EA036942B1 - Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза - Google Patents

Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза Download PDF

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Publication number
EA036942B1
EA036942B1 EA201690980A EA201690980A EA036942B1 EA 036942 B1 EA036942 B1 EA 036942B1 EA 201690980 A EA201690980 A EA 201690980A EA 201690980 A EA201690980 A EA 201690980A EA 036942 B1 EA036942 B1 EA 036942B1
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EA
Eurasian Patent Office
Prior art keywords
chlorophenyl
compound
compounds
treatment
present
Prior art date
Application number
EA201690980A
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English (en)
Russian (ru)
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EA201690980A1 (ru
Inventor
Шон Кэнпил
Джуд Кэнон
Пол Хьюз
Джонатан Д. Олинер
Ричард Дж. Риклес
Анн Й. Саики
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Эмджен Инк.
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Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA201690980A1 publication Critical patent/EA201690980A1/ru
Publication of EA036942B1 publication Critical patent/EA036942B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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EA201690980A 2013-11-11 2014-11-11 Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза EA036942B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361902717P 2013-11-11 2013-11-11
PCT/US2014/065034 WO2015070224A2 (en) 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

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EA201690980A1 EA201690980A1 (ru) 2016-09-30
EA036942B1 true EA036942B1 (ru) 2021-01-18

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EA201690980A EA036942B1 (ru) 2013-11-11 2014-11-11 Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза
EA202092456A EA202092456A3 (ru) 2013-11-11 2014-11-11 Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака

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EA202092456A EA202092456A3 (ru) 2013-11-11 2014-11-11 Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака

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Publication number Priority date Publication date Assignee Title
EP3159352B1 (en) 2007-03-28 2023-08-02 President and Fellows of Harvard College Stitched polypeptides
KR102104762B1 (ko) 2010-08-13 2020-04-24 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
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SMT202200241T1 (it) 2022-09-14
EP3068393A2 (en) 2016-09-21
IL285646A (en) 2021-09-30
MX2020001550A (es) 2022-04-26
KR20220167335A (ko) 2022-12-20
NZ758548A (en) 2022-02-25
MX393610B (es) 2025-03-24
UA120750C2 (uk) 2020-02-10
HUE059351T2 (hu) 2022-11-28
MX2020013670A (es) 2022-09-30
US20160287569A1 (en) 2016-10-06
US20220280495A1 (en) 2022-09-08
JP6972274B2 (ja) 2021-11-24
AU2014346354A1 (en) 2016-05-26
EA202092456A3 (ru) 2021-09-30
JP2023033414A (ja) 2023-03-10
PT3068393T (pt) 2022-06-14
KR20160074012A (ko) 2016-06-27
MX2022008175A (es) 2022-08-15
CL2016001131A1 (es) 2017-04-17
CY1125358T1 (el) 2024-09-20
JP2022009805A (ja) 2022-01-14
HRP20220718T1 (hr) 2022-09-30
KR102305351B1 (ko) 2021-09-24
EP3068393B1 (en) 2022-03-09

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