KR102036389B1 - 조작된 미생물 및 미생물 오일 생산을 위한 방법 - Google Patents
조작된 미생물 및 미생물 오일 생산을 위한 방법 Download PDFInfo
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- KR102036389B1 KR102036389B1 KR1020147013207A KR20147013207A KR102036389B1 KR 102036389 B1 KR102036389 B1 KR 102036389B1 KR 1020147013207 A KR1020147013207 A KR 1020147013207A KR 20147013207 A KR20147013207 A KR 20147013207A KR 102036389 B1 KR102036389 B1 KR 102036389B1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/649—Biodiesel, i.e. fatty acid alkyl esters
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
- C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
- C12N9/0083—Miscellaneous (1.14.99)
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- C—CHEMISTRY; METALLURGY
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0097—Oxidoreductases (1.) acting on reduced flavodoxin as donor (1.19)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/88—Lyases (4.)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6458—Glycerides by transesterification, e.g. interesterification, ester interchange, alcoholysis or acidolysis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6463—Glycerides obtained from glyceride producing microorganisms, e.g. single cell oil
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
- C12Y203/0102—Diacylglycerol O-acyltransferase (2.3.1.20)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y401/00—Carbon-carbon lyases (4.1)
- C12Y401/03—Oxo-acid-lyases (4.1.3)
- C12Y401/03006—Citrate (pro-3S)-lyase (4.1.3.6)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y604/00—Ligases forming carbon-carbon bonds (6.4)
- C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
- C12Y604/01002—Acetyl-CoA carboxylase (6.4.1.2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/19—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water (1.14.19)
- C12Y114/19001—Stearoyl-CoA 9-desaturase (1.14.19.1), i.e. DELTA9-desaturase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y203/00—Acyltransferases (2.3)
- C12Y203/03—Acyl groups converted into alkyl on transfer (2.3.3)
- C12Y203/03008—ATP citrate synthase (2.3.3.8)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161548901P | 2011-10-19 | 2011-10-19 | |
| US61/548,901 | 2011-10-19 | ||
| US201261663263P | 2012-06-22 | 2012-06-22 | |
| US61/663,263 | 2012-06-22 | ||
| PCT/US2012/061101 WO2013059649A1 (en) | 2011-10-19 | 2012-10-19 | Engineered microbes and methods for microbial oil production |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20140091004A KR20140091004A (ko) | 2014-07-18 |
| KR102036389B1 true KR102036389B1 (ko) | 2019-10-24 |
Family
ID=48141406
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147013207A Expired - Fee Related KR102036389B1 (ko) | 2011-10-19 | 2012-10-19 | 조작된 미생물 및 미생물 오일 생산을 위한 방법 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8951776B2 (enExample) |
| EP (2) | EP2768954B1 (enExample) |
| JP (1) | JP6294827B2 (enExample) |
| KR (1) | KR102036389B1 (enExample) |
| CN (2) | CN104160020A (enExample) |
| BR (1) | BR112014009245A2 (enExample) |
| RU (1) | RU2652875C2 (enExample) |
| WO (1) | WO2013059649A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011109548A2 (en) * | 2010-03-02 | 2011-09-09 | Massachusetts Institute Of Technology | Microbial engineering for the production of fatty acids and fatty acid derivatives |
| EP2768954B1 (en) * | 2011-10-19 | 2018-12-05 | Massachusetts Institute of Technology | Engineered microbes and methods for microbial oil production |
| CA2869020A1 (en) * | 2012-04-09 | 2013-10-17 | BP Biofuels UK Limited | Low polysaccharide microorganisms for production of biofuels and other renewable materials |
| CN105431529A (zh) * | 2013-05-03 | 2016-03-23 | 德克萨斯大学系统董事会 | 用于真菌脂质生产的组合物和方法 |
| CN106687595A (zh) * | 2014-05-01 | 2017-05-17 | 诺沃吉公司 | 通过提高二酰基甘油酰基转移酶活性并降低三酰甘油脂酶活性来提高细胞脂质产量 |
| AU2015266724B2 (en) | 2014-05-29 | 2021-09-23 | Ginkgo Bioworks, Inc. | Increasing lipid production in oleaginous yeast |
| KR102311681B1 (ko) | 2015-07-28 | 2021-10-12 | 삼성전자주식회사 | 내산성을 갖는 효모 세포, 그를 이용하여 유기산을 생산하는 방법 및 상기 내산성 효모 세포를 생산하는 방법 |
| JP2017039078A (ja) * | 2015-08-19 | 2017-02-23 | 太平洋セメント株式会社 | 排水の処理方法 |
| WO2017070065A1 (en) * | 2015-10-20 | 2017-04-27 | Massachusetts Institute Of Technology | Strain and bioprocess engineering for high lipid production |
| WO2019014309A1 (en) * | 2017-07-13 | 2019-01-17 | Verdezyne (Abc), Llc | BIOLOGICAL METHODS FOR MODIFYING A CELL CARBON FLOW |
| CN107904199A (zh) * | 2017-11-30 | 2018-04-13 | 杭州唯铂莱生物科技有限公司 | 用于合成山扁豆酸的工程改造的宿主细胞和方法 |
| CN110358692B (zh) * | 2018-04-09 | 2021-07-27 | 中国科学院青岛生物能源与过程研究所 | 生产神经酸的重组酵母菌株及其应用 |
| US20210261992A1 (en) * | 2018-06-13 | 2021-08-26 | Manus Bio, Inc. | Enzymes, methods, and host cells for producing carminic acid |
| CN109929870B (zh) * | 2019-02-20 | 2021-03-16 | 天津大学 | 糖代谢与脂质代谢协同提高解脂耶氏酵母合成脂肪酸衍生物的产量的应用 |
| GB202010630D0 (en) * | 2020-07-10 | 2020-08-26 | Imp College Innovations Ltd | Methods |
| WO2024097353A1 (en) * | 2022-11-04 | 2024-05-10 | Viridos, Inc. | Recombinant algae having high biomass and lipid productivity |
| WO2025229117A1 (en) | 2024-05-02 | 2025-11-06 | Vib Vzw | Yeast for increased lipid production |
| CN119799810A (zh) * | 2025-03-14 | 2025-04-11 | 山西鑫晋商生物科技有限公司 | 基于发酵工艺优化的二酯油微生物发酵方法及系统 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005118814A2 (en) | 2004-06-04 | 2005-12-15 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| US20100081178A1 (en) | 2008-10-23 | 2010-04-01 | Targeted Growth, Inc. | Modified photosynthetic microorganisms for producing triglycerides |
| WO2010075440A1 (en) | 2008-12-23 | 2010-07-01 | Targeted Growth, Inc. | Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1165803B1 (en) * | 1999-04-01 | 2007-03-07 | BASF Plant Science GmbH | Enzymes of the biosynthetic pathway for the production of triacylglycerol and recombinant dna molecules encoding these enzymes |
| US7267976B2 (en) * | 2003-07-02 | 2007-09-11 | E.I. Du Pont De Nemours And Company | Acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous yeasts |
| US7202356B2 (en) * | 2003-11-14 | 2007-04-10 | E. I. Du Pont De Nemours And Company | Fructose-bisphosphate aldolase regulatory sequences for gene expression in oleaginous yeast |
| US7198937B2 (en) * | 2004-11-04 | 2007-04-03 | E. I. Du Pont De Nemours And Company | Mortierella alpina diacylglycerol acyltransferase for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| US7588931B2 (en) | 2004-11-04 | 2009-09-15 | E. I. Du Pont De Nemours And Company | High arachidonic acid producing strains of Yarrowia lipolytica |
| US7273746B2 (en) * | 2004-11-04 | 2007-09-25 | E.I. Dupont De Nemours And Company | Diacylglycerol acyltransferases for alteration of polyunsaturated fatty acids and oil content in oleaginous organisms |
| CN102925479A (zh) | 2005-03-08 | 2013-02-13 | 巴斯福植物科学有限公司 | 增强表达的内含子序列 |
| CN101939434B (zh) * | 2007-05-24 | 2015-03-25 | 纳幕尔杜邦公司 | 用于在大豆中提高种子贮藏油脂的生成和改变脂肪酸谱的来自解脂耶氏酵母的dgat基因 |
| MX2010006169A (es) * | 2007-12-04 | 2010-06-23 | Univ Ohio State Res Found | Enfoques moleculares para la optimizacion de la produccion de biocombustibles. |
| EP2324120B1 (en) * | 2008-08-29 | 2016-01-27 | E. I. du Pont de Nemours and Company | Manipulation of snf1 protein kinase activity for altered oil content in oleaginous organisms |
| US20120156717A1 (en) | 2009-08-28 | 2012-06-21 | Phycal, Inc. | Biofuel from recombinant oleaginous algae using sugar carbon sources |
| WO2011079005A1 (en) * | 2009-12-24 | 2011-06-30 | E.I. Dupont De Nemours And Company | Plant membrane bound o-acyl transferase (mboat) family protein sequences and their uses for altering fatty acid compositions |
| US20110177564A1 (en) | 2010-01-15 | 2011-07-21 | Massachusetts Institute Of Technology | Bioprocess and microbe engineering for total carbon utilization in biofuel production |
| WO2011109548A2 (en) * | 2010-03-02 | 2011-09-09 | Massachusetts Institute Of Technology | Microbial engineering for the production of fatty acids and fatty acid derivatives |
| TW201144442A (en) | 2010-05-17 | 2011-12-16 | Dow Agrosciences Llc | Production of DHA and other LC-PUFAs in plants |
| AU2011349463B2 (en) | 2010-12-20 | 2016-10-27 | Lumen Bioscience, Inc. | Modified photosynthetic microorganisms for producing lipids |
| AU2011349444B2 (en) | 2010-12-20 | 2016-06-30 | Lumen Bioscience, Inc. | Modified photosynthetic microorganisms for producing lipids |
| TW201307553A (zh) | 2011-07-26 | 2013-02-16 | Dow Agrosciences Llc | 在植物中生產二十二碳六烯酸(dha)及其他長鏈多元不飽和脂肪酸(lc-pufa)之技術 |
| EP2768954B1 (en) | 2011-10-19 | 2018-12-05 | Massachusetts Institute of Technology | Engineered microbes and methods for microbial oil production |
| EP2809790A4 (en) * | 2012-02-03 | 2015-11-18 | Matrix Genetics Llc | MODIFIED PHOTOSYNTHETIC MICROORGANISMS FOR THE CONTINUOUS PRODUCTION OF CARBON-CONTAINING COMPOUNDS |
| US20150024442A1 (en) * | 2012-03-09 | 2015-01-22 | Matrix Genetics, Llc | Modified diacylglycerol acyltransferase proteins and methods of use thereof |
| US9096876B2 (en) | 2012-06-22 | 2015-08-04 | Massachusetts Institute Of Technology | Engineered microbes and methods for microbial oil overproduction from cellulosic materials |
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2012
- 2012-10-19 EP EP12840947.1A patent/EP2768954B1/en not_active Not-in-force
- 2012-10-19 CN CN201280060959.3A patent/CN104160020A/zh active Pending
- 2012-10-19 BR BR112014009245-1A patent/BR112014009245A2/pt not_active Application Discontinuation
- 2012-10-19 KR KR1020147013207A patent/KR102036389B1/ko not_active Expired - Fee Related
- 2012-10-19 WO PCT/US2012/061101 patent/WO2013059649A1/en not_active Ceased
- 2012-10-19 JP JP2014537306A patent/JP6294827B2/ja not_active Expired - Fee Related
- 2012-10-19 EP EP18161442.1A patent/EP3388516A1/en not_active Withdrawn
- 2012-10-19 RU RU2014119784A patent/RU2652875C2/ru active
- 2012-10-19 CN CN201811471219.4A patent/CN109468241A/zh active Pending
- 2012-10-19 US US13/656,086 patent/US8951776B2/en active Active
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2014
- 2014-11-19 US US14/547,304 patent/US9862977B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005118814A2 (en) | 2004-06-04 | 2005-12-15 | Fluxome Sciences A/S | Metabolically engineered cells for the production of polyunsaturated fatty acids |
| JP2008501323A (ja) * | 2004-06-04 | 2008-01-24 | フラクスオーム サイエンセズ エイ/エス | 多価不飽和脂肪酸生産のための代謝改変細胞 |
| US20100081178A1 (en) | 2008-10-23 | 2010-04-01 | Targeted Growth, Inc. | Modified photosynthetic microorganisms for producing triglycerides |
| WO2010075440A1 (en) | 2008-12-23 | 2010-07-01 | Targeted Growth, Inc. | Modified photosynthetic microorganisms with reduced glycogen and their use in producing carbon-based products |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130143282A1 (en) | 2013-06-06 |
| CN109468241A (zh) | 2019-03-15 |
| WO2013059649A1 (en) | 2013-04-25 |
| EP2768954A4 (en) | 2015-09-23 |
| KR20140091004A (ko) | 2014-07-18 |
| JP2014530626A (ja) | 2014-11-20 |
| EP3388516A1 (en) | 2018-10-17 |
| US8951776B2 (en) | 2015-02-10 |
| CN104160020A (zh) | 2014-11-19 |
| RU2652875C2 (ru) | 2018-05-03 |
| BR112014009245A2 (pt) | 2020-10-27 |
| RU2014119784A (ru) | 2015-11-27 |
| US20150167034A1 (en) | 2015-06-18 |
| EP2768954A1 (en) | 2014-08-27 |
| EP2768954B1 (en) | 2018-12-05 |
| JP6294827B2 (ja) | 2018-03-14 |
| US9862977B2 (en) | 2018-01-09 |
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