KR102048289B1 - 아밀로이드 β 펩타이드 관련 질환 또는 이상을 예방 또는 치료하기 위한 약학적 조성물 - Google Patents

아밀로이드 β 펩타이드 관련 질환 또는 이상을 예방 또는 치료하기 위한 약학적 조성물 Download PDF

Info

Publication number
KR102048289B1
KR102048289B1 KR1020147018051A KR20147018051A KR102048289B1 KR 102048289 B1 KR102048289 B1 KR 102048289B1 KR 1020147018051 A KR1020147018051 A KR 1020147018051A KR 20147018051 A KR20147018051 A KR 20147018051A KR 102048289 B1 KR102048289 B1 KR 102048289B1
Authority
KR
South Korea
Prior art keywords
polar solvent
water
pharmaceutical composition
ethanol
amyloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020147018051A
Other languages
English (en)
Korean (ko)
Other versions
KR20150002576A (ko
Inventor
항칭 린
무환 수
영밍 후앙
징징 탕
Original Assignee
신파 티엔리 파머슈티컬 컴퍼니 리미티드 (항저우)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 신파 티엔리 파머슈티컬 컴퍼니 리미티드 (항저우) filed Critical 신파 티엔리 파머슈티컬 컴퍼니 리미티드 (항저우)
Publication of KR20150002576A publication Critical patent/KR20150002576A/ko
Application granted granted Critical
Publication of KR102048289B1 publication Critical patent/KR102048289B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G4/00—Chewing gum
    • A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
    • A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147018051A 2011-12-16 2012-12-17 아밀로이드 β 펩타이드 관련 질환 또는 이상을 예방 또는 치료하기 위한 약학적 조성물 Active KR102048289B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161576367P 2011-12-16 2011-12-16
US61/576,367 2011-12-16
PCT/CN2012/086796 WO2013087042A1 (zh) 2011-12-16 2012-12-17 预防或治疗淀粉样β肽相关疾病或状况的医药组合物

Publications (2)

Publication Number Publication Date
KR20150002576A KR20150002576A (ko) 2015-01-07
KR102048289B1 true KR102048289B1 (ko) 2020-01-08

Family

ID=48580733

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147018051A Active KR102048289B1 (ko) 2011-12-16 2012-12-17 아밀로이드 β 펩타이드 관련 질환 또는 이상을 예방 또는 치료하기 위한 약학적 조성물

Country Status (11)

Country Link
US (1) US20150087606A1 (enExample)
EP (1) EP2792361B1 (enExample)
JP (1) JP6134331B2 (enExample)
KR (1) KR102048289B1 (enExample)
CN (1) CN103156867B (enExample)
AU (1) AU2012350437B2 (enExample)
CA (1) CA2859227C (enExample)
MY (1) MY171048A (enExample)
SG (1) SG11201403265VA (enExample)
TW (1) TWI488630B (enExample)
WO (1) WO2013087042A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3130340A4 (en) * 2014-04-10 2017-09-27 Sinphar Tian-li Pharmaceutical Co., Ltd. (Hangzhou) Isoacteoside derivative and preparation method and use thereof
TWI650131B (zh) * 2014-07-03 2019-02-11 杏輝藥品工業股份有限公司 管花肉蓯蓉萃取物之用於製備保護眼部細胞之藥品或食品用途
CN104922137B (zh) * 2015-06-04 2018-07-31 苏州大学 苯乙醇苷类化合物Torenoside B的新用途
KR102018085B1 (ko) * 2017-12-06 2019-09-04 김좌진 악테오사이드를 함유하는 뇌종양 치료 및 전이 억제용 약학 조성물
KR102135148B1 (ko) * 2019-08-28 2020-07-20 김좌진 악테오사이드를 함유하는 뇌종양 치료 및 전이 억제용 약학 조성물
CN110812375A (zh) * 2019-12-12 2020-02-21 中国海洋大学 一种老鼠簕中苯乙醇苷类提取物及其制备方法与作为抗肝损伤药物的应用
CN111632058A (zh) * 2020-06-24 2020-09-08 新疆医科大学 毛蕊花糖苷在制备预防和治疗神经退行性疾病药物中的应用
CN112225766A (zh) * 2020-10-27 2021-01-15 杏辉天力（杭州）药业有限公司 一种由肉苁蓉萃取物中富集及分离苯乙醇苷类化合物的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1526400A (zh) * 2003-03-04 2004-09-08 杭州天力药业有限公司 来源于管花肉苁蓉的含有苯乙醇苷的制剂及其制备方法和用途
US20070004011A1 (en) 2005-06-20 2007-01-04 I.R.B. Istituto Di Ricerche Biotecnologiche S.R.I. Extracts obtained from cell line cultures from plants belonging to the Oleaceae family (e.g. Syringa vulgaris), their preparation and use
JP2009196905A (ja) 2008-02-19 2009-09-03 Univ Kinki カンカニクジュヨウから得られる肝保護剤及び抗ＴＮＦ−α作用剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100500584B1 (ko) * 2002-08-12 2005-07-12 경희대학교 산학협력단 신경성장인자와 유사 작용을 갖는 육종용 추출물 및 이를함유하는 조성물
KR100514076B1 (ko) * 2003-01-10 2005-09-13 주식회사 엘컴사이언스 페닐에타노이드 유도체를 포함하는 퇴행성 뇌신경계질환의 예방 및 치료용 조성물
TW200416036A (en) * 2003-02-18 2004-09-01 Sinphar Pharmaceutical Co Ltd Medicinal preparation containing phenylethanoid glycosides extracted from herbaceous plant, cistanche tubulosa (schenk.) wight, process of making the same, and uses of the same
CN100345857C (zh) * 2004-07-16 2007-10-31 北京华医神农医药科技有限公司 一种从肉苁蓉药材中提取、分离松果菊苷的方法
CN101411753B (zh) * 2008-12-04 2012-02-29 闫明 列当总苷在制备抗老年痴呆的药物中的应用
CN101797307B (zh) * 2010-04-09 2011-08-10 广州中医药大学 一种含苯乙醇苷的枇杷叶紫珠提取物及其制备方法
TWI486162B (zh) 2010-06-16 2015-06-01 Sinphar Pharmaceutical Co Ltd 異類葉升麻苷或其醫藥學上可接受之鹽於抑制澱粉樣β肽生成、累積或聚集、以及製備預防或治療澱粉樣β肽相關疾病或狀況的藥物之用途
CN102670631B (zh) * 2011-12-01 2013-07-31 河南科技大学 一种四楞麻总苯乙醇苷组合物、制备方法及应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1526400A (zh) * 2003-03-04 2004-09-08 杭州天力药业有限公司 来源于管花肉苁蓉的含有苯乙醇苷的制剂及其制备方法和用途
US20070004011A1 (en) 2005-06-20 2007-01-04 I.R.B. Istituto Di Ricerche Biotecnologiche S.R.I. Extracts obtained from cell line cultures from plants belonging to the Oleaceae family (e.g. Syringa vulgaris), their preparation and use
JP2009196905A (ja) 2008-02-19 2009-09-03 Univ Kinki カンカニクジュヨウから得られる肝保護剤及び抗ＴＮＦ−α作用剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Brain Research, 1283, pp.139-147(2009) 1부.*

Also Published As

Publication number Publication date
JP6134331B2 (ja) 2017-05-24
KR20150002576A (ko) 2015-01-07
WO2013087042A1 (zh) 2013-06-20
EP2792361B1 (en) 2019-03-27
CA2859227C (en) 2019-01-22
TW201325597A (zh) 2013-07-01
CA2859227A1 (en) 2013-06-20
AU2012350437B2 (en) 2017-06-29
CN103156867A (zh) 2013-06-19
US20150087606A1 (en) 2015-03-26
JP2015500300A (ja) 2015-01-05
MY171048A (en) 2019-09-23
AU2012350437A1 (en) 2014-07-31
CN103156867B (zh) 2019-04-30
SG11201403265VA (en) 2014-09-26
EP2792361A4 (en) 2015-05-13
EP2792361A1 (en) 2014-10-22
TWI488630B (zh) 2015-06-21

Similar Documents

Publication Publication Date Title
KR102048289B1 (ko) 아밀로이드 β 펩타이드 관련 질환 또는 이상을 예방 또는 치료하기 위한 약학적 조성물
Tian et al. The anti-aging mechanism of ginsenosides with medicine and food homology
CN102743402B (zh) 人参二醇皂苷组分在制备防治皮炎和疤痕药物中的用途
Jiang et al. Hypoglycemic, hypolipidemic and antioxidant effects of peptides from red deer antlers in streptozotocin-induced diabetic mice
KR101845862B1 (ko) 특발성 폐섬유증의 치료 또는 예방을 위한 약학적 조성물
JP2022070891A (ja) 抗糖尿病及び他の有用な活性を有する植物抽出物
KR101705938B1 (ko) 피부 콜라겐 생성 촉진제
KR101847501B1 (ko) 아이소액티오사이드 또는 이의 약학적으로 허용가능한 염의 용도
CN105440103B (zh) 从皱纹盘鲍鲍鱼内脏中分离的抗炎肽及其用途
Zhang et al. Revolutionizing diabetic foot ulcer care: The senotherapeutic approach
US20130225501A1 (en) Skin collagen production-promoting agent
KR101628853B1 (ko) 자가면역 질환을 치료하기 위한 조성물 및 방법
KR20220073985A (ko) 모노메틸푸마레이트를 유효성분으로 포함하는 장기 섬유증의 예방 또는 치료용 약학적 조성물
Kim et al. Improvements in cognitive and motor function by a nutrient delivery system containing sialic acid from edible bird's nest
JP2017052750A (ja) 新規エラジタンニンおよび口腔用剤
KR101349361B1 (ko) 등골나물 추출물의 근위축 예방, 치료 또는 개선을 위한 용도
KR101093778B1 (ko) 치매의 예방 또는 치료용 조성물
CN110101710A (zh) 阿克苷和/或紫茎女贞苷a在制备药物中的用途
KR101785970B1 (ko) 올레산 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 근육손실 예방 및 치료용 약학적 조성물
Zhang et al. Advances regarding the mechanism of endoplasmic reticulum stress in diabetic kidney disease and pharmacological interventions
Stoyanov et al. Sambucus ebulus Fruit
KR101751393B1 (ko) 리놀레산 또는 이의 약학적으로 허용가능한 염을 유효성분으로 함유하는 근육손실 예방 및 치료용 약학적 조성물
CN117883456A (zh) 川牛膝甾酮类化合物在制备治疗类风湿关节炎的药物中的用途
Kim et al. Study of anti-Alzheimer Activities from Ginseng Radix Rubra Water Extract by Alzheimer's Protein APP-transgenic Fly
IT201800007774A1 (it) Composizione contenente cromo, estratto di una pianta del genere Morus e estratto di una pianta del genere Ilex per la prevenzione e il trattamento del pre-diabete e relative composizioni farmaceutiche e nutraceutiche

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

D13-X000 Search requested

St.27 status event code: A-1-2-D10-D13-srh-X000

D14-X000 Search report completed

St.27 status event code: A-1-2-D10-D14-srh-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 7