KR102651433B1 - 혈관 콜로니 형성 세포 - Google Patents
혈관 콜로니 형성 세포 Download PDFInfo
- Publication number
- KR102651433B1 KR102651433B1 KR1020227014323A KR20227014323A KR102651433B1 KR 102651433 B1 KR102651433 B1 KR 102651433B1 KR 1020227014323 A KR1020227014323 A KR 1020227014323A KR 20227014323 A KR20227014323 A KR 20227014323A KR 102651433 B1 KR102651433 B1 KR 102651433B1
- Authority
- KR
- South Korea
- Prior art keywords
- cells
- human
- hemangioblasts
- cell
- hematopoietic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
- C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/99—Serum-free medium
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/145—Thrombopoietin [TPO]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/165—Vascular endothelial growth factor [VEGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/26—Flt-3 ligand (CD135L, flk-2 ligand)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Developmental Biology & Embryology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020237033022A KR20230145494A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79222406P | 2006-04-14 | 2006-04-14 | |
| US60/792,224 | 2006-04-14 | ||
| US80199306P | 2006-05-19 | 2006-05-19 | |
| US60/801,993 | 2006-05-19 | ||
| US84616306P | 2006-09-20 | 2006-09-20 | |
| US60/846,163 | 2006-09-20 | ||
| US85214206P | 2006-10-16 | 2006-10-16 | |
| US60/852,142 | 2006-10-16 | ||
| US86067606P | 2006-11-22 | 2006-11-22 | |
| US60/860,676 | 2006-11-22 | ||
| US91883207P | 2007-03-19 | 2007-03-19 | |
| US60/918,832 | 2007-03-19 | ||
| KR1020217007639A KR102510368B1 (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| PCT/US2007/009106 WO2007120811A2 (en) | 2006-04-14 | 2007-04-13 | Hemangio-colony forming cells |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217007639A Division KR102510368B1 (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020237033022A Division KR20230145494A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20220057664A KR20220057664A (ko) | 2022-05-09 |
| KR102651433B1 true KR102651433B1 (ko) | 2024-03-25 |
Family
ID=38461853
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227014323A Active KR102651433B1 (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020197035159A Active KR102230288B1 (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020247043162A Pending KR20250008978A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020177023744A Ceased KR20170102040A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020147033315A Ceased KR20140146224A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020087027950A Ceased KR20090045886A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020217007639A Active KR102510368B1 (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020237033022A Ceased KR20230145494A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197035159A Active KR102230288B1 (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020247043162A Pending KR20250008978A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020177023744A Ceased KR20170102040A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020147033315A Ceased KR20140146224A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020087027950A Ceased KR20090045886A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020217007639A Active KR102510368B1 (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
| KR1020237033022A Ceased KR20230145494A (ko) | 2006-04-14 | 2007-04-13 | 혈관 콜로니 형성 세포 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US8017393B2 (https=) |
| EP (6) | EP2377924A1 (https=) |
| JP (6) | JP5630781B2 (https=) |
| KR (8) | KR102651433B1 (https=) |
| CN (3) | CN106434527A (https=) |
| AU (1) | AU2007238660C1 (https=) |
| WO (1) | WO2007120811A2 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106434527A (zh) | 2006-04-14 | 2017-02-22 | 安斯泰来再生医药协会 | 血管瘤集落形成细胞 |
| WO2008067142A2 (en) * | 2006-11-08 | 2008-06-05 | Wisconsin Alumni Research Foundation | In vitro differentiation of hematopoietic cells from primate embryonic stem cells |
| AU2008216748A1 (en) | 2007-02-12 | 2008-08-21 | Anthrogenesis Corporation | Hepatocytes and chondrocytes from adherent placental stem cells; and CD34+, CD45- placental stem cell-enriched cell populations |
| US9200253B1 (en) * | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
| US8222206B2 (en) * | 2008-03-04 | 2012-07-17 | Taiwan Advance Bio-Pharm Inc. | Method of enhancing the mobilization of hematopoietic stem cells using TAT-HOXB4H |
| US20110086424A1 (en) * | 2008-05-06 | 2011-04-14 | Advanced Cell Technology, Inc. | Methods for producing enucleated erythroid cells derived from pluripotent stem cells |
| CA3186451A1 (en) * | 2008-05-06 | 2009-11-12 | Astellas Institute For Regenerative Medicine | Hemangio colony forming cells and non-engrafting hemangio cells |
| US8372066B2 (en) * | 2009-04-17 | 2013-02-12 | Domain Surgical, Inc. | Inductively heated multi-mode surgical tool |
| GB0911060D0 (en) * | 2009-06-26 | 2009-08-12 | Ge Healthcare Uk Ltd | Methods for predicting the toxicity of a chemical |
| CN102725400A (zh) * | 2009-06-29 | 2012-10-10 | 麻省理工学院 | 制造人源化的非人类哺乳动物的方法 |
| US8586360B2 (en) | 2009-07-02 | 2013-11-19 | Anthrogenesis Corporation | Method of producing erythrocytes without feeder cells |
| KR20180086301A (ko) * | 2009-12-04 | 2018-07-30 | 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. | 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성 |
| CA3080368A1 (en) * | 2009-12-04 | 2011-06-09 | Stem Cell & Regenerative Medicine International, Inc. | Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts |
| PL2539441T3 (pl) * | 2010-02-22 | 2017-06-30 | Université Pierre Et Marie Curie (Paris 6) | Podłoże do hodowli komórkowej do wzrostu i różnicowania komórek linii hematopoetycznych |
| US8652845B2 (en) | 2010-03-18 | 2014-02-18 | Kyoto University | Method for producing mesodermal cells by culturing under adherent conditions and without co-culture with cells from a different species in a serum-free medium |
| WO2012103098A2 (en) * | 2011-01-24 | 2012-08-02 | Immunepath, Inc. | Compositions and methods for treating hematological cytopenias |
| CN102239821B (zh) * | 2011-05-10 | 2013-08-14 | 郑家伟 | 一种人血管瘤动物模型及其构建方法和应用 |
| SI2785359T1 (sl) | 2011-11-30 | 2018-11-30 | Astellas Institute For Regenerative Medicine | Mezenhimske stromalne celice in uporabe povezane z njimi |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| HK1208054A1 (en) | 2012-07-12 | 2016-02-19 | 爱姆斯坦生物技术公司 | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| CA2896053A1 (en) | 2012-12-21 | 2014-06-26 | Ocata Therapeutics, Inc. | Methods for production of platelets from pluripotent stem cells and compositions thereof |
| CN105051061B (zh) * | 2013-01-30 | 2020-02-21 | 康奈尔大学 | 用于扩增干细胞的组合物和方法 |
| DE102013105217A1 (de) * | 2013-05-22 | 2014-11-27 | Illinois Tool Works Inc. | Kompressor zum Erzeugen eines Druckmediums |
| CN108291196B (zh) * | 2015-07-20 | 2021-08-27 | 安吉克莱茵生物科学有限公司 | 表达ets转录因子的工程化的内皮细胞 |
| CN108697641A (zh) | 2015-08-18 | 2018-10-23 | 安斯泰来再生医药协会 | 临床制剂 |
| EP4520828A3 (en) | 2016-11-15 | 2025-07-09 | The Schepens Eye Research Institute, Inc. | Compositions and methods for the treatment of aberrant angiogenesis |
| WO2018119142A1 (en) | 2016-12-21 | 2018-06-28 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| CN109402047A (zh) * | 2017-09-18 | 2019-03-01 | 武汉原生原代生物医药科技有限公司 | 促组织粘附和生长生物粘合剂及其制备方法和用途 |
| US11739326B2 (en) | 2017-11-14 | 2023-08-29 | Massachusetts Eye And Ear Infirmary | RUNX1 inhibition for treatment of proliferative vitreoretinopathy and conditions associated with epithelial to mesenchymal transition |
| KR102167641B1 (ko) | 2018-08-27 | 2020-10-19 | 주식회사 사이루스 | 에리스로포이에틴 유래 펩티드를 함유하는 세포증식 촉진용 조성물 |
| EP3962503A4 (en) * | 2019-04-27 | 2022-12-21 | Figene, LLC | SELECTION OF FIBROBLAST DONORS FOR THE OPTIMIZATION OF REGENERATION INDUCED BY ALLOGENIC FIBROBLASTS |
| AU2020337444A1 (en) | 2019-08-28 | 2022-03-24 | Astellas Institute For Regenerative Medicine | Compositions and methods of treating vascular diseases |
| CN115003800A (zh) * | 2019-08-28 | 2022-09-02 | 安斯泰来再生医药协会 | 治疗血管疾病的方法 |
| US20210192477A1 (en) * | 2019-12-24 | 2021-06-24 | Up N' Go | App-less restaurant processing system using mobile devices and offering check splitting |
| CN112940097A (zh) * | 2021-02-08 | 2021-06-11 | 华东理工大学 | Survivin多点突变体重组蛋白及其应用 |
| EP4558154A1 (en) | 2022-07-18 | 2025-05-28 | Astellas Institute for Regenerative Medicine | Methods of treating brain injury |
Family Cites Families (139)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5399346A (en) | 1989-06-14 | 1995-03-21 | The United States Of America As Represented By The Department Of Health And Human Services | Gene therapy |
| US5128259A (en) | 1989-10-27 | 1992-07-07 | Hahnemann University | Factor-dependent hematopoietic cell line exhibiting epo-induced erythrocyte maturation |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US7153684B1 (en) | 1992-10-08 | 2006-12-26 | Vanderbilt University | Pluripotential embryonic stem cells and methods of making same |
| SG48813A1 (en) | 1993-08-12 | 1998-05-18 | Cytotherapeutics Inc | Improved composition and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules |
| US5599705A (en) | 1993-11-16 | 1997-02-04 | Cameron; Robert B. | In vitro method for producing differentiated universally compatible mature human blood cells |
| WO1995017500A1 (en) | 1993-12-23 | 1995-06-29 | Abs Global, Inc. | Embryonic stem cells as nuclear donors and nuclear transfer techniques to produce chimeric and transgenic animals |
| US5874301A (en) | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US6063593A (en) | 1996-11-12 | 2000-05-16 | University Of Southern California University Park Campus | TGFβ1 responsive bone marrow derived cells to express a recombinant protein |
| CA2278847A1 (en) | 1997-01-31 | 1998-08-06 | Hemosol Inc. | Method for the production of selected lymphocytes |
| EP0983345A1 (en) | 1997-05-21 | 2000-03-08 | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services | Methods and compositions for making dendritic cells from expanded populations of monocytes and for activating t cells |
| US6429012B1 (en) | 1997-10-06 | 2002-08-06 | Viacell, Inc. | Cell population containing non-fetal hemangioblasts and method for producing same |
| WO1999067360A2 (en) | 1998-06-25 | 1999-12-29 | Hemosol Inc. | Media and methods for expansion of erythroid stem cells for the production of hemoglobin |
| EP1270719A3 (en) | 1998-08-24 | 2003-06-25 | Viacell, Inc. | Cell population containing non-fetal hemangioblasts and method for producing same |
| IL129966A (en) | 1999-05-14 | 2009-12-24 | Technion Res & Dev Foundation | ISOLATED HUMAN EMBRYOID BODIES (hEB) DERIVED FROM HUMAN EMBRYONIC STEM CELLS |
| WO2001029206A1 (en) | 1999-10-15 | 2001-04-26 | Advanced Cell Technology, Inc. | Methods of producing differentiated progenitor cells and lineage-defective embryonic stem cells |
| CN1423523A (zh) | 1999-11-17 | 2003-06-11 | 罗切斯特大学 | 来自人体内的免疫系统 |
| AU2927501A (en) | 2000-01-07 | 2001-07-24 | Oregon Health And Science University | Clonal propagation of primate offspring by embryo splitting |
| AU2001229731A1 (en) | 2000-01-21 | 2001-07-31 | The Johns Hopkins University School Of Medicine | Human embryoid body-derived cells |
| US6602711B1 (en) | 2000-02-21 | 2003-08-05 | Wisconsin Alumni Research Foundation | Method of making embryoid bodies from primate embryonic stem cells |
| JP2004504834A (ja) * | 2000-08-01 | 2004-02-19 | イスム リサーチ ディベロップメント カンパニー | 胚性細胞の定方向分化 |
| EP1364197B1 (en) | 2001-01-29 | 2010-04-14 | Ivan N. Rich | ATP-based assay for the determination of the proliferation status of hematopoietic stem and progenitor cells |
| JP3660601B2 (ja) | 2001-03-30 | 2005-06-15 | 独立行政法人科学技術振興機構 | 胚性幹細胞からの神経幹細胞、運動ニューロン及びgaba作動性ニューロンの製造法 |
| WO2002078449A2 (en) | 2001-04-02 | 2002-10-10 | Advanced Cell Technology, Inc. | Method for facilitating the production of differentiated cell types and tissues from embryonic and adult pluripotent and multipotent cells |
| KR20020083634A (ko) | 2001-04-27 | 2002-11-04 | 크레아젠 주식회사 | 수지상 세포를 포함하는 자가면역 질환의 치료용 약제학적조성물 및 이를 이용한 치료방법 |
| US6861504B2 (en) | 2001-05-03 | 2005-03-01 | Cbr, Inc. | Compounds and methods for the modulation of CD154 |
| EP1393066A4 (en) * | 2001-05-15 | 2006-01-25 | Rappaport Family Inst For Res | INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONIC STEM CELLS |
| US20050042751A1 (en) | 2001-10-31 | 2005-02-24 | Michel Goldman | Generation and use of new types of dendritic cells |
| WO2003040319A2 (en) | 2001-11-02 | 2003-05-15 | Wisconsin Alumni Research Foundation | Endothelial cells derived from primate embryonic stem cells |
| MXPA04005010A (es) * | 2001-11-26 | 2005-04-08 | Advanced Cell Tech Inc | METODO PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS METODOS PARA HACER Y USAR NUCLEOS CELULARES SOMáTICOS HUMANOS REPROGRAMADOS Y CELULAS DEL TALLO HUMANAS AUTOLOGAS E ISOGENICAS. |
| IL162130A0 (en) * | 2001-12-07 | 2005-11-20 | Robarts Res Inst | Hematopoietic cells from human embryonic stem cells |
| US20030217374A1 (en) | 2002-01-15 | 2003-11-20 | Advanced Cell Technology | Cloning B and T lymphocytes |
| US20040091936A1 (en) | 2002-05-24 | 2004-05-13 | Michael West | Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank |
| EP1563058A4 (en) | 2002-07-12 | 2005-12-28 | Univ Singapore | Haemangioblasts-Progenitor Cells |
| US20040052771A1 (en) | 2002-07-12 | 2004-03-18 | Lim Sai Kiang | Hemangioblast progenitor cells |
| EP1536688B1 (en) | 2002-09-13 | 2011-12-28 | The Board Of Trustees Of The Leland Stanford Junior University | Mammalian megakaryocyte progenitor cell |
| US7427603B2 (en) | 2002-09-26 | 2008-09-23 | The Children's Medical Center Corporation | Method of enhancing proliferation and/or hematopoietic differentiation of stem cells |
| WO2004029231A1 (en) * | 2002-09-26 | 2004-04-08 | Institut National De La Sante Et De La Recherche Medicale | Compositions and methods for amplification of human stem cells |
| AU2003269379A1 (en) | 2002-10-31 | 2004-05-25 | Pfizer Products Inc. | Suspension method for producing embryoid bodies, and compositions and methods related thereto |
| WO2004044146A2 (en) | 2002-11-06 | 2004-05-27 | Piniella Carlos J | Pluripotent cells from monocytes, and methods of making and using pluripotent cells |
| WO2004050826A2 (en) | 2002-11-29 | 2004-06-17 | Technion Research & Development Foundation Ltd. | Method of dynamically culturing embryonic stem cells |
| US20050032210A1 (en) | 2003-03-18 | 2005-02-10 | Kirin Beer Kabushiki Kaisha | Method of preparing immuno-regulatory dendritic cells and the use thereof |
| US20040229350A1 (en) | 2003-05-12 | 2004-11-18 | Nikolai Strelchenko | Morula derived embryonic stem cells |
| WO2004106502A1 (ja) | 2003-05-28 | 2004-12-09 | Riken | 間葉系幹細胞 |
| CA2558946C (en) | 2003-07-08 | 2013-05-21 | Axiogenesis Ag | Novel method for the preparation of embryoid bodies (ebs) and uses thereof |
| US20050054100A1 (en) | 2003-09-08 | 2005-03-10 | Rennard Stephen I. | Methods for fibroblast differentiation |
| WO2005040391A1 (en) | 2003-10-27 | 2005-05-06 | Murdoch Childrens Research Institute | Compositions and methods for differentiating stem cells |
| WO2005049812A1 (en) | 2003-11-19 | 2005-06-02 | Australian Stem Cell Centre Limited | Methods for producing blood products from pluripotent cells in cell culture |
| CN1286970C (zh) | 2003-12-30 | 2006-11-29 | 上海伯瑞生物技术发展有限公司 | 由脐血cd34+细胞体外诱导生成巨核细胞的方法 |
| KR100535326B1 (ko) | 2004-01-20 | 2005-12-09 | 한국생명공학연구원 | 줄기 세포로부터 자연살해 세포로의 분화 조절용 유전자를유효성분으로 포함하는 분화 조절제 |
| EP1713903A2 (en) * | 2004-02-09 | 2006-10-25 | Indiana University Research and Technology Corporation | Isolation, expansion and use of clonogenic endothelial progenitor cells |
| EP1735429A4 (en) | 2004-03-31 | 2008-06-11 | Newlink Genetics Corp | METHOD AND COMPOSITIONS FOR OBTAINING EMBRYONAL STEM CELLS OF ABSTINENT HEMATOPOETIC STEM CELLS AND USES THEREOF |
| CA2563872C (en) | 2004-05-07 | 2014-11-25 | Wisconsin Alumni Research Foundation | Method of forming mesenchymal stem cells from embryonic stem cells |
| WO2006001954A2 (en) | 2004-05-20 | 2006-01-05 | Puget Sound Blood Center And Program | Methods for promoting the formation of platelets and for treating blood and bone marrow disorders |
| EP1753859B1 (en) | 2004-06-04 | 2014-07-30 | Université Pierre et Marie Curie (Paris 6) | A method for producing red blood cells |
| WO2006001120A1 (ja) | 2004-06-24 | 2006-01-05 | Dnavec Research Inc. | マイナス鎖rnaウイルスを含む抗癌剤 |
| EP1784481A1 (en) | 2004-08-25 | 2007-05-16 | Technion Research And Development Foundation, Ltd. | Methods of generating embryoid bodies using three dimensional scaffolds |
| WO2006040763A2 (en) | 2004-10-12 | 2006-04-20 | Technion Research & Development Foundation Ltd. | Isolated primate embryonic cells and methods of generating and using same |
| AU2005302258B2 (en) | 2004-11-01 | 2010-10-21 | Wisconsin Alumni Research Foundation | Platelets from stem cells |
| CN101052710A (zh) | 2004-11-01 | 2007-10-10 | 威斯康星校友研究基金会 | 来自干细胞的血小板 |
| US7893315B2 (en) | 2004-11-04 | 2011-02-22 | Advanced Cell Technology, Inc. | Derivation of embryonic stem cells and embryo-derived cells |
| US7558394B2 (en) | 2005-02-14 | 2009-07-07 | Insound Medical, Inc. | Systems and methods for in situ cerumen removal from hearing devices |
| US20080166751A1 (en) | 2005-02-23 | 2008-07-10 | Takayuki Asahara | Method of Analyzing Dynamics in the Differentiation of Vascular Endothelial Progenitor Cells |
| EP1860180A4 (en) | 2005-02-23 | 2009-03-11 | Found Biomedical Res & Innov | METHOD FOR THE AMPLIFICATION OF AN ENDOTHEL PREPARATION CELL IN VITRO |
| DK1863905T3 (en) | 2005-03-17 | 2016-04-04 | Ucl Business Plc | PROCEDURE FOR ACTIVATING NATURAL KILLER CELLS USING VITRO TUMOR CELL PREPARATIONS |
| JP5020935B2 (ja) | 2005-04-08 | 2012-09-05 | アルゴス セラピューティクス,インコーポレイティド | 樹状細胞組成物および方法 |
| AU2006252576B2 (en) * | 2005-06-01 | 2011-01-20 | Wisconsin Alumni Research Foundation | Method of forming dendritic cells from embryonic stem cells |
| WO2007005595A1 (en) | 2005-07-05 | 2007-01-11 | The New England Medical Center Hospitals, Inc. | Pregnancy-associated progenitor cells |
| US9121008B2 (en) | 2005-08-31 | 2015-09-01 | University Of Utah Research Foundation | Development of natural killer cells and functional natural killer cell lines |
| EP1937801A1 (en) | 2005-09-02 | 2008-07-02 | Agency for Science, Technology and Research | Method of deriving mesenchymal stem cells |
| WO2008020815A1 (en) | 2006-08-15 | 2008-02-21 | Agency For Science, Technology And Research | Mesenchymal stem cell conditioned medium |
| EP1789435B1 (en) | 2005-09-12 | 2010-02-24 | Industry Foundation of Chonnam National University | A method for production of mature natural killer cell |
| JP2007089432A (ja) | 2005-09-27 | 2007-04-12 | Reprocell Inc | 幹細胞由来血小板産生増加法 |
| PL1941027T3 (pl) | 2005-09-28 | 2015-01-30 | Ipd Therapeutics B V | Metody i środki do proliferacji komórek macierzystych oraz wytwarzania i ekspansji komórek progenitorowych, a także produkcji komórek efektorowych jako leków klinicznych |
| US20070128727A1 (en) | 2005-11-08 | 2007-06-07 | Kraemer Fredric B | Methods for differentiation of embryonic stem cells |
| EP1981971A4 (en) | 2006-01-11 | 2009-08-12 | Technion Res & Dev Foundation | PROGENITORS OF CONNECTIVE TISSUES OBTAINED FROM ADULT STEM CELLS FOR TISSUE GENE |
| AU2007215276B2 (en) * | 2006-02-09 | 2013-09-19 | Maryna E. Gumenyuk | Erythroid cells producing adult-type beta-hemoglobin generated from human embryonic stem cells |
| CN101045914A (zh) | 2006-03-29 | 2007-10-03 | 中国人民解放军军事医学科学院野战输血研究所 | 体外诱导造血干/祖细胞分化为成熟红细胞的方法与应用 |
| CN101045915A (zh) | 2006-03-29 | 2007-10-03 | 旭日干 | 一种卵母细胞生发泡移植技术 |
| CN106434527A (zh) | 2006-04-14 | 2017-02-22 | 安斯泰来再生医药协会 | 血管瘤集落形成细胞 |
| NZ572842A (en) | 2006-04-14 | 2012-01-12 | Advanced Cell Tech Inc | Hemangio-colony forming cells |
| AU2013201444B2 (en) | 2006-04-14 | 2015-01-22 | Astellas Institute For Regenerative Medicine | Hemangio-colony forming cells |
| WO2007122233A1 (en) | 2006-04-25 | 2007-11-01 | Vrije Universiteit Brussel | Preparation of mesenchymal progenitor cells, particularly osteogenic progenitor cells |
| WO2007149926A1 (en) | 2006-06-20 | 2007-12-27 | Wisconsin Alumni Research Foundation | Method for culturing stem cells |
| US20070298496A1 (en) | 2006-06-23 | 2007-12-27 | Hung-Chih Kuo | Method of deriving pluripotent stem cells from a single blastomere |
| US20100233135A1 (en) | 2006-08-16 | 2010-09-16 | The General Hospital Corporation | Compositions and methods for hematopoietic stem cell expansion or for modulating angiogenesis |
| US20080081370A1 (en) | 2006-09-28 | 2008-04-03 | Peiman Hematti | Directed differentiation of human embryonic stem cells into mesenchymal/stromal cells |
| WO2008067142A2 (en) | 2006-11-08 | 2008-06-05 | Wisconsin Alumni Research Foundation | In vitro differentiation of hematopoietic cells from primate embryonic stem cells |
| EP2088190A4 (en) | 2006-11-09 | 2011-01-05 | Japan Government | METHOD FOR THE CULTURE AND PASSING OF AN EMBRYONAL PRIMATIVE STEM CELL AND METHOD FOR INDUCING THE DIFFERENTIATION OF THE EMBRYONAL STEM CELL |
| DE102006054041B3 (de) | 2006-11-16 | 2008-05-08 | Pierburg Gmbh | Regelvorrichtung für eine Verbrennungskraftmaschine |
| US20100184212A1 (en) | 2007-05-30 | 2010-07-22 | Steven Stice | Human embryonic stem cell derived mesoderm-like epithelium transitions to mesenchymal progenitor cells |
| WO2008151390A1 (en) | 2007-06-15 | 2008-12-18 | Australian Stem Cell Centre Ltd | Differentiation of human embryonic stem cells |
| WO2008151386A1 (en) | 2007-06-15 | 2008-12-18 | Australian Stem Cell Centre Ltd | Megakaryocyte differentiation |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US7615374B2 (en) | 2007-09-25 | 2009-11-10 | Wisconsin Alumni Research Foundation | Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions |
| NZ599825A (en) | 2007-09-28 | 2014-10-31 | Anthrogenesis Corp | Tumor suppression using human placental perfusate and human placenta-derived intermediate natural killer cells |
| US20120003738A1 (en) | 2007-10-04 | 2012-01-05 | University Hospitals Of Cleveland | Method For Amplification And Functional Enhancment Of Blood Derived Progenitor Cells Using A Closed Culture System |
| US8501474B2 (en) | 2007-10-15 | 2013-08-06 | Technion Research & Development Foundation Limited | Methods of generating embryoid bodies and uses of same |
| US20100304480A1 (en) | 2007-10-19 | 2010-12-02 | Goodell Margaret A | Hematopoietic Fingerprints: Methods of Use |
| US9683232B2 (en) | 2007-12-10 | 2017-06-20 | Kyoto University | Efficient method for nuclear reprogramming |
| WO2009104825A1 (en) | 2008-02-18 | 2009-08-27 | Kaist | Method for inducing the defferentiation of embryonic stem cells into hemangioblast |
| JPWO2009119105A1 (ja) | 2008-03-28 | 2011-07-21 | 国立大学法人 東京大学 | GPIbα+GPV+GPVI+血小板のインビトロ調製法 |
| WO2009122747A1 (ja) | 2008-04-01 | 2009-10-08 | 国立大学法人東京大学 | iPS細胞からの血小板の調製方法 |
| US20110086424A1 (en) | 2008-05-06 | 2011-04-14 | Advanced Cell Technology, Inc. | Methods for producing enucleated erythroid cells derived from pluripotent stem cells |
| CA3186451A1 (en) | 2008-05-06 | 2009-11-12 | Astellas Institute For Regenerative Medicine | Hemangio colony forming cells and non-engrafting hemangio cells |
| EP2294185A2 (en) | 2008-05-08 | 2011-03-16 | Coretherapix Slu | Multipotent adult stem cell population |
| EP2324109B1 (en) | 2008-09-03 | 2016-10-26 | Mesoblast, Inc. | Expansion of haemopoietic precursors |
| US8956867B2 (en) | 2008-11-07 | 2015-02-17 | Wisconsin Alumni Research Foundation | Method for culturing stem cells |
| KR101720961B1 (ko) | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| WO2011021194A2 (en) | 2009-08-17 | 2011-02-24 | Technion Research & Development Foundation Ltd. | Pericyte progenitor cells and methods of generating and using same |
| KR101193541B1 (ko) | 2009-08-24 | 2012-10-22 | 한국과학기술원 | 인간 배아줄기세포에서 중간엽 줄기세포로 분화시키는 방법 |
| WO2011026221A1 (en) | 2009-09-01 | 2011-03-10 | Mcmaster University | Methods of culturing embryoid bodies |
| KR101135636B1 (ko) | 2009-10-27 | 2012-04-17 | 서울대학교산학협력단 | 인간 만능줄기세포로부터 중배엽 줄기세포를 생산하는 방법 및 이에 의해 생성된 중배엽 줄기세포 |
| CA3080368A1 (en) | 2009-12-04 | 2011-06-09 | Stem Cell & Regenerative Medicine International, Inc. | Method of generating natural killer cells and dendritic cells from human embryonic stem cell-derived hemangioblasts |
| KR20180086301A (ko) | 2009-12-04 | 2018-07-30 | 스템 셀 앤드 리제너러티브 메디신 인터내셔날, 인크. | 기질 없는 조건 하에서 인간 배아줄기세포로부터 기능적 거핵구 및 혈소판의 대규모 생성 |
| EP2529009A4 (en) | 2010-01-28 | 2013-11-13 | Univ Queensland | METHOD OF STEM CELL DIFFERENTIATION |
| WO2011139132A2 (ko) | 2010-05-07 | 2011-11-10 | 한국생명공학연구원 | 줄기세포로부터 생성된 배아체를 대량 증식 및 유지하는 방법 |
| JP6283223B2 (ja) | 2010-09-07 | 2018-02-21 | テクニオン リサーチ アンド ディベロップメント ファウンデーション リミテッド | 多能性幹細胞を培養するための新規な方法および培養培地 |
| EP2686420B1 (en) | 2011-03-18 | 2017-03-01 | New York Blood Center, Inc. | Megakaryocyte and platelet production from stem cells |
| WO2013055297A1 (en) | 2011-10-13 | 2013-04-18 | Singapore Health Services Pte Ltd | Method for preparing mesenchymal stem cell-like cells and cardiomyocyte-like cells |
| SI2785359T1 (sl) * | 2011-11-30 | 2018-11-30 | Astellas Institute For Regenerative Medicine | Mezenhimske stromalne celice in uporabe povezane z njimi |
| KR101477016B1 (ko) | 2012-01-19 | 2014-12-29 | (주)차바이오텍 | 인간 배아줄기세포 유래 혈관주위 전구세포의 제조방법 및 이를 포함하는 세포치료 조성물 |
| JP6277187B2 (ja) | 2012-07-11 | 2018-02-07 | イムステム バイオテクノロジー,インコーポレイテッド | ヒト胚性幹細胞由来の間葉系様幹細胞、方法およびその使用 |
| HK1208054A1 (en) | 2012-07-12 | 2016-02-19 | 爱姆斯坦生物技术公司 | Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof |
| WO2014138485A1 (en) | 2013-03-08 | 2014-09-12 | Irm Llc | Ex vivo production of platelets from hematopoietic stem cells and the product thereof |
| HUE043785T2 (hu) | 2013-03-13 | 2019-09-30 | Wisconsin Alumni Res Found | Módszerek és anyagok humán pluripotens õssejtek hematoendothelialis differenciálására meghatározott körülmények között |
| US20140271616A1 (en) | 2013-03-15 | 2014-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions And Methods For Mesenchymal And/Or Chondrogenic Differentiation Of Stem Cells |
| WO2014146057A2 (en) | 2013-03-15 | 2014-09-18 | Cmr Technologies, Llc | Mesenchymal stem cells |
| KR101669124B1 (ko) | 2013-07-11 | 2016-10-25 | 서울대학교병원 | 인간 배아줄기세포에서 유래된 중간엽 줄기세포를 유효성분으로 함유하는 간섬유화 또는 간경화 예방 및 치료용 조성물 |
| US10538738B2 (en) | 2014-05-19 | 2020-01-21 | Eleftherios Papoutsakis | Megakaryocytic particles and microparticles for cell therapy and fate modification of stem and progenitor cells |
| ES2786373T3 (es) | 2014-06-10 | 2020-10-09 | Biomatrica Inc | Estabilización de trombocitos a temperaturas ambiente |
| JP6459257B2 (ja) | 2014-07-08 | 2019-01-30 | 富士ゼロックス株式会社 | 画像形成装置 |
| US20180237797A1 (en) | 2015-03-30 | 2018-08-23 | Jeffrey Thomas Loh | Methods for in vitro production of platelets and compositions and uses thereof |
| US11174461B2 (en) | 2016-03-16 | 2021-11-16 | Cynata Therapeutics Limited | Colony forming medium and use thereof |
| US20190161726A1 (en) | 2016-07-29 | 2019-05-30 | Daikin Industries, Ltd. | Differentiated cell production method and culture bag used therefor |
| CN109666630A (zh) | 2017-10-17 | 2019-04-23 | 澳门大学 | 多能干细胞分化为间充质干细胞的方法及其培养基和应用 |
| WO2019213366A1 (en) | 2018-05-02 | 2019-11-07 | The Trustees Of Columbia University In The City Of New York | Methods to induce terminal differentiation in stem cells by interfering with dna replication, methods of inducing pancreatic differentiation, and differentiated cells obtained thereof |
| AU2019336221B2 (en) | 2018-09-07 | 2025-05-15 | Wisconsin Alumni Research Foundation | Generation of hematopoietic progenitor cells from human pluripotent stem cells |
-
2007
- 2007-04-13 CN CN201610328018.3A patent/CN106434527A/zh active Pending
- 2007-04-13 JP JP2009505494A patent/JP5630781B2/ja active Active
- 2007-04-13 EP EP11155495A patent/EP2377924A1/en not_active Withdrawn
- 2007-04-13 US US11/787,262 patent/US8017393B2/en active Active
- 2007-04-13 KR KR1020227014323A patent/KR102651433B1/ko active Active
- 2007-04-13 EP EP11155399A patent/EP2377923A1/en not_active Withdrawn
- 2007-04-13 EP EP11155500A patent/EP2377925A1/en not_active Withdrawn
- 2007-04-13 AU AU2007238660A patent/AU2007238660C1/en active Active
- 2007-04-13 CN CNA2007800218226A patent/CN101528915A/zh active Pending
- 2007-04-13 KR KR1020197035159A patent/KR102230288B1/ko active Active
- 2007-04-13 EP EP11155482A patent/EP2426197A1/en not_active Withdrawn
- 2007-04-13 KR KR1020247043162A patent/KR20250008978A/ko active Pending
- 2007-04-13 KR KR1020177023744A patent/KR20170102040A/ko not_active Ceased
- 2007-04-13 EP EP20169139.1A patent/EP3712258B1/en active Active
- 2007-04-13 CN CN2012101320883A patent/CN102660495A/zh active Pending
- 2007-04-13 KR KR1020147033315A patent/KR20140146224A/ko not_active Ceased
- 2007-04-13 KR KR1020087027950A patent/KR20090045886A/ko not_active Ceased
- 2007-04-13 EP EP07755391A patent/EP2013331A2/en not_active Ceased
- 2007-04-13 WO PCT/US2007/009106 patent/WO2007120811A2/en not_active Ceased
- 2007-04-13 KR KR1020217007639A patent/KR102510368B1/ko active Active
- 2007-04-13 KR KR1020237033022A patent/KR20230145494A/ko not_active Ceased
-
2011
- 2011-07-26 US US13/190,988 patent/US20120027731A1/en not_active Abandoned
-
2013
- 2013-03-25 JP JP2013061471A patent/JP2013126423A/ja not_active Withdrawn
-
2015
- 2015-09-29 US US14/869,561 patent/US9938500B2/en active Active
-
2016
- 2016-01-29 JP JP2016015304A patent/JP6525899B2/ja active Active
-
2018
- 2018-02-22 US US15/902,817 patent/US11566228B2/en active Active
-
2019
- 2019-05-07 JP JP2019087461A patent/JP2019165732A/ja active Pending
-
2022
- 2022-06-16 JP JP2022097159A patent/JP2022141641A/ja active Pending
- 2022-12-13 US US18/080,134 patent/US20230313141A1/en active Pending
-
2024
- 2024-07-29 JP JP2024122128A patent/JP2024170392A/ja active Pending
Non-Patent Citations (2)
| Title |
|---|
| Guo, H. et al., Experimental Hematology, 2003, vol.31, pp.650-658* |
| Tian, X. et al., Experimental Hematology (2004) 32:1000-1009* |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20230313141A1 (en) | Hemangio-colony forming cells | |
| US20200263132A1 (en) | Methods for producing enucleated erythroid cells derived from pluripotent stem cells | |
| US20200157503A1 (en) | Hemangio colony forming cells and non-engrafting hemangio cells | |
| JP2019165732A5 (https=) | ||
| AU2013201444B2 (en) | Hemangio-colony forming cells | |
| NZ572842A (en) | Hemangio-colony forming cells | |
| HK40037741A (en) | Hemangio-colony forming cells |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A107 | Divisional application of patent | ||
| PA0104 | Divisional application for international application |
Comment text: Divisional Application for International Patent Patent event code: PA01041R01D Patent event date: 20220427 Application number text: 1020217007639 Filing date: 20210312 |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20220527 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20220620 Patent event code: PE09021S01D |
|
| AMND | Amendment | ||
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20230525 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20220620 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |
|
| AMND | Amendment | ||
| J201 | Request for trial against refusal decision | ||
| PJ0201 | Trial against decision of rejection |
Patent event date: 20230825 Comment text: Request for Trial against Decision on Refusal Patent event code: PJ02012R01D Patent event date: 20230525 Comment text: Decision to Refuse Application Patent event code: PJ02011S01I Appeal kind category: Appeal against decision to decline refusal Appeal identifier: 2023101001833 Request date: 20230825 |
|
| PB0901 | Examination by re-examination before a trial |
Comment text: Amendment to Specification, etc. Patent event date: 20230825 Patent event code: PB09011R02I Comment text: Request for Trial against Decision on Refusal Patent event date: 20230825 Patent event code: PB09011R01I Comment text: Amendment to Specification, etc. Patent event date: 20230120 Patent event code: PB09011R02I |
|
| E90F | Notification of reason for final refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Final Notice of Reason for Refusal Patent event date: 20231024 Patent event code: PE09021S02D |
|
| B701 | Decision to grant | ||
| PB0701 | Decision of registration after re-examination before a trial |
Patent event date: 20240102 Comment text: Decision to Grant Registration Patent event code: PB07012S01D Patent event date: 20230926 Comment text: Transfer of Trial File for Re-examination before a Trial Patent event code: PB07011S01I |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
Comment text: Registration of Establishment Patent event date: 20240321 Patent event code: PR07011E01D |
|
| PR1002 | Payment of registration fee |
Payment date: 20240321 End annual number: 3 Start annual number: 1 |
|
| PG1601 | Publication of registration |