JP6545106B2 - ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用 - Google Patents

ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用 Download PDF

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Publication number
JP6545106B2
JP6545106B2 JP2015560346A JP2015560346A JP6545106B2 JP 6545106 B2 JP6545106 B2 JP 6545106B2 JP 2015560346 A JP2015560346 A JP 2015560346A JP 2015560346 A JP2015560346 A JP 2015560346A JP 6545106 B2 JP6545106 B2 JP 6545106B2
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mmol
chloro
methyl
pyrazolo
ethyl
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JP2016510035A (ja
JP2016510035A5 (OSRAM
Inventor
ユン−ロン・リ
ウェンチン・ヤオ
アンドリュー・ピー・コームズ
エディ・ダブリュー・ユー
メイ・ソン
ウェンユー・ジュー
ジョセフ・グレン
トーマス・ピー・マダスキー・ジュニア
リチャード・ビー・スパークス
ブレント・ダウティ
ホァ・チュンホン
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Incyte Holdings Corp
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Incyte Holdings Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2015560346A 2013-03-01 2014-02-28 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用 Active JP6545106B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771480P 2013-03-01 2013-03-01
US61/771,480 2013-03-01
PCT/US2014/019372 WO2014134426A1 (en) 2013-03-01 2014-02-28 USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS

Related Child Applications (1)

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JP2019084393A Division JP6776399B2 (ja) 2013-03-01 2019-04-25 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用

Publications (3)

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JP2016510035A JP2016510035A (ja) 2016-04-04
JP2016510035A5 JP2016510035A5 (OSRAM) 2017-04-13
JP6545106B2 true JP6545106B2 (ja) 2019-07-17

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Family Applications (5)

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JP2015560346A Active JP6545106B2 (ja) 2013-03-01 2014-02-28 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用
JP2019084393A Active JP6776399B2 (ja) 2013-03-01 2019-04-25 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用
JP2020169551A Active JP7189185B2 (ja) 2013-03-01 2020-10-07 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用
JP2022192954A Active JP7556010B2 (ja) 2013-03-01 2022-12-01 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用
JP2024157116A Pending JP2025003975A (ja) 2013-03-01 2024-09-11 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用

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JP2019084393A Active JP6776399B2 (ja) 2013-03-01 2019-04-25 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用
JP2020169551A Active JP7189185B2 (ja) 2013-03-01 2020-10-07 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用
JP2022192954A Active JP7556010B2 (ja) 2013-03-01 2022-12-01 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用
JP2024157116A Pending JP2025003975A (ja) 2013-03-01 2024-09-11 ＰＩ３Ｋδ関連障害治療のためのピラゾロピリミジン誘導体の使用

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US (6) US9932341B2 (OSRAM)
EP (3) EP2961410B1 (OSRAM)
JP (5) JP6545106B2 (OSRAM)
KR (5) KR102454308B1 (OSRAM)
CN (2) CN105120871B (OSRAM)
AR (1) AR094964A1 (OSRAM)
AU (5) AU2014223257B2 (OSRAM)
BR (1) BR112015020941A2 (OSRAM)
CA (1) CA2901993C (OSRAM)
CL (1) CL2015002442A1 (OSRAM)
CR (1) CR20150472A (OSRAM)
CY (1) CY1122712T1 (OSRAM)
DK (1) DK2961410T3 (OSRAM)
EA (2) EA202192151A1 (OSRAM)
ES (2) ES2774436T3 (OSRAM)
HR (1) HRP20200263T1 (OSRAM)
HU (1) HUE047719T2 (OSRAM)
IL (6) IL301180A (OSRAM)
LT (1) LT2961410T (OSRAM)
MX (2) MX367713B (OSRAM)
MY (1) MY177875A (OSRAM)
PE (1) PE20151996A1 (OSRAM)
PH (3) PH12021552233A1 (OSRAM)
PL (1) PL2961410T3 (OSRAM)
PT (1) PT2961410T (OSRAM)
RS (1) RS59958B1 (OSRAM)
SG (3) SG11201506654UA (OSRAM)
SI (1) SI2961410T1 (OSRAM)
SM (1) SMT202000043T1 (OSRAM)
TW (5) TWI657090B (OSRAM)
UA (1) UA119641C2 (OSRAM)
WO (1) WO2014134426A1 (OSRAM)

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CN105120871A (zh) 2015-12-02
MY177875A (en) 2020-09-24
IL311666A (en) 2024-05-01
KR102717616B1 (ko) 2024-10-16
KR102586858B1 (ko) 2023-10-11
DK2961410T3 (da) 2020-02-17
SG10201707130UA (en) 2017-10-30
JP2019142941A (ja) 2019-08-29
US20210332059A1 (en) 2021-10-28
ES2774436T3 (es) 2020-07-21
PH12019501321A1 (en) 2020-10-12
EA202192151A1 (ru) 2021-12-31
CR20150472A (es) 2016-01-04
MX367713B (es) 2019-09-03
AR094964A1 (es) 2015-09-09
PH12015501920A1 (en) 2016-01-18
PH12021552233A1 (en) 2022-07-18
JP7556010B2 (ja) 2024-09-25
KR20230145517A (ko) 2023-10-17
IL240784A0 (en) 2015-10-29
IL240784B (en) 2020-06-30
IL267853A (en) 2019-09-26
PL2961410T3 (pl) 2020-05-18
TW201444846A (zh) 2014-12-01
SG11201506654UA (en) 2015-09-29
SG10201912275YA (en) 2020-04-29
AU2018264053A1 (en) 2018-12-06
EP3632442A1 (en) 2020-04-08
IL283943B1 (en) 2023-04-01
KR20150135327A (ko) 2015-12-02
IL301180A (en) 2023-05-01
US20140249132A1 (en) 2014-09-04
JP6776399B2 (ja) 2020-10-28
KR102454308B1 (ko) 2022-10-14
TW202019428A (zh) 2020-06-01
WO2014134426A1 (en) 2014-09-04
UA119641C2 (uk) 2019-07-25
IL267853B (en) 2020-03-31
AU2014223257A1 (en) 2015-09-24
TW202214254A (zh) 2022-04-16
JP2016510035A (ja) 2016-04-04
KR20240152422A (ko) 2024-10-21
TWI736135B (zh) 2021-08-11
EP2961410B1 (en) 2019-12-11
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