HUE058627T2 - Új eljárás nagy tisztaságú prosztaglandinok elõállítására - Google Patents

Új eljárás nagy tisztaságú prosztaglandinok elõállítására

Info

Publication number
HUE058627T2
HUE058627T2 HUE15715811A HUE15715811A HUE058627T2 HU E058627 T2 HUE058627 T2 HU E058627T2 HU E15715811 A HUE15715811 A HU E15715811A HU E15715811 A HUE15715811 A HU E15715811A HU E058627 T2 HUE058627 T2 HU E058627T2
Authority
HU
Hungary
Prior art keywords
prostaglandins
preparation
high purity
new process
new
Prior art date
Application number
HUE15715811A
Other languages
English (en)
Inventor
Ervin Vajda
Iren Hortobagyi
Istvan Laszlofi
Peter Buzder-Lantos
Gabor Havasi
Laszlo Takacs
Zsuzsanna Kardos
Original Assignee
Euroapi Hungary Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euroapi Hungary Llc filed Critical Euroapi Hungary Llc
Publication of HUE058627T2 publication Critical patent/HUE058627T2/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32Bonded phase chromatography
    • B01D15/322Normal bonded phase
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/42Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424Elution mode
    • B01D15/426Specific type of solvent
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HUE15715811A 2014-03-13 2015-03-11 Új eljárás nagy tisztaságú prosztaglandinok elõállítására HUE058627T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU1400140A HU231214B1 (hu) 2014-03-13 2014-03-13 Új eljárás nagytisztaságú prosztaglandinok előállítására

Publications (1)

Publication Number Publication Date
HUE058627T2 true HUE058627T2 (hu) 2022-09-28

Family

ID=89991440

Family Applications (2)

Application Number Title Priority Date Filing Date
HU1400140A HU231214B1 (hu) 2014-03-13 2014-03-13 Új eljárás nagytisztaságú prosztaglandinok előállítására
HUE15715811A HUE058627T2 (hu) 2014-03-13 2015-03-11 Új eljárás nagy tisztaságú prosztaglandinok elõállítására

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU1400140A HU231214B1 (hu) 2014-03-13 2014-03-13 Új eljárás nagytisztaságú prosztaglandinok előállítására

Country Status (11)

Country Link
US (1) US10501410B2 (hu)
EP (1) EP3116854B1 (hu)
JP (1) JP6659563B2 (hu)
KR (1) KR102422465B1 (hu)
CN (1) CN106103409B (hu)
DK (1) DK3116854T3 (hu)
ES (1) ES2911673T3 (hu)
HU (2) HU231214B1 (hu)
MA (1) MA39480A (hu)
TW (1) TWI671285B (hu)
WO (1) WO2015136317A1 (hu)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11458041B2 (en) 2015-10-08 2022-10-04 Ocular Therapeutix, Inc. Punctal plug and bioadhesives
HU231175B1 (hu) * 2015-12-04 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával
KR20220151622A (ko) 2020-02-06 2022-11-15 오큘라 테라퓨틱스, 인코포레이티드 안질환 치료를 위한 조성물 및 방법
US20240010615A1 (en) 2020-12-23 2024-01-11 Kyowa Pharma Chemical Co., Ltd. Method for separating geometrical isomer
CN112851510B (zh) * 2021-01-27 2022-07-19 Agc株式会社 他氟前列素的纯化方法
CN112832150B (zh) * 2021-01-27 2022-06-24 中交第三公路工程局有限公司 一种涵洞通道等立面垂直凿毛装置

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3728382A (en) 1970-05-04 1973-04-17 Upjohn Co 15-methyl and 15-ethyl prostaglandin analogs
JP2590184B2 (ja) * 1988-02-29 1997-03-12 ダイセル化学工業株式会社 分離方法
ES2213504T1 (es) * 1988-09-06 2004-09-01 Pfizer Health Ab Derivados de prostaglandina para el tratamiento del glaucoma o hipertension ocular.
HU212570B (en) 1991-06-24 1996-08-29 Chinoin Gyogyszer Es Vegyeszet Process for producing 13,14-dihydro-15(r)-17-phenyl-18,19,20-trinor-pgf2alfa-isopropylester
US5242368A (en) 1992-07-09 1993-09-07 Pitney Bowes Inc. Cross folder transport
US5510383A (en) 1993-08-03 1996-04-23 Alcon Laboratories, Inc. Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension
US7166730B2 (en) * 2000-01-27 2007-01-23 Fine Tech Laboratories, Ltd Process for the preparation of prostaglandin derivatives
IL143477A (en) * 2001-05-31 2009-07-20 Finetech Pharmaceutical Ltd Process for the preparation of 17-phenyl-18,19,20-trinor-pgf2?? and its derivatives
IL134241A (en) * 2000-01-27 2006-06-11 Finetech Pharmaceutical Ltd Process for the preparation of latanoprost
GB0112699D0 (en) 2001-05-24 2001-07-18 Resolution Chemicals Ltd Process for the preparation of prostglandins and analogues thereof
RU2267480C2 (ru) * 2001-07-17 2006-01-10 Фармация Энд Апджон Компани Способ и промежуточные соединения для получения латанопроста
PL212658B1 (pl) * 2005-04-18 2012-11-30 Inst Farmaceutyczny Sposób otrzymywania pochodnych 13,14-dihydro-PGF<sub>2</sub><sub>α</sub>
IT1392492B1 (it) 2008-12-24 2012-03-09 Ind Chimica Srl Processo per la purificazione del latanoprost, analogo sintetico della prostaglandina pgf2alfa.
WO2010109476A2 (en) 2009-01-19 2010-09-30 Matrix Laboratories Ltd Improved process for the preparation of prostaglandins and analogues thereof
KR101045935B1 (ko) 2009-03-11 2011-07-01 연성정밀화학(주) 프로스타글란딘 유도체의 제조방법
JP6087147B2 (ja) * 2009-06-22 2017-03-01 ジョンソン、マッセイ、パブリック、リミテッド、カンパニーJohnson Matthey Public Limited Company プロスタグランジンの精製方法
RU2012122367A (ru) 2009-11-05 2013-12-10 Биокон Лимитед Способ получения простагландинов и промежуточные соединения для их получения
WO2011095990A2 (en) 2010-02-03 2011-08-11 Fdc Limited Process for the purification of prostaglandins and analogues thereof
JP6212485B2 (ja) * 2011-06-02 2017-10-11 キノイン・ゼー・エル・テー プロスタグランジンアミドの新規製造方法
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
EP2822927A1 (en) 2012-03-09 2015-01-14 Instytut Farmaceutyczny PROCESS FOR PREPARATION OF PROSTAGLANDIN F2alpha ANALOGUES
GB201210235D0 (en) * 2012-06-11 2012-07-25 Univ Bristol Compound and method

Also Published As

Publication number Publication date
TWI671285B (zh) 2019-09-11
TW201623229A (zh) 2016-07-01
US20170037002A1 (en) 2017-02-09
CN106103409A (zh) 2016-11-09
MA39480A (fr) 2015-09-17
KR20160134741A (ko) 2016-11-23
JP6659563B2 (ja) 2020-03-04
HU231214B1 (hu) 2021-11-29
WO2015136317A1 (en) 2015-09-17
HUP1400140A2 (en) 2015-09-28
EP3116854B1 (en) 2022-01-26
EP3116854A1 (en) 2017-01-18
US10501410B2 (en) 2019-12-10
JP2017513816A (ja) 2017-06-01
ES2911673T3 (es) 2022-05-20
CN106103409B (zh) 2020-10-30
DK3116854T3 (da) 2022-05-02
KR102422465B1 (ko) 2022-07-20

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