KR102049900B1 - 변형 인자 x 폴리펩티드 및 이의 용도 - Google Patents

변형 인자 x 폴리펩티드 및 이의 용도 Download PDF

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Publication number
KR102049900B1
KR102049900B1 KR1020157004694A KR20157004694A KR102049900B1 KR 102049900 B1 KR102049900 B1 KR 102049900B1 KR 1020157004694 A KR1020157004694 A KR 1020157004694A KR 20157004694 A KR20157004694 A KR 20157004694A KR 102049900 B1 KR102049900 B1 KR 102049900B1
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position corresponding
amino acid
polypeptide
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Korean (ko)
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KR20160073937A (ko
Inventor
크리스토퍼. 타노스
에드윈 엘. 매디슨
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카탈리스트 바이오사이언시즈, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6432—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21006—Coagulation factor Xa (3.4.21.6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020157004694A 2012-07-25 2013-03-15 변형 인자 x 폴리펩티드 및 이의 용도 Expired - Fee Related KR102049900B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261741806P 2012-07-25 2012-07-25
US61/741,806 2012-07-25
PCT/US2013/032616 WO2014018120A1 (en) 2012-07-25 2013-03-15 Modified factor x polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
KR20160073937A KR20160073937A (ko) 2016-06-27
KR102049900B1 true KR102049900B1 (ko) 2019-11-28

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KR1020157004694A Expired - Fee Related KR102049900B1 (ko) 2012-07-25 2013-03-15 변형 인자 x 폴리펩티드 및 이의 용도

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Country Link
US (2) US9145552B2 (https=)
EP (1) EP2877487B1 (https=)
JP (2) JP6363600B2 (https=)
KR (1) KR102049900B1 (https=)
CN (1) CN104755492A (https=)
AU (1) AU2013293573B2 (https=)
BR (1) BR112015001628A2 (https=)
CA (1) CA2879785C (https=)
EA (1) EA028865B1 (https=)
ES (1) ES2704083T3 (https=)
IL (1) IL236449B (https=)
IN (1) IN2015DN01404A (https=)
MX (1) MX365612B (https=)
NZ (1) NZ703148A (https=)
SG (1) SG11201500579SA (https=)
WO (1) WO2014018120A1 (https=)
ZA (1) ZA201500097B (https=)

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JP5219819B2 (ja) 2005-10-21 2013-06-26 カタリスト・バイオサイエンシーズ・インコーポレイテッド 補体活性化を阻害する修飾プロテアーゼ
SG175602A1 (en) 2006-07-05 2011-11-28 Catalyst Biosciences Inc Protease screening methods and proteases identified thereby
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TWI465247B (zh) 2008-04-11 2014-12-21 Catalyst Biosciences Inc 經修飾的因子ｖｉｉ多肽和其用途
TWI557135B (zh) 2010-11-03 2016-11-11 介控生化科技公司 經修飾之第九因子多胜肽及其用途
WO2014018120A1 (en) 2012-07-25 2014-01-30 Catalyst Biosciences, Inc. Modified factor x polypeptides and uses thereof
EP3049434A1 (en) 2013-09-24 2016-08-03 Pfizer Inc. Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins
BR112016014617A2 (pt) * 2014-01-24 2017-09-19 Pfizer Variante do fator xa (fxa) e usos da referida variante
US10444715B2 (en) * 2014-05-01 2019-10-15 Belkin International, Inc. Controlling settings and attributes related to operation of devices in a network
EA202190813A1 (ru) * 2014-05-26 2021-12-31 Академиш Зикенхёйс Лейден Прогемостатические белки для лечения кровотечений
WO2016110510A1 (en) * 2015-01-07 2016-07-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Mutated factor x polypeptides and uses thereof for the treatment of haemophilia
WO2017017109A1 (en) * 2015-07-27 2017-02-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Mutated factor x polypeptides and uses thereof for the treatment of haemophilia
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FR3050992A1 (fr) * 2016-05-06 2017-11-10 Lab Francais Du Fractionnement Mutants du facteur x
FR3077296A1 (fr) * 2018-02-01 2019-08-02 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Dimeres de variants du facteur x
WO2019201868A1 (en) * 2018-04-16 2019-10-24 Swedish Orphan Biovitrum Ab (Publ) Coagulation factor based fusion protein with half-life extending polypeptide
EP3833381B1 (en) 2019-08-15 2022-08-03 Catalyst Biosciences, Inc. Modified factor vii polypeptides for subcutaneous administration
EP3831843A1 (en) * 2019-12-08 2021-06-09 Royal College Of Surgeons In Ireland A hemostatic agent and uses thereof
WO2023086388A1 (en) * 2021-11-09 2023-05-19 YewSavin, Inc. Compositions and methods for treating bleeding and bleeding disorders
CN115725594B (zh) * 2022-03-03 2024-11-08 南京医科大学 Pipiserpin蛋白在蚊媒种群控制中的应用
CN114681597A (zh) * 2022-03-11 2022-07-01 兆科药业（合肥）有限公司 蝰蛇蛇毒血凝酶在制备用于逆转凝血因子Xa抑制剂的抗凝作用的药物中的应用
CN116426510B (zh) * 2023-06-13 2023-09-22 北京沃森赛瑟生物技术有限公司 含修饰Xa因子的利伐沙班检测试剂盒及检测方法与应用

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SG11201500579SA (en) 2015-02-27
IL236449A0 (en) 2015-02-26
AU2013293573B2 (en) 2016-10-27
CA2879785C (en) 2019-06-18
EP2877487B1 (en) 2018-10-17
MX365612B (es) 2019-06-07
CA2879785A1 (en) 2014-01-30
JP2015524801A (ja) 2015-08-27
BR112015001628A2 (pt) 2017-11-07
KR20160073937A (ko) 2016-06-27
ZA201500097B (en) 2016-09-28
US9145552B2 (en) 2015-09-29
MX2015001083A (es) 2015-04-08
JP6363600B2 (ja) 2018-07-25
US20140234290A1 (en) 2014-08-21
US9856467B2 (en) 2018-01-02
EA201500172A1 (ru) 2015-09-30
JP2018183147A (ja) 2018-11-22
IL236449B (en) 2019-02-28
HK1210790A1 (en) 2016-05-06
EP2877487A1 (en) 2015-06-03
WO2014018120A1 (en) 2014-01-30
IN2015DN01404A (https=) 2015-07-03
ES2704083T3 (es) 2019-03-14
NZ703148A (en) 2016-08-26
EA028865B1 (ru) 2018-01-31
US20140030247A1 (en) 2014-01-30
CN104755492A (zh) 2015-07-01
AU2013293573A1 (en) 2015-02-05

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