JP2016535795A - Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 - Google Patents

Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 Download PDF

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JP2016535795A
JP2016535795A JP2016553270A JP2016553270A JP2016535795A JP 2016535795 A JP2016535795 A JP 2016535795A JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016553270 A JP2016553270 A JP 2016553270A JP 2016535795 A JP2016535795 A JP 2016535795A
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chlorophenyl
inhibitor
pharmaceutically acceptable
methyl
oxopiperidin
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JP2016535795A5 (enExample
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カーンピール，ショーン
キャノン，ジュード
ヒューズ，ポール
オリナー，ジョナサン・ディー
リックルズ，リチャード・ジェイ
サイキ，アン・ワイ
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アムジエン・インコーポレーテツド
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JP2016553270A 2013-11-11 2014-11-11 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法 Ceased JP2016535795A (ja)

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US201361902717P 2013-11-11 2013-11-11
US61/902,717 2013-11-11
PCT/US2014/065034 WO2015070224A2 (en) 2013-11-11 2014-11-11 Combination therapy including an mdm2 inhibitor and one or more additional pharmaceutically active agents for the treatment of cancers

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JP2019078325A Division JP2019142916A (ja) 2013-11-11 2019-04-17 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法

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JP2016535795A true JP2016535795A (ja) 2016-11-17
JP2016535795A5 JP2016535795A5 (enExample) 2017-12-21

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JP2016553270A Ceased JP2016535795A (ja) 2013-11-11 2014-11-11 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2019078325A Pending JP2019142916A (ja) 2013-11-11 2019-04-17 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2020172367A Expired - Fee Related JP6972274B2 (ja) 2013-11-11 2020-10-13 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2021178554A Pending JP2022009805A (ja) 2013-11-11 2021-11-01 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2023003579A Pending JP2023033414A (ja) 2013-11-11 2023-01-13 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法

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JP2019078325A Pending JP2019142916A (ja) 2013-11-11 2019-04-17 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2020172367A Expired - Fee Related JP6972274B2 (ja) 2013-11-11 2020-10-13 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2021178554A Pending JP2022009805A (ja) 2013-11-11 2021-11-01 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2023003579A Pending JP2023033414A (ja) 2013-11-11 2023-01-13 Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法

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US (3) US20160287569A1 (enExample)
EP (2) EP3068393B9 (enExample)
JP (5) JP2016535795A (enExample)
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021525795A (ja) * 2018-05-25 2021-09-27 カルトス セラピューティクス，インコーポレイテッド 骨髄増殖性腫瘍を治療する方法
JP2023033414A (ja) * 2013-11-11 2023-03-10 アムジエン・インコーポレーテツド Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2430067T3 (es) 2007-03-28 2013-11-18 President And Fellows Of Harvard College Polipéptidos cosidos
PL2603600T3 (pl) 2010-08-13 2019-06-28 Aileron Therapeutics, Inc. Makrocykle peptidomometyczne
WO2013049250A1 (en) 2011-09-27 2013-04-04 Amgen Inc. Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
CA2852468A1 (en) 2011-10-18 2013-04-25 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
SG11201503052RA (en) 2012-11-01 2015-05-28 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof
US11407721B2 (en) 2013-02-19 2022-08-09 Amgen Inc. CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
WO2014151863A1 (en) 2013-03-14 2014-09-25 Amgen Inc. Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
SG11201702223UA (en) 2014-09-24 2017-04-27 Aileron Therapeutics Inc Peptidomimetic macrocycles and uses thereof
US10905739B2 (en) 2014-09-24 2021-02-02 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
CN107427501B (zh) 2015-02-20 2023-12-01 第一三共株式会社 通过联合使用治疗癌症的方法
AU2016235424A1 (en) 2015-03-20 2017-10-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
EP3341023A1 (en) * 2015-08-28 2018-07-04 Novartis AG Combination therapy using pi3k inhbitor and mdm2 inhibitor
CN111821306A (zh) * 2015-08-28 2020-10-27 诺华股份有限公司 Mdm2抑制剂和其组合
WO2017200826A1 (en) * 2016-05-16 2017-11-23 Albert Einstein College Of Medicine, Inc. Assays and compounds for treatment of cancer
CN109152843A (zh) 2016-05-20 2019-01-04 豪夫迈·罗氏有限公司 Protac抗体缀合物及其使用方法
US20190240210A1 (en) * 2016-10-17 2019-08-08 Daiichi Sankyo Company, Limited Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor
AU2018209164B2 (en) 2017-01-17 2021-11-04 Heparegenix Gmbh Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death
IL308399B2 (en) * 2018-04-30 2025-08-01 Kartos Therapeutics Inc Methods of treating cancer
US11091522B2 (en) 2018-07-23 2021-08-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN110963958B (zh) * 2018-09-30 2025-10-10 上海长森药业有限公司 一种mdm2抑制剂，及其制备方法、药物组合物和应用
AR116904A1 (es) * 2018-12-11 2021-06-23 Kartos Therapeutics Inc Métodos y composiciones para el tratamiento de un trastorno oftálmico
CN111434353A (zh) * 2019-02-02 2020-07-21 中国科学院上海营养与健康研究所 Ras抑制剂筛选及疗效标志物
EP4003332A4 (en) 2019-07-26 2023-05-10 Ascentage Pharma (Suzhou) Co., Ltd. PHARMACEUTICAL COMPOSITION OF AN MDM2 INHIBITOR AND ITS USE TO PREVENT AND/OR TREAT DISEASES
TW202128156A (zh) * 2019-11-14 2021-08-01 美商夸格智財控股有限公司 用於癌症治療之btk抑制劑及mdm2抑制劑之組合
CN113801120B (zh) * 2020-06-15 2024-03-22 苏州亚盛药业有限公司 Mdm2抑制剂的微悬浮液以及治疗应用
AR123227A1 (es) * 2020-08-12 2022-11-09 Servier Pharmaceuticals Llc Terapias combinadas para su uso en el tratamiento del cáncer
WO2023056069A1 (en) 2021-09-30 2023-04-06 Angiex, Inc. Degrader-antibody conjugates and methods of using same
CN115089585A (zh) * 2022-08-05 2022-09-23 中国科学院大学宁波华美医院 Mdm2抑制剂rg7112联合依托泊苷在治疗肺癌中的应用
WO2024240858A1 (en) 2023-05-23 2024-11-28 Valerio Therapeutics Protac molecules directed against dna damage repair system and uses thereof
WO2024254156A1 (en) * 2023-06-05 2024-12-12 Kartos Therapeutics, Inc. Treatment of endometrial cancer with mdm2 inhibitors
WO2025098488A1 (zh) * 2023-11-09 2025-05-15 深圳艾欣达伟医药科技有限公司 上调p53蛋白表达或激活p53功能的药物与DNA烷化剂联用治疗癌症

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110319378A1 (en) * 2010-06-04 2011-12-29 Amgen Inc. Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EE05450B1 (et) 2000-07-19 2011-08-15 Warner-Lambert Company 4-jodofenlaminobenshdroksaamhapete oksgeenitud estrid, nende kristallvormid ja farmatseutilised kompositsioonid ning kasutamine
MX2007004551A (es) 2004-10-18 2007-05-23 Amgen Inc Compuestos tiadiazol y metodos de uso.
EP1981884B1 (en) 2006-01-18 2012-06-13 Amgen, Inc Thiazole compounds as protein kinase b (pkb) inhibitors
PL2137186T3 (pl) 2007-03-23 2016-09-30 Związki heterocykliczne i ich zastosowania
US7705018B2 (en) 2007-03-23 2010-04-27 Amgen Inc. Substituted quinolines and their uses in treatment of inflammatory and related conditions
AU2008231384B2 (en) 2007-03-23 2011-09-15 Amgen Inc. Heterocyclic compounds and their use
US7625895B2 (en) 2007-04-12 2009-12-01 Hoffmann-Le Roche Inc. Diphenyl-dihydro-imidazopyridinones
WO2008153947A2 (en) 2007-06-07 2008-12-18 Amgen Inc. Heterocyclic compounds as raf kinase modulators
AU2008276521B2 (en) 2007-07-17 2011-11-03 Amgen Inc. Heterocyclic modulators of PKB
AU2008276512A1 (en) 2007-07-17 2009-01-22 Amgen Inc. Thiadiazole modulators of PKB
ES2401557T3 (es) 2007-08-02 2013-04-22 Amgen, Inc Moduladores de Pl3 cinasas y métodos de uso
US7820665B2 (en) 2007-12-19 2010-10-26 Amgen Inc. Imidazopyridazine inhibitors of PI3 kinase for cancer treatment
CA2709202C (en) 2007-12-19 2013-04-23 Amgen Inc. Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors
WO2009126584A1 (en) 2008-04-07 2009-10-15 Amgen Inc. Gem-disubstituted and spirocyclic amino pyridines/pyrimidines as cell cycle inhibitors
WO2009155121A2 (en) 2008-05-30 2009-12-23 Amgen Inc. Inhibitors of pi3 kinase
US20110263647A1 (en) 2009-01-15 2011-10-27 Amgen Inc. Fluoroisoquinoline substituted thiazole compounds and methods of use
CA2752527C (en) 2009-02-18 2014-09-23 Amgen Inc. Indole/benzimidazole compounds as mtor kinase inhibitors
MX2011009796A (es) 2009-03-20 2011-12-14 Amgen Inc Inhibidores de la cinasa pi3.
UY32582A (es) 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
JP2012526836A (ja) 2009-05-13 2012-11-01 アムジエン・インコーポレーテツド Ｐｉｋｋ阻害薬としてのヘテロアリール化合物
CA2765819A1 (en) 2009-06-25 2010-12-29 Amgen Inc. Heterocyclic compounds and their uses as inhibitors of pi3 k activity
US8754089B2 (en) 2009-06-25 2014-06-17 Amgen Inc. Heterocyclic compounds and their uses
SG176986A1 (en) 2009-06-25 2012-02-28 Amgen Inc Polycyclic derivatives of pyridine and their use in the treatment of (inter alia) rheumatoid arthritis and similar diseases
WO2010151791A1 (en) 2009-06-25 2010-12-29 Amgen Inc. Heterocyclic compounds and their uses
EP2818170B1 (en) 2009-09-11 2018-12-05 Amgen, Inc N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridin yl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine for use in the treatment of antimitotic agent resistant cancer
KR20120031734A (ko) * 2010-09-27 2012-04-04 삼성전자주식회사 급성 골수성 백혈병 환자의 시타라빈 민감성을 예측하기 위한 키트 및 방법
WO2012106299A1 (en) * 2011-01-31 2012-08-09 Celgene Corporation Pharmaceutical compositions of cytidine analogs and methods of use thereof
WO2013049250A1 (en) 2011-09-27 2013-04-04 Amgen Inc. Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer
US9216170B2 (en) * 2012-03-19 2015-12-22 Hoffmann-La Roche Inc. Combination therapy for proliferative disorders
JP2015511632A (ja) 2012-03-30 2015-04-20 武田薬品工業株式会社 メラノーマの治療におけるｒａｆ阻害剤およびｍｅｋ阻害剤の投与
EP2958902B1 (en) 2013-02-19 2017-11-15 Amgen Inc. Cis-morpholinone and other compounds as mdm2 inhibitors for the treatment of cancer
CN105121407B (zh) 2013-02-28 2017-07-18 美国安进公司 用于治疗癌症的苯甲酸衍生物mdm2抑制剂
WO2014151863A1 (en) 2013-03-14 2014-09-25 Amgen Inc. Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer
JOP20200296A1 (ar) 2013-06-10 2017-06-16 Amgen Inc عمليات صنع وأشكال بلورية من mdm2 مثبط
MX2016001084A (es) 2013-07-26 2016-04-25 Boehringer Ingelheim Int Volasertib en combinacion con decitabina para el tratamiento de leucemia mieloide aguda y sindrome mielodisplasico.
PT3068393T (pt) * 2013-11-11 2022-06-14 Amgen Inc Terapia de combinação, incluindo um inibidor de mdm2 e um ou mais agentes farmaceuticamente ativos adicionais para o tratamento de cancros

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110319378A1 (en) * 2010-06-04 2011-12-29 Amgen Inc. Piperidinone derivatives as mdm2 inhibitors for the treatment of cancer

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CANCER RES., vol. 70(6), JPN6019009514, 15 March 2010 (2010-03-15), pages 2424 - 2434, ISSN: 0003999806 *
JOURNAL OF INVESTIGATIVE DERMATOLOGY, vol. 132, JPN6019009515, 2012, pages 356 - 364, ISSN: 0003999807 *
MOL CANCER THER., vol. 11(4), JPN6019009519, 2012, pages 909 - 920, ISSN: 0003999809 *
N ENGL J MED., vol. 367, JPN6019009517, 1 November 2012 (2012-11-01), pages 1694 - 1703, ISSN: 0003999808 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023033414A (ja) * 2013-11-11 2023-03-10 アムジエン・インコーポレーテツド Ｍｄｍ２阻害剤及び１つ以上の追加の医薬活性剤を含む癌治療のための併用療法
JP2021525795A (ja) * 2018-05-25 2021-09-27 カルトス セラピューティクス，インコーポレイテッド 骨髄増殖性腫瘍を治療する方法
US12268681B2 (en) 2018-05-25 2025-04-08 Kartos Therapeutics, Inc. Methods of treating myeloproliferative neoplasms
JP2025072429A (ja) * 2018-05-25 2025-05-09 カルトス セラピューティクス，インコーポレイテッド 骨髄増殖性腫瘍を治療する方法

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