KR20010093290A - 사람 파필로마바이러스 백신 제제 - Google Patents
사람 파필로마바이러스 백신 제제 Download PDFInfo
- Publication number
- KR20010093290A KR20010093290A KR1020017009504A KR20017009504A KR20010093290A KR 20010093290 A KR20010093290 A KR 20010093290A KR 1020017009504 A KR1020017009504 A KR 1020017009504A KR 20017009504 A KR20017009504 A KR 20017009504A KR 20010093290 A KR20010093290 A KR 20010093290A
- Authority
- KR
- South Korea
- Prior art keywords
- hpv
- vaccine
- aluminum
- vaccine formulation
- nacl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 76
- 238000009472 formulation Methods 0.000 title claims abstract description 69
- 229940124866 human papillomavirus vaccine Drugs 0.000 title 1
- 241000701806 Human papillomavirus Species 0.000 claims abstract description 103
- 229910052782 aluminium Inorganic materials 0.000 claims abstract description 65
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims abstract description 44
- 229960005486 vaccine Drugs 0.000 claims abstract description 44
- 239000000872 buffer Substances 0.000 claims abstract description 30
- 150000003839 salts Chemical class 0.000 claims abstract description 29
- 239000003381 stabilizer Substances 0.000 claims abstract description 16
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 11
- 229920000831 ionic polymer Polymers 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 9
- 239000003599 detergent Substances 0.000 claims abstract description 5
- 241000700605 Viruses Species 0.000 claims abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 72
- 239000011780 sodium chloride Substances 0.000 claims description 36
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 35
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 26
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 25
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 25
- 239000000243 solution Substances 0.000 claims description 21
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 19
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- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 18
- 229940068968 polysorbate 80 Drugs 0.000 claims description 18
- 239000002671 adjuvant Substances 0.000 claims description 16
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 16
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 9
- 241000701828 Human papillomavirus type 11 Species 0.000 claims description 8
- -1 glutathione oxide Chemical compound 0.000 claims description 7
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 6
- 108091034057 RNA (poly(A)) Proteins 0.000 claims description 6
- 229920000669 heparin Polymers 0.000 claims description 6
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- 238000000034 method Methods 0.000 claims description 6
- 239000011734 sodium Substances 0.000 claims description 5
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- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims description 4
- 239000001103 potassium chloride Substances 0.000 claims description 4
- 229940068977 polysorbate 20 Drugs 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- 239000001488 sodium phosphate Substances 0.000 claims description 3
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 3
- 239000004094 surface-active agent Substances 0.000 claims description 3
- IDOQDZANRZQBTP-UHFFFAOYSA-N 2-[2-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=CC=C1OCCO IDOQDZANRZQBTP-UHFFFAOYSA-N 0.000 claims description 2
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 claims description 2
- IEQAICDLOKRSRL-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO IEQAICDLOKRSRL-UHFFFAOYSA-N 0.000 claims description 2
- 108010088751 Albumins Proteins 0.000 claims description 2
- 102000009027 Albumins Human genes 0.000 claims description 2
- 108010071390 Serum Albumin Proteins 0.000 claims description 2
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- PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims description 2
- 239000013504 Triton X-100 Substances 0.000 claims description 2
- 229920004890 Triton X-100 Polymers 0.000 claims description 2
- 229920004929 Triton X-114 Polymers 0.000 claims description 2
- PVGBHEUCHKGFQP-UHFFFAOYSA-N sodium;n-[5-amino-2-(4-aminophenyl)sulfonylphenyl]sulfonylacetamide Chemical compound [Na+].CC(=O)NS(=O)(=O)C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=C1 PVGBHEUCHKGFQP-UHFFFAOYSA-N 0.000 claims description 2
- 239000007864 aqueous solution Substances 0.000 claims 3
- 229960002566 papillomavirus vaccine Drugs 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 229920006318 anionic polymer Polymers 0.000 claims 1
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims 1
- 230000007774 longterm Effects 0.000 abstract description 4
- 241000341655 Human papillomavirus type 16 Species 0.000 description 20
- 239000000546 pharmaceutical excipient Substances 0.000 description 19
- 230000000694 effects Effects 0.000 description 16
- 150000002500 ions Chemical class 0.000 description 15
- 235000018102 proteins Nutrition 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 15
- 238000000338 in vitro Methods 0.000 description 13
- 208000022361 Human papillomavirus infectious disease Diseases 0.000 description 10
- 238000003556 assay Methods 0.000 description 8
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- 230000000087 stabilizing effect Effects 0.000 description 6
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- 150000001413 amino acids Chemical class 0.000 description 4
- 230000008696 hypoxemic pulmonary vasoconstriction Effects 0.000 description 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 3
- 108010020346 Polyglutamic Acid Proteins 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
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- 238000002474 experimental method Methods 0.000 description 3
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- 229920002643 polyglutamic acid Polymers 0.000 description 3
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- 108091033319 polynucleotide Proteins 0.000 description 3
- 102000040430 polynucleotide Human genes 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
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- 210000004027 cell Anatomy 0.000 description 2
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- 230000003993 interaction Effects 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 229920001983 poloxamer Polymers 0.000 description 2
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- 230000006641 stabilisation Effects 0.000 description 2
- 238000011105 stabilization Methods 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 206010058314 Dysplasia Diseases 0.000 description 1
- ZZIFPJZQHRJERU-WDSKDSINSA-N Glu-Cys-Gly Chemical compound OC(=O)CC[C@H](N)C(=O)N[C@@H](CS)C(=O)NCC(O)=O ZZIFPJZQHRJERU-WDSKDSINSA-N 0.000 description 1
- 108010053070 Glutathione Disulfide Proteins 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
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- 238000000149 argon plasma sintering Methods 0.000 description 1
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- YPZRWBKMTBYPTK-BJDJZHNGSA-N glutathione disulfide Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@H](C(=O)NCC(O)=O)CSSC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O YPZRWBKMTBYPTK-BJDJZHNGSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
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- 230000001590 oxidative effect Effects 0.000 description 1
- YPZRWBKMTBYPTK-UHFFFAOYSA-N oxidized gamma-L-glutamyl-L-cysteinylglycine Natural products OC(=O)C(N)CCC(=O)NC(C(=O)NCC(O)=O)CSSCC(C(=O)NCC(O)=O)NC(=O)CCC(N)C(O)=O YPZRWBKMTBYPTK-UHFFFAOYSA-N 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/108331—Preservative, buffer, anticoagulant or diluent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Reproductive Health (AREA)
- Endocrinology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11872399P | 1999-02-05 | 1999-02-05 | |
| US60/118,723 | 1999-02-05 | ||
| PCT/US2000/002463 WO2000045841A2 (en) | 1999-02-05 | 2000-02-01 | Human papilloma virus vaccine formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20010093290A true KR20010093290A (ko) | 2001-10-27 |
Family
ID=22380362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020017009504A Withdrawn KR20010093290A (ko) | 1999-02-05 | 2000-02-01 | 사람 파필로마바이러스 백신 제제 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6251678B1 (https=) |
| EP (1) | EP1150712B1 (https=) |
| JP (2) | JP4841726B2 (https=) |
| KR (1) | KR20010093290A (https=) |
| AR (1) | AR022510A1 (https=) |
| AT (1) | ATE413188T1 (https=) |
| AU (1) | AU764138B2 (https=) |
| CA (1) | CA2361837C (https=) |
| CY (1) | CY1108702T1 (https=) |
| DE (1) | DE60040727D1 (https=) |
| DK (1) | DK1150712T3 (https=) |
| ES (1) | ES2313881T3 (https=) |
| PT (1) | PT1150712E (https=) |
| SI (1) | SI1150712T1 (https=) |
| WO (1) | WO2000045841A2 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104479892A (zh) * | 2014-11-06 | 2015-04-01 | 王越 | 一种具有植物杀菌功能洗衣液的制备方法 |
| KR20200083540A (ko) * | 2017-11-01 | 2020-07-08 | 머크 샤프 앤드 돔 코포레이션 | 시토메갈로바이러스의 안정한 제형 |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA982950B (en) * | 1997-04-08 | 1998-10-19 | Merck & Co Inc | Stabilized human papillomavirus formulations |
| GB9921146D0 (en) * | 1999-09-07 | 1999-11-10 | Smithkline Beecham Biolog | Novel composition |
| US7456009B2 (en) | 2000-03-07 | 2008-11-25 | Merck & Co., Inc. | Adenovirus formulations |
| JP5118798B2 (ja) * | 2000-03-07 | 2013-01-16 | メルク・シャープ・エンド・ドーム・コーポレイション | アデノウイルス製剤 |
| JP5485489B2 (ja) * | 2000-08-11 | 2014-05-07 | 中外製薬株式会社 | 抗体含有安定化製剤 |
| CA2327950A1 (en) * | 2000-12-08 | 2002-06-08 | Groupe Minutia Inc. | Grain refining agent for cast aluminum or magnesium products |
| GB0118249D0 (en) * | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| DE10137102A1 (de) | 2001-07-30 | 2003-02-27 | Deutsches Krebsforsch | Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
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- 2000-02-01 AU AU27492/00A patent/AU764138B2/en not_active Expired
- 2000-02-01 SI SI200031009T patent/SI1150712T1/sl unknown
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- 2000-02-01 DE DE60040727T patent/DE60040727D1/de not_active Expired - Lifetime
- 2000-02-01 PT PT00905886T patent/PT1150712E/pt unknown
- 2000-02-01 DK DK00905886T patent/DK1150712T3/da active
- 2000-02-01 AT AT00905886T patent/ATE413188T1/de active
- 2000-02-01 KR KR1020017009504A patent/KR20010093290A/ko not_active Withdrawn
- 2000-02-01 JP JP2000596960A patent/JP4841726B2/ja not_active Expired - Lifetime
- 2000-02-01 WO PCT/US2000/002463 patent/WO2000045841A2/en not_active Ceased
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- 2000-02-02 US US09/496,812 patent/US6251678B1/en not_active Expired - Lifetime
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104479892A (zh) * | 2014-11-06 | 2015-04-01 | 王越 | 一种具有植物杀菌功能洗衣液的制备方法 |
| KR20200083540A (ko) * | 2017-11-01 | 2020-07-08 | 머크 샤프 앤드 돔 코포레이션 | 시토메갈로바이러스의 안정한 제형 |
Also Published As
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|---|---|
| PT1150712E (pt) | 2008-12-22 |
| DK1150712T3 (da) | 2009-02-02 |
| SI1150712T1 (sl) | 2009-02-28 |
| WO2000045841A3 (en) | 2000-12-14 |
| WO2000045841A2 (en) | 2000-08-10 |
| EP1150712A2 (en) | 2001-11-07 |
| AU2749200A (en) | 2000-08-25 |
| ES2313881T3 (es) | 2009-03-16 |
| JP2002536340A (ja) | 2002-10-29 |
| CA2361837C (en) | 2011-06-07 |
| JP4841726B2 (ja) | 2011-12-21 |
| ATE413188T1 (de) | 2008-11-15 |
| DE60040727D1 (de) | 2008-12-18 |
| JP2011225578A (ja) | 2011-11-10 |
| AU764138B2 (en) | 2003-08-14 |
| AR022510A1 (es) | 2002-09-04 |
| US6251678B1 (en) | 2001-06-26 |
| EP1150712B1 (en) | 2008-11-05 |
| CY1108702T1 (el) | 2013-09-04 |
| CA2361837A1 (en) | 2000-08-10 |
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