KR102717614B1 - 진단 및 인비보 영상용 화학발광 프로브 - Google Patents

진단 및 인비보 영상용 화학발광 프로브 Download PDF

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KR102717614B1
KR102717614B1 KR1020187024288A KR20187024288A KR102717614B1 KR 102717614 B1 KR102717614 B1 KR 102717614B1 KR 1020187024288 A KR1020187024288 A KR 1020187024288A KR 20187024288 A KR20187024288 A KR 20187024288A KR 102717614 B1 KR102717614 B1 KR 102717614B1
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alkylene
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KR20180108697A (ko
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도론 사바트
로니트 사트치-파인아로
니르 하난야
오리 그린
탈 엘론
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라모트 앳 텔-아비브 유니버시티 리미티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
    • A61K49/0052—Small organic molecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
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    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
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    • C07F7/02—Silicon compounds
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    • C07F9/06—Phosphorus compounds without P—C bonds
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    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
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    • C09B11/10—Amino derivatives of triarylmethanes
    • C09B11/24—Phthaleins containing amino groups ; Phthalanes; Fluoranes; Phthalides; Rhodamine dyes; Phthaleins having heterocyclic aryl rings; Lactone or lactame forms of triarylmethane dyes
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    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
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  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020187024288A 2016-01-26 2017-01-24 진단 및 인비보 영상용 화학발광 프로브 Active KR102717614B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662287127P 2016-01-26 2016-01-26
US62/287,127 2016-01-26
US201662431618P 2016-12-08 2016-12-08
US62/431,618 2016-12-08
PCT/IL2017/050088 WO2017130191A1 (en) 2016-01-26 2017-01-24 Chemiluminescent probes for diagnostics and in vivo imaging

Publications (2)

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KR20180108697A KR20180108697A (ko) 2018-10-04
KR102717614B1 true KR102717614B1 (ko) 2024-10-16

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US (4) US10660974B2 (https=)
EP (1) EP3408349B1 (https=)
JP (1) JP6915943B2 (https=)
KR (1) KR102717614B1 (https=)
CN (1) CN108884386B (https=)
CA (1) CA3011328C (https=)
ES (1) ES2866900T3 (https=)
WO (1) WO2017130191A1 (https=)

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WO2018216013A1 (en) 2017-05-24 2018-11-29 Ramot At Tel-Aviv University Ltd. Near-infrared chemiluminescent probes for in-vivo imaging
CN110944985B (zh) 2017-05-24 2022-12-13 特拉维夫大学拉玛特有限公司 用于蛋白酶的成像/检测的化学发光探针
EP3802512A1 (en) 2018-05-25 2021-04-14 Nemis Technologies AG Long wavelength emitting chemiluminescent probes
EP3802511A1 (en) * 2018-05-25 2021-04-14 Nemis Technologies AG Dioxetane compounds and their use for the detection of microorganisms
CN111073633B (zh) * 2018-10-22 2023-07-25 北京工商大学 一种萘环类苯硫酚荧光探针
US12296027B2 (en) * 2019-02-01 2025-05-13 Nanyang Technological University Molecular renal probes for detecting acute kidney injury
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WO2021086977A1 (en) * 2019-10-28 2021-05-06 Beckman Coulter, Inc. Rapid, high-intensity chemiluminescent dioxetanes
KR102332454B1 (ko) * 2019-12-18 2021-11-29 고려대학교 산학협력단 암 세포 검출용 발광 프로브 화합물 및 이를 포함하는 암 세포 검출용 발광 센서
US20240277873A1 (en) * 2021-08-11 2024-08-22 Nanyang Technological University Ultrabright chemiluminescent probes for detection and imaging
CN114315791B (zh) * 2021-12-22 2023-12-08 东南大学 用于实现手术导航和微小转移瘤成像的小分子化学发光探针及其制备方法和用途
CN114478473B (zh) * 2022-01-25 2024-05-03 南方医科大学 一种亮氨酸氨基肽酶化学发光检测试剂的合成及应用
JP2023110666A (ja) 2022-01-28 2023-08-09 シスメックス株式会社 化合物またはその塩、組成物、化学発光方法、化学発光シグナル測定方法、試薬、試薬キットおよび被検物質測定方法
CN115417863B (zh) * 2022-09-30 2024-02-02 徐州医科大学 一种二氧化硫近红外化学发光探针及其制备方法和应用
CN115894581B (zh) * 2022-10-26 2024-07-09 徐州医科大学 一种β-葡萄糖醛酸苷酶化学发光探针及其制备方法和应用
CN115819416B (zh) * 2022-11-29 2024-06-25 遵义医科大学 一种用于检测和区分的多模态化学发光分子及其应用
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WO2024147125A1 (en) * 2023-01-04 2024-07-11 Ramot At Tel-Aviv University Ltd. Cyclobutyl-substituted phenoxy-dioxetanes and uses thereof
CN116606220A (zh) * 2023-03-21 2023-08-18 华东理工大学 一种单组分有机余辉化合物及其生物检测的应用
CN116410064A (zh) * 2023-04-13 2023-07-11 西安交通大学 一种合成2-(α-甲氧基-3-羟基苯亚甲基)金刚烷类化合物的方法
CN116655716A (zh) * 2023-04-27 2023-08-29 湖南师范大学 一种检测β-半乳糖苷酶的化学发光探针、制备方法及其应用
US12393660B2 (en) 2023-05-17 2025-08-19 The Government of the United States of America, as represented by the Secretary of Homeland Security DNA access control systems
CN117059804B (zh) * 2023-10-13 2024-03-19 瑞浦兰钧能源股份有限公司 一种化学预锂剂、锂离子电池及其制备方法
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WO2026047187A1 (en) 2024-08-30 2026-03-05 Biosynth Ag Method of making chemiluminescent 1,2-dioxetanes
CN119409748A (zh) * 2025-01-06 2025-02-11 四川省医学科学院·四川省人民医院 一种N-乙酰-β-D-氨基葡萄糖酶的化学发光探针、试剂盒及其制备方法和应用
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