KR102484804B1 - 이미다졸계 화합물의 결정 형태, 염 형태 및 그의 제조 방법 - Google Patents

이미다졸계 화합물의 결정 형태, 염 형태 및 그의 제조 방법 Download PDF

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KR102484804B1
KR102484804B1 KR1020207027160A KR20207027160A KR102484804B1 KR 102484804 B1 KR102484804 B1 KR 102484804B1 KR 1020207027160 A KR1020207027160 A KR 1020207027160A KR 20207027160 A KR20207027160 A KR 20207027160A KR 102484804 B1 KR102484804 B1 KR 102484804B1
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compound
crystalline form
formula
spectrum
weight loss
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KR20200124710A (ko
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지안 시옹
시아오신 천
징징 왕
주오웨이 리우
케빈 엑스 천
청우 리우
청 시에
차오펑 롱
펑 리
지안 리
슈후이 천
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광둥 레이노벤트 바이오테크 컴퍼니 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020207027160A 2018-03-05 2019-03-05 이미다졸계 화합물의 결정 형태, 염 형태 및 그의 제조 방법 Active KR102484804B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201810180641.8 2018-03-05
CN201810180641 2018-03-05
PCT/CN2019/076916 WO2019170067A1 (zh) 2018-03-05 2019-03-05 一种吡啶并咪唑类化合物的晶型、盐型及其制备方法

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KR20200124710A KR20200124710A (ko) 2020-11-03
KR102484804B1 true KR102484804B1 (ko) 2023-01-04

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KR1020207027160A Active KR102484804B1 (ko) 2018-03-05 2019-03-05 이미다졸계 화합물의 결정 형태, 염 형태 및 그의 제조 방법

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US (1) US11535613B2 (https=)
EP (1) EP3763713A4 (https=)
JP (1) JP7031002B2 (https=)
KR (1) KR102484804B1 (https=)
CN (1) CN111819177B (https=)
AU (1) AU2019230497B2 (https=)
CA (1) CA3092315C (https=)
NZ (1) NZ767352A (https=)
RU (1) RU2769050C1 (https=)
TW (1) TWI794433B (https=)
WO (1) WO2019170067A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201901894TA (en) * 2016-09-05 2019-04-29 Guangdong Raynovent Biotech Co Ltd Anti-influenza virus pyrimidine derivatives
WO2021012864A1 (zh) * 2019-07-22 2021-01-28 广东众生睿创生物科技有限公司 嘧啶衍生物的优势盐型及其晶型
CN114502150B (zh) * 2019-09-10 2023-03-24 广东众生睿创生物科技有限公司 一种用于治疗病毒性感冒的药物组合物及其制剂
CN113116899B (zh) * 2020-03-06 2022-12-20 广东众生睿创生物科技有限公司 一种用于治疗流感的药物组合物及含有该药物组合物的制剂
WO2022089261A1 (zh) * 2020-10-29 2022-05-05 广东众生睿创生物科技有限公司 一种嘧啶衍生物的晶型及其制备方法
WO2022166548A1 (zh) * 2021-02-03 2022-08-11 苏州欧康维视生物科技有限公司 吡唑取代的咪唑并[1,2-a]喹喔啉衍生物的盐型及晶型
BR112023018348A2 (pt) * 2021-03-11 2023-12-05 Jiangxi Jemincare Group Co Ltd Forma de cristal de composto de óxido de nitrogênio e piridina e uso da mesma
WO2025237212A1 (zh) * 2024-05-11 2025-11-20 广东众生睿创生物科技有限公司 一种嘧啶衍生物葡甲胺盐及其晶型

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017097234A1 (en) 2015-12-09 2017-06-15 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
WO2017133667A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof
WO2017133670A1 (en) 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS57869B1 (sr) 2009-06-17 2018-12-31 Vertex Pharma Inhibitori replikacije virusa gripa
AU2011343642A1 (en) * 2010-12-16 2013-05-02 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
US8476281B2 (en) * 2011-01-14 2013-07-02 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea
UA124609C2 (uk) * 2014-08-08 2021-10-20 Янссен Саєнсиз Айрленд Юсі Індоли для застосування при інфекції, спричиненій вірусом грипу
RU2018134937A (ru) * 2016-03-07 2020-04-08 Хайтек Пауэр, Инк. Способ формирования и распределения второго топлива для двигателя внутреннего сгорания
SG11201901894TA (en) * 2016-09-05 2019-04-29 Guangdong Raynovent Biotech Co Ltd Anti-influenza virus pyrimidine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017097234A1 (en) 2015-12-09 2017-06-15 Sunshine Lake Pharma Co., Ltd. Inhibitors of influenza virus replication, application methods and uses thereof
WO2017133667A1 (en) * 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyrimidine and pyridine derivatives and use in treatment, amelioration or prevention of influenza thereof
WO2017133670A1 (en) 2016-02-05 2017-08-10 Savira Pharmaceuticals Gmbh Pyridine and pyrimidine derivatives and their use in treatment, amelioration or prevention of influenza

Also Published As

Publication number Publication date
US20200407354A1 (en) 2020-12-31
CA3092315A1 (en) 2019-09-12
TWI794433B (zh) 2023-03-01
AU2019230497A1 (en) 2020-09-17
US11535613B2 (en) 2022-12-27
KR20200124710A (ko) 2020-11-03
JP2021514967A (ja) 2021-06-17
WO2019170067A1 (zh) 2019-09-12
CN111819177B (zh) 2022-03-04
EP3763713A1 (en) 2021-01-13
NZ767352A (en) 2023-05-26
TW201938558A (zh) 2019-10-01
CA3092315C (en) 2023-08-29
EP3763713A4 (en) 2021-11-24
RU2769050C1 (ru) 2022-03-28
CN111819177A (zh) 2020-10-23
JP7031002B2 (ja) 2022-03-07
AU2019230497B2 (en) 2021-08-05

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