EA036942B1 - Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза - Google Patents

Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза Download PDF

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Publication number
EA036942B1
EA036942B1 EA201690980A EA201690980A EA036942B1 EA 036942 B1 EA036942 B1 EA 036942B1 EA 201690980 A EA201690980 A EA 201690980A EA 201690980 A EA201690980 A EA 201690980A EA 036942 B1 EA036942 B1 EA 036942B1
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EA
Eurasian Patent Office
Prior art keywords
chlorophenyl
compound
compounds
treatment
present
Prior art date
Application number
EA201690980A
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English (en)
Russian (ru)
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EA201690980A1 (ru
Inventor
Шон Кэнпил
Джуд Кэнон
Пол Хьюз
Джонатан Д. Олинер
Ричард Дж. Риклес
Анн Й. Саики
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Эмджен Инк.
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Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA201690980A1 publication Critical patent/EA201690980A1/ru
Publication of EA036942B1 publication Critical patent/EA036942B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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EA201690980A 2013-11-11 2014-11-11 Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза EA036942B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361902717P 2013-11-11 2013-11-11
PCT/US2014/065034 WO2015070224A2 (en) 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

Publications (2)

Publication Number Publication Date
EA201690980A1 EA201690980A1 (ru) 2016-09-30
EA036942B1 true EA036942B1 (ru) 2021-01-18

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EA201690980A EA036942B1 (ru) 2013-11-11 2014-11-11 Применение amg232 в комбинации с цитарабином или децитабином для лечения острого миелогенного лейкоза
EA202092456A EA202092456A3 (ru) 2013-11-11 2014-11-11 Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака

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EA202092456A EA202092456A3 (ru) 2013-11-11 2014-11-11 Комбинированная терапия, включающая ингибитор mdm2 и один или более дополнительных фармацевтически активных агентов, для лечения различных видов рака

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EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
MX352672B (es) 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
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MX2022008175A (es) 2022-08-15
AP2016009243A0 (en) 2016-05-31
EP3068393B1 (en) 2022-03-09
KR20160074012A (ko) 2016-06-27
MX391859B (es) 2025-03-12
JP2021004259A (ja) 2021-01-14
JP2023033414A (ja) 2023-03-10
NZ720766A (en) 2022-02-25
AU2020201321B2 (en) 2022-03-10
AU2014346354A1 (en) 2016-05-26
CA2930244A1 (en) 2015-05-14
US10881648B2 (en) 2021-01-05
PT3068393T (pt) 2022-06-14
ZA201603342B (en) 2025-04-30
IL245568B (en) 2021-09-30
MX2016006025A (es) 2016-12-02
MX393610B (es) 2025-03-24
IL245568A0 (en) 2016-06-30
PL3068393T3 (pl) 2022-10-03
MA39094A1 (fr) 2018-07-31
MX2020001550A (es) 2022-04-26
MY192088A (en) 2022-07-26
TN2016000176A1 (en) 2017-10-06
MA39094B1 (fr) 2020-06-30

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