KR102183406B1 - 진단 및 치료를 위한 엑소좀 내 miRNA 생합성 - Google Patents

진단 및 치료를 위한 엑소좀 내 miRNA 생합성 Download PDF

Info

Publication number
KR102183406B1
KR102183406B1 KR1020157028765A KR20157028765A KR102183406B1 KR 102183406 B1 KR102183406 B1 KR 102183406B1 KR 1020157028765 A KR1020157028765 A KR 1020157028765A KR 20157028765 A KR20157028765 A KR 20157028765A KR 102183406 B1 KR102183406 B1 KR 102183406B1
Authority
KR
South Korea
Prior art keywords
mir
hsa
mmu
mirna
exosomes
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020157028765A
Other languages
English (en)
Korean (ko)
Other versions
KR20160006673A (ko
Inventor
라구 칼루리
소니아 멜로
Original Assignee
보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템
베쓰 이스라엘 디코니스 메디칼 센터 인크
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템, 베쓰 이스라엘 디코니스 메디칼 센터 인크 filed Critical 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템
Publication of KR20160006673A publication Critical patent/KR20160006673A/ko
Application granted granted Critical
Publication of KR102183406B1 publication Critical patent/KR102183406B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/02Arrangements for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
    • A61B6/03Computed tomography [CT]
    • A61B6/037Emission tomography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
    • G01N33/57415Specifically defined cancers of breast
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06QINFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES; SYSTEMS OR METHODS SPECIALLY ADAPTED FOR ADMINISTRATIVE, COMMERCIAL, FINANCIAL, MANAGERIAL OR SUPERVISORY PURPOSES, NOT OTHERWISE PROVIDED FOR
    • G06Q10/00Administration; Management
    • G06Q10/10Office automation; Time management
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H15/00ICT specially adapted for medical reports, e.g. generation or transmission thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
    • G01N2333/47Assays involving proteins of known structure or function as defined in the subgroups
    • G01N2333/4701Details
    • G01N2333/4703Regulators; Modulating activity
    • G01N2333/4704Inhibitors; Supressors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
KR1020157028765A 2013-03-15 2014-03-14 진단 및 치료를 위한 엑소좀 내 miRNA 생합성 Active KR102183406B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361791301P 2013-03-15 2013-03-15
US61/791,301 2013-03-15
PCT/US2014/027541 WO2014152622A1 (en) 2013-03-15 2014-03-14 Mirna biogenesis in exosomes for diagnosis and therapy

Publications (2)

Publication Number Publication Date
KR20160006673A KR20160006673A (ko) 2016-01-19
KR102183406B1 true KR102183406B1 (ko) 2020-12-11

Family

ID=51581257

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157028765A Active KR102183406B1 (ko) 2013-03-15 2014-03-14 진단 및 치료를 위한 엑소좀 내 miRNA 생합성

Country Status (15)

Country Link
US (2) US20160024503A1 (enExample)
EP (2) EP2971162B1 (enExample)
JP (2) JP6554458B2 (enExample)
KR (1) KR102183406B1 (enExample)
CN (2) CN109852695B (enExample)
AU (2) AU2014239309B2 (enExample)
BR (1) BR112015023275B1 (enExample)
CA (2) CA2905081C (enExample)
ES (1) ES2966571T3 (enExample)
HK (1) HK1218143A1 (enExample)
IL (2) IL241409B (enExample)
MX (2) MX373957B (enExample)
PT (1) PT3527670T (enExample)
RU (2) RU2018101152A (enExample)
WO (1) WO2014152622A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102310302B1 (ko) * 2021-02-08 2021-10-06 을지대학교 산학협력단 엑소좀 기반 방광암 진단을 위한 정보 제공 방법

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016150475A1 (en) * 2015-03-22 2016-09-29 Universite De Liege Circulating micrornas for the diagnosis of breast cancer
CN104774966B (zh) * 2015-05-01 2017-07-28 北京博奥医学检验所有限公司 肺腺癌miRNA标记物
CA2988585A1 (en) 2015-06-10 2016-12-15 Raghu Kalluri Use of exosomes for the treatment of disease
CN107151661A (zh) * 2016-03-02 2017-09-12 上海润腾生物科技有限公司 一种人外泌体蛋白、试剂盒及其应用
CN106202984B (zh) * 2016-08-26 2018-09-04 赵毅 一种基于多层复杂网络对肿瘤miRNA标志物的筛选方法
WO2018071806A1 (en) * 2016-10-13 2018-04-19 University Of Louisville Research Foundation, Inc. Exosomal biomarkers for diagnosis and prognosis of cancer and related methods
CN110024037B (zh) 2016-11-30 2023-06-27 微软技术许可有限责任公司 经由连接的dna随机存取存储系统
US10793897B2 (en) * 2017-02-08 2020-10-06 Microsoft Technology Licensing, Llc Primer and payload design for retrieval of stored polynucleotides
US11377699B2 (en) * 2017-11-30 2022-07-05 Provincial Health Services Authority Methods for evaluating head and neck cancers
JP7474702B2 (ja) 2018-03-28 2024-04-25 ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム エキソソームから単離されたdnaにおけるエピジェネティック変化の同定法
KR20210005031A (ko) 2018-03-29 2021-01-13 테크니온 리서치 엔드 디벨로프먼트 화운데이션 엘티디. Pten 억제제를 포함하는 소포 및 이의 용도
TWI805739B (zh) * 2018-04-17 2023-06-21 臺北榮民總醫院 阻斷緊迫導致腫瘤生成之方法
JP7462227B2 (ja) * 2018-04-25 2024-04-05 東レ株式会社 膀胱がんの検出のためのキット、デバイス及び方法
US12339205B2 (en) 2018-10-17 2025-06-24 H.U. Group Research Institute G. K. Method for recovering extracellular vesicles
US11766484B2 (en) 2019-01-03 2023-09-26 International Business Machines Corporation Exosome vessels for delivery of molecular cargo
AU2020217747B2 (en) 2019-02-08 2025-01-02 Board Of Regents, The University Of Texas System Telomerase-containing exosomes for treatment of diseases associated with aging and age-related organ dysfunction
WO2020163553A1 (en) * 2019-02-08 2020-08-13 Virginia Commonwealth University Mda-7/il-24 for cancer treatment and methods of monitoring same
CN118512468A (zh) * 2019-02-26 2024-08-20 首尔大学校产学协力团 包含末端尿苷酰基转移酶4/7表达调控因子的用于预防或治疗癌症的药学组合物
MX2022000074A (es) * 2019-07-02 2022-04-06 Ohio State Innovation Foundation Terapias para enfermedades neurodegenerativas que usan el eje piel cerebro.
US20220275455A1 (en) * 2019-07-08 2022-09-01 Preferred Networks, Inc. Data processing and classification for determining a likelihood score for breast disease
CN110358835A (zh) * 2019-07-26 2019-10-22 泗水县人民医院 生物标志物在胃癌检测、诊断中的应用
KR102212699B1 (ko) * 2019-08-12 2021-02-05 한국원자력의학원 유방암 예방 또는 치료용 조성물
CN110607361A (zh) * 2019-10-08 2019-12-24 南京市儿童医院 miR-431作为靶点在制备促进SP表达的药物中的应用
EP4067472A4 (en) 2019-12-23 2023-12-27 Fujirebio Inc. METHOD FOR OBTAINING EXTRACELLULAR VESICLES AND BLOOD COLLECTION TUBE
EP3862442A3 (en) * 2020-02-04 2021-10-27 Artemisia S.p.A. Method for the early diagnosis of cancer by means of ddpcr analysis of mirna in liquid biopsy
EP3862441A3 (en) * 2020-02-04 2021-10-27 Artemisia S.p.A. Method for the early diagnosis of cancer by means of ddpcr analysis of mirna and protein markers in liquid biopsy
KR102318328B1 (ko) * 2020-04-13 2021-10-27 고려대학교 산학협력단 Gcc2 단백질을 과발현하는 엑소좀 기반 암 진단 또는 예후 예측용 마커 조성물
US20230227916A1 (en) 2020-04-15 2023-07-20 H.U. Group Research Institute G.K. Method for recovering extracellular vesicle
CN111920961B (zh) * 2020-08-14 2023-09-08 福建医科大学附属协和医院 一种治疗癌症的药物
JP7662161B2 (ja) * 2020-09-08 2025-04-15 ウロテック. カンパニー リミテッド 前立腺癌診断スコアを算出するための方法及びそれの使用
KR102497196B1 (ko) 2020-09-08 2023-02-07 (주)유로테크 전립선암 진단 점수 계산 방법 및 그 용도
JP7460203B2 (ja) * 2020-11-11 2024-04-02 国立研究開発法人物質・材料研究機構 細胞で産生された膜小胞に由来する塩基配列を解析する方法、その装置、及び、そのプログラム
CN112662752B (zh) * 2021-01-18 2022-08-23 中国农业大学 一种诊断用生物标志物的应用
CN112760381B (zh) * 2021-02-08 2022-11-01 复旦大学附属中山医院 一种检测肺腺癌预后的miRNA试剂盒
CN117802235B (zh) * 2022-09-30 2025-08-19 上海思路迪生物医学科技有限公司 血液胞外囊泡miRNA在卵巢癌诊断中的应用
CN116121377A (zh) * 2022-11-01 2023-05-16 山西医科大学 一种食管鳞癌外泌体富含的miRNA作为诊断食管鳞癌的标志物中的应用
CN117778574B (zh) * 2023-12-25 2024-09-03 山东中医药大学 Mir937基因组拷贝数扩增在卵巢癌诊断和/或治疗中的应用
CN118421798B (zh) * 2024-05-22 2025-02-07 南通市海门区人民医院 用于检测结直肠癌相关血清生物标志物、sers传感器及制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110172295A1 (en) 2008-04-11 2011-07-14 The University Of North Carolina At Chapel Hill METHODS AND COMPOSITIONS FOR THE REGULATION OF microRNA PROCESSING
US20150038549A1 (en) 2011-04-20 2015-02-05 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Components That Self Assemble in Cells and Produce RNAi Activity

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030064949A1 (en) 1998-02-17 2003-04-03 Loretta Nielsen Combined tumor suppressor gene therapy and chemotherapy in the treatment of neoplasms
FR2766205B1 (fr) 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
KR100519384B1 (ko) 2002-08-13 2005-10-06 (주)누백스 유전자 이입을 이용한 엑소좀의 제조방법 및 상기 엑소좀의 용도
CN1281279C (zh) * 2004-09-16 2006-10-25 浙江大学 针对表皮生长因子基因的小干扰核糖核酸分子及其用途
CA2676113C (en) * 2007-07-25 2014-07-08 University Of Louisville Research Foundation, Inc. Exosome-associated microrna as a diagnostic marker
US8455199B2 (en) * 2007-09-14 2013-06-04 The Ohio State University Research Foundation MicroRNA expression in human peripheral blood microvesicles and uses thereof
EP2197497B1 (en) * 2007-09-27 2016-06-01 ImmunoVaccine Technologies Inc. Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo
EP2604704B1 (en) 2008-02-01 2018-10-03 The General Hospital Corporation Use of microvesicles in diagnosis and prognosis of brain tumor
WO2009108860A2 (en) * 2008-02-28 2009-09-03 The Ohio University Rasearch Foundation Microrna-based methods and compositions for the diagnosis, pronosis and treatment of prostate related disorders
EP2294196A1 (en) 2008-06-06 2011-03-16 Centre National de la Recherche Scientifique - CNRS Use of endo-lysosomal system and secreted vesicles (exosome-like) in treatments and diagnostics based on small rna and experimental study of small rna
EP3181705A1 (en) 2008-11-12 2017-06-21 Caris Life Sciences Switzerland Holdings GmbH Methods and systems of using exosomes for determining phenotypes
CA2795776A1 (en) * 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
US10081542B2 (en) * 2010-04-20 2018-09-25 University of Florida Research Foundation, lnc. Nanozymes, methods of making nanozymes, and methods of using nanozymes
CN109432126B (zh) * 2011-03-11 2022-06-14 儿童医学中心公司 与间充质干细胞外来体相关的方法和组合物
KR20140067001A (ko) * 2011-08-08 2014-06-03 카리스 라이프 사이언스 룩셈부르크 홀딩스, 에스.에이.알.엘. 생물지표 조성물 및 방법
US9777042B2 (en) 2011-12-15 2017-10-03 Morehouse School Of Medicine Method of purifying HIV/SIV Nef from exosomal fusion proteins
DK3076949T3 (da) 2013-12-04 2019-11-25 Univ Texas Fremgangsmåde til isolering af kræftcelle-afledte eksosomer
HUE059718T2 (hu) * 2016-09-02 2022-12-28 Dicerna Pharmaceuticals Inc 4'-foszfát analógok és azokat tartalmazó oligonukleotidok

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110172295A1 (en) 2008-04-11 2011-07-14 The University Of North Carolina At Chapel Hill METHODS AND COMPOSITIONS FOR THE REGULATION OF microRNA PROCESSING
US20150038549A1 (en) 2011-04-20 2015-02-05 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Components That Self Assemble in Cells and Produce RNAi Activity

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102310302B1 (ko) * 2021-02-08 2021-10-06 을지대학교 산학협력단 엑소좀 기반 방광암 진단을 위한 정보 제공 방법

Also Published As

Publication number Publication date
AU2020203590A1 (en) 2020-06-18
EP3527670B1 (en) 2023-10-18
AU2020203590B2 (en) 2023-06-22
US20200255831A1 (en) 2020-08-13
CA3209023A1 (en) 2014-09-25
CN105264092B (zh) 2019-02-22
CN105264092A (zh) 2016-01-20
JP6807351B2 (ja) 2021-01-06
KR20160006673A (ko) 2016-01-19
RU2644247C2 (ru) 2018-02-08
AU2014239309A1 (en) 2015-10-08
US20160024503A1 (en) 2016-01-28
CN109852695B (zh) 2023-11-21
MX373957B (es) 2020-07-13
EP2971162A4 (en) 2016-11-16
BR112015023275A2 (pt) 2017-07-18
PT3527670T (pt) 2024-01-18
IL241409A0 (en) 2015-11-30
BR112015023275A8 (pt) 2018-01-23
BR112015023275B1 (pt) 2022-06-21
JP6554458B2 (ja) 2019-07-31
EP3527670A1 (en) 2019-08-21
RU2018101152A3 (enExample) 2019-02-21
EP2971162B1 (en) 2019-05-08
WO2014152622A1 (en) 2014-09-25
EP2971162A1 (en) 2016-01-20
CN109852695A (zh) 2019-06-07
IL273829A (en) 2020-05-31
RU2015144212A (ru) 2017-04-21
AU2014239309B2 (en) 2020-03-05
IL241409B (en) 2020-04-30
RU2018101152A (ru) 2019-02-21
JP2016520803A (ja) 2016-07-14
US11926824B2 (en) 2024-03-12
MX2020005165A (es) 2020-08-20
CA2905081C (en) 2023-10-03
CA2905081A1 (en) 2014-09-25
JP2018138057A (ja) 2018-09-06
ES2966571T3 (es) 2024-04-23
MX2015013141A (es) 2016-06-21
IL273829B (en) 2021-12-01
HK1218143A1 (zh) 2017-02-03

Similar Documents

Publication Publication Date Title
AU2020203590B2 (en) Mirna biogenesis in exosomes for diagnosis and therapy
Li et al. Exosomal lncRNA ZFAS1 regulates esophageal squamous cell carcinoma cell proliferation, invasion, migration and apoptosis via microRNA-124/STAT3 axis
Zhang et al. Cell-derived microvesicles mediate the delivery of miR-29a/c to suppress angiogenesis in gastric carcinoma
Liang et al. MicroRNA-223 delivered by platelet-derived microvesicles promotes lung cancer cell invasion via targeting tumor suppressor EPB41L3
US9315809B2 (en) Differentially expressed microRNA molecules for the treatment and diagnosis of cancer
Chen et al. Loss of expression of miR-335 is implicated in hepatic stellate cell migration and activation
CN102027129A (zh) 用于前列腺相关病症的诊断、预后和治疗的基于微rna的方法和组合物
Menachem et al. Intercellular transfer of small RNAs from astrocytes to lung tumor cells induces resistance to chemotherapy
CN103648505A (zh) 与微rna-21、错配修复和结肠直肠癌相关的材料和方法
INCHE ZAINAL ABIDIN Role of MicroRNAs in determining the cancer-associated fibroblast phenotype
Aiqun et al. miR-199a-3p inhibits proliferation of rat basilar artery smooth muscle cells by targeting mTOR.
Liu MicroRNA regulation of prostate cancer stem/progenitor cells and prostate cancer development
Gaur The Role of MIR-34a in inhibition of prostate tumor growth in the bone and Induction of Autophagy
Shah The Contribution of Cancer Associated Fibroblasts in Breast Cancer Progression
Qi Regulation of the Proliferation of Glioma Stem Cell-Like Cells
Gordanpour MicroRNAs as Prognostic Biomarkers in Prostate Cancer
Kim The function of microRNAs in p53-regulated epithelial-mesenchymal transition
Elgamal Transcriptional and Post Transcriptional Regulation of Gene Expression: Applications to Biology and Cancer
Yang Molecular and Functional Characterization of MicroRNA-137 in Oligodendroglial Tumors
Blelloch MicroRNAs to Pathways in Prostate Cancer Progression

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20151012

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20190313

Comment text: Request for Examination of Application

PA0302 Request for accelerated examination

Patent event date: 20190313

Patent event code: PA03022R01D

Comment text: Request for Accelerated Examination

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20190528

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20200225

PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20201120

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20201123

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20241016

Start annual number: 5

End annual number: 5