KR102356433B1 - 치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법 - Google Patents

치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법 Download PDF

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KR102356433B1
KR102356433B1 KR1020187028514A KR20187028514A KR102356433B1 KR 102356433 B1 KR102356433 B1 KR 102356433B1 KR 1020187028514 A KR1020187028514 A KR 1020187028514A KR 20187028514 A KR20187028514 A KR 20187028514A KR 102356433 B1 KR102356433 B1 KR 102356433B1
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cancer
compound
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aminopurine
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KR20180126497A (ko
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존 에프. 보이랜
고든 엘. 브레이
엘렌 필바로프
로버트 허바드
데이비드 미코론
헤더 레이먼
타오 쉬
탐 엠. 트란
토시야 쯔지
릴리 엘. 웡
쉬찬 쉬
단 쥬
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시그날 파마소티칼 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020187028514A 2016-04-01 2017-03-31 치환된 아미노퓨린 화합물, 이의 조성물, 및 그것에 의한 치료 방법 Active KR102356433B1 (ko)

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US201662317412P 2016-04-01 2016-04-01
US62/317,412 2016-04-01
PCT/US2017/025252 WO2017173206A1 (en) 2016-04-01 2017-03-31 Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith

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KR20180126497A KR20180126497A (ko) 2018-11-27
KR102356433B1 true KR102356433B1 (ko) 2022-01-27

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PT3436019T (pt) 2016-04-01 2021-11-04 Signal Pharm Llc (1s,4s)-4-(2-(((3s,4r)-3-fluorotetra-hidro-2h-piran-4- il)amino)-8-((2,4,6-triclorofenil)amino)-9h-purin-9-il)-1- metilciclo-hexano-1-carboxamida e métodos de utilização dos mesmos
SG11201808237UA (en) 2016-04-01 2018-10-30 Janssen Pharmaceuticals Inc Substituted indole compound derivatives as dengue viral replication inhibitors
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JOP20180026A1 (ar) 2017-03-31 2019-01-30 Univ Leuven Kath مشتقات اندولين مستبدلة بصفتها مانعات للتكاثر الفيروسي لحمى الفنك
US11407715B2 (en) 2017-05-22 2022-08-09 Janssen Pharmaceuticals, Inc. Substituted indoline derivatives as dengue viral replication inhibitors
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JP7422084B2 (ja) 2018-04-03 2024-01-25 ブループリント メディシンズ コーポレイション Ｒｅｔ変化を有する癌の処置において使用するためのｒｅｔ阻害剤
EP3833372A4 (en) * 2018-08-10 2022-06-08 Blueprint Medicines Corporation TREATMENT OF EGFR MUTANT CANCER
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US12122787B2 (en) 2019-09-20 2024-10-22 Shanghai Jemincare Pharmaceuticals Co., Ltd Fused pyridone compound, and preparation method therefor and use thereof
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TW202202498A (zh) * 2020-07-01 2022-01-16 大陸商四川海思科製藥有限公司 一種並環雜環衍生物及其在醫藥上的應用
KR102664454B1 (ko) * 2021-08-03 2024-05-09 한국생명공학연구원 젬시타빈에 대한 민감성 향상을 위한 신규 표적 및 이의 활용
CN114681456A (zh) * 2022-02-23 2022-07-01 中山大学附属第六医院 Plx3397在结直肠癌的治疗中的用途

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BR112018070163A2 (pt) 2019-01-29
JP2019510066A (ja) 2019-04-11
IL262007A (en) 2018-10-31
KR20180126497A (ko) 2018-11-27
IL262007B2 (en) 2023-04-01
EA201892229A1 (ru) 2019-03-29
CN109069512B (zh) 2022-06-14
CN109069512A (zh) 2018-12-21
US10576085B2 (en) 2020-03-03
MX379513B (es) 2025-03-11
WO2017173206A1 (en) 2017-10-05
CL2018002787A1 (es) 2019-01-18
EP3436018A1 (en) 2019-02-06
NZ746554A (en) 2023-03-31
MX2018011992A (es) 2019-01-24
SG11201808388QA (en) 2018-10-30
EA039392B1 (ru) 2022-01-21
US20170281633A1 (en) 2017-10-05
JP7014731B2 (ja) 2022-02-01
AU2017241837A1 (en) 2018-10-25
EP3436018A4 (en) 2019-11-13
CA3018986A1 (en) 2017-10-05
IL262007B (en) 2022-12-01
AU2017241837B2 (en) 2021-07-22
SG10202009589UA (en) 2020-10-29

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