KR102716092B1 - Prmt5 저해제로서 사용하기 위한 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체 - Google Patents
Prmt5 저해제로서 사용하기 위한 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체 Download PDFInfo
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- KR102716092B1 KR102716092B1 KR1020187007810A KR20187007810A KR102716092B1 KR 102716092 B1 KR102716092 B1 KR 102716092B1 KR 1020187007810 A KR1020187007810 A KR 1020187007810A KR 20187007810 A KR20187007810 A KR 20187007810A KR 102716092 B1 KR102716092 B1 KR 102716092B1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562209941P | 2015-08-26 | 2015-08-26 | |
| US62/209,941 | 2015-08-26 | ||
| EP15184011.3 | 2015-09-07 | ||
| EP15184011 | 2015-09-07 | ||
| US201662306233P | 2016-03-10 | 2016-03-10 | |
| US62/306,233 | 2016-03-10 | ||
| PCT/EP2016/070097 WO2017032840A1 (en) | 2015-08-26 | 2016-08-25 | Novel 6-6 bicyclic aromatic ring substituted nucleoside analogues for use as prmt5 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20180041222A KR20180041222A (ko) | 2018-04-23 |
| KR102716092B1 true KR102716092B1 (ko) | 2024-10-10 |
Family
ID=54065259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020187007810A Active KR102716092B1 (ko) | 2015-08-26 | 2016-08-25 | Prmt5 저해제로서 사용하기 위한 신규한 6-6 이환식 방향족 고리 치환 뉴클레오시드 유사체 |
Country Status (35)
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI870767B (zh) * | 2015-08-26 | 2025-01-21 | 比利時商健生藥品公司 | 使用作為prmt5抑制劑之新穎經6-6雙環芳香環取代之核苷類似物 |
| TN2018000310A1 (en) * | 2016-03-10 | 2020-01-16 | Janssen Pharmaceutica Nv | Substituted nucleoside analogues for use as prmt5 inhibitors |
| CA2969295A1 (en) * | 2016-06-06 | 2017-12-06 | Pfizer Inc. | Substituted carbonucleoside derivatives, and use thereof as a prmt5 inhibitor |
| CN109689663B (zh) | 2016-09-14 | 2023-04-14 | 詹森药业有限公司 | Menin-mll相互作用的螺二环抑制剂 |
| MA46228A (fr) | 2016-09-14 | 2019-07-24 | Janssen Pharmaceutica Nv | Inhibiteurs bicycliques fusionnés de l'interaction ménine-mll |
| US12084462B2 (en) | 2016-09-14 | 2024-09-10 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| CN115626935B (zh) | 2016-10-03 | 2025-07-15 | 詹森药业有限公司 | 用作prmt5抑制剂的单环和双环系统取代的卡巴核苷类似物 |
| BR112019012106A2 (pt) | 2016-12-15 | 2019-10-29 | Janssen Pharmaceutica Nv | inibidores de azepano de interação menin-mill |
| GB201700526D0 (en) * | 2017-01-12 | 2017-03-01 | Univ Of Hull | Therapeutic use |
| EA201990851A1 (ru) | 2017-02-24 | 2019-09-30 | Янссен Фармацевтика Нв | Новые аналоги карбануклеозида, замещенные моноциклической и бициклической кольцевой системой, для применения в качестве ингибиторов prmt5 |
| CN110382707A (zh) | 2017-02-27 | 2019-10-25 | 詹森药业有限公司 | 生物标志在鉴定将对用prmt5抑制剂治疗有响应的癌症患者中的用途 |
| PL3665179T3 (pl) | 2017-08-09 | 2021-11-29 | Prelude Therapeutics, Incorporated | Selektywne inhibitory metylotransferazy argininowej białek 5 (prmt5) |
| WO2019084470A1 (en) * | 2017-10-26 | 2019-05-02 | Prelude Therapeutics, Incorporated | SELECTIVE INHIBITORS OF THE PROTEIN ARGININE METHYLTRANSFERASE 5 (PRMT5) |
| CA3084253A1 (en) * | 2017-12-05 | 2019-06-13 | Angex Pharmaceutical, Inc. | Heterocyclic compounds as prmt5 inhibitors |
| IL275129B2 (en) * | 2017-12-08 | 2023-10-01 | Janssen Pharmaceutica Nv | Novel spirobicyclic analogues |
| HUE059945T2 (hu) | 2017-12-13 | 2023-01-28 | Lupin Ltd | Helyettesített biciklusos heterociklusos vegyületek, mint PRMT5 inhibitorok |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| US10711007B2 (en) | 2018-03-14 | 2020-07-14 | Prelude Therapeutics Incorporated | Selective inhibitors of protein arginine methyltransferase 5 (PRMT5) |
| BR112020018636A2 (pt) * | 2018-03-14 | 2020-12-29 | Prelude Therapeutics, Incorporated | Inibidores seletivos de proteína arginina metiltransferase 5 (prmt5) |
| WO2020033282A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| US11981701B2 (en) | 2018-08-07 | 2024-05-14 | Merck Sharp & Dohme Llc | PRMT5 inhibitors |
| WO2020033288A1 (en) | 2018-08-07 | 2020-02-13 | Merck Sharp & Dohme Corp. | Prmt5 inhibitors |
| EP3833669A4 (en) * | 2018-08-07 | 2022-05-11 | Merck Sharp & Dohme Corp. | PRMT5 INHIBITORS |
| WO2020132603A2 (en) * | 2018-12-21 | 2020-06-25 | Memorial Sloan-Kettering Cancer Center | Salicyl-adenosinemonosulfamate analogs and uses thereof |
| CN109400545B (zh) * | 2018-12-24 | 2022-03-25 | 济南大学 | 一种精氨酸甲基转移酶5抑制剂及其应用 |
| CN109369507A (zh) * | 2018-12-26 | 2019-02-22 | 重庆市碚圣医药科技股份有限公司 | 一种n-(2,2-二乙氧基乙基)邻苯二甲酰亚胺的提纯方法 |
| AU2020223058A1 (en) * | 2019-02-13 | 2021-09-09 | Prelude Therapeutics, Incorporated | Selective inhibitor of protein arginine methyltransferase 5 (PRMT5) |
| WO2020190073A1 (ko) * | 2019-03-20 | 2020-09-24 | 한국화학연구원 | 신규한 아졸로피리미딘 헤테로고리 화합물을 유효 성분으로 함유하는 약제학적 조성물 |
| EP3947387B1 (en) * | 2019-03-25 | 2024-10-23 | California Institute Of Technology | Prmt5 inhibitors and uses thereof |
| AU2020256166A1 (en) | 2019-04-02 | 2021-10-14 | Aligos Therapeutics, Inc. | Compounds targeting PRMT5 |
| US20220152072A1 (en) * | 2019-04-05 | 2022-05-19 | Prelude Therapeutics, Incorporated | Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5) |
| WO2020206299A1 (en) | 2019-04-05 | 2020-10-08 | Prelude Therapeutics, Incorporated | Selective inhibitors of protein arginine methyltransferase 5 |
| KR20220016194A (ko) * | 2019-05-30 | 2022-02-08 | 앤젝스 파마수티컬, 인크. | Prmt5 억제제로서의 헤테로시클릭 화합물 |
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| PL3980417T3 (pl) * | 2019-06-10 | 2024-03-18 | Lupin Limited | Inhibitory prmt5 |
| JP7598338B2 (ja) * | 2019-06-12 | 2024-12-11 | ヤンセン ファーマシューティカ エヌ．ベー． | 新規なスピロ二環式中間体 |
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| AU2020372002A1 (en) * | 2019-10-21 | 2022-05-26 | Accent Therapeutics, Inc | Mettl3 modulators |
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| EP4076460B1 (en) | 2019-12-17 | 2026-01-21 | Merck Sharp & Dohme LLC | 1,4-dihydro-2h-spiro[isoquinoline-3,4'-piperidine derivatives as prmt5 inhibitors for the treatment of cancer |
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| JP7554829B2 (ja) | 2019-12-19 | 2024-09-20 | ヤンセン ファーマシューティカ エヌ．ベー． | 置換直鎖スピロ誘導体 |
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| TWI775313B (zh) * | 2020-02-18 | 2022-08-21 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| AU2021224588B2 (en) | 2020-02-18 | 2024-07-18 | Gilead Sciences, Inc. | Antiviral compounds |
| CN111233869B (zh) * | 2020-03-12 | 2022-09-16 | 杭州新博思生物医药有限公司 | 用于制备瑞德西韦关键中间体的新化合物及其制备方法 |
| WO2021202480A1 (en) * | 2020-04-01 | 2021-10-07 | Aligos Therapeutics, Inc. | Compounds targeting prmt5 |
| US20240101589A1 (en) * | 2020-10-08 | 2024-03-28 | Strom Therapeutics Limited | Inhibitors of mettl3 |
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