KR102454308B1 - PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도 - Google Patents

PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도 Download PDF

Info

Publication number
KR102454308B1
KR102454308B1 KR1020217027697A KR20217027697A KR102454308B1 KR 102454308 B1 KR102454308 B1 KR 102454308B1 KR 1020217027697 A KR1020217027697 A KR 1020217027697A KR 20217027697 A KR20217027697 A KR 20217027697A KR 102454308 B1 KR102454308 B1 KR 102454308B1
Authority
KR
South Korea
Prior art keywords
mmol
chloro
methyl
ethyl
pyrazolo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020217027697A
Other languages
English (en)
Korean (ko)
Other versions
KR20210110409A (ko
Inventor
윈-륭 리
원칭 야오
앤드류 피. 콤스
에디 더블유. 웨
쓩 메이
원위 주
조셉 글렌
주니어 토마스 피. 마두스쾌이
리차드 비. 스파크스
브렌트 두티
춘흉 허
Original Assignee
인사이트 홀딩스 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 인사이트 홀딩스 코포레이션 filed Critical 인사이트 홀딩스 코포레이션
Priority to KR1020227035039A priority Critical patent/KR102586858B1/ko
Publication of KR20210110409A publication Critical patent/KR20210110409A/ko
Application granted granted Critical
Publication of KR102454308B1 publication Critical patent/KR102454308B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020217027697A 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도 Active KR102454308B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227035039A KR102586858B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361771480P 2013-03-01 2013-03-01
US61/771,480 2013-03-01
KR1020157027010A KR102298150B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도
PCT/US2014/019372 WO2014134426A1 (en) 2013-03-01 2014-02-28 USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020157027010A Division KR102298150B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020227035039A Division KR102586858B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도

Publications (2)

Publication Number Publication Date
KR20210110409A KR20210110409A (ko) 2021-09-07
KR102454308B1 true KR102454308B1 (ko) 2022-10-14

Family

ID=50288319

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020217027697A Active KR102454308B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도
KR1020247033698A Pending KR20240152422A (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도
KR1020237033761A Active KR102717616B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도
KR1020157027010A Active KR102298150B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도
KR1020227035039A Active KR102586858B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도

Family Applications After (4)

Application Number Title Priority Date Filing Date
KR1020247033698A Pending KR20240152422A (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도
KR1020237033761A Active KR102717616B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도
KR1020157027010A Active KR102298150B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도
KR1020227035039A Active KR102586858B1 (ko) 2013-03-01 2014-02-28 PI3Kδ 관련 장애의 치료를 위한 피라졸로피리미딘 유도체의 용도

Country Status (32)

Country Link
US (6) US9932341B2 (OSRAM)
EP (3) EP2961410B1 (OSRAM)
JP (5) JP6545106B2 (OSRAM)
KR (5) KR102454308B1 (OSRAM)
CN (2) CN105120871B (OSRAM)
AR (1) AR094964A1 (OSRAM)
AU (5) AU2014223257B2 (OSRAM)
BR (1) BR112015020941A2 (OSRAM)
CA (1) CA2901993C (OSRAM)
CL (1) CL2015002442A1 (OSRAM)
CR (1) CR20150472A (OSRAM)
CY (1) CY1122712T1 (OSRAM)
DK (1) DK2961410T3 (OSRAM)
EA (2) EA201591612A1 (OSRAM)
ES (2) ES2945212T3 (OSRAM)
HR (1) HRP20200263T1 (OSRAM)
HU (1) HUE047719T2 (OSRAM)
IL (6) IL311666A (OSRAM)
LT (1) LT2961410T (OSRAM)
MX (2) MX367713B (OSRAM)
MY (1) MY177875A (OSRAM)
PE (1) PE20151996A1 (OSRAM)
PH (3) PH12021552233A1 (OSRAM)
PL (1) PL2961410T3 (OSRAM)
PT (1) PT2961410T (OSRAM)
RS (1) RS59958B1 (OSRAM)
SG (3) SG11201506654UA (OSRAM)
SI (1) SI2961410T1 (OSRAM)
SM (1) SMT202000043T1 (OSRAM)
TW (5) TWI657090B (OSRAM)
UA (1) UA119641C2 (OSRAM)
WO (1) WO2014134426A1 (OSRAM)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102482278B (zh) 2009-06-29 2015-04-22 因塞特公司 作为pi3k抑制剂的嘧啶酮类
TWI648277B (zh) 2011-09-02 2019-01-21 美商英塞特控股公司 作為ｐｉ３ｋ抑制劑之雜環基胺
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
CA2897333C (en) 2013-01-15 2021-07-06 Incyte Corporation Thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
TWI657090B (zh) 2013-03-01 2019-04-21 英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ 相關病症之用途
CR20160135A (es) 2013-08-23 2016-08-05 Incyte Corp Compuestos de carboxamida de furo y tienopiridina útiles como inhibidores de cinasas pim
MY185686A (en) 2014-04-08 2021-05-30 Incyte Corp Treatment of b-cell malignancies by a combination jak and p13k inhibitor
WO2015191677A1 (en) 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016010897A1 (en) 2014-07-14 2016-01-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors
WO2016130501A1 (en) 2015-02-09 2016-08-18 Incyte Corporation Aza-heteroaryl compounds as pi3k-gamma inhibitors
CA3285092A1 (en) 2015-02-27 2025-11-29 Incyte Holdings Corporation Salts of pi3k inhibitor and processes for their preparation
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
TW201718546A (zh) 2015-10-02 2017-06-01 英塞特公司 適用作pim激酶抑制劑之雜環化合物
US10065963B2 (en) 2015-11-06 2018-09-04 Incyte Corporation Heterocyclic compounds as PI3K-γ inhibitors
ES2995198T3 (en) 2016-01-05 2025-02-07 Incyte Corp Pyridine compounds as pi3k-gamma inhibitors
US9822122B2 (en) 2016-03-31 2017-11-21 Oncternal Therapeutics, Inc. Indoline analogs and uses thereof
AR108875A1 (es) 2016-06-24 2018-10-03 Incyte Corp COMPUESTOS HETEROCÍCLICOS COMO INHIBIDORES DE PI3K-g
TWI817956B (zh) * 2017-09-08 2023-10-11 英屬開曼群島商百濟神州有限公司 咪唑並[1,5-A]吡嗪衍生物作爲PI3Kδ 抑制劑
MD3697789T2 (ro) 2017-10-18 2022-02-28 Incyte Corp Derivați imidazol condensați substituiți cu grupări hidroxi terțiare ca inhibitori PI3K-GAMA
WO2019113487A1 (en) 2017-12-08 2019-06-13 Incyte Corporation Low dose combination therapy for treatment of myeloproliferative neoplasms
TWI839788B (zh) 2018-01-10 2024-04-21 瑞士商愛杜西亞製藥有限公司 C5a受體調節劑
RS63124B1 (sr) 2018-03-08 2022-05-31 Incyte Corp Aminopirazin diol jedinjenja kao pi3k-y inhibitori
CN120053645A (zh) 2018-06-01 2025-05-30 因赛特公司 治疗pi3k相关病症的给药方案
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
TWI727392B (zh) * 2018-08-13 2021-05-11 美商基利科學股份有限公司 噻二唑irak4抑制劑
CN110833552A (zh) * 2018-08-15 2020-02-25 广西梧州制药（集团）股份有限公司 吡唑并嘧啶衍生物在治疗狼疮肾炎的用途
CR20250050A (es) * 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
JP2023551519A (ja) 2020-11-30 2023-12-08 インサイト・コーポレイション 抗ｃｄ１９抗体とパルサクリシブの組み合わせ療法
WO2022115120A1 (en) 2020-11-30 2022-06-02 Incyte Corporation Combination therapy with an anti-cd19 antibody and parsaclisib
CN112808550B (zh) * 2020-12-28 2021-10-01 青岛理工大学 用于海洋工程的劣化免疫仿生防护界面及制备方法
TW202329976A (zh) 2021-12-16 2023-08-01 美商英塞特公司 Ｐ１３Ｋ—δ抑制劑之局部調配物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010036380A1 (en) 2008-09-26 2010-04-01 Intellikine, Inc. Heterocyclic kinase inhibitors

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
JP4516690B2 (ja) 1998-08-11 2010-08-04 ノバルティス アーゲー 血管形成阻害活性を有するイソキノリン誘導体
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
DE60105023T2 (de) 2000-06-28 2005-08-18 Smithkline Beecham P.L.C., Brentford Nassvermahlungsverfahren
AU2002337142B2 (en) 2001-09-19 2007-10-11 Aventis Pharma S.A. Indolizines as kinase protein inhibitors
DK1441737T3 (da) 2001-10-30 2006-11-13 Novartis Ag Staurosporin-derivater som inhibitorer af FLT3-receptor-tyrosinkinase-aktivitet
AR037647A1 (es) 2002-05-29 2004-12-01 Novartis Ag Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
PE20050952A1 (es) 2003-09-24 2005-12-19 Novartis Ag Derivados de isoquinolina como inhibidores de b-raf
RU2401265C2 (ru) 2004-06-10 2010-10-10 Айрм Ллк Соединения и композиции в качестве ингибиторов протеинкиназы
AU2005309019A1 (en) 2004-11-24 2006-06-01 Novartis Ag Combinations of JAK inhibitors and at least one of Bcr-Abl, Flt-3, FAK or RAF kinase inhibitors
EP2537849A3 (en) 2006-01-17 2013-04-03 Vertex Pharmaceuticals, Inc. Azaindoles useful as inhibitors of janus kinases
WO2009026701A1 (en) 2007-08-29 2009-03-05 Methylgene Inc. Sirtuin inhibitors
EP2310391A1 (en) 2008-06-27 2011-04-20 S*BIO Pte Ltd Pyrazine substituted purines
AR073651A1 (es) 2008-09-24 2010-11-24 Novartis Ag Formulaciones galenicas de compuestos organicos
AU2010234360A1 (en) 2009-04-09 2011-09-29 Oncothyreon, Incorporated Methods and compositions of PI-3 kinase inhibitors for treating fibrosis
CN102482278B (zh) 2009-06-29 2015-04-22 因塞特公司 作为pi3k抑制剂的嘧啶酮类
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
ES2432315T3 (es) 2009-08-28 2013-12-02 Takeda Pharmaceutical Company Limited Compuestos de hexahidrooxazinopterina para su uso como inhibidores de mTOR
US8680108B2 (en) 2009-12-18 2014-03-25 Incyte Corporation Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors
WO2011075643A1 (en) 2009-12-18 2011-06-23 Incyte Corporation Substituted heteroaryl fused derivatives as pi3k inhibitors
EP2558463A1 (en) 2010-04-14 2013-02-20 Incyte Corporation Fused derivatives as i3 inhibitors
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
TW201249844A (en) 2010-12-20 2012-12-16 Incyte Corp N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors
WO2012106343A2 (en) 2011-02-01 2012-08-09 The Board Of Trustees Of The University Of Illinois Hdac inhibitors and therapeutic methods using the same
US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
US9126948B2 (en) 2011-03-25 2015-09-08 Incyte Holdings Corporation Pyrimidine-4,6-diamine derivatives as PI3K inhibitors
TWI648277B (zh) * 2011-09-02 2019-01-21 美商英塞特控股公司 作為ｐｉ３ｋ抑制劑之雜環基胺
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
TWI657090B (zh) 2013-03-01 2019-04-21 英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ 相關病症之用途
WO2015191677A1 (en) * 2014-06-11 2015-12-17 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors
CA3285092A1 (en) * 2015-02-27 2025-11-29 Incyte Holdings Corporation Salts of pi3k inhibitor and processes for their preparation
CN120053645A (zh) 2018-06-01 2025-05-30 因赛特公司 治疗pi3k相关病症的给药方案
US11161838B2 (en) * 2018-11-13 2021-11-02 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010036380A1 (en) 2008-09-26 2010-04-01 Intellikine, Inc. Heterocyclic kinase inhibitors

Also Published As

Publication number Publication date
IL301180A (en) 2023-05-01
TW202019428A (zh) 2020-06-01
US20220106318A1 (en) 2022-04-07
TW201929860A (zh) 2019-08-01
US20140249132A1 (en) 2014-09-04
IL240784A0 (en) 2015-10-29
TWI841376B (zh) 2024-05-01
JP2019142941A (ja) 2019-08-29
KR20220143146A (ko) 2022-10-24
EP4233869A3 (en) 2023-11-01
AU2014223257B2 (en) 2018-11-29
JP2023036609A (ja) 2023-03-14
AU2014223257A1 (en) 2015-09-24
AU2020210278A1 (en) 2020-08-20
BR112015020941A2 (pt) 2017-07-18
EP4233869A2 (en) 2023-08-30
EP2961410A1 (en) 2016-01-06
PH12021552233A1 (en) 2022-07-18
IL283943B2 (en) 2023-08-01
ES2945212T3 (es) 2023-06-29
JP7556010B2 (ja) 2024-09-25
IL267853B (en) 2020-03-31
AU2022218495A1 (en) 2022-09-08
MX2019010422A (es) 2019-10-15
EP3632442B1 (en) 2023-04-05
HUE047719T2 (hu) 2020-05-28
EA202192151A1 (ru) 2021-12-31
CN105120871B (zh) 2018-08-10
HRP20200263T1 (hr) 2020-05-29
US20190040067A1 (en) 2019-02-07
PL2961410T3 (pl) 2020-05-18
JP6776399B2 (ja) 2020-10-28
IL274771A (en) 2020-07-30
AU2018264053A1 (en) 2018-12-06
SG11201506654UA (en) 2015-09-29
KR20230145517A (ko) 2023-10-17
PH12019501321B1 (en) 2020-10-12
EP2961410B1 (en) 2019-12-11
US9932341B2 (en) 2018-04-03
IL267853A (en) 2019-09-26
PH12015501920A1 (en) 2016-01-18
UA119641C2 (uk) 2019-07-25
IL283943B1 (en) 2023-04-01
MX2015011273A (es) 2015-12-03
CY1122712T1 (el) 2021-03-12
TW201444846A (zh) 2014-12-01
JP2016510035A (ja) 2016-04-04
CR20150472A (es) 2016-01-04
KR20150135327A (ko) 2015-12-02
US12152033B2 (en) 2024-11-26
TWI736135B (zh) 2021-08-11
SI2961410T1 (sl) 2020-03-31
KR20240152422A (ko) 2024-10-21
SMT202000043T1 (it) 2020-03-13
EA201591612A1 (ru) 2016-05-31
ES2774436T3 (es) 2020-07-21
CA2901993A1 (en) 2014-09-04
CA2901993C (en) 2023-03-07
CN105120871A (zh) 2015-12-02
US20210332059A1 (en) 2021-10-28
TW202214254A (zh) 2022-04-16
AU2018264053B2 (en) 2020-08-20
DK2961410T3 (da) 2020-02-17
MY177875A (en) 2020-09-24
RS59958B1 (sr) 2020-03-31
US20220119393A1 (en) 2022-04-21
CL2015002442A1 (es) 2016-02-05
PE20151996A1 (es) 2016-01-13
JP7189185B2 (ja) 2022-12-13
KR102586858B1 (ko) 2023-10-11
PH12015501920B1 (en) 2016-01-18
PT2961410T (pt) 2020-03-02
TWI687220B (zh) 2020-03-11
JP6545106B2 (ja) 2019-07-17
EP3632442A1 (en) 2020-04-08
JP2025003975A (ja) 2025-01-14
WO2014134426A1 (en) 2014-09-04
AU2020210278B2 (en) 2022-05-26
AR094964A1 (es) 2015-09-09
PH12019501321A1 (en) 2020-10-12
US20250289823A1 (en) 2025-09-18
KR20210110409A (ko) 2021-09-07
KR102298150B1 (ko) 2021-09-07
IL240784B (en) 2020-06-30
IL311666A (en) 2024-05-01
CN109010343A (zh) 2018-12-18
TWI657090B (zh) 2019-04-21
SG10201912275YA (en) 2020-04-29
AU2022218495B2 (en) 2024-10-03
HK1221398A1 (en) 2017-06-02
IL283943A (en) 2021-07-29
TW202333734A (zh) 2023-09-01
KR102717616B1 (ko) 2024-10-16
MX367713B (es) 2019-09-03
JP2021020914A (ja) 2021-02-18
AU2024287194A1 (en) 2025-01-23
LT2961410T (lt) 2020-02-10
SG10201707130UA (en) 2017-10-30

Similar Documents

Publication Publication Date Title
AU2022218495B2 (en) USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS
JP6266743B2 (ja) Ｐｉ３ｋ阻害剤としてのヘテロシクリルアミン
HK40098131A (en) Use of pyrazolopyrimidine derivatives for the treatment of pi3k related disorders
HK40027828A (en) Use of pyrazolopyrimidine derivatives for the treatment of pi3k related disorders
HK1221398B (en) Use of pyrazolopyrimidine derivatives for the treatment of pi3k related disorders

Legal Events

Date Code Title Description
A107 Divisional application of patent
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20210830

Application number text: 1020157027010

Filing date: 20150930

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20210928

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20211021

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20220706

PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20221007

Application number text: 1020157027010

Filing date: 20150930

PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20221007

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20221011

End annual number: 3

Start annual number: 1

PG1601 Publication of registration