JP2016535795A - Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 - Google Patents
Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 Download PDFInfo
- Publication number
- JP2016535795A JP2016535795A JP2016553270A JP2016553270A JP2016535795A JP 2016535795 A JP2016535795 A JP 2016535795A JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016535795 A JP2016535795 A JP 2016535795A
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- Prior art keywords
- chlorophenyl
- inhibitor
- pharmaceutically acceptable
- methyl
- oxopiperidin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- XUNOGXLYFDRAST-KODJGSRDSA-N CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cccc(C)c2)c(cc2F)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)(C)S(C[C@H](C1CC1)N([C@@H]([C@H](C[C@]1(C)CC(O)=O)c2cccc(C)c2)c(cc2F)ccc2Cl)C1=O)(=O)=O XUNOGXLYFDRAST-KODJGSRDSA-N 0.000 description 1
- BGDMSFNZRUPWNB-GKWDUZDBSA-N CC(C)S(C[C@H](C(C)=C)N([C@@H]([C@H](C[C@]1(C)CC=C)c2cccc(Cl)c2)c(cc2)ccc2Cl)C1=O)(=O)=O Chemical compound CC(C)S(C[C@H](C(C)=C)N([C@@H]([C@H](C[C@]1(C)CC=C)c2cccc(Cl)c2)c(cc2)ccc2Cl)C1=O)(=O)=O BGDMSFNZRUPWNB-GKWDUZDBSA-N 0.000 description 1
- JUZAULJTNPAZEJ-UPXZWNHRSA-N CC(C)[C@@H](CO)NC([C@](C)(C[C@@H](C(c(cc1)ccc1Cl)O)c1cc(Cl)ccc1)CC=C)=O Chemical compound CC(C)[C@@H](CO)NC([C@](C)(C[C@@H](C(c(cc1)ccc1Cl)O)c1cc(Cl)ccc1)CC=C)=O JUZAULJTNPAZEJ-UPXZWNHRSA-N 0.000 description 1
- RUNHNSOVQYTCBA-DYXWJJEUSA-N C[C@](CC=C)(C[C@@H]([C@H](c(cc1)ccc1N)O1)c2cccc(N)c2)C1=O Chemical compound C[C@](CC=C)(C[C@@H]([C@H](c(cc1)ccc1N)O1)c2cccc(N)c2)C1=O RUNHNSOVQYTCBA-DYXWJJEUSA-N 0.000 description 1
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
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- Molecular Biology (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Hematology (AREA)
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- Dermatology (AREA)
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- Physiology (AREA)
- Nutrition Science (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361902717P | 2013-11-11 | 2013-11-11 | |
| US61/902,717 | 2013-11-11 | ||
| PCT/US2014/065034 WO2015070224A2 (en) | 2013-11-11 | 2014-11-11 | Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078325A Division JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016535795A true JP2016535795A (ja) | 2016-11-17 |
| JP2016535795A5 JP2016535795A5 (enExample) | 2017-12-21 |
Family
ID=52001089
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016553270A Ceased JP2016535795A (ja) | 2013-11-11 | 2014-11-11 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2019078325A Pending JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2020172367A Expired - Fee Related JP6972274B2 (ja) | 2013-11-11 | 2020-10-13 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2021178554A Pending JP2022009805A (ja) | 2013-11-11 | 2021-11-01 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2023003579A Pending JP2023033414A (ja) | 2013-11-11 | 2023-01-13 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019078325A Pending JP2019142916A (ja) | 2013-11-11 | 2019-04-17 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2020172367A Expired - Fee Related JP6972274B2 (ja) | 2013-11-11 | 2020-10-13 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2021178554A Pending JP2022009805A (ja) | 2013-11-11 | 2021-11-01 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2023003579A Pending JP2023033414A (ja) | 2013-11-11 | 2023-01-13 | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Country Status (33)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021525795A (ja) * | 2018-05-25 | 2021-09-27 | カルトス セラピューティクス,インコーポレイテッド | 骨髄増殖性腫瘍を治療する方法 |
| JP2023033414A (ja) * | 2013-11-11 | 2023-03-10 | アムジエン・インコーポレーテツド | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160061439A (ko) | 2007-03-28 | 2016-05-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 스티칭된 폴리펩티드 |
| WO2012021875A1 (en) | 2010-08-13 | 2012-02-16 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles with triazole linkers |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| JP6342808B2 (ja) | 2011-10-18 | 2018-06-13 | エイルロン セラピューティクス,インコーポレイテッド | ペプチドミメティック大環状化合物 |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| WO2014151863A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| EP3197477A4 (en) | 2014-09-24 | 2018-07-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and formulations thereof |
| SG10201902594QA (en) | 2014-09-24 | 2019-04-29 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| WO2016133194A1 (ja) | 2015-02-20 | 2016-08-25 | 第一三共株式会社 | がんの併用治療法 |
| AU2016235424A1 (en) | 2015-03-20 | 2017-10-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN108348611A (zh) * | 2015-08-28 | 2018-07-31 | 诺华股份有限公司 | 使用pi3k抑制剂和mdm2抑制剂的联合疗法 |
| EP3340989B1 (en) * | 2015-08-28 | 2023-08-16 | Novartis AG | Mdm2 inhibitors and combinations thereof |
| WO2017200826A1 (en) * | 2016-05-16 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Assays and compounds for treatment of cancer |
| ES2858151T3 (es) | 2016-05-20 | 2021-09-29 | Hoffmann La Roche | Conjugados de PROTAC-anticuerpo y procedimientos de uso |
| CN109843329A (zh) * | 2016-10-17 | 2019-06-04 | 第一三共株式会社 | 使用mdm2抑制剂和dna甲基转移酶抑制剂的组合治疗方法 |
| US11040027B2 (en) | 2017-01-17 | 2021-06-22 | Heparegenix Gmbh | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| IL308399B2 (en) | 2018-04-30 | 2025-08-01 | Kartos Therapeutics Inc | Methods of treating cancer |
| WO2020023502A1 (en) | 2018-07-23 | 2020-01-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| CN110963958B (zh) * | 2018-09-30 | 2025-10-10 | 上海长森药业有限公司 | 一种mdm2抑制剂,及其制备方法、药物组合物和应用 |
| AR116904A1 (es) * | 2018-12-11 | 2021-06-23 | Kartos Therapeutics Inc | Métodos y composiciones para el tratamiento de un trastorno oftálmico |
| CN111434353A (zh) * | 2019-02-02 | 2020-07-21 | 中国科学院上海营养与健康研究所 | Ras抑制剂筛选及疗效标志物 |
| AU2020323033A1 (en) | 2019-07-26 | 2021-04-22 | Ascentage Pharma (Suzhou) Co., Ltd. | Pharmaceutical composition of MDM2 inhibitor and use thereof for preventing and/or treating disease |
| TW202128156A (zh) * | 2019-11-14 | 2021-08-01 | 美商夸格智財控股有限公司 | 用於癌症治療之btk抑制劑及mdm2抑制劑之組合 |
| US20230218575A1 (en) * | 2020-06-15 | 2023-07-13 | Ascentage Pharma (Suzhou) Co., Ltd. | Microsuspension of an mdm2 inhibitor and therapeautic applications thereof |
| WO2022036067A1 (en) * | 2020-08-12 | 2022-02-17 | Servier Pharmaceuticals, Llc | Combination therapies for use in treating cancer |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| CN115089585A (zh) * | 2022-08-05 | 2022-09-23 | 中国科学院大学宁波华美医院 | Mdm2抑制剂rg7112联合依托泊苷在治疗肺癌中的应用 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
| WO2024254156A1 (en) * | 2023-06-05 | 2024-12-12 | Kartos Therapeutics, Inc. | Treatment of endometrial cancer with mdm2 inhibitors |
| WO2025098488A1 (zh) * | 2023-11-09 | 2025-05-15 | 深圳艾欣达伟医药科技有限公司 | 上调p53蛋白表达或激活p53功能的药物与DNA烷化剂联用治疗癌症 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110319378A1 (en) * | 2010-06-04 | 2011-12-29 | Amgen Inc. | Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA12333A (en) | 2000-07-19 | 2004-04-06 | Warner Lambert Co | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids. |
| EP1809282B1 (en) | 2004-10-18 | 2013-01-09 | Amgen, Inc | Thiadiazole compounds and methods of use |
| AU2007207743B2 (en) | 2006-01-18 | 2010-07-08 | Amgen Inc. | Thiazole compounds as protein kinase B (PKB) inhibitors |
| WO2008118454A2 (en) | 2007-03-23 | 2008-10-02 | Amgen Inc. | Derivatives of quinoline or benzopyrazine and their uses for the treatment of (inter alia) inflammatory diseases, autoimmune diseases or various kinds of cancer |
| HUE028954T2 (en) | 2007-03-23 | 2017-01-30 | Amgen Inc | Heterocyclic compounds and their use |
| PT2139882E (pt) | 2007-03-23 | 2014-01-30 | Amgen Inc | Derivados de quinolina ou quinoxalina 3-substituídos e sua utilização como inibidores de fosfatidilinositol 3-cinase (pi3k) |
| US7625895B2 (en) | 2007-04-12 | 2009-12-01 | Hoffmann-Le Roche Inc. | Diphenyl-dihydro-imidazopyridinones |
| CA2689092C (en) | 2007-06-07 | 2013-01-15 | Amgen Inc. | Raf kinase modulators and methods of use |
| CA2692713A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Heterocyclic modulators of pkb |
| CA2693473A1 (en) | 2007-07-17 | 2009-01-22 | Amgen Inc. | Thiadiazole modulators of pkb |
| CA2694136C (en) | 2007-08-02 | 2013-09-17 | Amgen Inc. | Pi3 kinase modulators and methods of use |
| BRPI0821209A2 (pt) | 2007-12-19 | 2019-09-24 | Amgen Inc | composto, composição farmacêutica, métodos de tratar câncer, para reduzir o tamanho de tumor, para tratar distúrbios, e para reduzir metástase em um tumor. |
| WO2009085230A1 (en) | 2007-12-19 | 2009-07-09 | Amgen Inc. | Inhibitors of pi3 kinase |
| WO2009126584A1 (en) | 2008-04-07 | 2009-10-15 | Amgen Inc. | Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors |
| EP2307400B1 (en) | 2008-05-30 | 2014-04-23 | Amgen, Inc | Inhibitors of pi3 kinase |
| EP2387570A1 (en) | 2009-01-15 | 2011-11-23 | Amgen, Inc | Fluoroisoquinoline substituted thiazole compounds and methods of use |
| MX2011008674A (es) | 2009-02-18 | 2011-11-04 | Amgen Inc | Compuestos de indol/bencimidazol como inhibidores de quinasa mtor. |
| JP2012521354A (ja) | 2009-03-20 | 2012-09-13 | アムジエン・インコーポレーテツド | Pi3キナーゼの阻害薬 |
| UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| WO2010132598A1 (en) | 2009-05-13 | 2010-11-18 | Amgen Inc. | Heteroaryl compounds as pikk inhibitors |
| JP2012531436A (ja) | 2009-06-25 | 2012-12-10 | アムジエン・インコーポレーテツド | 複素環式化合物およびそれらのpi3k活性阻害剤としての使用 |
| MX2011013901A (es) | 2009-06-25 | 2012-05-08 | Amgen Inc | Derivados de 4h-pirido [1,2-a] pirimidin-4-ona como inhibidores de pi3k. |
| EP2445900B1 (en) | 2009-06-25 | 2016-03-02 | Amgen, Inc | Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases |
| JP2012531438A (ja) | 2009-06-25 | 2012-12-10 | アムジエン・インコーポレーテツド | 複素環式化合物およびその使用 |
| NZ598758A (en) | 2009-09-11 | 2013-12-20 | Amgen Inc | N-4 (-((3-(2-amino-4 pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer |
| KR20120031734A (ko) * | 2010-09-27 | 2012-04-04 | 삼성전자주식회사 | 급성 골수성 백혈병 환자의 시타라빈 민감성을 예측하기 위한 키트 및 방법 |
| MX2013006020A (es) * | 2011-01-31 | 2013-10-01 | Celgene Corp | Composicion farmaceutica de analogos de citidina y metodos para su uso. |
| MX352672B (es) | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| US9216170B2 (en) * | 2012-03-19 | 2015-12-22 | Hoffmann-La Roche Inc. | Combination therapy for proliferative disorders |
| WO2013144923A1 (en) | 2012-03-30 | 2013-10-03 | Takeda Pharmaceutical Company Limited | Administration of a raf inhibitor and a mek inhibitor in the treatment of melanoma |
| JP6417338B2 (ja) | 2013-02-19 | 2018-11-07 | アムジエン・インコーポレーテツド | 癌の治療のためのmdm2阻害剤としてのシス−モルホリノン及び他の化合物 |
| JP6266659B2 (ja) | 2013-02-28 | 2018-01-24 | アムジエン・インコーポレーテツド | 癌の治療のための安息香酸誘導体mdm2阻害剤 |
| WO2014151863A1 (en) | 2013-03-14 | 2014-09-25 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| JOP20200296A1 (ar) | 2013-06-10 | 2017-06-16 | Amgen Inc | عمليات صنع وأشكال بلورية من mdm2 مثبط |
| US20150031642A1 (en) | 2013-07-26 | 2015-01-29 | Boehringer Ingelheim International Gmbh | Combination treatment of acute myeloid leukemia and myelodysplastic syndrome i |
| SMT202200241T1 (it) * | 2013-11-11 | 2022-09-14 | Amgen Inc | Politerapia che include un inibitore di mdm2 e uno o più agenti farmaceuticamente attivi aggiuntivi per il trattamento di cancri |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110319378A1 (en) * | 2010-06-04 | 2011-12-29 | Amgen Inc. | Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer |
Non-Patent Citations (4)
| Title |
|---|
| CANCER RES., vol. 70(6), JPN6019009514, 15 March 2010 (2010-03-15), pages 2424 - 2434, ISSN: 0003999806 * |
| JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, JPN6019009515, 2012, pages 356 - 364, ISSN: 0003999807 * |
| MOL CANCER THER., vol. 11(4), JPN6019009519, 2012, pages 909 - 920, ISSN: 0003999809 * |
| N ENGL J MED., vol. 367, JPN6019009517, 1 November 2012 (2012-11-01), pages 1694 - 1703, ISSN: 0003999808 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023033414A (ja) * | 2013-11-11 | 2023-03-10 | アムジエン・インコーポレーテツド | Mdm2阻害剤及び1つ以上の追加の医薬活性剤を含む癌治療のための併用療法 |
| JP2021525795A (ja) * | 2018-05-25 | 2021-09-27 | カルトス セラピューティクス,インコーポレイテッド | 骨髄増殖性腫瘍を治療する方法 |
| US12268681B2 (en) | 2018-05-25 | 2025-04-08 | Kartos Therapeutics, Inc. | Methods of treating myeloproliferative neoplasms |
| JP2025072429A (ja) * | 2018-05-25 | 2025-05-09 | カルトス セラピューティクス,インコーポレイテッド | 骨髄増殖性腫瘍を治療する方法 |
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