KR102767739B1 - T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물 - Google Patents
T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물 Download PDFInfo
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- KR102767739B1 KR102767739B1 KR1020217002231A KR20217002231A KR102767739B1 KR 102767739 B1 KR102767739 B1 KR 102767739B1 KR 1020217002231 A KR1020217002231 A KR 1020217002231A KR 20217002231 A KR20217002231 A KR 20217002231A KR 102767739 B1 KR102767739 B1 KR 102767739B1
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- KR
- South Korea
- Prior art keywords
- methyl
- dehydro
- oxo
- naphthyridine
- carbonitrile
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862690439P | 2018-06-27 | 2018-06-27 | |
| US62/690,439 | 2018-06-27 | ||
| US201962840459P | 2019-04-30 | 2019-04-30 | |
| US62/840,459 | 2019-04-30 | ||
| PCT/US2019/039135 WO2020006018A1 (en) | 2018-06-27 | 2019-06-26 | Substituted naphthyridinone compounds useful as t cell activators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20210024586A KR20210024586A (ko) | 2021-03-05 |
| KR102767739B1 true KR102767739B1 (ko) | 2025-02-12 |
Family
ID=67439335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217002231A Active KR102767739B1 (ko) | 2018-06-27 | 2019-06-26 | T 세포 활성화제로서 유용한 치환된 나프티리디논 화합물 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US10669272B2 (https=) |
| EP (1) | EP3814348B9 (https=) |
| JP (1) | JP7432532B2 (https=) |
| KR (1) | KR102767739B1 (https=) |
| CN (1) | CN112654621B (https=) |
| AU (1) | AU2019291794B2 (https=) |
| BR (1) | BR112020026681A2 (https=) |
| CA (1) | CA3104654A1 (https=) |
| CL (1) | CL2020003260A1 (https=) |
| CY (1) | CY1126280T1 (https=) |
| DK (1) | DK3814348T3 (https=) |
| ES (1) | ES2960754T3 (https=) |
| FI (1) | FI3814348T3 (https=) |
| HR (1) | HRP20231253T1 (https=) |
| HU (1) | HUE064531T2 (https=) |
| IL (1) | IL279728B2 (https=) |
| LT (1) | LT3814348T (https=) |
| MX (1) | MX2020013817A (https=) |
| PE (1) | PE20210469A1 (https=) |
| PL (1) | PL3814348T3 (https=) |
| PT (1) | PT3814348T (https=) |
| RS (1) | RS64641B1 (https=) |
| SG (1) | SG11202012972YA (https=) |
| SI (1) | SI3814348T1 (https=) |
| SM (1) | SMT202300466T1 (https=) |
| TW (1) | TW202019924A (https=) |
| WO (1) | WO2020006018A1 (https=) |
| ZA (1) | ZA202100555B (https=) |
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| CN111471059B (zh) * | 2019-01-23 | 2022-12-02 | 药捷安康(南京)科技股份有限公司 | Pde9抑制剂及其用途 |
| AU2020266529B2 (en) | 2019-04-29 | 2026-01-29 | Solent Therapeutics, Llc | 3-amino-4H-benzo[E][1,2,4]thiadiazine 1,1-dioxide derivatives as inhibitors of MRGX2 |
| AR119821A1 (es) | 2019-08-28 | 2022-01-12 | Bristol Myers Squibb Co | Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t |
| CN115210225A (zh) | 2019-11-28 | 2022-10-18 | 拜耳公司 | 取代的氨基喹诺酮类作为免疫激活的dgkalpha抑制剂 |
| US20230064809A1 (en) | 2019-11-28 | 2023-03-02 | Bayer Aktiengesellschaft | Substituted aminoquinolones as dgkalpha inhibitors for immune activation |
| KR20220122637A (ko) | 2019-11-28 | 2022-09-02 | 바이엘 악티엔게젤샤프트 | 면역 활성화를 위한 dgk알파 억제제로서의 치환된 아미노퀴놀론 |
| BR112022009631A2 (pt) * | 2019-12-19 | 2022-08-09 | Bristol Myers Squibb Co | Combinações de inibidores de dgk e antagonistas do ponto de checagem |
| KR20220119456A (ko) * | 2019-12-23 | 2022-08-29 | 브리스톨-마이어스 스큅 컴퍼니 | T 세포 활성화제로서 유용한 치환된 퀴놀리노닐 피페라진 화합물 |
| AR120823A1 (es) * | 2019-12-23 | 2022-03-23 | Bristol Myers Squibb Co | Compuestos bicíclicos sustituidos útiles como activadores de células t |
| IL294273A (en) * | 2019-12-23 | 2022-08-01 | Bristol Myers Squibb Co | Substituted heteroaryl compounds are useful as t-cell activators |
| EP4081522A1 (en) * | 2019-12-23 | 2022-11-02 | Bristol-Myers Squibb Company | Substituted piperazine derivatives useful as t cell activators |
| CN114846007B (zh) | 2019-12-23 | 2024-11-22 | 百时美施贵宝公司 | 可用作t细胞激活剂的经取代的喹唑啉基化合物 |
| LT4081305T (lt) | 2019-12-24 | 2024-11-25 | Carna Biosciences, Inc. | Diacilglicerolio kinazę moduliuojantys junginiai |
| AR120896A1 (es) * | 2019-12-25 | 2022-03-30 | Astellas Pharma Inc | COMPUESTO DE PIRIDAZINIL-TIAZOLCARBOXAMIDA COMO INHIBIDORES DE DGKz |
| PL4139286T3 (pl) | 2020-04-24 | 2025-08-11 | Bayer Aktiengesellschaft | Podstawione aminotiazole jako inhibitory dgkzeta do aktywacji immunologicznej |
| WO2021258010A1 (en) * | 2020-06-19 | 2021-12-23 | Gossamer Bio Services, Inc. | Oxime compounds useful as t cell activators |
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| WO2022271659A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2022271677A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| CA3222277A1 (en) | 2021-06-23 | 2022-12-29 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| KR20240005901A (ko) | 2021-06-23 | 2024-01-12 | 길리애드 사이언시즈, 인코포레이티드 | 디아실글리세롤 키나제 조절 화합물 |
| WO2023122777A1 (en) * | 2021-12-22 | 2023-06-29 | Gossamer Bio Services, Inc. | Oxime derivatives useful as t cell activators |
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| KR20240156394A (ko) | 2022-03-01 | 2024-10-29 | 인실리코 메디신 아이피 리미티드 | 디아실글리세롤 키나아제 (dgk) 알파 억제제 및 이의 용도 |
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