HRP20010913A2 - Tricyclic analgesics - Google Patents
Tricyclic analgesics Download PDFInfo
- Publication number
- HRP20010913A2 HRP20010913A2 HR20010913A HRP20010913A HRP20010913A2 HR P20010913 A2 HRP20010913 A2 HR P20010913A2 HR 20010913 A HR20010913 A HR 20010913A HR P20010913 A HRP20010913 A HR P20010913A HR P20010913 A2 HRP20010913 A2 HR P20010913A2
- Authority
- HR
- Croatia
- Prior art keywords
- piperidine
- naphthalene
- oxospiro
- dihydro
- methoxy
- Prior art date
Links
- 229940035676 analgesics Drugs 0.000 title description 2
- 239000000730 antalgic agent Substances 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims description 70
- 238000000034 method Methods 0.000 claims description 23
- 208000002193 Pain Diseases 0.000 claims description 21
- 239000000203 mixture Substances 0.000 claims description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims description 20
- 239000001257 hydrogen Substances 0.000 claims description 19
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 17
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 14
- 238000011282 treatment Methods 0.000 claims description 14
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 13
- 241000124008 Mammalia Species 0.000 claims description 10
- 230000036407 pain Effects 0.000 claims description 10
- 150000002431 hydrogen Chemical class 0.000 claims description 9
- 125000005843 halogen group Chemical group 0.000 claims description 8
- 150000003839 salts Chemical class 0.000 claims description 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 6
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- UFTZAIGLEUTKQH-UHFFFAOYSA-N spiro[3,4-dihydronaphthalene-2,4'-piperidine]-1-one Chemical compound O=C1C2=CC=CC=C2CCC11CCNCC1 UFTZAIGLEUTKQH-UHFFFAOYSA-N 0.000 claims description 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 5
- 125000003342 alkenyl group Chemical group 0.000 claims description 5
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- ODLAPCNVGLBQPY-UHFFFAOYSA-N 1'-(cyclopropylmethyl)spiro[8,9-dihydro-7h-benzo[7]annulene-6,4'-piperidine]-5-one Chemical compound O=C1C2=CC=CC=C2CCCC1(CC1)CCN1CC1CC1 ODLAPCNVGLBQPY-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13786899P | 1999-06-07 | 1999-06-07 | |
| PCT/EP2000/005783 WO2000075116A2 (en) | 1999-06-07 | 2000-06-07 | Tricyclic analgesics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20010913A2 true HRP20010913A2 (en) | 2003-04-30 |
Family
ID=22479397
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010913A HRP20010913A2 (en) | 1999-06-07 | 2001-12-07 | Tricyclic analgesics |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1235808A2 (xx) |
| JP (1) | JP2003513006A (xx) |
| KR (1) | KR20020010923A (xx) |
| CN (1) | CN1635998A (xx) |
| AP (1) | AP2001002356A0 (xx) |
| AU (1) | AU6428400A (xx) |
| BG (1) | BG106162A (xx) |
| BR (1) | BR0011427A (xx) |
| CA (1) | CA2376076A1 (xx) |
| EA (1) | EA200101117A1 (xx) |
| HR (1) | HRP20010913A2 (xx) |
| HU (1) | HUP0203317A2 (xx) |
| IL (1) | IL146755A0 (xx) |
| IS (1) | IS6175A (xx) |
| MA (1) | MA26795A1 (xx) |
| MX (1) | MXPA01012694A (xx) |
| NO (1) | NO20015966D0 (xx) |
| PL (1) | PL357340A1 (xx) |
| SK (1) | SK17512001A3 (xx) |
| TR (1) | TR200103531T2 (xx) |
| WO (1) | WO2000075116A2 (xx) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| FR2915099B1 (fr) * | 2007-04-19 | 2009-06-05 | Sanofi Aventis Sa | Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes craniens |
| SI2670752T1 (sl) * | 2011-02-02 | 2016-10-28 | Vertex Pharmaceuticals Incorporated | Pirolopirazin-spirociklični piperidin amidi kot modulatorji ionskih kanalčkov |
| CN115872873A (zh) * | 2022-12-29 | 2023-03-31 | 上海泰坦科技股份有限公司 | 一种双（2-溴乙基）胺氢溴酸盐的重结晶纯化方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8917069D0 (en) * | 1989-07-26 | 1989-09-13 | Merck Sharp & Dohme | Therapeutic agents |
| IL96507A0 (en) * | 1989-12-08 | 1991-08-16 | Merck & Co Inc | Nitrogen-containing spirocycles and pharmaceutical compositions containing them |
| JPH08505880A (ja) * | 1993-01-28 | 1996-06-25 | メルク エンド カンパニー インコーポレーテッド | タキキニン受容体拮抗薬としてのスピロ置換アザ環式化合物 |
| US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
| WO1998025604A1 (en) * | 1996-12-13 | 1998-06-18 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
| US6013644A (en) * | 1997-12-12 | 2000-01-11 | Merck & Co., Inc. | Spiro-substituted azacycles as modulators of chemokine receptor activity |
-
2000
- 2000-06-07 WO PCT/EP2000/005783 patent/WO2000075116A2/en not_active Application Discontinuation
- 2000-06-07 SK SK1751-2001A patent/SK17512001A3/sk unknown
- 2000-06-07 CA CA002376076A patent/CA2376076A1/en not_active Abandoned
- 2000-06-07 JP JP2001501597A patent/JP2003513006A/ja active Pending
- 2000-06-07 MX MXPA01012694A patent/MXPA01012694A/es unknown
- 2000-06-07 BR BR0011427-8A patent/BR0011427A/pt not_active IP Right Cessation
- 2000-06-07 CN CNA008086427A patent/CN1635998A/zh active Pending
- 2000-06-07 KR KR1020017015730A patent/KR20020010923A/ko not_active Application Discontinuation
- 2000-06-07 AP APAP/P/2001/002356A patent/AP2001002356A0/en unknown
- 2000-06-07 EP EP00951290A patent/EP1235808A2/en not_active Withdrawn
- 2000-06-07 HU HU0203317A patent/HUP0203317A2/hu unknown
- 2000-06-07 IL IL14675500A patent/IL146755A0/xx unknown
- 2000-06-07 AU AU64284/00A patent/AU6428400A/en not_active Abandoned
- 2000-06-07 EA EA200101117A patent/EA200101117A1/ru unknown
- 2000-06-07 TR TR2001/03531T patent/TR200103531T2/xx unknown
- 2000-06-07 PL PL00357340A patent/PL357340A1/xx not_active Application Discontinuation
-
2001
- 2001-11-23 IS IS6175A patent/IS6175A/is unknown
- 2001-11-30 BG BG106162A patent/BG106162A/bg unknown
- 2001-11-30 MA MA26431A patent/MA26795A1/fr unknown
- 2001-12-06 NO NO20015966A patent/NO20015966D0/no not_active Application Discontinuation
- 2001-12-07 HR HR20010913A patent/HRP20010913A2/hr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR200103531T2 (tr) | 2002-06-21 |
| NO20015966L (no) | 2001-12-06 |
| MXPA01012694A (es) | 2003-10-15 |
| AP2001002356A0 (en) | 2001-12-31 |
| EA200101117A1 (ru) | 2002-06-27 |
| WO2000075116A2 (en) | 2000-12-14 |
| KR20020010923A (ko) | 2002-02-06 |
| MA26795A1 (fr) | 2004-12-20 |
| IL146755A0 (en) | 2002-07-25 |
| CA2376076A1 (en) | 2000-12-14 |
| BR0011427A (pt) | 2002-03-26 |
| CN1635998A (zh) | 2005-07-06 |
| AU6428400A (en) | 2000-12-28 |
| EP1235808A2 (en) | 2002-09-04 |
| SK17512001A3 (sk) | 2002-11-06 |
| BG106162A (bg) | 2002-05-31 |
| HUP0203317A2 (hu) | 2003-02-28 |
| JP2003513006A (ja) | 2003-04-08 |
| PL357340A1 (en) | 2004-07-26 |
| WO2000075116A3 (en) | 2002-07-04 |
| NO20015966D0 (no) | 2001-12-06 |
| IS6175A (is) | 2001-11-23 |
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