KR20050055781A - 신규한 데포 주사 제형 - Google Patents
신규한 데포 주사 제형 Download PDFInfo
- Publication number
- KR20050055781A KR20050055781A KR1020057006986A KR20057006986A KR20050055781A KR 20050055781 A KR20050055781 A KR 20050055781A KR 1020057006986 A KR1020057006986 A KR 1020057006986A KR 20057006986 A KR20057006986 A KR 20057006986A KR 20050055781 A KR20050055781 A KR 20050055781A
- Authority
- KR
- South Korea
- Prior art keywords
- ziprasidone
- depot
- cyclodextrin
- formulation
- sbecd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000000203 mixture Substances 0.000 title claims description 80
- 238000009472 formulation Methods 0.000 title claims description 68
- MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 claims abstract description 80
- 229960000607 ziprasidone Drugs 0.000 claims abstract description 78
- 229920000858 Cyclodextrin Polymers 0.000 claims description 52
- 238000002347 injection Methods 0.000 claims description 32
- 239000007924 injection Substances 0.000 claims description 32
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 23
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- WLQZEFFFIUHSJB-UHFFFAOYSA-N ziprasidone mesylate trihydrate Chemical compound O.O.O.CS(O)(=O)=O.C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 WLQZEFFFIUHSJB-UHFFFAOYSA-N 0.000 claims description 12
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- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 claims description 8
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- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 3
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- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 2
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- 125000004095 oxindolyl group Chemical group N1(C(CC2=CC=CC=C12)=O)* 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000007928 solubilization Effects 0.000 description 1
- 238000005063 solubilization Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 150000003890 succinate salts Chemical class 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 229940095064 tartrate Drugs 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Dispersion Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42147302P | 2002-10-25 | 2002-10-25 | |
| US60/421,473 | 2002-10-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20050055781A true KR20050055781A (ko) | 2005-06-13 |
Family
ID=32176718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020057006986A Ceased KR20050055781A (ko) | 2002-10-25 | 2003-10-13 | 신규한 데포 주사 제형 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20040138237A1 (enExample) |
| EP (1) | EP1575616A2 (enExample) |
| JP (1) | JP2006514923A (enExample) |
| KR (1) | KR20050055781A (enExample) |
| CN (1) | CN1849110A (enExample) |
| AR (1) | AR041722A1 (enExample) |
| AU (1) | AU2003267788A1 (enExample) |
| BR (1) | BR0315568A (enExample) |
| CA (1) | CA2503076A1 (enExample) |
| MX (1) | MXPA05002561A (enExample) |
| NL (1) | NL1024590C2 (enExample) |
| NO (1) | NO20052463L (enExample) |
| PA (1) | PA8586201A1 (enExample) |
| PE (1) | PE20040499A1 (enExample) |
| PL (1) | PL377679A1 (enExample) |
| RU (1) | RU2310450C2 (enExample) |
| TW (1) | TW200423941A (enExample) |
| UY (1) | UY28038A1 (enExample) |
| WO (1) | WO2004037289A2 (enExample) |
| ZA (1) | ZA200501921B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100908517B1 (ko) * | 2006-07-04 | 2009-07-20 | (주)아모레퍼시픽 | 호흡기계 약제 전달을 위한 서방형 다공성 미세입자 및 그제조 방법 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080113025A1 (en) * | 1998-11-02 | 2008-05-15 | Elan Pharma International Limited | Compositions comprising nanoparticulate naproxen and controlled release hydrocodone |
| US20040001889A1 (en) | 2002-06-25 | 2004-01-01 | Guohua Chen | Short duration depot formulations |
| EP2959893A1 (en) | 2002-12-13 | 2015-12-30 | DURECT Corporation | Oral drug delivery system comprising high viscosity liquid carrier materials |
| CN1874761A (zh) * | 2003-09-02 | 2006-12-06 | 辉瑞产品公司 | 齐拉西酮的持续释放剂型 |
| CA2581287C (en) * | 2004-09-17 | 2015-08-25 | Durect Corporation | Sustained local anesthetic composition containing bupivacaine and saib |
| US20080254114A1 (en) * | 2005-03-03 | 2008-10-16 | Elan Corporation Plc | Controlled Release Compositions Comprising Heterocyclic Amide Derivative Nanoparticles |
| RU2407529C2 (ru) * | 2005-04-13 | 2010-12-27 | Пфайзер Продактс Инк. | Инъецируемые препаративные формы депо и способы обеспечения замедленного высвобождения композиций, состоящих из наночастиц |
| US20080305161A1 (en) * | 2005-04-13 | 2008-12-11 | Pfizer Inc | Injectable depot formulations and methods for providing sustained release of nanoparticle compositions |
| CA2603189A1 (en) * | 2005-04-13 | 2006-10-19 | Pfizer Products Inc. | Injectable depot formulations and methods for providing sustained release of poorly soluble drugs comprising nanoparticles |
| KR20080024206A (ko) * | 2005-06-20 | 2008-03-17 | 엘란 파마 인터내셔널 리미티드 | 아릴-헤테로시클릭 화합물을 함유하는 나노입자형 조절방출 조성물 |
| US20070027105A1 (en) | 2005-07-26 | 2007-02-01 | Alza Corporation | Peroxide removal from drug delivery vehicle |
| US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
| EP2117521B1 (en) | 2006-11-03 | 2012-06-27 | Durect Corporation | Transdermal delivery systems comprising bupivacaine |
| EP2152315B1 (en) | 2007-05-25 | 2016-01-06 | Indivior UK Limited | Sustained delivery formulations of risperidone compounds |
| WO2009088414A2 (en) | 2007-12-06 | 2009-07-16 | Durect Corporation | Oral pharmaceutical dosage forms |
| US20110144202A1 (en) * | 2008-06-16 | 2011-06-16 | Uwe Marx | Concentrated oxaliplatin solution and its method of preparation |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| GB2513060B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
| US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
| CA2905131A1 (en) | 2013-03-15 | 2014-09-18 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
| CN104688686A (zh) * | 2015-02-10 | 2015-06-10 | 万全万特制药江苏有限公司 | 一种含有齐拉西酮及其盐的脂肪乳注射剂 |
| KR102413459B1 (ko) | 2016-07-06 | 2022-06-24 | 듀렉트 코퍼레이션 | 약물 조성물, 장벽 층 및 약물 층을 갖는 경구 투여 형태 |
| WO2018015915A1 (en) * | 2016-07-22 | 2018-01-25 | Cadila Healthcare Limited | A parenteral controlled release composition of an atypical antipsychotic agent |
| JP2020063244A (ja) | 2018-10-15 | 2020-04-23 | アヴェント インコーポレイテッド | 神経アブレーションのための組成物、システム、キット及び方法 |
| KR20220140711A (ko) | 2020-01-13 | 2022-10-18 | 듀렉트 코퍼레이션 | 불순물이 감소된 지속 방출 약물 전달 시스템 및 관련 방법 |
| EP4277702A1 (en) | 2021-01-12 | 2023-11-22 | Durect Corporation | Sustained release drug delivery systems and related methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4029782A (en) * | 1975-04-28 | 1977-06-14 | Eli Lilly And Company | Cefazolin suspension for parenteral administration |
| US4512986A (en) * | 1983-07-26 | 1985-04-23 | Research Triangle Institute | Progrestationally active steroids |
| UA57734C2 (uk) * | 1996-05-07 | 2003-07-15 | Пфайзер Інк. | Комплекси включення арилгетероциклічних солей |
| US6130200A (en) * | 1996-12-20 | 2000-10-10 | Alza Corporation | Gel composition and methods |
| US6117949A (en) * | 1998-10-01 | 2000-09-12 | Macromed, Inc. | Biodegradable low molecular weight triblock poly (lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| US6201072B1 (en) * | 1997-10-03 | 2001-03-13 | Macromed, Inc. | Biodegradable low molecular weight triblock poly(lactide-co- glycolide) polyethylene glycol copolymers having reverse thermal gelation properties |
| DK1073432T3 (da) * | 1998-04-14 | 2007-12-17 | Gen Hospital Corp | Anvendelse af D serin eller D alanin til behandling af skizofreni |
| KR100477782B1 (ko) * | 1999-05-27 | 2005-03-21 | 화이자 프로덕츠 인코포레이티드 | 지프라시돈 현탁액 |
| US6753011B2 (en) * | 2000-01-14 | 2004-06-22 | Osmotica Corp | Combined diffusion/osmotic pumping drug delivery system |
| WO2002074200A1 (en) * | 2001-03-20 | 2002-09-26 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
| EP1269994A3 (en) * | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
-
2003
- 2003-10-13 CA CA002503076A patent/CA2503076A1/en not_active Abandoned
- 2003-10-13 JP JP2004546264A patent/JP2006514923A/ja not_active Abandoned
- 2003-10-13 EP EP03748483A patent/EP1575616A2/en not_active Withdrawn
- 2003-10-13 PL PL377679A patent/PL377679A1/pl not_active Application Discontinuation
- 2003-10-13 AU AU2003267788A patent/AU2003267788A1/en not_active Abandoned
- 2003-10-13 WO PCT/IB2003/004576 patent/WO2004037289A2/en not_active Ceased
- 2003-10-13 MX MXPA05002561A patent/MXPA05002561A/es unknown
- 2003-10-13 CN CNA2003801019024A patent/CN1849110A/zh active Pending
- 2003-10-13 BR BR0315568-4A patent/BR0315568A/pt not_active IP Right Cessation
- 2003-10-13 RU RU2005112207/15A patent/RU2310450C2/ru not_active IP Right Cessation
- 2003-10-13 KR KR1020057006986A patent/KR20050055781A/ko not_active Ceased
- 2003-10-14 PA PA20038586201A patent/PA8586201A1/es unknown
- 2003-10-21 US US10/690,078 patent/US20040138237A1/en not_active Abandoned
- 2003-10-22 NL NL1024590A patent/NL1024590C2/nl not_active IP Right Cessation
- 2003-10-22 PE PE2003001071A patent/PE20040499A1/es not_active Application Discontinuation
- 2003-10-24 TW TW092129568A patent/TW200423941A/zh unknown
- 2003-10-24 UY UY28038A patent/UY28038A1/es not_active Application Discontinuation
- 2003-10-24 AR ARP030103894A patent/AR041722A1/es not_active Application Discontinuation
-
2005
- 2005-03-07 ZA ZA200501921A patent/ZA200501921B/xx unknown
- 2005-05-23 NO NO20052463A patent/NO20052463L/no not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100908517B1 (ko) * | 2006-07-04 | 2009-07-20 | (주)아모레퍼시픽 | 호흡기계 약제 전달을 위한 서방형 다공성 미세입자 및 그제조 방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2003267788A1 (en) | 2004-05-13 |
| PA8586201A1 (es) | 2004-09-16 |
| RU2310450C2 (ru) | 2007-11-20 |
| NO20052463L (no) | 2005-05-23 |
| US20040138237A1 (en) | 2004-07-15 |
| TW200423941A (en) | 2004-11-16 |
| NL1024590A1 (nl) | 2004-04-27 |
| CA2503076A1 (en) | 2004-05-06 |
| WO2004037289A2 (en) | 2004-05-06 |
| ZA200501921B (en) | 2006-10-25 |
| UY28038A1 (es) | 2004-05-31 |
| CN1849110A (zh) | 2006-10-18 |
| NL1024590C2 (nl) | 2005-05-23 |
| WO2004037289A3 (en) | 2005-12-01 |
| PL377679A1 (pl) | 2006-02-06 |
| AR041722A1 (es) | 2005-05-26 |
| PE20040499A1 (es) | 2004-08-18 |
| MXPA05002561A (es) | 2005-05-05 |
| BR0315568A (pt) | 2005-08-23 |
| EP1575616A2 (en) | 2005-09-21 |
| RU2005112207A (ru) | 2005-09-10 |
| JP2006514923A (ja) | 2006-05-18 |
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