KR20010108228A - 도파민 ｄ1 수용체 효능제 화합물 - Google Patents

도파민 ｄ1 수용체 효능제 화합물 Download PDF

Info

Publication number
KR20010108228A
KR20010108228A KR1020017010418A KR20017010418A KR20010108228A KR 20010108228 A KR20010108228 A KR 20010108228A KR 1020017010418 A KR1020017010418 A KR 1020017010418A KR 20017010418 A KR20017010418 A KR 20017010418A KR 20010108228 A KR20010108228 A KR 20010108228A
Authority
KR
South Korea
Prior art keywords
hydrogen
tetrahydro
chloro
mmol
dopamine
Prior art date
Application number
KR1020017010418A
Other languages
English (en)
Korean (ko)
Inventor
틸브룩게리
Original Assignee
스미스 티. 더블유
세너스 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 스미스 티. 더블유, 세너스 리미티드 filed Critical 스미스 티. 더블유
Publication of KR20010108228A publication Critical patent/KR20010108228A/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
KR1020017010418A 1999-02-17 2000-02-17 도파민 ｄ1 수용체 효능제 화합물 KR20010108228A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9903671.7 1999-02-17
GBGB9903671.7A GB9903671D0 (en) 1999-02-17 1999-02-17 Dopamine D-1 receptor agonist compounds
PCT/GB2000/000570 WO2000049000A1 (en) 1999-02-17 2000-02-17 Dopamine d1 receptor agonist compounds

Publications (1)

Publication Number Publication Date
KR20010108228A true KR20010108228A (ko) 2001-12-07

Family

ID=10847990

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020017010418A KR20010108228A (ko) 1999-02-17 2000-02-17 도파민 ｄ1 수용체 효능제 화합물

Country Status (17)

Country Link
EP (1) EP1157009A1 (de)
JP (1) JP2002537288A (de)
KR (1) KR20010108228A (de)
CN (1) CN1142916C (de)
AU (1) AU767332B2 (de)
BR (1) BR0008329A (de)
CA (1) CA2363695A1 (de)
CZ (1) CZ20012973A3 (de)
EA (1) EA004745B1 (de)
GB (1) GB9903671D0 (de)
HU (1) HUP0200057A3 (de)
IL (1) IL144810A0 (de)
MX (1) MXPA01008294A (de)
NO (1) NO20013978L (de)
PL (1) PL349838A1 (de)
WO (1) WO2000049000A1 (de)
ZA (1) ZA200106478B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0130576D0 (en) * 2001-12-20 2002-02-06 Cenes Ltd Dopamine D1 receptor agonist pro-drug compounds & derivatives
KR20080044840A (ko) 2005-07-15 2008-05-21 에이엠알 테크놀로지, 인크. 아릴- 및 헤테로아릴-치환된 테트라히드로벤자제핀, 및노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기위한 용도
AU2006278514A1 (en) * 2005-08-03 2007-02-15 Mia Levite Killing human lymphoma and leukemia cancer cells and TCR-activated normal human cells by dopamine D1R agonists
CN101684096A (zh) * 2008-09-23 2010-03-31 中国科学院上海药物研究所 一类新型苯并氮杂卓类化合物及其制备方法和用途
CN102276531A (zh) * 2011-05-30 2011-12-14 扬子江药业集团广州海瑞药业有限公司 一种甲磺酸非诺多泮的制备方法
CA2916653C (en) 2013-06-27 2017-07-18 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1561305A (en) * 1975-07-02 1980-02-20 Smithkline Corp Benzazepine derivatives and pharmeceutical compositions containing them
US4111957A (en) * 1977-02-02 1978-09-05 Smithkline Corporation Substituted 1-thienyl and furyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4265889A (en) * 1978-05-05 1981-05-05 Smithkline Corporation 6-Lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
US4707483A (en) * 1985-12-20 1987-11-17 Smithkline Beckman Corporation 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
US4861771A (en) * 1989-01-27 1989-08-29 Smithkline Beckman Corporation Carbamates of 6-chloro-7,8-dihydroxy-1-(4'-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine as prodrugs

Also Published As

Publication number Publication date
AU2563200A (en) 2000-09-04
WO2000049000A1 (en) 2000-08-24
ZA200106478B (en) 2002-02-07
HUP0200057A2 (en) 2002-08-28
NO20013978D0 (no) 2001-08-15
CN1341102A (zh) 2002-03-20
NO20013978L (no) 2001-08-15
BR0008329A (pt) 2002-01-29
MXPA01008294A (es) 2002-07-02
AU767332B2 (en) 2003-11-06
EP1157009A1 (de) 2001-11-28
CN1142916C (zh) 2004-03-24
CZ20012973A3 (cs) 2002-01-16
GB9903671D0 (en) 1999-04-14
IL144810A0 (en) 2002-06-30
EA004745B1 (ru) 2004-08-26
HUP0200057A3 (en) 2004-03-29
PL349838A1 (en) 2002-09-23
CA2363695A1 (en) 2000-08-24
EA200100783A1 (ru) 2002-02-28
JP2002537288A (ja) 2002-11-05

Similar Documents

Publication Publication Date Title
EP0690843B1 (de) Formyl- oder Cyano- substituierte Indolderivate mit dopaminergischer Wirkung
JP3299321B2 (ja) ２−アミノメチル−クロマン類
US20050032873A1 (en) 3-Amino chroman and 2-amino tetralin derivatives
CN113874355B (zh) 制造(6ar,10ar)-7-丙基-6,6a,7,8,9,10,10a,11-八氢-[1,3]二氧杂环戊并[4’,5’:5,6]苯并[1,2-g]喹啉和(4ar,10ar)-1-丙基-1,2,3,4,4a,5,10,10a-八氢-苯并[g]喹啉-6,7-二醇的方法
JPH05279357A (ja) アザヘテロサイクリルメチル−クロマン類
NZ512732A (en) Piperidine, tetrahydropyridine and piperazine derivatives useful in treating affective disorders
CA2612109A1 (en) Tricyclic compounds useful as serotonin inhibitors and 5-ht1a agonists and antagonists
KR970005323B1 (ko) 치료용으로 유용한 테트랄린 유도체
JP2818692B2 (ja) 新規な８―置換―２―アミノテトラリン類
JPH03120218A (ja) 痛みおよび／または中枢神経系障害の新規治療用医薬およびそれに用いる複素環式化合物
HU222728B1 (hu) Kroménszármazékok, eljárás elżállításukra és az ezeket tartalmazó gyógyászati készítmények
KR20010108228A (ko) 도파민 ｄ1 수용체 효능제 화합물
IE58883B1 (en) Nitrogen containing compounds
CA1079639A (en) 3-benzazepine derivatives
JP7390401B2 (ja) 縮合環化合物、その製造方法及び用途
US5196454A (en) Method of treating disorders of the dopaminergic systems using 2,5-diaminotetralines
JPH08507498A (ja) 複素環式化合物、それらの使用および製法
IE61006B1 (en) New tricyclic amines derived from 2,3,5,6,7,8-hexahydronaphto (2,3-b) furan and from 2,3,6,7,8,9-hexahydro-5H-benzocyclohepta (2,3-b) furan, the processes for preparing them and the pharmaceutical compositions which contain them
JPH093068A (ja) ベンズイソチアゾリル置換アミノメチルクロマン
US6800637B2 (en) Antidepressant indolealkyl derivatives of heterocycle-fused benzodioxan methylamines
JP2000239270A (ja) 新規複素環化合物、その製造方法、及びそれを含有する医薬組成物
KR850000383B1 (ko) 2-(4-하이드록시알킬-1-퍼페라지닐)-2,4,6-사이클로헵타트리엔-1-온 유도체의 제조방법
FR2588258A1 (fr) Nouveaux derives d'amino-5 valeronitrile, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
WO2003053936A1 (en) Dopamine d1 receptor agonist pro-drug compounds & derivatives
JP2005504823A (ja) 神経栄養剤としてのトリアゼピン誘導体

Legal Events

Date Code Title Description
N231 Notification of change of applicant
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid