TR200200351T2 - Yoğunlaştırılmış indolin türevleri, bunların 5HT, özellikle 5HT2C, reseptör ligandları olarak kullanımı - Google Patents
Yoğunlaştırılmış indolin türevleri, bunların 5HT, özellikle 5HT2C, reseptör ligandları olarak kullanımıInfo
- Publication number
- TR200200351T2 TR200200351T2 TR2002/00351T TR200200351T TR200200351T2 TR 200200351 T2 TR200200351 T2 TR 200200351T2 TR 2002/00351 T TR2002/00351 T TR 2002/00351T TR 200200351 T TR200200351 T TR 200200351T TR 200200351 T2 TR200200351 T2 TR 200200351T2
- Authority
- TR
- Turkey
- Prior art keywords
- alkyl
- hydrogen
- ring
- concentrated
- carbo
- Prior art date
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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- C07D209/56—Ring systems containing three or more rings
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- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/06—Peri-condensed systems
Abstract
Bir formül (I) bilesigi ve bunun farmasötik olarak uygun tuzlari,ekleme bilesikleri ve ön ilaçlari,burada R1 ve R2 bagimsiz olarak hidrojen ve alkilden seçilir; R3 alkildir; R4 ve R5 hidrojen ve alkilden seçilir; R6 ve R7 bagimsiz olarak hidrojen, halojen, hidroksi, alkil, aril, amino, alkilamino, dialkilamino, alkoksi, ariloksi, alkiltio, alkilsülfoksil, alkilsülfonil, nitro, karbonitril, karbo-alkoksi, karbo-ariloksi ve karboksilden seçilir; ve A, opsiyonel olarak bir veya daha fazla heteroatom içeren 5-veya 6-elemanli halkadir ki burada A halkasinin bagli oldugu fenil halkasinin doymamis karbon atomlari disindaki A halkasi atomlari doymus veya doymamistir; ve bunlarin tedavi amaciyla, özellikle bir 5HT reseptörü özellikle bir 5HT2C reseptörü agonisti veya antagonisti olarak, örnegin merkezi sinir sistemi rahatsizliklari, merkezi sinir sisteminin zarar görmesi; kardiyovasküler rahatsizliklar; mide-bagirsak rahatsizliklari; (DEVAMI VAR).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9918965.6A GB9918965D0 (en) | 1999-08-11 | 1999-08-11 | Chemical compounds xxi |
Publications (1)
Publication Number | Publication Date |
---|---|
TR200200351T2 true TR200200351T2 (tr) | 2002-06-21 |
Family
ID=10858983
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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TR2002/00351T TR200200351T2 (tr) | 1999-08-11 | 2000-08-04 | Yoğunlaştırılmış indolin türevleri, bunların 5HT, özellikle 5HT2C, reseptör ligandları olarak kullanımı |
Country Status (19)
Country | Link |
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US (10) | US6962939B1 (tr) |
EP (1) | EP1202964B1 (tr) |
JP (1) | JP2003507366A (tr) |
KR (2) | KR20070086814A (tr) |
CN (1) | CN1167681C (tr) |
AR (1) | AR030913A1 (tr) |
AT (1) | ATE306470T1 (tr) |
AU (1) | AU774337B2 (tr) |
BR (1) | BR0013314A (tr) |
CA (1) | CA2377637A1 (tr) |
DE (1) | DE60023146T2 (tr) |
ES (1) | ES2250167T3 (tr) |
GB (1) | GB9918965D0 (tr) |
MX (1) | MXPA01013252A (tr) |
PE (1) | PE20010575A1 (tr) |
TR (1) | TR200200351T2 (tr) |
UY (1) | UY26290A1 (tr) |
WO (1) | WO2001012602A1 (tr) |
ZA (1) | ZA200110218B (tr) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9918965D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
SE0004245D0 (sv) | 2000-11-20 | 2000-11-20 | Pharmacia Ab | Novel compounds and their use |
DK1337518T3 (da) | 2000-11-20 | 2009-10-19 | Biovitrum Ab Publ | Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren |
WO2002074746A1 (fr) * | 2001-03-16 | 2002-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Derives de benzazepine |
BR0211140A (pt) | 2001-07-13 | 2005-10-25 | Upjohn Co | Compostos e composições de indóis de hexaidroazepina (4, 5-g) e indolinas como ligantes de receptores 5-ht |
TWI312781B (en) | 2002-04-25 | 2009-08-01 | [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents | |
TW200307540A (en) * | 2002-04-25 | 2003-12-16 | Wyeth Corp | [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents |
TW200307682A (en) | 2002-04-25 | 2003-12-16 | Wyeth Corp | 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents |
AU2003243089B2 (en) | 2002-06-19 | 2010-01-07 | Biovitrum Ab (Publ) | Novel compounds, their use and preparation |
CL2004000826A1 (es) | 2003-04-25 | 2005-03-04 | Pfizer | Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129 |
GB0314967D0 (en) | 2003-06-26 | 2003-07-30 | Hoffmann La Roche | Piperazine derivatives |
AR046890A1 (es) | 2003-12-15 | 2005-12-28 | Alcon Inc | [1,4] oxazino [2,3-g] indazoles sustituidos para el tratamiento del glaucoma. |
WO2006022420A1 (ja) | 2004-08-25 | 2006-03-02 | Takeda Pharmaceutical Company Limited | 腹圧性尿失禁の予防・治療剤及びそのスクリーニング方法 |
GT200500317A (es) | 2004-11-05 | 2006-10-27 | Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos | |
US7425572B2 (en) | 2004-12-08 | 2008-09-16 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
AR054849A1 (es) | 2005-07-26 | 2007-07-18 | Wyeth Corp | Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas |
WO2007025144A1 (en) * | 2005-08-24 | 2007-03-01 | University Of Illinois - Chicago | 5-ht2c receptor agonists as anorectic agents |
JP5528699B2 (ja) | 2006-05-16 | 2014-06-25 | 武田薬品工業株式会社 | 縮合複素環化合物およびその用途 |
DE102006033114A1 (de) * | 2006-07-18 | 2008-01-24 | Grünenthal GmbH | Spirocyclische Azaindol-Derivate |
WO2009063992A1 (ja) | 2007-11-15 | 2009-05-22 | Takeda Pharmaceutical Company Limited | 縮合ピリジン誘導体およびその用途 |
EP2510949A4 (en) | 2009-12-11 | 2013-11-13 | Astellas Pharma Inc | THERAPEUTICS FOR FIBROMYALGIA |
JP5810099B2 (ja) | 2010-02-04 | 2015-11-11 | ザ・ボード・オブ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・イリノイThe Board Of Trustees Of The University Of Illinois | 5−ht(2b)受容体でアンタゴニスト活性を有する高選択性5−ht(2c)受容体アゴニスト |
ES2889876T3 (es) | 2015-01-29 | 2022-01-14 | Univ Illinois | Ciclopropilmetanaminas como agonistas selectivos del receptor 5-HT(2C) |
WO2018151240A1 (ja) * | 2017-02-17 | 2018-08-23 | 第一三共株式会社 | 3,6,7,8-テトラヒドロシクロペンタ[e]インドール化合物 |
WO2018151239A1 (ja) * | 2017-02-17 | 2018-08-23 | 第一三共株式会社 | 3,6-ジヒドロ-2H-フロ[2,3-e]インドール化合物 |
EP3733204A4 (en) | 2017-12-27 | 2021-09-15 | Takeda Pharmaceutical Company Limited | THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE |
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US2541211A (en) | 1948-10-15 | 1951-02-13 | Searle & Co | Tertiary-aminoalkyl-tetrahydrocarbazoles |
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DE930988C (de) | 1953-01-01 | 1955-07-28 | Bayer Ag | Verfahren zur Herstellung von basisch alkylierten Tetrahydrocarbazolen oder Indolen |
US3329571A (en) | 1961-10-24 | 1967-07-04 | American Home Prod | Methods for treating depression |
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TW334423B (en) * | 1993-10-22 | 1998-06-21 | Hoffmann La Roche | Tricyclic 1-aminoethylpyrrole-derivatives |
GB9326192D0 (en) * | 1993-12-22 | 1994-02-23 | Glaxo Group Ltd | Chemical compounds |
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FR2742047B1 (fr) * | 1995-12-06 | 1998-01-16 | Oreal | Compositions de teinture des fibres keratiniques contenant des derives n-substitues de la 4-hydroxy indoline, nouveaux derives, leur procede de synthese, leur utilisation pour la teinture, et procede de teinture |
AU5343298A (en) | 1997-01-13 | 1998-08-03 | Yamanouchi Pharmaceutical Co., Ltd. | 5-ht2c receptor agonists and aminoalkylindazole derivatives |
AU727654B2 (en) * | 1997-06-13 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Tricyclic pyrazole derivative |
GB9819019D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds II |
GB9819035D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
GB9819033D0 (en) | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds VI |
GB9918965D0 (en) * | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxi |
GB9918962D0 (en) | 1999-08-11 | 1999-10-13 | Cerebrus Ltd | Chemical compounds xxii |
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1999
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2000
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- 2000-08-04 EP EP00951696A patent/EP1202964B1/en not_active Expired - Lifetime
- 2000-08-04 TR TR2002/00351T patent/TR200200351T2/tr unknown
- 2000-08-04 KR KR1020077014953A patent/KR20070086814A/ko not_active Application Discontinuation
- 2000-08-04 JP JP2001517500A patent/JP2003507366A/ja not_active Abandoned
- 2000-08-04 AT AT00951696T patent/ATE306470T1/de not_active IP Right Cessation
- 2000-08-04 DE DE60023146T patent/DE60023146T2/de not_active Expired - Fee Related
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- 2000-08-04 BR BR0013314-0A patent/BR0013314A/pt not_active IP Right Cessation
- 2000-08-04 KR KR1020027001107A patent/KR20020015077A/ko active IP Right Grant
- 2000-08-04 WO PCT/GB2000/003008 patent/WO2001012602A1/en active IP Right Grant
- 2000-08-04 CA CA002377637A patent/CA2377637A1/en not_active Abandoned
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- 2000-08-11 UY UY26290A patent/UY26290A1/es not_active Application Discontinuation
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2001
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2005
- 2005-04-29 US US11/117,460 patent/US7166632B2/en not_active Expired - Fee Related
- 2005-04-29 US US11/117,488 patent/US7173056B2/en not_active Expired - Fee Related
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2006
- 2006-12-12 US US11/637,042 patent/US7323473B2/en not_active Expired - Fee Related
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2007
- 2007-11-21 US US11/984,734 patent/US20080125455A1/en not_active Abandoned
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- 2007-12-04 US US11/987,774 patent/US20080090858A1/en not_active Abandoned
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