KR20020010923A - 트리시클릭 진통제 - Google Patents

트리시클릭 진통제 Download PDF

Info

Publication number
KR20020010923A
KR20020010923A KR1020017015730A KR20017015730A KR20020010923A KR 20020010923 A KR20020010923 A KR 20020010923A KR 1020017015730 A KR1020017015730 A KR 1020017015730A KR 20017015730 A KR20017015730 A KR 20017015730A KR 20020010923 A KR20020010923 A KR 20020010923A
Authority
KR
South Korea
Prior art keywords
piperidine
naphthalene
dihydro
oxospiro
methoxy
Prior art date
Application number
KR1020017015730A
Other languages
English (en)
Korean (ko)
Inventor
알랭 깔베뜨
앙리 자꼬벨리
조셀린느 뿌오드
프랑소아 제이. 로망
자끄 하몽
아그네스 그로엘
Original Assignee
로즈 암스트롱, 크리스틴 에이. 트러트웨인
워너-램버트 캄파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 로즈 암스트롱, 크리스틴 에이. 트러트웨인, 워너-램버트 캄파니 filed Critical 로즈 암스트롱, 크리스틴 에이. 트러트웨인
Publication of KR20020010923A publication Critical patent/KR20020010923A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020017015730A 1999-06-07 2000-06-07 트리시클릭 진통제 KR20020010923A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13786899P 1999-06-07 1999-06-07
US60/137,868 1999-06-07
PCT/EP2000/005783 WO2000075116A2 (en) 1999-06-07 2000-06-07 Tricyclic analgesics

Publications (1)

Publication Number Publication Date
KR20020010923A true KR20020010923A (ko) 2002-02-06

Family

ID=22479397

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017015730A KR20020010923A (ko) 1999-06-07 2000-06-07 트리시클릭 진통제

Country Status (21)

Country Link
EP (1) EP1235808A2 (xx)
JP (1) JP2003513006A (xx)
KR (1) KR20020010923A (xx)
CN (1) CN1635998A (xx)
AP (1) AP2001002356A0 (xx)
AU (1) AU6428400A (xx)
BG (1) BG106162A (xx)
BR (1) BR0011427A (xx)
CA (1) CA2376076A1 (xx)
EA (1) EA200101117A1 (xx)
HR (1) HRP20010913A2 (xx)
HU (1) HUP0203317A2 (xx)
IL (1) IL146755A0 (xx)
IS (1) IS6175A (xx)
MA (1) MA26795A1 (xx)
MX (1) MXPA01012694A (xx)
NO (1) NO20015966D0 (xx)
PL (1) PL357340A1 (xx)
SK (1) SK17512001A3 (xx)
TR (1) TR200103531T2 (xx)
WO (1) WO2000075116A2 (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
FR2915099B1 (fr) * 2007-04-19 2009-06-05 Sanofi Aventis Sa Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes craniens
KR101923367B1 (ko) * 2011-02-02 2018-12-04 버텍스 파마슈티칼스 인코포레이티드 이온 채널의 조절제로서의 피롤로피라진―스피로사이클릭 피페리딘 아미드
CN115872873A (zh) * 2022-12-29 2023-03-31 上海泰坦科技股份有限公司 一种双（2-溴乙基）胺氢溴酸盐的重结晶纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8917069D0 (en) * 1989-07-26 1989-09-13 Merck Sharp & Dohme Therapeutic agents
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
EP0681571B1 (en) * 1993-01-28 1998-07-29 Merck & Co. Inc. Spiro-substituted azacycles as tachykinin receptor antagonists
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
AU5604998A (en) * 1996-12-13 1998-07-03 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013644A (en) * 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
WO2000075116A2 (en) 2000-12-14
AP2001002356A0 (en) 2001-12-31
TR200103531T2 (tr) 2002-06-21
BG106162A (bg) 2002-05-31
AU6428400A (en) 2000-12-28
EP1235808A2 (en) 2002-09-04
EA200101117A1 (ru) 2002-06-27
SK17512001A3 (sk) 2002-11-06
HRP20010913A2 (en) 2003-04-30
MA26795A1 (fr) 2004-12-20
NO20015966L (no) 2001-12-06
CA2376076A1 (en) 2000-12-14
WO2000075116A3 (en) 2002-07-04
JP2003513006A (ja) 2003-04-08
NO20015966D0 (no) 2001-12-06
MXPA01012694A (es) 2003-10-15
IS6175A (is) 2001-11-23
HUP0203317A2 (hu) 2003-02-28
CN1635998A (zh) 2005-07-06
BR0011427A (pt) 2002-03-26
IL146755A0 (en) 2002-07-25
PL357340A1 (en) 2004-07-26

Similar Documents

Publication Publication Date Title
KR101027570B1 (ko) 중추 및 말초 신경계 장애의 치료를 위한 방법 및 조성물, 및 그에 유용한 신규 화합물
AU629835B2 (en) Novel benzopyrido piperidine, piperidylidene and piperazine compounds, compositions, methods of manufacture and methods of use
EP0546388B1 (de) Azaheterocyclylmethyl-chromane als Wirkstoffe zur Behandlung von Erkrankungen des Zentralnervensystems
US5652246A (en) Piperidine compounds
DE60214990T2 (de) Benzolsulfonsäureester-indol-5-yl als 5-ht6 rezeptor-antagonisten
JPH08502511A (ja) ４−カルボキサミドピペリジン誘導体、中間体及びノイロキニンアンタゴニストとしての使用
US6642257B2 (en) Agents for treating neuropathic pain
EA011635B1 (ru) Новые производные амида гетероциклической карбоновой кислоты
JP2010502606A (ja) カルシウムチャンネル遮断薬としてのインドロキノリン化合物
JP3498849B2 (ja) ニューロキニンａ拮抗剤としての二環式複素環化合物
JP2015143255A (ja) 疼痛症候群および他の障害の治療法
JP3286268B2 (ja) ジアザ−スピロ〔３，５〕−ノナン誘導体
DE60017446T2 (de) Isochinolin- und Chinazolinderivate mit kombinierter 5-HT1A-, 5-HT1B- und 5-HT1D- Rezeptoraffinität
FR2471981A1 (fr) Nouveaux derives de la (piperidyl-4)-2 (quinolyl-4)-1 ethanone, produits intermediaires et procedes pour leur preparation, et leur utilisation comme medicaments
EP1075471B1 (en) Indolyl derivatives as serotonergic agents
NZ195329A (en) 6,7-benzomorphan derivatives and pharmaceutical compositions
KR850000026B1 (ko) 1-(4-아릴-사이클로헥실) 피페리딘 유도체의 제조방법
KR20020010923A (ko) 트리시클릭 진통제
SK278557B6 (en) Piperidylmethyl substituted derivatives of chroman, producing method and use thereof, and pharmaceutical composition containing same
CA1100136A (en) 4a-aryl octahydro-1h-2-pyrindines
US20040266802A1 (en) Tricyclic analgesics
WO1990001025A1 (en) Enamine quaternary compounds, methods of making and their use as muscle relaxants
EA003991B1 (ru) Производные 2-аминопиридинов, способ ингибирования синтазы оксида азота, фармацевтические композиции и способы лечения
US20050154020A1 (en) 4-Aryl piperidines
DE3124086A1 (de) Heterozyklische verbindungen, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, welche diese verbindungen enthalten

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid