ATE437954T1 - Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase - Google Patents

Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase

Info

Publication number
ATE437954T1
ATE437954T1 AT07712350T AT07712350T ATE437954T1 AT E437954 T1 ATE437954 T1 AT E437954T1 AT 07712350 T AT07712350 T AT 07712350T AT 07712350 T AT07712350 T AT 07712350T AT E437954 T1 ATE437954 T1 AT E437954T1
Authority
AT
Austria
Prior art keywords
cyanate
oxazolidinones
substituted
optically active
producing optically
Prior art date
Application number
AT07712350T
Other languages
English (en)
Inventor
Bernhard Hauer
Elenkov Maja Majeric
Dirk Barend Janssen
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Application granted granted Critical
Publication of ATE437954T1 publication Critical patent/ATE437954T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/14—Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT07712350T 2006-03-03 2007-02-28 Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase ATE437954T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06110638 2006-03-03
PCT/EP2007/051861 WO2007099107A1 (en) 2006-03-03 2007-02-28 Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase

Publications (1)

Publication Number Publication Date
ATE437954T1 true ATE437954T1 (de) 2009-08-15

Family

ID=38008312

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07712350T ATE437954T1 (de) 2006-03-03 2007-02-28 Verfahren zur herstellung optisch aktiver 5- substituierter 2-oxazolidinone aus racemischen epoxiden und cyanat unter einsatz einer halohydrin-dehalogenase

Country Status (8)

Country Link
US (1) US7993904B2 (de)
EP (1) EP1994162B1 (de)
JP (1) JP5191399B2 (de)
CN (1) CN101437955B (de)
AT (1) ATE437954T1 (de)
DE (1) DE602007001794D1 (de)
ES (1) ES2328183T3 (de)
WO (1) WO2007099107A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007071599A2 (en) * 2005-12-21 2007-06-28 Basf Se A process for the production of an optically enriched tertiary alcohol
EP2379713A4 (de) 2008-12-18 2013-07-10 Codexis Inc Rekombinante halohydrin-dehalogenase-polypeptide
CN104745556B (zh) * 2015-03-05 2017-09-22 浙江工业大学 一种重组卤醇脱卤酶、突变体、工程菌及其应用
CN105838700A (zh) * 2016-03-25 2016-08-10 浙江工业大学 一种固定化卤醇脱卤酶及其应用
CN112251479B (zh) * 2020-10-27 2023-05-16 遵义医科大学 一种双酶级联催化合成手性噁唑烷酮类化合物的方法
CN115927276B (zh) * 2022-08-31 2024-08-27 中国科学院天津工业生物技术研究所 卤醇脱卤酶突变体及其合成手性噁唑烷酮的应用
CN118222538B (zh) * 2024-05-23 2024-09-20 南京工业大学 一种卤醇脱卤酶突变体及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1158054A1 (de) 2000-05-25 2001-11-28 Rijksuniversiteit te Groningen Enzymatische Umwandlung von Epoxiden
EP1654356A1 (de) 2003-08-11 2006-05-10 Codexis, Inc. Verbesserte halohydrin dehalogenases und verwandte polynukleotide
EP1694636A1 (de) * 2003-12-18 2006-08-30 GE Healthcare Limited Syntheseverfahren zur markierung mit kohlenstoffisotopen durch rhodiumvermittelte carbonylierung über isocyanat mit aziden und isotopem kohlenmonoxyd

Also Published As

Publication number Publication date
ES2328183T3 (es) 2009-11-10
EP1994162A1 (de) 2008-11-26
JP5191399B2 (ja) 2013-05-08
DE602007001794D1 (de) 2009-09-10
EP1994162B1 (de) 2009-07-29
WO2007099107A1 (en) 2007-09-07
US7993904B2 (en) 2011-08-09
JP2009528039A (ja) 2009-08-06
CN101437955B (zh) 2012-10-31
CN101437955A (zh) 2009-05-20
US20090042261A1 (en) 2009-02-12

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