KR102993248B1 - 방광암을 치료하기 위한 방법 - Google Patents

방광암을 치료하기 위한 방법

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Publication number
KR102993248B1
KR102993248B1 KR1020207037794A KR20207037794A KR102993248B1 KR 102993248 B1 KR102993248 B1 KR 102993248B1 KR 1020207037794 A KR1020207037794 A KR 1020207037794A KR 20207037794 A KR20207037794 A KR 20207037794A KR 102993248 B1 KR102993248 B1 KR 102993248B1
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KR
South Korea
Prior art keywords
compound
pharmaceutically acceptable
vol
sting
acceptable salt
Prior art date
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KR1020207037794A
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English (en)
Korean (ko)
Other versions
KR20210015937A (ko
Inventor
대식 김
프랭크 팡
아츠시 엔도
형욱 최
밍홍 하오
싱펭 바오
콴춘 황
Original Assignee
에자이 알앤드디 매니지먼트 가부시키가이샤
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Publication of KR20210015937A publication Critical patent/KR20210015937A/ko
Application granted granted Critical
Publication of KR102993248B1 publication Critical patent/KR102993248B1/ko
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020207037794A 2018-06-01 2019-05-31 방광암을 치료하기 위한 방법 Active KR102993248B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862679495P 2018-06-01 2018-06-01
US62/679,495 2018-06-01
US201962826347P 2019-03-29 2019-03-29
US62/826,347 2019-03-29
PCT/US2019/034933 WO2019232392A1 (en) 2018-06-01 2019-05-31 Methods for the treatment of bladder cancer

Publications (2)

Publication Number Publication Date
KR20210015937A KR20210015937A (ko) 2021-02-10
KR102993248B1 true KR102993248B1 (ko) 2026-07-21

Family

ID=67138025

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207037794A Active KR102993248B1 (ko) 2018-06-01 2019-05-31 방광암을 치료하기 위한 방법

Country Status (11)

Country Link
US (1) US12251394B2 (enExample)
EP (1) EP3801561B1 (enExample)
JP (1) JP7335277B2 (enExample)
KR (1) KR102993248B1 (enExample)
CN (1) CN112512531B (enExample)
AU (1) AU2019277679B2 (enExample)
BR (1) BR112020024605A2 (enExample)
CA (1) CA3101623A1 (enExample)
MX (1) MX2020012964A (enExample)
SG (1) SG11202011434SA (enExample)
WO (1) WO2019232392A1 (enExample)

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Publication number Priority date Publication date Assignee Title
US20230141284A1 (en) 2020-04-10 2023-05-11 Ono Pharmaceutical Co., Ltd. Cancer therapeutic method
EP4398901A1 (en) 2021-09-09 2024-07-17 Eisai R&D Management Co., Ltd. Biomarkers for sting agonists and methods of using the same

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WO2017027645A1 (en) 2015-08-13 2017-02-16 Merck Sharp & Dohme Corp. Cyclic di-nucleotide compounds as sting agonists

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CN102199183B (zh) 2010-03-26 2013-12-18 北京大学 环二鸟苷酸及其类似物和制备方法
SG11201502796RA (en) 2012-12-13 2015-05-28 Aduro Biotech Inc Compositions comprising cyclic purine dinucleotides having defined stereochemistries and methods for their preparation and use
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EP3071229A4 (en) 2013-11-22 2017-05-10 Brock University Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants
EP3152217B1 (en) 2014-06-04 2018-08-01 GlaxoSmithKline Intellectual Property Development Limited Cyclic di-nucleotides as modulators of sting
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EP3233089A4 (en) 2014-12-17 2018-11-14 Lipogen LLC Method of treating cancer with cgamp or cgasmp
TWI706958B (zh) 2015-03-10 2020-10-11 美商艾杜諾生物科技公司 活化「干擾素基因刺激因子」依賴性訊息傳導之組合物及方法
KR20180066241A (ko) 2015-10-28 2018-06-18 아두로 바이오테크, 인코포레이티드 “인터페론 유전자의 자극제”-의존성 신호전달을 활성화시키기 위한 조성물 및 방법
JP6411676B2 (ja) 2015-12-03 2018-10-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｓｔｉｎｇの調節因子としての環状プリンジヌクレオチド
WO2017123657A1 (en) 2016-01-11 2017-07-20 Gary Glick Cyclic dinucleotides for treating conditions associated with sting activity such as cancer
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UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
TWI808092B (zh) 2017-08-30 2023-07-11 中國大陸商北京軒義醫藥科技有限公司 作為干擾素基因調節劑之刺激劑的環狀二核苷酸
EP3676277A1 (en) 2017-08-31 2020-07-08 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
EP3675859A4 (en) 2017-08-31 2021-06-30 Sperovie Biosciences, Inc. COMPOUNDS, COMPOSITIONS AND PROCEDURES FOR TREATMENT OF DISEASES
US10947263B2 (en) 2017-08-31 2021-03-16 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
JP7208225B2 (ja) 2017-08-31 2023-01-18 ブリストル－マイヤーズ スクイブ カンパニー 抗癌剤としての環状ジヌクレオチド

Patent Citations (2)

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WO2016120305A1 (en) 2015-01-29 2016-08-04 Glaxosmithkline Intellectual Property Development Limited Cyclic dinucleotides useful for the treatment of inter alia cancer
WO2017027645A1 (en) 2015-08-13 2017-02-16 Merck Sharp & Dohme Corp. Cyclic di-nucleotide compounds as sting agonists

Also Published As

Publication number Publication date
JP2021525758A (ja) 2021-09-27
US20210205348A1 (en) 2021-07-08
EP3801561B1 (en) 2025-03-19
CA3101623A1 (en) 2019-12-05
JP7335277B2 (ja) 2023-08-29
CN112512531B (zh) 2024-04-09
CN112512531A (zh) 2021-03-16
WO2019232392A1 (en) 2019-12-05
MX2020012964A (es) 2021-02-16
BR112020024605A2 (pt) 2021-04-06
SG11202011434SA (en) 2020-12-30
AU2019277679B2 (en) 2024-11-28
EP3801561A1 (en) 2021-04-14
US12251394B2 (en) 2025-03-18
AU2019277679A1 (en) 2020-12-24
KR20210015937A (ko) 2021-02-10

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