BR0011427A - Analgésicos tricìclicos - Google Patents

Analgésicos tricìclicos

Info

Publication number
BR0011427A
BR0011427A BR0011427-8A BR0011427A BR0011427A BR 0011427 A BR0011427 A BR 0011427A BR 0011427 A BR0011427 A BR 0011427A BR 0011427 A BR0011427 A BR 0011427A
Authority
BR
Brazil
Prior art keywords
alkyl
hydrogen
cycloalkyl
alkenyl
hydroxy
Prior art date
Application number
BR0011427-8A
Other languages
English (en)
Portuguese (pt)
Inventor
Alain Calvet
Henri Jacobelli
Jocelyne Puaud
Francois J Roman
Jacques Hamon
Agnes Grouhel
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of BR0011427A publication Critical patent/BR0011427A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
BR0011427-8A 1999-06-07 2000-06-07 Analgésicos tricìclicos BR0011427A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13786899P 1999-06-07 1999-06-07
PCT/EP2000/005783 WO2000075116A2 (en) 1999-06-07 2000-06-07 Tricyclic analgesics

Publications (1)

Publication Number Publication Date
BR0011427A true BR0011427A (pt) 2002-03-26

Family

ID=22479397

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0011427-8A BR0011427A (pt) 1999-06-07 2000-06-07 Analgésicos tricìclicos

Country Status (21)

Country Link
EP (1) EP1235808A2 (xx)
JP (1) JP2003513006A (xx)
KR (1) KR20020010923A (xx)
CN (1) CN1635998A (xx)
AP (1) AP2001002356A0 (xx)
AU (1) AU6428400A (xx)
BG (1) BG106162A (xx)
BR (1) BR0011427A (xx)
CA (1) CA2376076A1 (xx)
EA (1) EA200101117A1 (xx)
HR (1) HRP20010913A2 (xx)
HU (1) HUP0203317A2 (xx)
IL (1) IL146755A0 (xx)
IS (1) IS6175A (xx)
MA (1) MA26795A1 (xx)
MX (1) MXPA01012694A (xx)
NO (1) NO20015966D0 (xx)
PL (1) PL357340A1 (xx)
SK (1) SK17512001A3 (xx)
TR (1) TR200103531T2 (xx)
WO (1) WO2000075116A2 (xx)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030045449A1 (en) * 2001-08-15 2003-03-06 Pfizer, Inc. Pharmaceutical combinations for the treatment of neurodegenerative diseases
FR2915099B1 (fr) * 2007-04-19 2009-06-05 Sanofi Aventis Sa Utilisation du 4-cyclopropylmethoxy-n-(3,5-dichloro-1-oxydo- pyridin-4-yl)-5-(methoxy)pyridine-2-carboxamide pour le traitement des traumatismes craniens
SI2670752T1 (sl) * 2011-02-02 2016-10-28 Vertex Pharmaceuticals Incorporated Pirolopirazin-spirociklični piperidin amidi kot modulatorji ionskih kanalčkov
CN115872873A (zh) * 2022-12-29 2023-03-31 上海泰坦科技股份有限公司 一种双（2-溴乙基）胺氢溴酸盐的重结晶纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8917069D0 (en) * 1989-07-26 1989-09-13 Merck Sharp & Dohme Therapeutic agents
IL96507A0 (en) * 1989-12-08 1991-08-16 Merck & Co Inc Nitrogen-containing spirocycles and pharmaceutical compositions containing them
JPH08505880A (ja) * 1993-01-28 1996-06-25 メルク エンド カンパニー インコーポレーテッド タキキニン受容体拮抗薬としてのスピロ置換アザ環式化合物
US5439914A (en) * 1994-02-18 1995-08-08 Merck & Co., Inc. Spirocycles
WO1998025604A1 (en) * 1996-12-13 1998-06-18 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity
US6013644A (en) * 1997-12-12 2000-01-11 Merck & Co., Inc. Spiro-substituted azacycles as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
TR200103531T2 (tr) 2002-06-21
NO20015966L (no) 2001-12-06
MXPA01012694A (es) 2003-10-15
AP2001002356A0 (en) 2001-12-31
EA200101117A1 (ru) 2002-06-27
WO2000075116A2 (en) 2000-12-14
KR20020010923A (ko) 2002-02-06
MA26795A1 (fr) 2004-12-20
HRP20010913A2 (en) 2003-04-30
IL146755A0 (en) 2002-07-25
CA2376076A1 (en) 2000-12-14
CN1635998A (zh) 2005-07-06
AU6428400A (en) 2000-12-28
EP1235808A2 (en) 2002-09-04
SK17512001A3 (sk) 2002-11-06
BG106162A (bg) 2002-05-31
HUP0203317A2 (hu) 2003-02-28
JP2003513006A (ja) 2003-04-08
PL357340A1 (en) 2004-07-26
WO2000075116A3 (en) 2002-07-04
NO20015966D0 (no) 2001-12-06
IS6175A (is) 2001-11-23

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7O, 8O E 9O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 DA RPI 2008 DE 30/06/2009.