KR102135485B1 - 반복 다이사카라이드 단위를 포함하는 비-항응고 글리코스아미노글리칸 및 이의 의학적 용도 - Google Patents

반복 다이사카라이드 단위를 포함하는 비-항응고 글리코스아미노글리칸 및 이의 의학적 용도 Download PDF

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KR102135485B1
KR102135485B1 KR1020147016676A KR20147016676A KR102135485B1 KR 102135485 B1 KR102135485 B1 KR 102135485B1 KR 1020147016676 A KR1020147016676 A KR 1020147016676A KR 20147016676 A KR20147016676 A KR 20147016676A KR 102135485 B1 KR102135485 B1 KR 102135485B1
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heparin
delete delete
glycosaminoglycan
chemically modified
kda
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KR20140113652A (ko
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한스-피터 에커
퍼-올로브 에릭슨
울프 린달
에릭 홀머
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딜라포 아베
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/04—Drugs for genital or sexual disorders; Contraceptives for inducing labour or abortion; Uterotonics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Biochemistry (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020147016676A 2011-12-19 2012-12-19 반복 다이사카라이드 단위를 포함하는 비-항응고 글리코스아미노글리칸 및 이의 의학적 용도 Active KR102135485B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161577223P 2011-12-19 2011-12-19
US61/577,223 2011-12-19
PCT/SE2012/051433 WO2013095279A1 (en) 2011-12-19 2012-12-19 Non anti-coagulative glycosaminoglycans comprising repeating disaccharide unit and their medical use

Publications (2)

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KR20140113652A KR20140113652A (ko) 2014-09-24
KR102135485B1 true KR102135485B1 (ko) 2020-07-17

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US (1) US9475888B2 (cg-RX-API-DMAC7.html)
EP (1) EP2794665B1 (cg-RX-API-DMAC7.html)
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CN (1) CN104144950B (cg-RX-API-DMAC7.html)
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CL (1) CL2014001651A1 (cg-RX-API-DMAC7.html)
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RU (1) RU2617764C2 (cg-RX-API-DMAC7.html)
SI (1) SI2794665T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201800143T1 (cg-RX-API-DMAC7.html)
WO (1) WO2013095279A1 (cg-RX-API-DMAC7.html)
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CA2868479A1 (en) * 2012-03-26 2013-10-03 Dilafor Ab Method for treatment of labor arrest
MX2014013449A (es) * 2012-05-08 2014-12-08 Dilafor Ab Tratamiento de la hemorragia postparto (pph) con heparina modificada quimicamente o sulfato de heparan y un agente uterotonico.
GB2515315A (en) * 2013-06-19 2014-12-24 Dilafor Ab New Processes
CN103788222B (zh) * 2014-01-08 2016-08-31 中国科学院昆明植物研究所 Fuc3S4S取代的低聚糖胺聚糖及其制备方法
CN107001488B (zh) * 2014-04-30 2020-05-12 新加坡科技研究局 硫酸乙酰肝素
CN108424474B (zh) * 2017-02-15 2023-07-25 清华大学 去抗凝肝素衍生物及其用于炎症性肠病的治疗
EP4106765A1 (en) 2020-02-17 2022-12-28 Dilafor AB Tafoxiparin for the treatment of preeclampsia
JP2025514038A (ja) 2022-05-03 2025-05-02 ディラフォール アクチエボラグ タフォキシパリンの新規な医学的使用
EP4272749A1 (en) 2022-05-03 2023-11-08 Dilafor AB New medical use of tafoxiparin
GB202407366D0 (en) * 2024-05-23 2024-07-10 Glycos Biomedical Ltd Preparation of medium molecular weight heparin

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Also Published As

Publication number Publication date
KR20140113652A (ko) 2014-09-24
US9475888B2 (en) 2016-10-25
EP2794665B1 (en) 2017-11-22
HUE036523T2 (hu) 2018-07-30
CL2014001651A1 (es) 2014-10-10
RU2014129816A (ru) 2016-02-20
RU2617764C2 (ru) 2017-04-26
HRP20180124T1 (hr) 2018-02-23
EP2794665A1 (en) 2014-10-29
JP6543467B2 (ja) 2019-07-10
IL232905A0 (en) 2014-07-31
JP2018111825A (ja) 2018-07-19
IL232905A (en) 2017-02-28
ME02994B (me) 2018-10-20
SMT201800143T1 (it) 2018-05-02
MX351104B (es) 2017-10-02
CN104144950A (zh) 2014-11-12
RS56874B1 (sr) 2018-04-30
BR112014014454A2 (pt) 2017-06-13
EP2794665A4 (en) 2015-08-26
SI2794665T1 (en) 2018-03-30
LT2794665T (lt) 2017-12-27
MX2014007122A (es) 2015-03-05
JP2015500388A (ja) 2015-01-05
WO2013095279A1 (en) 2013-06-27
NO2904345T3 (cg-RX-API-DMAC7.html) 2018-07-21
ZA201403640B (en) 2017-06-28
ES2656613T3 (es) 2018-02-27
CY1119899T1 (el) 2018-06-27
CA2856492A1 (en) 2013-06-27
PT2794665T (pt) 2018-01-24
AU2012354229A1 (en) 2014-06-05
PL2794665T3 (pl) 2018-04-30
US20150011505A1 (en) 2015-01-08
HK1202883A1 (en) 2015-10-09
CO7061069A2 (es) 2014-09-19
BR112014014454B1 (pt) 2021-03-09
DK2794665T3 (da) 2018-01-29
CN104144950B (zh) 2017-09-05
AU2012354229B2 (en) 2016-12-01
CA2856492C (en) 2017-01-10

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