AR107547A1 - Maleato de agonista de tlr7, sus formas cristalinas c, d y e, sus procesos de preparación y su uso - Google Patents
Maleato de agonista de tlr7, sus formas cristalinas c, d y e, sus procesos de preparación y su usoInfo
- Publication number
- AR107547A1 AR107547A1 ARP170100296A ARP170100296A AR107547A1 AR 107547 A1 AR107547 A1 AR 107547A1 AR P170100296 A ARP170100296 A AR P170100296A AR P170100296 A ARP170100296 A AR P170100296A AR 107547 A1 AR107547 A1 AR 107547A1
- Authority
- AR
- Argentina
- Prior art keywords
- maleate
- preparation processes
- crystal forms
- tlr7 agonist
- crystalline form
- Prior art date
Links
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title abstract 3
- 229940124615 TLR 7 agonist Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente se refiere a un maleato del compuesto de fórmula (1), el proceso de preparación de la sal, la composición farmacéutica que contiene la sal y su uso. Además se refiere a la forma cristalina C, la forma cristalina D y la forma cristalina E del maleato del compuesto de fórmula (1); a sus procesos de preparación, composiciones cristalinas y composiciones farmacéuticas que las contienen, y a su uso.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610082030.0A CN107043380A (zh) | 2016-02-05 | 2016-02-05 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR107547A1 true AR107547A1 (es) | 2018-05-09 |
Family
ID=59500111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP170100296A AR107547A1 (es) | 2016-02-05 | 2017-02-06 | Maleato de agonista de tlr7, sus formas cristalinas c, d y e, sus procesos de preparación y su uso |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US10780091B2 (es) |
| EP (1) | EP3412671B1 (es) |
| JP (1) | JP6898336B2 (es) |
| KR (1) | KR102393279B1 (es) |
| CN (2) | CN107043380A (es) |
| AR (1) | AR107547A1 (es) |
| AU (1) | AU2017215800B2 (es) |
| CA (1) | CA3013682C (es) |
| CL (1) | CL2018002089A1 (es) |
| DK (1) | DK3412671T3 (es) |
| EA (1) | EA038794B1 (es) |
| ES (1) | ES2834303T3 (es) |
| HK (1) | HK1259175A1 (es) |
| HU (1) | HUE052211T2 (es) |
| IL (1) | IL260965B (es) |
| MX (1) | MX2018009500A (es) |
| MY (1) | MY196762A (es) |
| NZ (1) | NZ745231A (es) |
| PH (1) | PH12018501644A1 (es) |
| SG (1) | SG11201806682TA (es) |
| TW (1) | TWI778951B (es) |
| UA (1) | UA123781C2 (es) |
| WO (1) | WO2017133683A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107043379A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的晶型a、其制备方法和医药用途 |
| CN107043378A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
| CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| KR20210013183A (ko) * | 2018-05-25 | 2021-02-03 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Tlr7 작용제 및 폐암을 치료하기 위한 이의 약학 조합물 |
| MX2021009496A (es) | 2019-02-08 | 2021-09-08 | Progeneer Inc | Complejo de colesterol-agonista del receptor 7 u 8 tipo larga distancia, y uso del mismo. |
| CN115666637A (zh) | 2020-03-02 | 2023-01-31 | 蛋白科技先锋 | 基于病原体细胞壁骨架的模拟活病原体的纳米粒子及其制备方法 |
| US20230355750A1 (en) | 2020-08-04 | 2023-11-09 | Progeneer Inc. | Kinetically acting adjuvant ensemble |
| JP2023536954A (ja) | 2020-08-04 | 2023-08-30 | プロジェニア インコーポレイテッド | 活性化部位が一時的に不活性化したトール様受容体７または８作用薬と機能性薬物の結合体およびその用途 |
| US20230346924A1 (en) | 2020-08-04 | 2023-11-02 | Progeneer Inc. | Mrna vaccine comprising adjuvant capable of kinetic control |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3376479B2 (ja) * | 1991-08-12 | 2003-02-10 | 武田薬品工業株式会社 | 縮合ピリミジン誘導体、その製造法および用途 |
| NZ329798A (en) | 1996-07-03 | 1999-04-29 | Japan Energy Corp | Purine derivatives their tautomers and salts thereof and interferon secretion inducers, antiviral agents and anticancer drugs containing the same |
| AU732361B2 (en) | 1997-11-28 | 2001-04-26 | Dainippon Sumitomo Pharma Co., Ltd. | Novel heterocyclic compounds |
| ES2577514T3 (es) | 2005-08-22 | 2016-07-15 | The Regents Of The University Of California | Antagonistas de TLR |
| EA024359B1 (ru) | 2007-06-29 | 2016-09-30 | Джилид Сайэнс, Инк. | Пуриновые производные и их применение в качестве модуляторов толл-подобного рецептора 7 |
| DE602008005470D1 (en) | 2007-08-03 | 2011-04-21 | Pfizer Ltd | Imidazopyridinone |
| AU2009333559B2 (en) | 2008-12-09 | 2015-03-12 | Gilead Sciences, Inc. | Modulators of toll-like receptors |
| JP5813785B2 (ja) | 2011-02-04 | 2015-11-17 | デュケイン ユニバーシティー オブ ザ ホリー スピリット | 抗チューブリン活性を有する二環式および三環式のピリミジンチロシンキナーゼ阻害剤ならびに患者の処置方法 |
| EP2800569B1 (en) | 2012-01-05 | 2018-07-25 | Northeastern University | Allosteric modulators of cb1 cannabinoid receptors |
| JP6293765B2 (ja) | 2012-10-10 | 2018-03-14 | ヤンセン・サイエンシズ・アイルランド・ユーシー | ウイルス感染症および他の疾患の処置のためのピロロ［３，２−ｄ］ピリミジン誘導体 |
| WO2014081644A1 (en) | 2012-11-20 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds |
| WO2014081645A1 (en) | 2012-11-20 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds |
| CA2890198A1 (en) * | 2012-11-20 | 2014-05-30 | Diane Mary Coe | Novel compounds |
| CN106029668B (zh) | 2014-02-20 | 2018-02-23 | 葛兰素史克知识产权第二有限公司 | 吡咯并[3,2]嘧啶衍生物作为人类干扰素诱导剂 |
| WO2015168269A1 (en) | 2014-05-01 | 2015-11-05 | Novartis Ag | Compounds and compositions as toll-like receptor 7 agonists |
| SG11201608299TA (en) * | 2014-05-01 | 2016-11-29 | Novartis Ag | Compounds and compositions as toll-like receptor 7 agonists |
| CN105367576A (zh) * | 2014-08-15 | 2016-03-02 | 正大天晴药业集团股份有限公司 | 作为tlr7激动剂的吡咯并嘧啶化合物 |
| SG11201701169XA (en) * | 2014-08-15 | 2017-03-30 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Pyrrolopyrimidine compounds used as tlr7 agonist |
| CN105732635A (zh) | 2014-12-29 | 2016-07-06 | 南京明德新药研发股份有限公司 | 一类Toll样受体7激动剂 |
| TWI714661B (zh) | 2015-11-05 | 2021-01-01 | 法商賽諾菲公司 | 新穎念珠藻素化合物及接合物、其製備與其治療用途 |
| US10555526B2 (en) | 2015-11-05 | 2020-02-11 | Basf Se | Substituted oxadiazoles for combating phytopathogenic fungi |
| AU2016349080B2 (en) | 2015-11-05 | 2019-03-14 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | 7-(thiazol-5-yl) pyrrolopyrimidine compound as TLR7 agonist |
| CN107043377A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的三氟乙酸盐、晶型b及其制备方法、药物组合物和用途 |
| CN107043380A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的马来酸盐、其晶型c、晶型d、晶型e、制备方法和用途 |
| CN107043379A (zh) * | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种tlr7激动剂的晶型a、其制备方法和医药用途 |
| CN107043378A (zh) | 2016-02-05 | 2017-08-15 | 正大天晴药业集团股份有限公司 | 一种吡咯并[3,2-d]嘧啶类化合物的制备方法及其中间体 |
-
2016
- 2016-02-05 CN CN201610082030.0A patent/CN107043380A/zh active Pending
-
2017
- 2017-02-03 TW TW106103694A patent/TWI778951B/zh active
- 2017-02-04 UA UAA201809085A patent/UA123781C2/uk unknown
- 2017-02-04 AU AU2017215800A patent/AU2017215800B2/en active Active
- 2017-02-04 DK DK17747003.6T patent/DK3412671T3/da active
- 2017-02-04 NZ NZ745231A patent/NZ745231A/en unknown
- 2017-02-04 WO PCT/CN2017/072890 patent/WO2017133683A1/zh active Application Filing
- 2017-02-04 CN CN201780009746.0A patent/CN108602830B/zh active Active
- 2017-02-04 HU HUE17747003A patent/HUE052211T2/hu unknown
- 2017-02-04 SG SG11201806682TA patent/SG11201806682TA/en unknown
- 2017-02-04 ES ES17747003T patent/ES2834303T3/es active Active
- 2017-02-04 JP JP2018540750A patent/JP6898336B2/ja active Active
- 2017-02-04 MX MX2018009500A patent/MX2018009500A/es active IP Right Grant
- 2017-02-04 EA EA201891770A patent/EA038794B1/ru unknown
- 2017-02-04 MY MYPI2018702706A patent/MY196762A/en unknown
- 2017-02-04 US US16/075,080 patent/US10780091B2/en active Active
- 2017-02-04 CA CA3013682A patent/CA3013682C/en active Active
- 2017-02-04 EP EP17747003.6A patent/EP3412671B1/en active Active
- 2017-02-04 KR KR1020187024626A patent/KR102393279B1/ko active IP Right Grant
- 2017-02-06 AR ARP170100296A patent/AR107547A1/es active IP Right Grant
-
2018
- 2018-08-02 PH PH12018501644A patent/PH12018501644A1/en unknown
- 2018-08-02 IL IL260965A patent/IL260965B/en unknown
- 2018-08-03 CL CL2018002089A patent/CL2018002089A1/es unknown
-
2019
- 2019-01-24 HK HK19101224.5A patent/HK1259175A1/zh unknown
-
2020
- 2020-08-12 US US16/991,639 patent/US20200368241A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |