JP2016535795A - Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 - Google Patents

Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 Download PDF

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JP2016535795A
JP2016535795A JP2016553270A JP2016553270A JP2016535795A JP 2016535795 A JP2016535795 A JP 2016535795A JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016535795 A JP2016535795 A JP 2016535795A
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chlorophenyl
inhibitor
pharmaceutically acceptable
methyl
oxopiperidin
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JP2016535795A5 (enExample
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カーンピール,ショーン
キャノン,ジュード
ヒューズ,ポール
オリナー,ジョナサン・ディー
リックルズ,リチャード・ジェイ
サイキ,アン・ワイ
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アムジエン・インコーポレーテツド
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JP2016553270A 2013-11-11 2014-11-11 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 Ceased JP2016535795A (ja)

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US201361902717P 2013-11-11 2013-11-11
US61/902,717 2013-11-11
PCT/US2014/065034 WO2015070224A2 (en) 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

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JP2019078325A Division JP2019142916A (ja) 2013-11-11 2019-04-17 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法

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JP2016535795A true JP2016535795A (ja) 2016-11-17
JP2016535795A5 JP2016535795A5 (enExample) 2017-12-21

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JP2016553270A Ceased JP2016535795A (ja) 2013-11-11 2014-11-11 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2019078325A Pending JP2019142916A (ja) 2013-11-11 2019-04-17 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2020172367A Expired - Fee Related JP6972274B2 (ja) 2013-11-11 2020-10-13 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2021178554A Pending JP2022009805A (ja) 2013-11-11 2021-11-01 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2023003579A Pending JP2023033414A (ja) 2013-11-11 2023-01-13 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法

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JP2019078325A Pending JP2019142916A (ja) 2013-11-11 2019-04-17 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2020172367A Expired - Fee Related JP6972274B2 (ja) 2013-11-11 2020-10-13 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2021178554A Pending JP2022009805A (ja) 2013-11-11 2021-11-01 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2023003579A Pending JP2023033414A (ja) 2013-11-11 2023-01-13 Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021525795A (ja) * 2018-05-25 2021-09-27 カルトス セラピューティクス,インコーポレイテッド 骨髄増殖性腫瘍を治療する方法
JP2023033414A (ja) * 2013-11-11 2023-03-10 アムジエン・インコーポレーテツド Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20160061439A (ko) 2007-03-28 2016-05-31 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
WO2012021875A1 (en) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with triazole linkers
MX352672B (es) 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
JP6342808B2 (ja) 2011-10-18 2018-06-13 エイルロン セラピューティクス,インコーポレイテッド ペプチドミメティック大環状化合物
BR112015009470A2 (pt) 2012-11-01 2019-12-17 Aileron Therapeutics Inc aminoácidos dissubstituídos e seus métodos de preparação e uso
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
WO2014151863A1 (en) 2013-03-14 2014-09-25 Amgen Inc. Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
EP3197477A4 (en) 2014-09-24 2018-07-04 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
SG10201902594QA (en) 2014-09-24 2019-04-29 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
WO2016133194A1 (ja) 2015-02-20 2016-08-25 第一三共株式会社 がんの併用治療法
AU2016235424A1 (en) 2015-03-20 2017-10-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN108348611A (zh) * 2015-08-28 2018-07-31 诺华股份有限公司 使用pi3k抑制剂和mdm2抑制剂的联合疗法
EP3340989B1 (en) * 2015-08-28 2023-08-16 Novartis AG Mdm2 inhibitors and combinations thereof
WO2017200826A1 (en) * 2016-05-16 2017-11-23 Albert Einstein College Of Medicine, Inc. Assays and compounds for treatment of cancer
ES2858151T3 (es) 2016-05-20 2021-09-29 Hoffmann La Roche Conjugados de PROTAC-anticuerpo y procedimientos de uso
CN109843329A (zh) * 2016-10-17 2019-06-04 第一三共株式会社 使用mdm2抑制剂和dna甲基转移酶抑制剂的组合治疗方法
US11040027B2 (en) 2017-01-17 2021-06-22 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
IL308399B2 (en) 2018-04-30 2025-08-01 Kartos Therapeutics Inc Methods of treating cancer
WO2020023502A1 (en) 2018-07-23 2020-01-30 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN110963958B (zh) * 2018-09-30 2025-10-10 上海长森药业有限公司 一种mdm2抑制剂,及其制备方法、药物组合物和应用
AR116904A1 (es) * 2018-12-11 2021-06-23 Kartos Therapeutics Inc Métodos y composiciones para el tratamiento de un trastorno oftálmico
CN111434353A (zh) * 2019-02-02 2020-07-21 中国科学院上海营养与健康研究所 Ras抑制剂筛选及疗效标志物
AU2020323033A1 (en) 2019-07-26 2021-04-22 Ascentage Pharma (Suzhou) Co., Ltd. Pharmaceutical composition of MDM2 inhibitor and use thereof for preventing and/or treating disease
TW202128156A (zh) * 2019-11-14 2021-08-01 美商夸格智財控股有限公司 用於癌症治療之btk抑制劑及mdm2抑制劑之組合
US20230218575A1 (en) * 2020-06-15 2023-07-13 Ascentage Pharma (Suzhou) Co., Ltd. Microsuspension of an mdm2 inhibitor and therapeautic applications thereof
WO2022036067A1 (en) * 2020-08-12 2022-02-17 Servier Pharmaceuticals, Llc Combination therapies for use in treating cancer
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
CN115089585A (zh) * 2022-08-05 2022-09-23 中国科学院大学宁波华美医院 Mdm2抑制剂rg7112联合依托泊苷在治疗肺癌中的应用
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof
WO2024254156A1 (en) * 2023-06-05 2024-12-12 Kartos Therapeutics, Inc. Treatment of endometrial cancer with mdm2 inhibitors
WO2025098488A1 (zh) * 2023-11-09 2025-05-15 深圳艾欣达伟医药科技有限公司 上调p53蛋白表达或激活p53功能的药物与DNA烷化剂联用治疗癌症

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110319378A1 (en) * 2010-06-04 2011-12-29 Amgen Inc. Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
OA12333A (en) 2000-07-19 2004-04-06 Warner Lambert Co Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids.
EP1809282B1 (en) 2004-10-18 2013-01-09 Amgen, Inc Thiadiazole compounds and methods of use
AU2007207743B2 (en) 2006-01-18 2010-07-08 Amgen Inc. Thiazole compounds as protein kinase B (PKB) inhibitors
WO2008118454A2 (en) 2007-03-23 2008-10-02 Amgen Inc. Derivatives of quinoline or benzopyrazine and their uses for the treatment of (inter alia) inflammatory diseases, autoimmune diseases or various kinds of cancer
HUE028954T2 (en) 2007-03-23 2017-01-30 Amgen Inc Heterocyclic compounds and their use
PT2139882E (pt) 2007-03-23 2014-01-30 Amgen Inc Derivados de quinolina ou quinoxalina 3-substituídos e sua utilização como inibidores de fosfatidilinositol 3-cinase (pi3k)
US7625895B2 (en) 2007-04-12 2009-12-01 Hoffmann-Le Roche Inc. Diphenyl-dihydro-imidazopyridinones
CA2689092C (en) 2007-06-07 2013-01-15 Amgen Inc. Raf kinase modulators and methods of use
CA2692713A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Heterocyclic modulators of pkb
CA2693473A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of pkb
CA2694136C (en) 2007-08-02 2013-09-17 Amgen Inc. Pi3 kinase modulators and methods of use
BRPI0821209A2 (pt) 2007-12-19 2019-09-24 Amgen Inc composto, composição farmacêutica, métodos de tratar câncer, para reduzir o tamanho de tumor, para tratar distúrbios, e para reduzir metástase em um tumor.
WO2009085230A1 (en) 2007-12-19 2009-07-09 Amgen Inc. Inhibitors of pi3 kinase
WO2009126584A1 (en) 2008-04-07 2009-10-15 Amgen Inc. Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
EP2307400B1 (en) 2008-05-30 2014-04-23 Amgen, Inc Inhibitors of pi3 kinase
EP2387570A1 (en) 2009-01-15 2011-11-23 Amgen, Inc Fluoroisoquinoline substituted thiazole compounds and methods of use
MX2011008674A (es) 2009-02-18 2011-11-04 Amgen Inc Compuestos de indol/bencimidazol como inhibidores de quinasa mtor.
JP2012521354A (ja) 2009-03-20 2012-09-13 アムジエン・インコーポレーテツド Pi3キナーゼの阻害薬
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
WO2010132598A1 (en) 2009-05-13 2010-11-18 Amgen Inc. Heteroaryl compounds as pikk inhibitors
JP2012531436A (ja) 2009-06-25 2012-12-10 アムジエン・インコーポレーテツド 複素環式化合物およびそれらのpi3k活性阻害剤としての使用
MX2011013901A (es) 2009-06-25 2012-05-08 Amgen Inc Derivados de 4h-pirido [1,2-a] pirimidin-4-ona como inhibidores de pi3k.
EP2445900B1 (en) 2009-06-25 2016-03-02 Amgen, Inc Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases
JP2012531438A (ja) 2009-06-25 2012-12-10 アムジエン・インコーポレーテツド 複素環式化合物およびその使用
NZ598758A (en) 2009-09-11 2013-12-20 Amgen Inc N-4 (-((3-(2-amino-4 pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer
KR20120031734A (ko) * 2010-09-27 2012-04-04 삼성전자주식회사 급성 골수성 백혈병 환자의 시타라빈 민감성을 예측하기 위한 키트 및 방법
MX2013006020A (es) * 2011-01-31 2013-10-01 Celgene Corp Composicion farmaceutica de analogos de citidina y metodos para su uso.
MX352672B (es) 2011-09-27 2017-12-04 Amgen Inc Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
US9216170B2 (en) * 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
WO2013144923A1 (en) 2012-03-30 2013-10-03 Takeda Pharmaceutical Company Limited Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma
JP6417338B2 (ja) 2013-02-19 2018-11-07 アムジエン・インコーポレーテツド 癌の治療のためのmdm2阻害剤としてのシス−モルホリノン及び他の化合物
JP6266659B2 (ja) 2013-02-28 2018-01-24 アムジエン・インコーポレーテツド 癌の治療のための安息香酸誘導体mdm2阻害剤
WO2014151863A1 (en) 2013-03-14 2014-09-25 Amgen Inc. Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
US20150031642A1 (en) 2013-07-26 2015-01-29 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia and myelodysplastic syndrome i
SMT202200241T1 (it) * 2013-11-11 2022-09-14 Amgen Inc Politerapia che include un inibitore di mdm2 e uno o più agenti farmaceuticamente attivi aggiuntivi per il trattamento di cancri

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110319378A1 (en) * 2010-06-04 2011-12-29 Amgen Inc. Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CANCER RES., vol. 70(6), JPN6019009514, 15 March 2010 (2010-03-15), pages 2424 - 2434, ISSN: 0003999806 *
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, JPN6019009515, 2012, pages 356 - 364, ISSN: 0003999807 *
MOL CANCER THER., vol. 11(4), JPN6019009519, 2012, pages 909 - 920, ISSN: 0003999809 *
N ENGL J MED., vol. 367, JPN6019009517, 1 November 2012 (2012-11-01), pages 1694 - 1703, ISSN: 0003999808 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023033414A (ja) * 2013-11-11 2023-03-10 アムジエン・インコーポレーテツド Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2021525795A (ja) * 2018-05-25 2021-09-27 カルトス セラピューティクス,インコーポレイテッド 骨髄増殖性腫瘍を治療する方法
US12268681B2 (en) 2018-05-25 2025-04-08 Kartos Therapeutics, Inc. Methods of treating myeloproliferative neoplasms
JP2025072429A (ja) * 2018-05-25 2025-05-09 カルトス セラピューティクス,インコーポレイテッド 骨髄増殖性腫瘍を治療する方法

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