HU231045B1 - Novel process for the preparation of carboprost tromethamine - Google Patents

Novel process for the preparation of carboprost tromethamine Download PDF

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Publication number
HU231045B1
HU231045B1 HU1500584A HUP1500584A HU231045B1 HU 231045 B1 HU231045 B1 HU 231045B1 HU 1500584 A HU1500584 A HU 1500584A HU P1500584 A HUP1500584 A HU P1500584A HU 231045 B1 HU231045 B1 HU 231045B1
Authority
HU
Hungary
Prior art keywords
preparation
novel process
carboprost tromethamine
carboprost
tromethamine
Prior art date
Application number
HU1500584A
Other languages
English (en)
Inventor
Peter Buzder-Lantos
Kardos Zsuzsanna Dr
Iren Hortobagyi
Istvan Laszlofi
Imre Juhasz
Laszlo Fonagy
Csaba Varadi
Borko Agnes Nagyne
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Zrt
Priority to HU1500584A priority Critical patent/HU231045B1/hu
Priority to KR1020187018423A priority patent/KR20180101353A/ko
Priority to US15/780,896 priority patent/US10442762B2/en
Priority to HUE16810011A priority patent/HUE050782T2/hu
Priority to EP16810011.3A priority patent/EP3383844B8/en
Priority to CN201680080245.7A priority patent/CN108602769B/zh
Priority to RU2018123738A priority patent/RU2729626C2/ru
Priority to PCT/HU2016/000067 priority patent/WO2017093770A1/en
Priority to JP2018528222A priority patent/JP6862448B2/ja
Priority to ES16810011T priority patent/ES2812770T3/es
Priority to TW105139179A priority patent/TWI738687B/zh
Publication of HUP1500584A2 publication Critical patent/HUP1500584A2/hu
Publication of HU231045B1 publication Critical patent/HU231045B1/hu

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/265—Adsorption chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • B01D15/426—Specific type of solvent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/10—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate
    • B01J20/103—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising silica or silicate comprising silica
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C7/00—Purification; Separation; Use of additives
    • C07C7/12—Purification; Separation; Use of additives by adsorption, i.e. purification or separation of hydrocarbons with the aid of solids, e.g. with ion-exchangers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
HU1500584A 2015-12-01 2015-12-01 Novel process for the preparation of carboprost tromethamine HU231045B1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
HU1500584A HU231045B1 (en) 2015-12-01 2015-12-01 Novel process for the preparation of carboprost tromethamine
KR1020187018423A KR20180101353A (ko) 2015-12-01 2016-11-10 카르보프로스트 및 이의 트로메타민 염의 제조 방법
US15/780,896 US10442762B2 (en) 2015-12-01 2016-11-10 Process for the preparation of carboprost and its tromethamine salt
HUE16810011A HUE050782T2 (hu) 2015-12-01 2016-11-10 Eljárás Carboprost és trometamin sójának elõállítására
EP16810011.3A EP3383844B8 (en) 2015-12-01 2016-11-10 Process for the preparation of carboprost and its tromethamine salt
CN201680080245.7A CN108602769B (zh) 2015-12-01 2016-11-10 制备卡前列素及其氨丁三醇盐的方法
RU2018123738A RU2729626C2 (ru) 2015-12-01 2016-11-10 Способ получения карбопроста и его трометаминовой соли
PCT/HU2016/000067 WO2017093770A1 (en) 2015-12-01 2016-11-10 Process for the preparation of carboprost and its tromethamine salt
JP2018528222A JP6862448B2 (ja) 2015-12-01 2016-11-10 カルボプロストおよびそのトロメタミン塩を製造する方法
ES16810011T ES2812770T3 (es) 2015-12-01 2016-11-10 Proceso para la preparación de carboprost y su sal de trometamina
TW105139179A TWI738687B (zh) 2015-12-01 2016-11-29 製備卡前列素氨丁三醇之新穎方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1500584A HU231045B1 (en) 2015-12-01 2015-12-01 Novel process for the preparation of carboprost tromethamine

Publications (2)

Publication Number Publication Date
HUP1500584A2 HUP1500584A2 (en) 2017-06-28
HU231045B1 true HU231045B1 (en) 2020-01-28

Family

ID=89992009

Family Applications (2)

Application Number Title Priority Date Filing Date
HU1500584A HU231045B1 (en) 2015-12-01 2015-12-01 Novel process for the preparation of carboprost tromethamine
HUE16810011A HUE050782T2 (hu) 2015-12-01 2016-11-10 Eljárás Carboprost és trometamin sójának elõállítására

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE16810011A HUE050782T2 (hu) 2015-12-01 2016-11-10 Eljárás Carboprost és trometamin sójának elõállítására

Country Status (10)

Country Link
US (1) US10442762B2 (hu)
EP (1) EP3383844B8 (hu)
JP (1) JP6862448B2 (hu)
KR (1) KR20180101353A (hu)
CN (1) CN108602769B (hu)
ES (1) ES2812770T3 (hu)
HU (2) HU231045B1 (hu)
RU (1) RU2729626C2 (hu)
TW (1) TWI738687B (hu)
WO (1) WO2017093770A1 (hu)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110117242B (zh) * 2018-02-06 2021-06-22 广州楷模生物科技有限公司 卡前列素、氨丁三醇卡前列素的合成方法
KR102200892B1 (ko) * 2019-05-13 2021-01-12 대원제약주식회사 펠루비프로펜의 신규 염, 이의 제조방법 및 이를 포함하는 약학적 조성물
CN110746333B (zh) * 2019-10-31 2021-06-04 武汉嘉诺康医药技术有限公司 一种分离卡前列素异构体的方法
CN112645861A (zh) * 2020-12-21 2021-04-13 上海彩迩文生化科技有限公司 一种分离卡前列素15位异构体的方法
TWI805504B (zh) * 2021-08-23 2023-06-11 佳和桂科技股份有限公司 卡前列素緩血酸胺之結晶形式及其製備方法
US20230097470A1 (en) 2021-08-23 2023-03-30 Chirogate International Inc. Processes and intermediates for the preparations of carboprost and carboprost tromethamine, and carboprost tromethamine prepared therefrom
CN113548993B (zh) * 2021-09-01 2022-05-27 河北化工医药职业技术学院 一种卡前列素的制备方法
CN114573489B (zh) * 2022-03-10 2023-08-22 河北化工医药职业技术学院 一种卡前列素的分离方法
CN115010692A (zh) * 2022-05-21 2022-09-06 上海彩迩文生化科技有限公司 一类新颖大环内酯的设计、制备及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728382A (en) * 1970-05-04 1973-04-17 Upjohn Co 15-methyl and 15-ethyl prostaglandin analogs
IN185790B (hu) 1997-05-13 2001-04-28 Council Scient Ind Res
US20100041912A1 (en) 2007-01-05 2010-02-18 Astra Zeneca Method for the wittig reaction in the preparation of carboprost
EP2454227B1 (en) 2009-07-13 2020-08-19 Patheon API Services Inc. Synthesis of prostanoids
CN102336693B (zh) * 2010-07-21 2014-01-22 上海天伟生物制药有限公司 卡前列素氨丁三醇的晶体及其制备方法和用途
CN102816099A (zh) 2011-06-09 2012-12-12 上海天伟生物制药有限公司 一种高纯度的卡前列素氨丁三醇及其制备方法和用途

Also Published As

Publication number Publication date
JP6862448B2 (ja) 2021-04-21
EP3383844B8 (en) 2020-08-19
ES2812770T3 (es) 2021-03-18
HUE050782T2 (hu) 2021-01-28
CN108602769A (zh) 2018-09-28
RU2018123738A3 (hu) 2020-02-17
US10442762B2 (en) 2019-10-15
CN108602769B (zh) 2020-11-13
TW201733980A (zh) 2017-10-01
TWI738687B (zh) 2021-09-11
WO2017093770A1 (en) 2017-06-08
JP2019502666A (ja) 2019-01-31
RU2729626C2 (ru) 2020-08-11
HUP1500584A2 (en) 2017-06-28
EP3383844B1 (en) 2020-06-03
KR20180101353A (ko) 2018-09-12
EP3383844A1 (en) 2018-10-10
RU2018123738A (ru) 2020-01-09
US20180362457A1 (en) 2018-12-20

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