KR102139918B1 - ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법 - Google Patents

ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법 Download PDF

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KR102139918B1
KR102139918B1 KR1020147032288A KR20147032288A KR102139918B1 KR 102139918 B1 KR102139918 B1 KR 102139918B1 KR 1020147032288 A KR1020147032288 A KR 1020147032288A KR 20147032288 A KR20147032288 A KR 20147032288A KR 102139918 B1 KR102139918 B1 KR 102139918B1
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dsrna
pharmaceutical composition
hemophilia
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seq
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KR20150003344A (ko
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아킨 아킨크
알피카 세갈
이반카 토우드자르스카
도날드 포스터
스튜어트 밀스테인
브라이언 베텐코트
마르틴 마이에르
클라우스 카리쎄
사트야나라야나 쿠치만치
칼란토타틸 지. 라제브
무티아 마노하란
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젠자임 코포레이션
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N15/09—Recombinant DNA-technology
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3521—Methyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3523—Allyl
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3525—MOE, methoxyethoxy
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
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    • C12N2310/3533—Halogen
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications

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  • General Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020147032288A 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법 Active KR102139918B1 (ko)

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US201261638952P 2012-04-26 2012-04-26
US61/638,952 2012-04-26
US201261669249P 2012-07-09 2012-07-09
US61/669,249 2012-07-09
US201261734573P 2012-12-07 2012-12-07
US61/734,573 2012-12-07
US13/837,129 US9127274B2 (en) 2012-04-26 2013-03-15 Serpinc1 iRNA compositions and methods of use thereof
US13/837,129 2013-03-15
PCT/US2013/038218 WO2013163430A2 (en) 2012-04-26 2013-04-25 Serpinc1 irna compositions and methods of use thereof

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KR20150003344A KR20150003344A (ko) 2015-01-08
KR102139918B1 true KR102139918B1 (ko) 2020-08-05

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KR1020227008361A Pending KR20220038521A (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
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KR1020257029360A Pending KR20250134150A (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법

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KR1020227008361A Pending KR20220038521A (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
KR1020217014582A Active KR102375607B1 (ko) 2012-04-26 2013-04-25 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
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US (6) US9127274B2 (enExample)
EP (2) EP2841443B1 (enExample)
JP (4) JP6466832B2 (enExample)
KR (5) KR102139918B1 (enExample)
CN (4) CN104520310B (enExample)
AR (1) AR090869A1 (enExample)
AU (5) AU2013251494A1 (enExample)
CA (1) CA2869922A1 (enExample)
CL (1) CL2016000188A1 (enExample)
CO (1) CO7240361A2 (enExample)
ES (1) ES2934152T3 (enExample)
FI (1) FI2841443T3 (enExample)
HR (1) HRP20221498T1 (enExample)
HU (1) HUE060846T2 (enExample)
IL (4) IL234941B (enExample)
LT (1) LT2841443T (enExample)
MX (2) MX365419B (enExample)
PL (1) PL2841443T3 (enExample)
PT (1) PT2841443T (enExample)
RS (1) RS63838B1 (enExample)
RU (1) RU2691580C2 (enExample)
SI (1) SI2841443T1 (enExample)
WO (1) WO2013163430A2 (enExample)
ZA (2) ZA201407293B (enExample)

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CN120041447A (zh) * 2018-12-19 2025-05-27 阿尼拉制药公司 淀粉样前体蛋白（APP）RNAi剂组成物及其使用方法
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