KR102393279B1 - Tlr7 작용제 말레에이트 염, 이의 결정형 c, d 및 e, 말레에이트 염 및 결정형의 제조 방법 및 용도 - Google Patents

Tlr7 작용제 말레에이트 염, 이의 결정형 c, d 및 e, 말레에이트 염 및 결정형의 제조 방법 및 용도 Download PDF

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KR102393279B1
KR102393279B1 KR1020187024626A KR20187024626A KR102393279B1 KR 102393279 B1 KR102393279 B1 KR 102393279B1 KR 1020187024626 A KR1020187024626 A KR 1020187024626A KR 20187024626 A KR20187024626 A KR 20187024626A KR 102393279 B1 KR102393279 B1 KR 102393279B1
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crystalline
formula
compound
maleate
ray powder
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KR20180104116A (ko
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자오종 딩
페이 순
잉후 후
이룽 주
젱 왕
링 양
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치아타이 티안큉 파마수티컬 그룹 주식회사
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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KR1020187024626A 2016-02-05 2017-02-04 Tlr7 작용제 말레에이트 염, 이의 결정형 c, d 및 e, 말레에이트 염 및 결정형의 제조 방법 및 용도 Active KR102393279B1 (ko)

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CN201610082030.0 2016-02-05
CN201610082030.0A CN107043380A (zh) 2016-02-05 2016-02-05 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
PCT/CN2017/072890 WO2017133683A1 (zh) 2016-02-05 2017-02-04 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e及其制备方法和用途

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KR102393279B1 true KR102393279B1 (ko) 2022-05-02

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CN107043379A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
AU2019272478B2 (en) * 2018-05-25 2024-06-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. TLR7 agonist and pharmaceutical combination thereof for treating lung cancer
WO2020162705A1 (ko) 2019-02-08 2020-08-13 성균관대학교산학협력단 톨-유사 수용체 7 또는 8 작용자와 콜레스테롤의 결합체 및 그 용도
CA3170551A1 (en) 2020-03-02 2021-09-10 Yong Taik Lim Live-pathogen-mimetic nanoparticles based on pathogen cell wall skeleton, and production method thereof
US20230277525A1 (en) 2020-08-04 2023-09-07 Progeneer Inc Conjugate of functional drug and toll-like receptor 7 or 8 agonist of which active site is temporarily inactivated and use thereof
JP7690221B2 (ja) 2020-08-04 2025-06-10 プロジェニア インコーポレイテッド 動力学的に作用するアジュバントアンサンブル
US20230346924A1 (en) 2020-08-04 2023-11-02 Progeneer Inc. Mrna vaccine comprising adjuvant capable of kinetic control

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CN107043380A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途
CN107043379A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的晶型a、其制备方法和医药用途
CN107043377A (zh) 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途
CN107043378A (zh) * 2016-02-05 2017-08-15 正大天晴药业集团股份有限公司 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体

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AU2017215800B2 (en) 2020-08-20
CA3013682A1 (en) 2017-08-10
UA123781C2 (uk) 2021-06-02
AU2017215800A1 (en) 2018-08-30
ZA201805185B (en) 2024-08-28
NZ745231A (en) 2022-07-29
SG11201806682TA (en) 2018-09-27
EP3412671A1 (en) 2018-12-12
MX2018009500A (es) 2018-12-11
JP2019505532A (ja) 2019-02-28
CA3013682C (en) 2022-06-21
US20200368241A1 (en) 2020-11-26
ES2834303T3 (es) 2021-06-17
US10780091B2 (en) 2020-09-22
CL2018002089A1 (es) 2018-12-07
PH12018501644A1 (en) 2019-06-03
CN108602830A (zh) 2018-09-28
JP6898336B2 (ja) 2021-07-07
TWI778951B (zh) 2022-10-01
EA038794B1 (ru) 2021-10-20
DK3412671T3 (da) 2020-11-09
MY196762A (en) 2023-05-03
MX374295B (es) 2025-03-06
EA201891770A1 (ru) 2019-01-31
US20190070179A1 (en) 2019-03-07
PH12018501644B1 (en) 2022-09-07
BR112018015881A2 (pt) 2018-12-26
AR107547A1 (es) 2018-05-09
IL260965B (en) 2022-02-01
CN107043380A (zh) 2017-08-15
KR20180104116A (ko) 2018-09-19
HUE052211T2 (hu) 2021-04-28
TW201728588A (zh) 2017-08-16
WO2017133683A1 (zh) 2017-08-10
CN108602830B (zh) 2020-07-28
EP3412671A4 (en) 2019-07-24
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