SI2961410T1 - Uporaba derivatov pirazolopirimidina za zdravljenje motenj povezanih s PI3K - Google Patents

Uporaba derivatov pirazolopirimidina za zdravljenje motenj povezanih s PI3K

Info

Publication number
SI2961410T1
SI2961410T1 SI201431449T SI201431449T SI2961410T1 SI 2961410 T1 SI2961410 T1 SI 2961410T1 SI 201431449 T SI201431449 T SI 201431449T SI 201431449 T SI201431449 T SI 201431449T SI 2961410 T1 SI2961410 T1 SI 2961410T1
Authority
SI
Slovenia
Prior art keywords
pi3k
treatment
related disorders
pyrazolopyrimidine derivatives
pyrazolopyrimidine
Prior art date
Application number
SI201431449T
Other languages
English (en)
Slovenian (sl)
Inventor
Yun-Long Li
Wenqing Yao
Andrew P. Combs
Eddy W. Yue
Song Mei
Wenyu Zhu
Joseph Glenn
Jr. Thomas P. Maduskuie
Richard B. Sparks
Brent Douty
Chunhong He
Original Assignee
Incyte Holdings Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Holdings Corporation filed Critical Incyte Holdings Corporation
Publication of SI2961410T1 publication Critical patent/SI2961410T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SI201431449T 2013-03-01 2014-02-28 Uporaba derivatov pirazolopirimidina za zdravljenje motenj povezanih s PI3K SI2961410T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361771480P 2013-03-01 2013-03-01
EP14710739.5A EP2961410B1 (en) 2013-03-01 2014-02-28 Use of pyrazolopyrimidine derivatives for the treatment of pi3k related disorders
PCT/US2014/019372 WO2014134426A1 (en) 2013-03-01 2014-02-28 USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3Kδ RELATED DISORDERS

Publications (1)

Publication Number Publication Date
SI2961410T1 true SI2961410T1 (sl) 2020-03-31

Family

ID=50288319

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201431449T SI2961410T1 (sl) 2013-03-01 2014-02-28 Uporaba derivatov pirazolopirimidina za zdravljenje motenj povezanih s PI3K

Country Status (32)

Country Link
US (6) US9932341B2 (OSRAM)
EP (3) EP2961410B1 (OSRAM)
JP (5) JP6545106B2 (OSRAM)
KR (5) KR102454308B1 (OSRAM)
CN (2) CN105120871B (OSRAM)
AR (1) AR094964A1 (OSRAM)
AU (5) AU2014223257B2 (OSRAM)
BR (1) BR112015020941A2 (OSRAM)
CA (1) CA2901993C (OSRAM)
CL (1) CL2015002442A1 (OSRAM)
CR (1) CR20150472A (OSRAM)
CY (1) CY1122712T1 (OSRAM)
DK (1) DK2961410T3 (OSRAM)
EA (2) EA202192151A1 (OSRAM)
ES (2) ES2774436T3 (OSRAM)
HR (1) HRP20200263T1 (OSRAM)
HU (1) HUE047719T2 (OSRAM)
IL (6) IL301180A (OSRAM)
LT (1) LT2961410T (OSRAM)
MX (2) MX367713B (OSRAM)
MY (1) MY177875A (OSRAM)
PE (1) PE20151996A1 (OSRAM)
PH (3) PH12021552233A1 (OSRAM)
PL (1) PL2961410T3 (OSRAM)
PT (1) PT2961410T (OSRAM)
RS (1) RS59958B1 (OSRAM)
SG (3) SG11201506654UA (OSRAM)
SI (1) SI2961410T1 (OSRAM)
SM (1) SMT202000043T1 (OSRAM)
TW (5) TWI657090B (OSRAM)
UA (1) UA119641C2 (OSRAM)
WO (1) WO2014134426A1 (OSRAM)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20140754T2 (hr) 2009-06-29 2015-07-17 Incyte Corporation Pirimidinoni kao inhibitori pi3k
LT3196202T (lt) 2011-09-02 2019-07-10 Incyte Holdings Corporation Heterociklilaminai, kaip pi3k slopikliai
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
JP6437452B2 (ja) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物
LT2945939T (lt) 2013-01-15 2020-07-27 Incyte Holdings Corporation Triazolkarboksamidai ir piridinkarboksamido junginiai, naudotini kaip pim kinazės inhibitoriai
TWI657090B (zh) 2013-03-01 2019-04-21 英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ 相關病症之用途
EP3036238A1 (en) 2013-08-23 2016-06-29 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
NZ763326A (en) 2014-04-08 2023-04-28 Incyte Holdings Corp Treatment of b-cell malignancies by a combination jak and pi3k inhibitor
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
WO2016130501A1 (en) 2015-02-09 2016-08-18 Incyte Corporation Aza-heteroaryl compounds as pi3k-gamma inhibitors
CN117736209A (zh) * 2015-02-27 2024-03-22 因赛特控股公司 Pi3k抑制剂的盐及其制备方法
WO2016183063A1 (en) 2015-05-11 2016-11-17 Incyte Corporation Crystalline forms of a pi3k inhibitor
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
AR106595A1 (es) 2015-11-06 2018-01-31 Incyte Corp COMPUESTOS HETEROCÍCLICOS COMO INHIBIDORES DE PI3K-g
EP3400221B1 (en) 2016-01-05 2020-08-26 Incyte Corporation Pyrazol / imidazol substituted pyridines as pi3k-gamma inhibitors
JP6864379B2 (ja) 2016-03-31 2021-04-28 オンターナル セラピューティック インコーポレイテッドOncternal Therapeutics, Inc. インドール類似体及びその使用
TW201803871A (zh) 2016-06-24 2018-02-01 英塞特公司 作為PI3K-γ抑制劑之雜環化合物
BR112020004500A2 (pt) * 2017-09-08 2020-12-01 Beigene, Ltd. derivados de imidazo [1,5-a] pirazina como inibidores de pi3kdelta
BR112020007593A2 (pt) 2017-10-18 2020-09-24 Incyte Corporation derivados de imidazol condensados substituídos por grupos hidróxi terciários como inibidores de pi3k-gama
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
AU2019207666B2 (en) 2018-01-10 2023-12-21 Idorsia Pharmaceuticals Ltd 2,4,6,7-tetrahydro-pyrazolo[4,3-d]pyrimidin-5-one derivatives and related compounds as C5a receptor modulators for treating vasculitis and inflammatory diseases
PT3762368T (pt) 2018-03-08 2022-05-06 Incyte Corp Compostos de aminopirazina diol como inibidores de pi3k-y
PE20211208A1 (es) 2018-06-01 2021-07-05 Incyte Corp Regimen de dosificacion para el tratamiento de trastornos relacionados con pi3k
WO2020010003A1 (en) 2018-07-02 2020-01-09 Incyte Corporation AMINOPYRAZINE DERIVATIVES AS PI3K-γ INHIBITORS
TWI727392B (zh) * 2018-08-13 2021-05-11 美商基利科學股份有限公司 噻二唑irak4抑制劑
CN110833552A (zh) * 2018-08-15 2020-02-25 广西梧州制药(集团)股份有限公司 吡唑并嘧啶衍生物在治疗狼疮肾炎的用途
CR20250050A (es) 2018-09-05 2025-03-19 Incyte Corp Formas cristalinas de un inhibidor de fosfoinositida 3–quinasa (pi3k) (divisional 2021-0165)
WO2022115762A1 (en) 2020-11-30 2022-06-02 Incyte Corporation Combination therapy with an anti-cd19 antibody and parsaclisib
WO2022115120A1 (en) 2020-11-30 2022-06-02 Incyte Corporation Combination therapy with an anti-cd19 antibody and parsaclisib
CN112808550B (zh) * 2020-12-28 2021-10-01 青岛理工大学 用于海洋工程的劣化免疫仿生防护界面及制备方法
WO2023114369A2 (en) 2021-12-16 2023-06-22 Incyte Corporation Topical formulations of pi3k-delta inhibitors

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
EP1107964B8 (en) 1998-08-11 2010-04-07 Novartis AG Isoquinoline derivatives with angiogenesis inhibiting activity
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
EP1294358B1 (en) 2000-06-28 2004-08-18 Smithkline Beecham Plc Wet milling process
WO2003024967A2 (en) 2001-09-19 2003-03-27 Aventis Pharma S.A. Indolizines as kinase protein inhibitors
EP1441737B1 (en) 2001-10-30 2006-08-09 Novartis AG Staurosporine derivatives as inhibitors of flt3 receptor tyrosine kinase activity
PE20040522A1 (es) 2002-05-29 2004-09-28 Novartis Ag Derivados de diarilurea dependientes de la cinasa de proteina
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
PE20050952A1 (es) 2003-09-24 2005-12-19 Novartis Ag Derivados de isoquinolina como inhibidores de b-raf
RU2401265C2 (ru) 2004-06-10 2010-10-10 Айрм Ллк Соединения и композиции в качестве ингибиторов протеинкиназы
KR20070085433A (ko) 2004-11-24 2007-08-27 노파르티스 아게 Jak 저해제들과 bcr-abl, flt-3, fak 또는raf 키나제 저해제들 중 하나 이상의 조합물
NZ601687A (en) 2006-01-17 2014-03-28 Vertex Pharma Azaindoles useful as inhibitors of janus kinases
WO2009026701A1 (en) 2007-08-29 2009-03-05 Methylgene Inc. Sirtuin inhibitors
WO2009157880A1 (en) 2008-06-27 2009-12-30 S*Bio Pte Ltd Pyrazine substituted purines
AR073651A1 (es) * 2008-09-24 2010-11-24 Novartis Ag Formulaciones galenicas de compuestos organicos
US8703778B2 (en) * 2008-09-26 2014-04-22 Intellikine Llc Heterocyclic kinase inhibitors
BRPI1015940A2 (pt) 2009-04-09 2016-04-19 Oncothyreon Inc métodos e composições de inibidores de pi-3 quinase para tratar fibrose
HRP20140754T2 (hr) 2009-06-29 2015-07-17 Incyte Corporation Pirimidinoni kao inhibitori pi3k
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
EP2470546B1 (en) 2009-08-28 2013-07-24 Takeda Pharmaceutical Company Limited Hexahydrooxazinopteridine compounds for use as mtor inhibitors
AR079529A1 (es) 2009-12-18 2012-02-01 Incyte Corp Derivados arilo y heteroarilo sustituidos y fundidos como inhibidores de la pi3k
US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
WO2011130342A1 (en) 2010-04-14 2011-10-20 Incyte Corporation FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
WO2012087881A1 (en) 2010-12-20 2012-06-28 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
CA2825599C (en) 2011-02-01 2021-07-13 The Board Of Trustees Of The University Of Illinois 4-methyl-n-hydroxybenzamide compounds as histone deacetylase (hdac) inhibitors
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
LT3196202T (lt) 2011-09-02 2019-07-10 Incyte Holdings Corporation Heterociklilaminai, kaip pi3k slopikliai
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
TWI657090B (zh) 2013-03-01 2019-04-21 英塞特控股公司 吡唑并嘧啶衍生物治療PI3Kδ 相關病症之用途
US10077277B2 (en) * 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
CN117736209A (zh) * 2015-02-27 2024-03-22 因赛特控股公司 Pi3k抑制剂的盐及其制备方法
PE20211208A1 (es) 2018-06-01 2021-07-05 Incyte Corp Regimen de dosificacion para el tratamiento de trastornos relacionados con pi3k
WO2020102150A1 (en) * 2018-11-13 2020-05-22 Incyte Corporation Heterocyclic derivatives as pi3k inhibitors

Also Published As

Publication number Publication date
CN105120871A (zh) 2015-12-02
MY177875A (en) 2020-09-24
IL311666A (en) 2024-05-01
KR102717616B1 (ko) 2024-10-16
KR102586858B1 (ko) 2023-10-11
DK2961410T3 (da) 2020-02-17
SG10201707130UA (en) 2017-10-30
JP2019142941A (ja) 2019-08-29
US20210332059A1 (en) 2021-10-28
ES2774436T3 (es) 2020-07-21
PH12019501321A1 (en) 2020-10-12
EA202192151A1 (ru) 2021-12-31
CR20150472A (es) 2016-01-04
MX367713B (es) 2019-09-03
AR094964A1 (es) 2015-09-09
PH12015501920A1 (en) 2016-01-18
PH12021552233A1 (en) 2022-07-18
JP7556010B2 (ja) 2024-09-25
KR20230145517A (ko) 2023-10-17
IL240784A0 (en) 2015-10-29
IL240784B (en) 2020-06-30
IL267853A (en) 2019-09-26
PL2961410T3 (pl) 2020-05-18
TW201444846A (zh) 2014-12-01
SG11201506654UA (en) 2015-09-29
SG10201912275YA (en) 2020-04-29
AU2018264053A1 (en) 2018-12-06
EP3632442A1 (en) 2020-04-08
IL283943B1 (en) 2023-04-01
KR20150135327A (ko) 2015-12-02
IL301180A (en) 2023-05-01
US20140249132A1 (en) 2014-09-04
JP6776399B2 (ja) 2020-10-28
KR102454308B1 (ko) 2022-10-14
TW202019428A (zh) 2020-06-01
WO2014134426A1 (en) 2014-09-04
UA119641C2 (uk) 2019-07-25
IL267853B (en) 2020-03-31
AU2014223257A1 (en) 2015-09-24
TW202214254A (zh) 2022-04-16
JP2016510035A (ja) 2016-04-04
KR20240152422A (ko) 2024-10-21
TWI736135B (zh) 2021-08-11
EP2961410B1 (en) 2019-12-11
AU2024287194A1 (en) 2025-01-23
SMT202000043T1 (it) 2020-03-13
AU2022218495A1 (en) 2022-09-08
TWI841376B (zh) 2024-05-01
CA2901993C (en) 2023-03-07
AU2018264053B2 (en) 2020-08-20
RS59958B1 (sr) 2020-03-31
JP6545106B2 (ja) 2019-07-17
AU2022218495B2 (en) 2024-10-03
CN105120871B (zh) 2018-08-10
US20220119393A1 (en) 2022-04-21
AU2014223257B2 (en) 2018-11-29
EP4233869A2 (en) 2023-08-30
KR20220143146A (ko) 2022-10-24
HUE047719T2 (hu) 2020-05-28
LT2961410T (lt) 2020-02-10
MX2015011273A (es) 2015-12-03
EP4233869A3 (en) 2023-11-01
IL274771A (en) 2020-07-30
TWI687220B (zh) 2020-03-11
HRP20200263T1 (hr) 2020-05-29
PH12015501920B1 (en) 2016-01-18
ES2945212T3 (es) 2023-06-29
CL2015002442A1 (es) 2016-02-05
IL283943A (en) 2021-07-29
PT2961410T (pt) 2020-03-02
US20190040067A1 (en) 2019-02-07
EA201591612A1 (ru) 2016-05-31
AU2020210278B2 (en) 2022-05-26
AU2020210278A1 (en) 2020-08-20
PH12019501321B1 (en) 2020-10-12
TW201929860A (zh) 2019-08-01
IL283943B2 (en) 2023-08-01
JP2021020914A (ja) 2021-02-18
JP2025003975A (ja) 2025-01-14
US12152033B2 (en) 2024-11-26
CY1122712T1 (el) 2021-03-12
BR112015020941A2 (pt) 2017-07-18
CA2901993A1 (en) 2014-09-04
TWI657090B (zh) 2019-04-21
PE20151996A1 (es) 2016-01-13
MX2019010422A (es) 2019-10-15
KR102298150B1 (ko) 2021-09-07
US9932341B2 (en) 2018-04-03
EP2961410A1 (en) 2016-01-06
US20250289823A1 (en) 2025-09-18
JP2023036609A (ja) 2023-03-14
CN109010343A (zh) 2018-12-18
EP3632442B1 (en) 2023-04-05
KR20210110409A (ko) 2021-09-07
JP7189185B2 (ja) 2022-12-13
TW202333734A (zh) 2023-09-01
US20220106318A1 (en) 2022-04-07
HK1221398A1 (en) 2017-06-02

Similar Documents

Publication Publication Date Title
IL283943B1 (en) Use of pyrazolopyrimidine derivatives for the treatment of p13k associated disorders
IL247841A0 (en) Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders
HRP20180697T1 (hr) Spojevi imidazo[4,5-c]kinolin-2-ona i njihova upotreba za liječenje raka
SI3033086T1 (sl) Kombinirana terapija za zdravljenje raka
PL3542798T3 (pl) Aceklidyna do zastosowania w leczeniu starczowzroczności
HUE059041T2 (hu) Eljárás KIT-tel összefüggõ rendellenességek kezelésére alkalmas kompozíciók elõállítására
HUE061761T2 (hu) Tetrahidropiranil-amino-pirrolopirimidinon felhasználásra BTK-által közvetített zavarok kezelésében
HRP20181679T1 (hr) Amidni spojevi za liječenje hiv
PT3811943T (pt) Composto para uso no tratamento de distúrbios oculares
PL3169328T3 (pl) Pochodne chinoliny do leczenia chorób zapalnych
HRP20180478T1 (hr) Crenolanib za liječenje flt3 mutiranih proliferativnih poremećaja
SI2872497T2 (sl) Derivati kromanila za zdravljenje mitohondrijske bolezni
SI2928477T1 (sl) Uporaba telomeraznega inhibitorja imetelstat za zdravljenje mielofibroze
DK2838539T3 (da) Østrogenderivater til anvendelse i behandlingen af neurologiske forstyrrelser
LT3007726T (lt) Tautopatijos gydymo būdai
SI2991633T1 (sl) Terapija za bakteriofagi
HRP20181122T1 (hr) Postupak za pripremu jopamidola
PL3236960T3 (pl) Fluralaner do zastosowania w leczeniu demodekozy
ZA201507718B (en) The local treatment of inflammatory ophthalmic diseases
HRP20200128T1 (hr) Pripreme za liječenje gd2 pozitivnog raka
HUE045148T2 (hu) Bumetanid parkinson-szindrómás neurodegeneratív betegségek kezelésére
HRP20190219T1 (hr) Spojevi za tretman pretilosti i postupci za njihovu uporabu
HUE047174T2 (hu) Imepitoin epilepsziás rendellenességek kezelésére történõ alkalmazásra macskafélékben
HUE042691T2 (hu) Tiazolo-pirimidinon felhasználása gyulladásos bélbetegségek kezeléséhez
HK40027828B (en) Use of pyrazolopyrimidine derivatives for the treatment of pi3k related disorders