcohol
ATE437954T1 (de) 2006-03-03 2009-08-15 Basf Se Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase
WO2008042876A2 (en) 2006-10-02 2008-04-10 Codexis, Inc. Compositions and methods for producing stereoisomerically pure statins and synthetic intermediates therefor
EP2130922A4 (en) * 2007-03-07 2010-03-31 Mitsubishi Rayon Co IMPROVED HALOHYDRIN EPOXIDASE
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス， インコーポレイテッド （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
US20090312196A1 (en) 2008-06-13 2009-12-17 Codexis, Inc. Method of synthesizing polynucleotide variants
DK3023494T3 (en) 2008-06-13 2019-02-25 Codexis Inc PROCEDURE FOR SYNTHESIS OF POLYNUCLEOTIDE VARIETIES
EP2329013B1 (en) 2008-08-27 2015-10-28 Codexis, Inc. Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
US8288131B2 (en) * 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides and uses thereof
WO2010080635A2 (en) * 2008-12-18 2010-07-15 Codexis, Inc. Recombinant halohydrin dehalogenase polypeptides
JP5707344B2 (ja) 2009-02-26 2015-04-30 コデクシス， インコーポレイテッド トランスアミナーゼ生体触媒
SG177331A1 (en) 2009-06-22 2012-02-28 Codexis Inc Ketoreductase-mediated stereoselective route to alpha chloroalcohols
WO2011005477A1 (en) 2009-06-22 2011-01-13 Codexis, Inc. Transaminase reactions
US20110082055A1 (en) * 2009-09-18 2011-04-07 Codexis, Inc. Reduced codon mutagenesis
DK3301208T3 (da) 2009-09-18 2020-12-14 Codexis Inc Reduceret codon-mutagenese
CN102884178B (zh) 2009-12-08 2014-12-03 科德克希思公司 拉唑化合物的合成
HUE026367T2 (en) 2010-05-04 2016-06-28 Codexis Inc Biocatalysts for ezetimibe synthesis
EP2606139B1 (en) 2010-08-16 2015-07-15 Codexis, Inc. Biocatalysts and methods for the synthesis of (1r,2r)-2-(3,4-dimethoxyphenethoxy)cyclohexanamine
EP2649187B1 (en) 2010-12-08 2017-11-22 Codexis, Inc. Biocatalysts and methods for the synthesis of armodafinil
HUE038800T2 (hu) 2011-04-13 2018-11-28 Codexis Inc Biokatalitikus eljárás eszlikarbazepin és ennek analógjai elõállítására
IN2014CN04470A (https=) 2011-11-18 2015-09-04 Codexis Inc
HUE036947T2 (hu) 2012-05-11 2018-08-28 Codexis Inc Átalakított iminreduktázok és eljárások keton- és aminvegyületek reduktív aminálására
CN104372038A (zh) * 2013-08-12 2015-02-25 南京朗恩生物科技有限公司 两步催化制备(r)-4-氰基-3-羟基丁酸乙酯的方法
CN106232619B (zh) 2013-11-13 2022-09-09 科德克希思公司 工程化的亚胺还原酶和用于酮和胺化合物的还原胺化的方法
US10370648B2 (en) 2014-11-25 2019-08-06 Codexis, Inc. Engineered imine reductases and methods for the reductive amination of ketone and amine compounds
WO2016130412A1 (en) 2015-02-10 2016-08-18 Codexis, Inc. Ketoreductase polypeptides for the synthesis of chiral compounds
CN104745557B (zh) * 2015-03-05 2017-09-22 浙江工业大学 来源于嗜清洁细小杆菌卤醇脱卤酶突变体及其应用
EP3093337A3 (en) 2015-05-13 2017-03-15 Samsung Electronics Co., Ltd. Microorganism including gene encoding protein having hydroxylase activity and method of reducing concentration of fluorinated methane in sample using the same
EP3178922B1 (en) 2015-12-07 2019-05-22 Samsung Electronics Co., Ltd. Bacterial cytochrome p450 protein variant and method of reducing concentration of fluorinated methane in sample using the same
ES2975412T3 (es) 2018-06-21 2024-07-05 Fis Fabbrica Italiana Sintetici Spa Proceso enzimático para la preparación de droxidopa
CN109295044A (zh) * 2018-10-26 2019-02-01 浙江大学 一种卤醇脱卤酶突变体及其应用
WO2020093142A1 (en) * 2018-11-07 2020-05-14 The Royal Institution For The Advancement Of Learning/Mcgill University Testosterone-inducing peptide compounds and associated combinations
CN120981566A (zh) 2023-01-12 2025-11-18 诺华股份有限公司 工程化酮还原酶多肽
CN119530210B (zh) * 2024-11-12 2025-10-03 南京师范大学 卤醇脱卤酶突变体及编码基因、重组载体、重组菌株、酶制剂和应用

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JP3171931B2 (ja) * 1992-06-02 2001-06-04 高砂香料工業株式会社 （Ｒ）−（−）−４−シアノ−３−ヒドロキシ酪酸ｔ−ブチルエステル及びその製造方法
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JP3728045B2 (ja) 1997-01-31 2005-12-21 三菱レイヨン株式会社 ハロヒドリンより光学活性ジオールへの変換を触媒する新規なタンパク質
EP0879890A1 (en) 1997-05-21 1998-11-25 Rijksuniversiteit te Groningen Enantioselective epoxide hydrolases and genes encoding these
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EP1077212B1 (en) * 1998-04-30 2003-08-20 Kaneka Corporation Process for producing 6-cyanomethyl-1,3-dioxane-4-acetic acid derivatives
PT1619191E (pt) * 1998-08-05 2010-12-21 Kaneka Corp Processo de produção de derivados opticamente activos do ácido 2-[6-(hidroximetil)-1,3-dioxan-4-il]acético
WO2001004336A1 (de) * 1999-07-09 2001-01-18 Forschungszentrum Jülich GmbH Verfahren zur reduktion von keto-carbonsäuren und deren estern
JP4510351B2 (ja) * 1999-12-03 2010-07-21 株式会社カネカ 新規カルボニル還元酵素、その遺伝子、およびその利用法
EP1158054A1 (en) 2000-05-25 2001-11-28 Rijksuniversiteit te Groningen Enzymatic conversion of epoxides
US7132267B2 (en) * 2002-08-09 2006-11-07 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives and vicinal cyano, hydroxy substituted carboxylic acid esters
WO2004015132A2 (en) 2002-08-09 2004-02-19 Codexis, Inc. Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives
US7588928B2 (en) 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
CA2535255A1 (en) 2003-08-11 2005-02-24 Codexis, Inc. Improved halohydrin dehalogenases and related polynucleotides
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides

Also Published As

Publication number Publication date
WO2005017141A1 (en) 2005-02-24
US8101395B2 (en) 2012-01-24
US20100167345A1 (en) 2010-07-01
CA2535255A1 (en) 2005-02-24
EP1654356A1 (en) 2006-05-10
MXPA06001725A (es) 2006-04-27
NO20060405L (no) 2006-03-10
IL173261A0 (en) 2006-06-11
JP2007502123A (ja) 2007-02-08
US8535910B2 (en) 2013-09-17
US20050153417A1 (en) 2005-07-14
US7824898B2 (en) 2010-11-02
US20120208259A1 (en) 2012-08-16
BRPI0413501A (pt) 2006-10-10
KR20060064617A (ko) 2006-06-13
AU2004265693A1 (en) 2005-02-24

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