KR102305351B1 - 암의 치료를 위한, mdm2 억제제 및 하나 이상의 추가적 약제학적 활성 제제를 포함하는 조합 요법 - Google Patents
암의 치료를 위한, mdm2 억제제 및 하나 이상의 추가적 약제학적 활성 제제를 포함하는 조합 요법 Download PDFInfo
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- KR102305351B1 KR102305351B1 KR1020167015298A KR20167015298A KR102305351B1 KR 102305351 B1 KR102305351 B1 KR 102305351B1 KR 1020167015298 A KR1020167015298 A KR 1020167015298A KR 20167015298 A KR20167015298 A KR 20167015298A KR 102305351 B1 KR102305351 B1 KR 102305351B1
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- chlorophenyl
- inhibitor
- provides
- compound
- pharmaceutically acceptable
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- CPXHVNNMWVSHMQ-XYGOSUJHSA-N CC(C)(C)SC[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC=C)c2cc(Cl)ccc2)c(cc2F)ccc2Cl)C1=O Chemical compound CC(C)(C)SC[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC=C)c2cc(Cl)ccc2)c(cc2F)ccc2Cl)C1=O CPXHVNNMWVSHMQ-XYGOSUJHSA-N 0.000 description 1
- QNQSZYRUBCVBEK-JECHBYEQSA-N C[C@@H](C[C@@H]([C@H](c(cc1)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O Chemical compound C[C@@H](C[C@@H]([C@H](c(cc1)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O QNQSZYRUBCVBEK-JECHBYEQSA-N 0.000 description 1
- IAUIVYMRTAWCOT-IXBGWNDUSA-N C[C@@H](C[C@@H]([C@H](c(cc1F)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O Chemical compound C[C@@H](C[C@@H]([C@H](c(cc1F)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O IAUIVYMRTAWCOT-IXBGWNDUSA-N 0.000 description 1
- QNQSZYRUBCVBEK-LQAWEQHXSA-N C[C@H](C[C@@H]([C@H](c(cc1)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O Chemical compound C[C@H](C[C@@H]([C@H](c(cc1)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O QNQSZYRUBCVBEK-LQAWEQHXSA-N 0.000 description 1
- IAUIVYMRTAWCOT-VMDBXTETSA-N C[C@H](C[C@@H]([C@H](c(cc1F)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O Chemical compound C[C@H](C[C@@H]([C@H](c(cc1F)ccc1Cl)O1)c2cc(Cl)ccc2)C1=O IAUIVYMRTAWCOT-VMDBXTETSA-N 0.000 description 1
- CKZUVMIXVHUVSC-GWZVJQKXSA-N C[C@](CC=C)(C[C@@H]1c2cccc(Cl)c2)C(OC[C@@H]2C3CC3)=[N+]2[C@@H]1c(cc1)ccc1Cl Chemical compound C[C@](CC=C)(C[C@@H]1c2cccc(Cl)c2)C(OC[C@@H]2C3CC3)=[N+]2[C@@H]1c(cc1)ccc1Cl CKZUVMIXVHUVSC-GWZVJQKXSA-N 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-M Cc(cc1)ccc1S([O-])(=O)=O Chemical compound Cc(cc1)ccc1S([O-])(=O)=O JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 description 1
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020217029928A KR102473485B1 (ko) | 2013-11-11 | 2014-11-11 | 암의 치료를 위한, mdm2 억제제 및 하나 이상의 추가적 약제학적 활성 제제를 포함하는 조합 요법 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902717P | 2013-11-11 | 2013-11-11 | |
| US61/902,717 | 2013-11-11 | ||
| PCT/US2014/065034 WO2015070224A2 (en) | 2013-11-11 | 2014-11-11 | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020217029928A Division KR102473485B1 (ko) | 2013-11-11 | 2014-11-11 | 암의 치료를 위한, mdm2 억제제 및 하나 이상의 추가적 약제학적 활성 제제를 포함하는 조합 요법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160074012A KR20160074012A (ko) | 2016-06-27 |
| KR102305351B1 true KR102305351B1 (ko) | 2021-09-24 |
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ID=52001089
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227041845A Ceased KR20220167335A (ko) | 2013-11-11 | 2014-11-11 | 암의 치료를 위한, mdm2 억제제 및 하나 이상의 추가적 약제학적 활성 제제를 포함하는 조합 요법 |
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