KR20020015077A - 축합 인돌린 유도체들과 5ｈｔ, 특히 5ｈｔ2ｃ, 수용체리간드로서 이들의 사용 - Google Patents

축합 인돌린 유도체들과 5ｈｔ, 특히 5ｈｔ2ｃ, 수용체리간드로서 이들의 사용 Download PDF

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KR20020015077A
KR20020015077A KR1020027001107A KR20027001107A KR20020015077A KR 20020015077 A KR20020015077 A KR 20020015077A KR 1020027001107 A KR1020027001107 A KR 1020027001107A KR 20027001107 A KR20027001107 A KR 20027001107A KR 20020015077 A KR20020015077 A KR 20020015077A
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South Korea
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compound
formula
indole
hydrogen
alkyl
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KR1020027001107A
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Korean (ko)
Inventor
조나단 리차드 안토니 로페이
제임스 에드워드 폴 데이비드슨
하워드 랑햄 만셀
리차드 존 햄린
데이비드 레지날드 아담스
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콜린 티 두리쉬
베르날리스 리서치 리미티드
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Publication of KR20020015077A publication Critical patent/KR20020015077A/ko
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Indole Compounds (AREA)
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KR1020027001107A 1999-08-11 2000-08-04 축합 인돌린 유도체들과 5ｈｔ, 특히 5ｈｔ2ｃ, 수용체리간드로서 이들의 사용 Abandoned KR20020015077A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9918965.6 1999-08-11
GBGB9918965.6A GB9918965D0 (en) 1999-08-11 1999-08-11 Chemical compounds xxi
PCT/GB2000/003008 WO2001012602A1 (en) 1999-08-11 2000-08-04 Condensed indoline derivatives and their use as 5ht, in particular 5ht2c, receptor ligands

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KR1020077014953A Division KR20070086814A (ko) 1999-08-11 2000-08-04 축합 인돌린 유도체들과 5ｈｔ, 특히 5ｈｔ2ｃ, 수용체리간드로서 이들의 사용

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KR20020015077A true KR20020015077A (ko) 2002-02-27

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KR1020027001107A Abandoned KR20020015077A (ko) 1999-08-11 2000-08-04 축합 인돌린 유도체들과 5ｈｔ, 특히 5ｈｔ2ｃ, 수용체리간드로서 이들의 사용
KR1020077014953A Ceased KR20070086814A (ko) 1999-08-11 2000-08-04 축합 인돌린 유도체들과 5ｈｔ, 특히 5ｈｔ2ｃ, 수용체리간드로서 이들의 사용

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US (10) US6962939B1 (enExample)
EP (1) EP1202964B1 (enExample)
JP (1) JP2003507366A (enExample)
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GB9918965D0 (en) * 1999-08-11 1999-10-13 Cerebrus Ltd Chemical compounds xxi
ATE433962T1 (de) 2000-11-20 2009-07-15 Biovitrum Ab Publ Piperazinylpyrazinverbindungen als antagonisten des serotonin-5-ht2-rezeptors
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
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ATE306470T1 (de) 2005-10-15
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US7323487B2 (en) 2008-01-29
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ES2250167T3 (es) 2006-04-16
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US20050197380A1 (en) 2005-09-08
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US20070099981A1 (en) 2007-05-03
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US20070105889A1 (en) 2007-05-10
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