KR102793118B1 - 카르보프로스트 및 이의 트로메타민 염의 제조 방법 - Google Patents

카르보프로스트 및 이의 트로메타민 염의 제조 방법 Download PDF

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Publication number
KR102793118B1
KR102793118B1 KR1020187018423A KR20187018423A KR102793118B1 KR 102793118 B1 KR102793118 B1 KR 102793118B1 KR 1020187018423 A KR1020187018423 A KR 1020187018423A KR 20187018423 A KR20187018423 A KR 20187018423A KR 102793118 B1 KR102793118 B1 KR 102793118B1
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chemical formula
carboprost
epimer
applying
silica gel
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KR20180101353A (ko
Inventor
페테르 부즈데르-을런토시
주전너 커르도시
이렌 호르토바지
이슈트반 라슬로피
임레 유하스
라슬로 포너지
처버 바러디
아그네시 너지네 보르코
Original Assignee
키노인 기요기스제르 에스 베기에스제티 테르메크에크 기야라 제트알티.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/12—Purification; Separation; Use of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Water Supply & Treatment (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020187018423A 2015-12-01 2016-11-10 카르보프로스트 및 이의 트로메타민 염의 제조 방법 Active KR102793118B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HUP1500584 2015-12-01
HU1500584A HU231045B1 (hu) 2015-12-01 2015-12-01 Új eljárás Carboprost trometamin elõállítására
PCT/HU2016/000067 WO2017093770A1 (en) 2015-12-01 2016-11-10 Process for the preparation of carboprost and its tromethamine salt

Publications (2)

Publication Number Publication Date
KR20180101353A KR20180101353A (ko) 2018-09-12
KR102793118B1 true KR102793118B1 (ko) 2025-04-07

Family

ID=89992009

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187018423A Active KR102793118B1 (ko) 2015-12-01 2016-11-10 카르보프로스트 및 이의 트로메타민 염의 제조 방법

Country Status (10)

Country Link
US (1) US10442762B2 (https=)
EP (1) EP3383844B8 (https=)
JP (1) JP6862448B2 (https=)
KR (1) KR102793118B1 (https=)
CN (1) CN108602769B (https=)
ES (1) ES2812770T3 (https=)
HU (2) HU231045B1 (https=)
RU (1) RU2729626C2 (https=)
TW (1) TWI738687B (https=)
WO (1) WO2017093770A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110117242B (zh) * 2018-02-06 2021-06-22 广州楷模生物科技有限公司 卡前列素、氨丁三醇卡前列素的合成方法
KR102200892B1 (ko) * 2019-05-13 2021-01-12 대원제약주식회사 펠루비프로펜의 신규 염, 이의 제조방법 및 이를 포함하는 약학적 조성물
CN110746333B (zh) * 2019-10-31 2021-06-04 武汉嘉诺康医药技术有限公司 一种分离卡前列素异构体的方法
CN114262288B (zh) * 2020-09-16 2023-07-07 凯特立斯（深圳）科技有限公司 一类前列腺素类化合物合成关键中间体及其制备方法
CN112645861A (zh) * 2020-12-21 2021-04-13 上海彩迩文生化科技有限公司 一种分离卡前列素15位异构体的方法
US12565468B2 (en) 2021-08-23 2026-03-03 Chirogate International Inc. Processes and intermediates for the preparations of Carboprost and Carboprost Tromethamine, and Carboprost Tromethamine prepared therefrom
TWI805504B (zh) * 2021-08-23 2023-06-11 佳和桂科技股份有限公司 卡前列素緩血酸胺之結晶形式及其製備方法
CN113548993B (zh) * 2021-09-01 2022-05-27 河北化工医药职业技术学院 一种卡前列素的制备方法
CN114573489B (zh) * 2022-03-10 2023-08-22 河北化工医药职业技术学院 一种卡前列素的分离方法
CN115010692A (zh) * 2022-05-21 2022-09-06 上海彩迩文生化科技有限公司 一类新颖大环内酯的设计、制备及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008081191A1 (en) 2007-01-05 2008-07-10 Astrazeneca Pharma India Limited Improved method for the wittig reaction in the preparation of carboprost
US20130190404A1 (en) 2010-07-21 2013-07-25 Shanghai Techwell Biopharmaceutical Co., Ltd. Crystals of carboprost tromethamine and the preparation method as well as the uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728382A (en) * 1970-05-04 1973-04-17 Upjohn Co 15-methyl and 15-ethyl prostaglandin analogs
IN185790B (https=) 1997-05-13 2001-04-28 Council Scient Ind Res
CA2768154C (en) 2009-07-13 2018-02-13 Irix Pharmaceuticals Synthesis of prostanoids
CN102816099A (zh) * 2011-06-09 2012-12-12 上海天伟生物制药有限公司 一种高纯度的卡前列素氨丁三醇及其制备方法和用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008081191A1 (en) 2007-01-05 2008-07-10 Astrazeneca Pharma India Limited Improved method for the wittig reaction in the preparation of carboprost
US20130190404A1 (en) 2010-07-21 2013-07-25 Shanghai Techwell Biopharmaceutical Co., Ltd. Crystals of carboprost tromethamine and the preparation method as well as the uses thereof

Also Published As

Publication number Publication date
CN108602769B (zh) 2020-11-13
EP3383844A1 (en) 2018-10-10
US20180362457A1 (en) 2018-12-20
JP6862448B2 (ja) 2021-04-21
KR20180101353A (ko) 2018-09-12
RU2729626C2 (ru) 2020-08-11
EP3383844B8 (en) 2020-08-19
HUE050782T2 (hu) 2021-01-28
JP2019502666A (ja) 2019-01-31
HU231045B1 (hu) 2020-01-28
TWI738687B (zh) 2021-09-11
EP3383844B1 (en) 2020-06-03
US10442762B2 (en) 2019-10-15
CN108602769A (zh) 2018-09-28
RU2018123738A (ru) 2020-01-09
WO2017093770A1 (en) 2017-06-08
TW201733980A (zh) 2017-10-01
RU2018123738A3 (https=) 2020-02-17
HUP1500584A2 (en) 2017-06-28
ES2812770T3 (es) 2021-03-18

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