KR102022747B1 - Transparent gel-like skin-sterilizing agent - Google Patents

Abstract

(A) a specific quaternary ammonium salt fungicide, (B) N- palm oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carbonate, (C) specific polyhydric alcohol, (D) ethanol, (E) It contains a carboxyvinyl polymer, content of the said (B) component is 0.01 mass%-0.3 mass%, content of the said (D) component is 15 mass%-35 mass%, The said (A) component and said (B The mass ratio [(C + D) / (A + B)] between the total content of the component and the total content of the component (C) and the component (D) is 100 to 400, pH 6.0 to 8.0, and appearance. This transparent transparent gel-like skin fungicide.

Description

Transparent gel skin disinfectant {TRANSPARENT GEL-LIKE SKIN-STERILIZING AGENT}

The present invention relates to a sterilizing agent for transparent gel-like skin.

Recently, a gel fungicide is used as a method for disinfecting skin such as fingers easily. In such gel-type fungicides, since the sterilization spectrum is broad and has an immediate effect, quaternary ammonium salt fungicides such as benzalkonium chloride are widely used. Although the quaternary ammonium salt fungicide has a higher pH, sterilization power is enhanced, but since skin irritation is stronger, it is necessary to set it as a neutral region of pH 8 or less.

Moreover, as a feeling of use of a gel-type fungicide, when it is taken by hand, it is desired that it is good to spread, and the thickener is mix | blended with this request.

However, when the quaternary ammonium salt fungicide is used in combination with an anionic thickener such as a carboxyvinyl polymer, it forms an anion-cation complex, so that not only turbidity occurs, the appearance is deteriorated, and bactericidal power is greatly lowered. There is a problem that this is damaged.

In addition, the gel-type fungicide is also required for quick drying as its property, and ethanol is blended in response to this request (see Patent Document 1, for example). The ethanol has a function of inhibiting the formation of the anion-cation complex, and also has a function of making the gel fungicide clear.

Since the ethanol has skin irritation, it is preferable to suppress it to less than 40% by mass for the purpose of suppressing skin irritation during continuous use. At this concentration, the formation of anion-cation complex is suppressed. There is a problem that cannot be suppressed and made transparent.

Moreover, in the gel-type fungicide which mix | blended said benzalkonium chloride, the said ethanol, and the said carboxyvinyl polymer, when the ethanol is made into less than 40 mass%, and pH is set to less than 8, the turbidity will generate | occur | produce further and sterilization power will become There is a problem that it is greatly reduced.

Therefore, it is a reality that there is a strong demand for providing a transparent gel-like skin disinfectant having an excellent appearance that is transparent in appearance, has low skin irritation, has excellent sterilizing power, is easy to spread, has quick drying properties, and has no stickiness after drying.

Japanese Patent Application Laid-Open No. 2011-153089

This invention solves the said problem in the past, and makes it a subject to achieve the following objectives. That is, an object of the present invention is to provide a transparent gel-type skin disinfectant having an excellent appearance, which is transparent in appearance, has low skin irritation, has excellent sterilizing power, is easy to spread, has quick drying properties, and is not sticky after drying. do.

MEANS TO SOLVE THE PROBLEM In order to solve the said subject, the present inventors earned the following knowledge as a result of earnestly examining. That is, in the transparent gel-like skin disinfectant containing a quaternary ammonium salt disinfectant, a carboxyvinyl polymer, and 15 mass%-35 mass% ethanol, N- palm oil fatty acid acyl L- arginine ethyl DL-P of a specific amount is further specified. It contains a lipridone carbonate and a polyhydric alcohol, the total content of the polyhydric alcohol and the ethanol, the quaternary ammonium salt fungicide and the N- palm oil fatty acid acyl L- arginine ethyl DL-pyrrolidone carbonate By setting the mass ratio with the total content to a specific mass ratio, pH 6.0 to 8.0, the external appearance can be made clear, the sterilizing power can be improved while the skin irritation is small, and it is easy to spread, has quick drying property, and stickiness after drying. It came to know that the outstanding usability can be provided and the completion of this invention was reached.

This invention is based on the said knowledge by the present inventors, The sterilizing agent for transparent gel form skin of this invention as a means for solving the said subject,

(A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzetonium chloride, and cetylpyridinium chloride,

(B) N- palm oil fatty acid acyl L-arginine ethyl-DL-pyrrolidone carbonate,

(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol,

(D) ethanol,

(E) carboxyvinyl polymer

It is contained, content of the said (B) component is 0.01 mass%-0.3 mass%, content of the said (D) component is 15 mass%-35 mass%, and the sum total of the said (A) component and the said (B) component Mass ratio [(C + D) / (A + B)] of content and the sum total content of the said (C) component and the said (D) component is 100-400, pH 6.0-8.0, and is transparent transparent gel It is a fungicide for shape skin.

According to the present invention, the above problems in the prior art can be solved, and the above object can be achieved, the appearance is transparent, the skin is less irritating, has excellent sterilizing power, is also easy to spread, has quick drying property, and is sticky after drying It is possible to provide a transparent gel-like skin disinfectant having an excellent feeling of elimination.

(Transparent Gel Sterilizing Agent)

The disinfectant for transparent gel-like skin of the present invention is a quaternary ammonium salt disinfectant (hereinafter may be referred to as "(A) component") and N-palm oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carbonate ( Hereinafter, "(B) component" may be referred to, polyhydric alcohol (hereinafter, may be referred to as "(C) component"), and ethanol (hereinafter, "(D) component" may be referred to. ) And a carboxyvinyl polymer (hereinafter may be referred to as "(E) component") at least, and containing other components as needed.

<(A) Component: Quaternary Ammonium Salt Sterilizer>

The quaternary ammonium salt fungicide as the above-mentioned (A) component is at least 1 sort (s) chosen from benzalkonium chloride, benzetonium chloride, and cetyl pyridinium chloride. The said (A) component is a component which has high sterilizing power with respect to bacteria, such as Escherichia coli.

Among these, benzalkonium chloride is preferable at the point which is excellent in sterilization power, quick drying, and no stickiness after drying.

As content of the said (A) component in the said transparent gel-type skin disinfectant, 0.01 mass%-0.3 mass% are preferable, and 0.02 mass%-0.2 mass% are more preferable. When content of the said (A) component is less than 0.01 mass%, sterilization power may become inadequate, and when it exceeds 0.3 mass%, it becomes cloudy, the sterilization power becomes insufficient, becomes difficult to spread, and dryness There may be a delay, stickiness after drying, and skin irritation.

<(B) component: N-palm oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carbonate>

N- palm oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate as said (B) component is advantageous at the point which can improve sterilization power by mix | blending with the said transparent gel-type skin disinfectant.

A commercial item can be used for the said (B) component. As a specific example of the said commercial item, CAE (registered trademark) (Cocoyl arginine ether PCA, the product of Ajinomoto Healthy Surf Co., Ltd.) etc. are mentioned.

Content of the said (B) component in the said transparent gel disinfectant for skin is 0.01 mass%-0.3 mass%, and 0.05 mass%-0.2 mass% are preferable at the point which is excellent in transparency and sterilization power. When content of the said (B) component is less than 0.01 mass%, sterilization power may become inadequate, and when it exceeds 0.3 mass%, turbidity will arise, sterilization power will become inadequate, stickiness after drying, Skin irritation may occur.

<(C) Component: Polyhydric Alcohol>

The polyhydric alcohol as the component (C) is at least one selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol. The said (C) component is advantageous at the point which can improve transparency of the said transparent gel-type skin disinfectant.

Among these, hexylene glycol and 1,2-pentanediol are preferable at the point which is excellent in transparency and sterilization power.

5 mass%-15 mass% are preferable, and, as for content of the said (C) component in the said transparent gel-type skin disinfectant, 8 mass%-12 mass% are more preferable. When content of the said (C) component is less than 5 mass%, turbidity may arise, sterilizing power may become inadequate, it may become difficult to spread, and when it exceeds 15 mass%, drying will become late and stickiness after drying This occurs.

<(D) Component: Ethanol>

By blending ethanol as the component (D) in the transparent gel-like skin disinfectant, it is advantageous in that transparency, sterilization power, and drying speed can be improved.

Content of the said (D) component in the said transparent gel disinfectant for skin is 15 mass%-35 mass%, 20 mass% from the point which is excellent in transparency, sterilization power, easy to spread, and quick drying, and has small skin irritation. 30 mass% is preferable. When content of the said (D) component is less than 15 mass%, turbidity arises, sterilization power becomes inadequate, it becomes difficult to spread, drying is delayed, and when it exceeds 35 mass%, it becomes difficult to spread And skin roughness during continuous use.

<(E) component: Carboxyvinyl polymer>

By blending the carboxyvinyl polymer as the component (E) into the transparent gel skin fungicide, thickening can be imparted to the transparent gel skin fungicide, so that it can be prevented from falling off from the skin, and the spreading effect is easy to spread. It is advantageous in that it can improve.

There is no restriction | limiting in particular as viscosity of the said (E) component, Although it can select suitably according to the objective, When the aqueous solution containing 0.2 mass% of said (E) components is neutralized with sodium hydroxide, and pH is 7.0-7.5, Since the viscosity in 20 degreeC is excellent in transparency, quick drying, and no stickiness after drying, the thing of 2,000 mPa * s-30,000 mPa * s is preferable, and 3,000 mPa * s-14,000 mPa * s is more preferable. When the said viscosity is less than 2,000 mPa * s, the said transparent gel-type skin disinfectant may not be thickened suitably, and when it exceeds 30,000 mPa * s, it becomes cloudy, late drying, and drying Stickiness may occur afterwards.

The said (E) component may be used individually by 1 type, and may use 2 or more types of things from which the said viscosity differs together.

The viscosity of the said (E) component can be measured with a BL type | mold viscometer or a BM type | mold viscometer (made by Tokyo machine company).

When the viscosity of the said (E) component is 100 mPa * s or more and less than 10,000 mPa * s, it is No. 3 rotor or no. Using 4 rotors, it can measure on the conditions of 1 minute at the rotation speed of 12 rpm at 20 degreeC.

When the viscosity of the said (E) component is 10,000 mPa * s or more and less than 50,000 mPa * s, it is No. Using 4 rotors, it can measure on 20 degreeC on the conditions of 1 minute at 12 rpm.

A commercial item can be used for the said (E) component. As a specific example of the said commercial item, in a brand name, Carbopol 981 (made by Nippon Buribazole Co., Ltd.), Carbopol ETD2050 (made by Nippon Buribazole Co., Ltd.), Hibisawako (registered trademark) 105 (made by Wako Pure Chemical Industries, Ltd.) The thing of 3,000 mPa * s-14,000 mPa * s in 20 degreeC when neutralizing 0.2 mass% aqueous solutions, such as these, with neutralizing sodium hydroxide and making pH 7.0-7.5; When neutralizing 0.2 mass% aqueous solution of Cabopol 980 (manufactured by Nihon Luburisol Co., Ltd.) and Hibis Wako (registered trademark) 104 (manufactured by Wako Pure Chemical Industries, Ltd.), the solution was neutralized with sodium hydroxide to adjust the pH to 7.0 to 7.5. The viscosity in 20 degreeC is a thing of 15,000 mPa * s-30,000 mPa * s, etc. are mentioned. These may be used individually by 1 type and may use 2 or more types together.

Among them, Carbopol 981 (0.2% by mass aqueous solution, pH 7.0 to 7.5, viscosity at 20 ° C.): 4,000 mPa · s to 7 in terms of excellent transparency, fast drying, and no stickiness after drying. , 500 mPa · s), Carbopol EDT2050 (0.2 mass% aqueous solution, pH 7.0 to 7.5, viscosity at 20 ° C .: 6,000 mPa · s to 14,000 mPa · s), Hibiswako (registered trademark) 105 (0.2 mass% neutralizing liquid and the viscosity on 20 degreeC conditions: 7,000 mPa * s-14,000 mPa * s) are preferable.

0.1 mass%-0.5 mass% are preferable at the point which content of the said (E) component in the said transparent gel-type skin disinfectant is excellent in transparency, sterilization power, easy spreading, quick drying, and no stickiness after drying, 0.3 mass%-0.4 mass% are more preferable. When content of the said (E) component is less than 0.1 mass%, it will be easy to flow and it will become difficult to spread on skin, and when it exceeds 0.5 mass%, it will become cloudy, and the sterilizing power will become insufficient and it will become difficult to spread. The feeling of things, such as a thing which becomes slow in drying, a stickiness after drying, etc. may worsen.

≪Mass ratio [(C + D) / (A + B)] ≫

Mass ratio [(C + D) / (A + B)] of the total content of the said (A) component and the said (B) component, and the total content of the said (C) component and the said (D) component is transparency, It is 100-400 and 150-300 are preferable at the point which is excellent in the quickness of drying and the absence of stickiness after drying. If the mass ratio [(C + D) / (A + B)] is less than 100, turbidity may occur, and the sterilizing power may become insufficient. If the mass ratio exceeds 400, the sterilizing power and drying speed and stickiness after drying. There may be insufficient point of blur.

<Other ingredients>

There is no restriction | limiting in particular as said other components in the said transparent gel-type disinfectant for skin, It can select suitably according to the objective, For example, Surfactant (anionic surfactant, cationic Surfactants, amphoteric surfactants, etc.), macromolecular compounds other than the above (E) component, humectants, vitamins, amino acids, anti-inflammatory agents, ultraviolet absorbers, cold-feeling agents, antioxidants, metal blockers, animal and plant extracts, or The derivative, colorant, fragrance | flavor, deodorant, preservatives other than the said (A) component, clathrate compound, solvents other than said (C), (D) component, pH adjuster, etc. are mentioned. These may be used individually by 1 type and may use 2 or more types together.

There is no restriction | limiting in particular as said pH adjuster, Although it can select suitably according to the objective, Triethanolamine and ethylenediamine-N, N, N ', N "-tetra-2-propanol (quadrol) are preferable.

There is no restriction | limiting in particular as content of the said other components in the said transparent gel-type disinfectant for skin, and it can select suitably according to the objective, as long as the effect of this invention is impaired.

`` Property ''

-pH-

The pH of the transparent gel disinfectant for skin is excellent in transparency, bactericidal power, and no stickiness after drying, and is 6.0-8.0, and 6.5-7.5 are preferable at the point that skin irritation is small. When the said pH is less than 6.0, there exist cloudiness, the sterilization power becomes inadequate, it becomes difficult to spread, etc., When it exceeds 8.0, drying may be delayed, skin irritation may arise, etc.

The pH of the said transparent gel-type skin disinfectant can be calculated | required by measuring pH in 25 degreeC using a pH meter (made by Todikeke Co., Ltd.).

-Viscosity-

There is no restriction | limiting in particular as a viscosity of the said transparent gel-type disinfectant for skin, Although it can select suitably according to the objective, The viscosity in 25 degreeC is 300 mPa * s-5,000 mPa * s, and 2,000 mPa * s- The thing of 4,000 mPa * s is more preferable. If the viscosity of the transparent gel-type disinfectant for skin is less than 300 mPa · s, since it tends to flow down, it becomes difficult to spread, and it may be difficult to rub it on the skin without fail, and if it exceeds 5,000 mPa · s, The viscosity of the transparent gel disinfectant for skin is so high that it is difficult to spread when rubbed onto the skin, resulting in poor usability. Moreover, the incompatibility that the discharge | emission property from a container worsens may also arise.

The viscosity of the said transparent gel-type skin disinfectant can be adjusted with the said (E) component.

The viscosity of the said transparent gel-type skin disinfectant was No. 1 using a BL type viscometer or a BM type viscometer (made by Tokyo Machine Co., Ltd.). 3 rotor or no. Using 4 rotors, it can measure at 25 degreeC on the conditions of 1 minute at 30 rpm.

Transmittance

There is no restriction | limiting in particular as a transmittance | permeability (% T) of the said transparent gel-type disinfectant for skin, Although it can select suitably according to the objective, 80% T or more is preferable and 90% T or more is more preferable at the point of transparency and sterilization power. . When the said transmittance | permeability is less than 80% T, turbidity arises, a favorable external appearance cannot be obtained, and sterilization power may also fall.

The transmittance | permeability (% T) of the said transparent gel-type skin disinfectant can be calculated | required by measuring the transmittance | permeability in 660 nm using an ultraviolet visible spectrophotometer (made by Nippon Spectrophotometer, Inc.).

≪Manufacturing method≫

There is no restriction | limiting in particular as a manufacturing method of the said transparent gel-type skin disinfectant, Although it can select suitably according to the objective, After uniformly disperse | distributing the said (E) component, stirring purified water at normal temperature (25 degreeC), (A) component, the said (B) component, the said (C) component, and the said (D) component, if necessary, further melt | dissolves by adding and adding the said other components, and adding a pH adjuster, and a desired pH The method of adjusting to a value is preferable.

≪How to use≫

There is no restriction | limiting in particular as a usage method of the said transparent gel-type skin disinfectant, Although it can select suitably according to the objective, a suitable amount (preferably about 1 g) is taken to a desired site | part, such as a finger, and it rubs on the whole skin until it dries. Application is preferred. The transparent gel-like skin disinfectant is particularly suitably used for fingers. In addition, in this invention, a "finger" means the whole hand including a palm, a back of a hand, and a finger.

Example

Although an Example of this invention is given to the following and this invention is concretely demonstrated to it, this invention is not limited to these Examples at all. In addition, in the following example and a comparative example, unless otherwise indicated, "%" represents the "mass%."

(Examples 1 to 41, Comparative Examples 1 to 14)

Purified water at 25 ° C according to the composition and content shown in Tables 1 to 8 below

After uniformly dispersing the component (E) while stirring with a three-one motor (BL-1200, manufactured by HEIDON), the component (C) or (C ') and the component (D) were added thereto to dissolve, followed by (A) component and said (B) component are added, it melt | dissolves, stirring, and it adds triethanolamine as a pH adjuster, and adjusts pH to the value shown to Tables 1-8, and is a transparent gel-type skin disinfectant (transparent gel-type finger sterilizer) ) Was prepared.

<Measurement of viscosity>

The viscosity of the transparent gel finger fungicides of Examples 1 to 41 and Comparative Examples 1 to 14 was obtained by using a BL-type viscometer (manufactured by Tokyo Machine Co., Ltd.). 3 rotor or no. Using 4 rotors, it measured at 25 degreeC on the conditions of 1 minute at rotation speed 30 rpm. The results are shown in Tables 1 to 8 below.

<Evaluation>

About the transparent gel finger disinfectant of Examples 1-41 and Comparative Examples 1-14, based on the following evaluation method, "transparency", "sterilization power", "easy to spread", "fast drying", "sticky after drying" "No tingling", and "skin irritation" were evaluated. The results are shown in Tables 1 to 8 below.

Evaluation of Transparency

The transmittance | permeability (% T) in 660 nm of each transparent gel-type finger fungicide of an Example and a comparative example was measured using the ultraviolet visible spectrophotometer (made by Nippon Spectrophotometer). Based on this measurement, it evaluated by the following evaluation criteria.

[Evaluation standard]

◎: 90% T or more

○: 80% T or more but less than 90% T

△: 70% T or more and less than 80% T

×: less than 70% T

Evaluation of bactericidal power

As a target bacterium, Escherichia coli (Esherichia coli NBRC3972, obtained from a product evaluation based organization, an independent administration) was used and evaluated by quantitative suspension.

The E. coli ( E. coli NBRC3972) was incubated for 18 hours at 37 ° C under aerobic conditions using SCD agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.). A proper amount of colonies formed on the SCD agar medium was agitated, suspended in physiological saline (manufactured by Otsuka Pharmaceutical Co., Ltd.) and adjusted to a bacterial concentration of 10 ⁸ cfu / ml to obtain a test bacterial solution. 0.005 ml of this test bacteria solution was ingested into 0.495 ml of each transparent gel-type finger fungicide of Examples and Comparative Examples, and after contacting for 30 seconds, the mixture was immediately diluted 10-fold in an SCDLP liquid medium (manufactured by Nippon Pharmaceutical Co., Ltd.). Inactivation was inactivated. The inactivated solution (hereinafter may be referred to as "inactivation liquid") was diluted 10-fold by 100-fold dilution, 1,000-fold dilution, and 10,000-fold dilution in SCDLP medium. 1 ml of inactivated liquid diluted to each concentration was sown in SCDLP agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.) (9 cm), respectively, and allowed to stand at 37 ° C for 24 hours under aerobic conditions by mixed plate culture. Incubated. After incubation, the total number of colonies formed was counted, and the remaining viable count was measured. When colony was not observed, it was set as less than 10 cfu / ml which is a detection limit. The residual viable count measured was determined by the following ratings, and based on the average value of the ratings, the following evaluation criteria were evaluated.

In addition, cfu is a colony forming unit.

[grade]

5 points | pieces: The number of remaining viable bacteria is less than 10 cfu / mL (below detection limit)

4 points | pieces: The residual viable count is 10 cfu / ml or more and less than 100 cfu / ml

3 points | pieces: The number of residual viable bacteria is 100 cfu / mL or more and less than 1,000 cfu / mL.

2 points | pieces: The number of remaining viable bacteria is 1,000 cfu / ml or more and less than 10,000 cfu / ml

1 point: The number of remaining viable bacteria is 10,000cfu / mL or more

[Evaluation standard]

◎: 4.0 points or more

○: 3.0 or more, less than 4.0

△: 2.0 points or more, less than 3.0 points

×: less than 2.0 points

-Evaluation-of the spreadability

Ten expert panelists take 1 g of each transparent gel-like finger fungicide of an Example and a comparative example in the environment of 25 degreeC, and rub it on the palm and the back, and it is easy to spread to the whole finger, Sensory evaluation was performed based on the following evaluation criteria based on the average value of the rating.

[grade]

4 points | pieces: It is easy to spread very much

3 points | pieces: It is easy to spread

2 points | pieces: It is difficult to spread

1 point: It is difficult to spread very much

[Evaluation standard]

◎: 4.0 points

○: 3.0 or more and less than 4.0

△: 2.0 or more and less than 3.0 points

×: less than 2.0 points

Fast evaluation of drying

Ten professional panelists take 1g of each transparent gel finger disinfectant of an Example and a comparative example in 25 degreeC environment, and rub it on the palm and the back, and measure time until the transparent gel finger disinfectant dries out It was. Based on the average value of the measurement time of ten people, it evaluated by the following evaluation criteria.

[Evaluation standard]

◎: less than 30 seconds

○: 30 seconds or more but less than 60 seconds

△: 60 seconds or more but less than 90 seconds

×: 90 seconds or more

-No evaluation-of stickiness after drying

Ten professional panelists take 1 g of each transparent gel finger disinfectant of Examples and Comparative Examples in a hand at 25 ° C., rub it on the palms and hands, and after the transparent gel finger disinfectant dries, hand stickiness The sensory evaluation was performed based on the following rating about the absence of and evaluated with the following evaluation criteria based on the average value of the rating.

[grade]

4 points: not sticky at all

3 points | pieces: It is not sticky

2 points: sticky

1 point | piece: Very sticky

[Evaluation standard]

◎: 4.0 points

○: 3.0 or more and less than 4.0

△: 2.0 or more and less than 3.0 points

×: less than 2.0 points

Skin irritation evaluation

Ten professional panelists based on the following ratings about the irritation to the skin when 1 g of each of the transparent gel-like finger fungicides of Examples and Comparative Examples were taken in a 25 ° C environment and rubbed onto the palms and the back of the hands The sensory evaluation was performed, and the following evaluation criteria evaluated based on the average value of the rating.

[grade]

4 points | pieces: It does not feel a stimulus at all.

3 points | pieces: I do not feel a stimulus

2 points | pieces: I feel a stimulus

1 point | piece: Very stimulating

[Evaluation standard]

◎: 4.0 points

○: 3.0 or more and less than 4.0

△: 2.0 or more and less than 3.0 points

×: less than 2.0 points

TABLE 1

TABLE 2

TABLE 3

TABLE 4

TABLE 5

TABLE 6

TABLE 7

TABLE 8

(Example 42)

According to the composition and the compounding quantity shown below, after uniformly dispersing (E) component at 25 degreeC, stirring purified water with a 3-one motor (BL-1200, product made by HEIDON), Then (C) component and said (D) The component was added to dissolve, followed by (A) component, the above (B) component, and other additive components, followed by stirring to dissolve, and the addition of a pH adjuster to adjust the pH to 7.5, thereby providing transparency of Example 42. A gel finger fungicide was prepared.

About the transparent gel finger fungicide of Example 42, by the method similar to Examples 1-41 and Comparative Examples 1-14, "transparency", "sterilization power", "easy to spread", "fast drying", "after drying" "No stickiness", and "skin irritation" were evaluated.

[Composition and Blending Amount]

Benzalkonium chloride [(A) component] 0.05%

N-palm oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carbonate [(B) component] 0.1%

Hexylene glycol [(C) component]. 10.0%

Ethanol [(D) component]. 30.0%

Carboxyvinyl polymer (* 1) [(E) component]... 0.3%

DL-pyrrolidone carboxylic acid sodium (50% aqueous solution) (* 4). 0.2%

Spices … 0.2%

Ethylenediamine-N, N, N ', N "-tetra-2-propanol (pH regulator)… appropriate amount

Purified water … Remainder (added to be 100% in total)

Mass ratio [(C + D) / (A + B)]: 266.7

Viscosity: 3850mPa · s (25 ℃)

PH: 7.5

[Evaluation results]

Transparency: ◎

· Sterilization power: ◎

Easy to spread: ◎

Fast drying: ◎

· No stickiness after drying: ◎

Skin irritation: ◎

(Example 43)

In Example 42, the transparent gel-like finger fungicide of Example 43 was prepared in the same manner as in Example 42, except that the composition and the compounding amount were changed to the composition and the compounding amount shown below.

About the transparent gel finger fungicide of Example 43, by the method similar to Examples 1-41 and Comparative Examples 1-14, "transparency", "sterilization power", "easy to spread", "fast drying", and "drying" "No stickiness later" was evaluated.

[Composition and Blending Amount]

Benzetonium chloride [(A) component] 0.05%

N-palm oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carbonate [(B) component] 0.1%

Xylitol [(C) component]... 10.0%

Ethanol [(D) component]. 30.0%

Carboxy vinyl polymer (* 2) [(E) component]... 0.3%

Ethylenediamine-N, N, N ', N "-tetra-2-propanol (pH regulator)… appropriate amount

Dipotassium glycyrrhinate (* 5). 0.01%

Spices … 0.2%

Purified water … Remainder (added to be 100% in total)

Mass ratio [(C + D) / (A + B)]: 266.7

Viscosity: 4,500mPa · s (25 ℃)

PH: 7.5

[Evaluation results]

Transparency: ○

Sterilization ability: ○

Easy to spread: ○

Fast drying: ◎

· No stickiness after drying: ◎

Skin irritation: ◎

Each component used for the Example and the comparative example is as showing in following Table 9.

TABLE 9

As an aspect of this invention, the following are mentioned, for example.

<1> (A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzetonium chloride and cetylpyridinium chloride,

(B) N- palm oil fatty acid acyl L-arginine ethyl-DL-pyrrolidone carbonate,

(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol,

(D) ethanol,

(E) contains a carboxyvinyl polymer,

Content of the said (B) component is 0.01 mass%-0.3 mass%, content of the said (D) component is 15 mass%-35 mass%,

Mass ratio [(C + D) / (A + B)] of the total content of the said (A) component and the said (B) component, and the total content of the said (C) component and the said (D) component is 100-400 It is pH 6.0-8.0, It is a transparent gel-type skin disinfectant which is transparent in appearance.

<2> Content of (A) component is 0.01 mass%-0.3 mass%, content of (C) component is 5 mass%-15 mass%, and content of (E) component is 0.1 mass%-0.5 mass% It is a transparent gel-type skin disinfectant as described in said <1>.

Mass ratio [(C + D) / (A + B)] of the total content of <3> (A) component and (B) component, and the total content of (C) component and (D) component is 150-300 Phosphorus for transparent gel-like skin in any one of said <1> to <2> which is phosphorus.

<4> (C) component is the transparent gel-like skin disinfectant in any one of said <1> to <3> which is at least any one of hexylene glycol and 1,2-pentanediol.

It is a transparent gel-like skin disinfectant in any one of said <1> to <4> which is <5> pH 6.5-7.5.

[Industrial Availability]

The transparent gel-like skin disinfectant of the present invention is transparent in appearance, has low skin irritation, has excellent sterilizing power, is easy to spread, has quick drying property, and has excellent feeling of no stickiness after drying. Not only for sterilizing the skin, but also for sterilizing the skin of fingers such as employees in the food-related industry such as processing meats and seafood, cooking in restaurants, hospitals, doctors, nurses, caregivers, patients, etc. It is possible.

Claims (5)

(A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzetonium chloride, and cetylpyridinium chloride,
(B) N- palm oil fatty acid acyl L-arginine ethyl-DL-pyrrolidone carbonate,
(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol,
(D) ethanol,
(E) contains a carboxyvinyl polymer,
Content of the said (B) component is 0.01 mass%-0.3 mass%, content of the said (D) component is 15 mass%-35 mass%,
Mass ratio [(C + D) / (A + B)] of the total content of the said (A) component and the said (B) component, and the total content of the said (C) component and the said (D) component is 100-400 It is pH 6.0-8.0 and is transparent in appearance, The transparent gel-type skin disinfectant characterized by the above-mentioned. The method of claim 1,
The content of the component (A) is 0.01% by mass to 0.3% by mass, the content of the component (C) is 5% by mass to 15% by mass, and the content of the component (E) is 0.1% by mass to 0.5% by mass. A transparent gel-like skin fungicide The method according to claim 1 or 2,
The mass ratio [(C + D) / (A + B)] between the total content of the component (A) and the component (B) and the total content of the component (C) and the component (D) is 150 to 300, characterized by Disinfectant for transparent gel-like skin. The method according to claim 1 or 2,
(C) The component is at least one of hexylene glycol and 1,2-pentanediol, The transparent gel-type skin disinfectant characterized by the above-mentioned. The method according to claim 1 or 2,
A sterilizing agent for transparent gel-like skin, characterized in that pH 6.5 to 7.5.