KR102038948B1 - 알파 코넥신 c-말단 (act) 펩타이드를 포함하는 국소 겔 - Google Patents
알파 코넥신 c-말단 (act) 펩타이드를 포함하는 국소 겔 Download PDFInfo
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- KR102038948B1 KR102038948B1 KR1020147027397A KR20147027397A KR102038948B1 KR 102038948 B1 KR102038948 B1 KR 102038948B1 KR 1020147027397 A KR1020147027397 A KR 1020147027397A KR 20147027397 A KR20147027397 A KR 20147027397A KR 102038948 B1 KR102038948 B1 KR 102038948B1
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| BRPI0811530B1 (pt) | 2007-05-14 | 2019-01-02 | Research Foundation Of State Univ Of New York | composição compreendendo indutor(es) de resposta fisiológica à dispersão ácido decanóico, superfície, solução, método ex vivo de tratamento ou inibição da formação de um biofilme sobre uma superfície |
| JP6185937B2 (ja) | 2012-03-01 | 2017-08-23 | ファーストストリング・リサーチ・インコーポレイテッドＦｉｒｓｔｓｔｒｉｎｇ Ｒｅｓｅａｒｃｈ，Ｉｎｃ． | アルファコネキシンｃ末端（ａｃｔ）ペプチド含有局所用ゲル剤 |
| US11246821B2 (en) * | 2016-08-30 | 2022-02-15 | Rohm And Haas Company | Personal care composition |
| MX2019009753A (es) * | 2017-02-16 | 2019-12-18 | Firststring Res Inc | Composicion y metodos para prevenir lesion por radiacion y promover la regeneracion de tejidos. |
| US20210137809A1 (en) * | 2017-06-14 | 2021-05-13 | Biosolution Co., Ltd | Cosmetic composition for wrinkle reduction or anti-inflammation, containing substance p |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| CN112969451A (zh) * | 2018-09-12 | 2021-06-15 | 福斯特斯特林研究公司 | 使用α连接蛋白C端肽的纳米粒子制剂和方法 |
| RU2691647C1 (ru) * | 2018-11-29 | 2019-06-17 | Артем Иванович Трофименко | Средство для профилактики образования патологических кожных рубцов |
| US11751056B2 (en) * | 2020-08-31 | 2023-09-05 | Oracle International Corporation | Methods, systems, and computer readable media for 5G user equipment (UE) historical mobility tracking and security screening using mobility patterns |
| CN116710474A (zh) | 2020-10-22 | 2023-09-05 | 撒凯尔生物公司 | 肽制剂及其眼科用途 |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20110065770A1 (en) | 1999-01-27 | 2011-03-17 | David Laurence Becker | Formulations comprising antisense nucleotides to connexins |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3603444A1 (de) | 1986-02-05 | 1987-08-06 | Thomae Gmbh Dr K | Pharmazeutische zubereitungsformen zur stabilisierung von interferon alpha |
| NZ235556A (en) * | 1986-11-05 | 1991-06-25 | Ethicon Inc | Breast milk substitute containing recombinant human egf |
| US5234809A (en) | 1989-03-23 | 1993-08-10 | Akzo N.V. | Process for isolating nucleic acid |
| CA2080538A1 (en) | 1991-10-21 | 1993-04-22 | Joseph V. Bondi | Lyophilized acidic fibroblast growth factor |
| US5401504B1 (en) * | 1993-12-28 | 1998-04-21 | Univ Mississippi Medical Cente | Use of tumeric in wound healing |
| FR2739621B1 (fr) | 1995-10-05 | 1997-12-05 | Centre Nat Rech Scient | Peptides utilisables comme vecteurs pour l'adressage intracellulaire de molecules actives |
| WO2000069896A2 (en) | 1999-05-14 | 2000-11-23 | Arbor Vita Corporation | Molecular interactions in haematopoietic cells |
| US7250397B2 (en) | 2000-02-23 | 2007-07-31 | Zealand Pharma A/S | Antiarrhythmic peptides |
| AU2002239336A1 (en) | 2000-11-10 | 2002-06-03 | Arbor Vita Corporation | Molecular interactions in hematopoietic cells |
| WO2002088370A2 (en) | 2001-04-30 | 2002-11-07 | Protiva Biotherapeutics Inc. | Autogene nucleic acids encoding a secretable rna polymerase |
| US6867283B2 (en) | 2001-05-16 | 2005-03-15 | Technion Research & Development Foundation Ltd. | Peptides capable of binding to MHC molecules, cells presenting such peptides, and pharmaceutical compositions comprising such peptides and/or cells |
| US20050053918A1 (en) | 2001-05-16 | 2005-03-10 | Technion Research & Development Foundation Ltd. | Method of identifying peptides capable of binding to MHC molecules, peptides identified thereby and their uses |
| CN1827766B (zh) | 2001-06-28 | 2010-08-25 | 徐荣祥 | 体外细胞的培养方法 |
| US6685971B2 (en) | 2001-06-28 | 2004-02-03 | Rongxiang Xu | Method and composition for repairing and promoting regeneration of mucosal tissue in the gastrointestinal tract |
| CA2457424A1 (en) | 2001-08-03 | 2003-02-20 | Arbor Vita Corporation | Molecular interactions in cells |
| WO2003032964A2 (en) | 2001-10-17 | 2003-04-24 | University Of Wales College Of Medecine | Gap junctions and endothelial-derived hyperpolarizing factor (edhf) |
| JP2003238441A (ja) | 2002-02-08 | 2003-08-27 | 英行 ▲高▼野 | 血管新生抑制剤 |
| US20030215424A1 (en) | 2002-05-15 | 2003-11-20 | Seul Kyung Hwan | Method of modulating angiogenesis |
| IL152573A (en) * | 2002-10-31 | 2009-11-18 | Transpharma Medical Ltd | A system for the transmission through the skin of a medical preparation against vomiting and nausea |
| US7560430B2 (en) | 2003-02-14 | 2009-07-14 | Human Matrix Sciences, Llc | Elastin digest compositions and methods utilizing same |
| US8034789B2 (en) | 2003-12-03 | 2011-10-11 | Coda Therapeutics, Inc. | Antisense compounds targeted to connexins and methods of use thereof |
| EP1827480B1 (en) | 2004-12-21 | 2016-11-09 | MUSC Foundation For Research Development | Compositions and methods for promoting wound healing and tissue regeneration |
| CN101151043B (zh) * | 2004-12-21 | 2013-09-04 | 南卡罗来纳州医科大学研究发展基金会 | 促进伤口愈合和组织再生的组合物和方法 |
| US9408381B2 (en) | 2004-12-21 | 2016-08-09 | Musc Foundation For Research Development | Alpha Connexin c-Terminal (ACT) peptides for use in transplant |
| AU2006257283A1 (en) | 2005-02-03 | 2006-12-21 | Coda Therapeutics Limited | Anti-connexin compounds and uses thereof |
| US20090131313A1 (en) * | 2005-06-17 | 2009-05-21 | Regenerx Biopharmaceuticals, Inc. | Lkktet and/or lkktnt peptide compositions and methods for treating or preventing tissue deterioration, injury or damage |
| CN101198346A (zh) * | 2005-06-17 | 2008-06-11 | 雷金纳克斯生物制药公司 | Lkktet和/或lkktnt肽组合物及方法 |
| EP1945307B1 (en) * | 2005-10-11 | 2013-03-27 | DPT Laboratories, LTD. | Surfactant-free dispersions, compositions, and use in topical formulations |
| GB0709513D0 (en) * | 2007-05-17 | 2007-06-27 | Helperby Therapeutics Ltd | Topical formulations |
| RU2542471C2 (ru) | 2006-11-15 | 2015-02-20 | Коуда Терапьютикс, Инк. | Улучшенные способы и композиции для заживления ран |
| CA2672220A1 (en) | 2006-12-11 | 2008-06-19 | Coda Therapeutics, Inc. | Impaired wound healing compositions and treatments |
| US20080299228A1 (en) * | 2007-05-29 | 2008-12-04 | Alan Gerald Harris | Topical compositions comprising a macromolecule and methods of using same |
| JP5552048B2 (ja) | 2007-06-21 | 2014-07-16 | ムスク ファンデーション フォー リサーチ ディベロップメント | 加齢性黄斑変性を治療するためのアルファコネキシンｃ末端（ａｃｔ）ペプチド |
| CA2592285C (en) | 2007-06-28 | 2019-10-01 | Musc Foundation For Research Development | Compositions comprising connexin polypeptides and methods for promoting wound healing and tissue regeneration using connexin polypeptides |
| CA2709151A1 (en) * | 2007-12-11 | 2009-06-18 | Coda Therapeutics, Inc. | Impaired wound healing compositions and treatments |
| WO2009075882A2 (en) | 2007-12-11 | 2009-06-18 | Coda Therapeutics, Inc. | Impaired wound healing compositions and treatments |
| CA2710388A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin polynucleotides for the treatment of abnormal or excessive scars |
| US20110245184A1 (en) | 2007-12-21 | 2011-10-06 | Bradford James Duft | Treatment of surgical adhesions |
| CA2710232A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Treatment of abnormal or excessive scars |
| WO2009085271A2 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of orthopedic conditions |
| WO2009085272A2 (en) * | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Improved medical devices |
| JP2011507857A (ja) | 2007-12-21 | 2011-03-10 | コーダ セラピューティクス， インコーポレイテッド | 線維症性の状態の処置のためのコネキシン４３の阻害剤の使用 |
| CA2710227A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Treatment of surgical adhesions |
| WO2009085275A2 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin polypeptide agent in combination with anti-connexin polynucleotide agent for the treatment of fibrotic conditions |
| AU2008343840A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin polynucleotides, peptides or antibodies for the treatment of orthopedic conditions |
| CA2711635A1 (en) * | 2008-01-07 | 2009-08-06 | Coda Therapeutics, Inc. | Wound healing compositions and treatments |
| CA2727015A1 (en) | 2008-06-04 | 2009-12-10 | Coda Therapeutics, Inc. | Treatment of pain with gap junction modulation compounds |
| EP2586436A1 (en) | 2011-10-31 | 2013-05-01 | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Use of anti-connexin agents for enhancing the therapeutic effect of acetylcholinesterase inhibitor |
| JP6185937B2 (ja) | 2012-03-01 | 2017-08-23 | ファーストストリング・リサーチ・インコーポレイテッドＦｉｒｓｔｓｔｒｉｎｇ Ｒｅｓｅａｒｃｈ，Ｉｎｃ． | アルファコネキシンｃ末端（ａｃｔ）ペプチド含有局所用ゲル剤 |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110065770A1 (en) | 1999-01-27 | 2011-03-17 | David Laurence Becker | Formulations comprising antisense nucleotides to connexins |
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