HUE059351T2 - MDM2 inhibitort és egy vagy több további gyógyszerhatóanyagot tartalmazó kombinációs terápia rákbetegségek kezelésére - Google Patents

MDM2 inhibitort és egy vagy több további gyógyszerhatóanyagot tartalmazó kombinációs terápia rákbetegségek kezelésére

Info

Publication number
HUE059351T2
HUE059351T2 HUE14805743A HUE14805743A HUE059351T2 HU E059351 T2 HUE059351 T2 HU E059351T2 HU E14805743 A HUE14805743 A HU E14805743A HU E14805743 A HUE14805743 A HU E14805743A HU E059351 T2 HUE059351 T2 HU E059351T2
Authority
HU
Hungary
Prior art keywords
cancers
treatment
active agents
pharmaceutically active
combination therapy
Prior art date
Application number
HUE14805743A
Other languages
English (en)
Hungarian (hu)
Inventor
Sean Caenepeel
Jude Canon
Paul Hughes
Jonathan D Oliner
Richard J Rickles
Anne Y Saiki
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of HUE059351T2 publication Critical patent/HUE059351T2/hu

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
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    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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  • Health & Medical Sciences (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
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  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
HUE14805743A 2013-11-11 2014-11-11 MDM2 inhibitort és egy vagy több további gyógyszerhatóanyagot tartalmazó kombinációs terápia rákbetegségek kezelésére HUE059351T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361902717P 2013-11-11 2013-11-11

Publications (1)

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HUE059351T2 true HUE059351T2 (hu) 2022-11-28

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HUE14805743A HUE059351T2 (hu) 2013-11-11 2014-11-11 MDM2 inhibitort és egy vagy több további gyógyszerhatóanyagot tartalmazó kombinációs terápia rákbetegségek kezelésére

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US (3) US20160287569A1 (enExample)
EP (2) EP3068393B9 (enExample)
JP (5) JP2016535795A (enExample)
KR (3) KR102473485B1 (enExample)
CN (2) CN112933236A (enExample)
AP (1) AP2016009243A0 (enExample)
AU (3) AU2014346354A1 (enExample)
BR (1) BR112016010564A2 (enExample)
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EA (2) EA036942B1 (enExample)
ES (1) ES2916721T3 (enExample)
HR (1) HRP20220718T1 (enExample)
HU (1) HUE059351T2 (enExample)
IL (2) IL245568B (enExample)
LT (1) LT3068393T (enExample)
MA (1) MA39094B1 (enExample)
MX (6) MX2020013670A (enExample)
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KR20180058866A (ko) 2010-08-13 2018-06-01 에일러론 테라퓨틱스 인코포레이티드 펩티도미메틱 거대고리
JP6093770B2 (ja) 2011-09-27 2017-03-08 アムジエン・インコーポレーテツド 癌の治療のためのｍｄｍ２阻害剤としての複素環化合物
BR112014009418A2 (pt) 2011-10-18 2017-04-18 Aileron Therapeutics Inc macrociclos peptidomiméticos
MX2015005244A (es) 2012-11-01 2015-07-14 Aileron Therapeutics Inc Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos.
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
CA2906538C (en) 2013-03-14 2021-02-02 Ana Gonzalez Buenrostro Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
TN2016000176A1 (en) * 2013-11-11 2017-10-06 Amgen Inc Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers.
AU2015320549A1 (en) 2014-09-24 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
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