JPH08157322A - Cosmetic containing neither antioxidant nor antiseptic specified by pharmaceutical affairs law - Google Patents

Abstract

PURPOSE: To obtain the subject cosmetic safe to the human body, containing, as quality stabilizer, a combination of each specified amount of an N-coconut oil fatty acid acyl-L-arginylethyl-DL-pyrrolidonecarboxylic acid and hinokitiol. CONSTITUTION: This cosmetic contains, as quality stabilizer, a combination of 0.01-0.05wt.% of an N-coconut oil fatty acid acyl-arginylethyl-DL- pyrrolidonecarboxylic acid (salt) of the formula (RCO is a coconut oil fatty acid residue) and 0.001-0.05wt.% of hinokitiol, containing neither antioxidant nor antiseptic specified by the Pharmaceutical Affairs Law. The quality stabilizer does not induce skin chapping and inflammation, having antimicrobial capability. The compound of the formula is not only highly safe but also has a wide spectrum of high germicidal power, also being excellent in biodegradability. The hinokitiol can be extracted from evergreen trees such as hinoki, having antimicrobial capability. The above quality stabilizer is highly effective for preventing cosmetics from deterioration or putrefaction.

Description

Detailed Description of the Invention

[0001]

FIELD OF THE INVENTION The present invention relates to cosmetics containing N-coconut oil fatty acid acyl-L-arginine ethyl-dl-pyrrolidone carboxylate and hinokitiol as quality stabilizers.

[0002]

2. Description of the Related Art Cosmetics such as cosmetic creams, milky lotions, lotions, facial cleansers, and hair washes are used for the purpose of preventing their oxidation or rot and improving the storage stability of the cosmetics.
Antioxidant or antiseptic is blended. And, as the antioxidant or preservative in this case, ethyl paraaminobenzoate specified by the Pharmaceutical Affairs Law, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, methyl paraoxybenzoate, acetic acid-
It is customary to use dl-α-tocopherol, edetate and the like, and when these are used, it is obligatory by the Pharmaceutical Affairs Law to indicate that fact on the container or packaging of cosmetics. However, cosmetics containing antioxidants or preservatives specified by the Pharmaceutical Affairs Law may cause rough skin or inflammation when used by people with sensitive skin. Cosmetics labeled as containing a preservative tend to be shunned by general consumers.

[0003]

Therefore, an object of the present invention is to use an antioxidant or an antiseptic agent specified by the Pharmaceutical Affairs Law without inducing rough skin or inflammation,
Moreover, it is intended to provide a cosmetic product having a quality stability which is not inferior to that of a cosmetic product in which a specific component having antibacterial properties is blended and a component designated as required by the Pharmaceutical Affairs Law is blended.

[0004]

The cosmetic product according to the present invention comprises:
N-coconut oil fatty acid acyl-L-arginine ethyl-DL
-Pyrrolidonecarboxylate is contained in an amount of 0.01 to 0.05% by weight and hinokitiol is included in an amount of 0.001 to 0.05% by weight. The N-coconut oil fatty acid acyl-L-arginine ethyl-DL-pyrrolidone carboxylate used in the present invention is L-arginine which is one of the amino acids, coconut oil fatty acid, ethanol and PCA which is a natural moisturizing factor. Amino acid-based cationic surfactant obtained from the above, and can be represented by the following chemical formula 1.

Embedded image Not only is this compound highly safe, it has a strong and wide range of bactericidal activity, and is also excellent in biodegradability.
In addition, cationic benzethorium chloride and benzalkonium chloride, which are of the same kind as the above N-coconut oil fatty acid acyl-L-arginine ethyl-DL-pyrrolidone carboxylate, have a corresponding antibacterial property against spoilage fungi and fungi. However, it is not used in the present invention because it is a label-designated component defined by the Pharmaceutical Affairs Law as well as having a problem in safety to the skin. Hinokitiol is extracted from evergreen trees such as cypress and hiba, and the present invention also utilizes its antibacterial properties.

Table 1 shows the safety of N-coconut oil fatty acid acyl-L-arginine ethyl-DL-pyrrolidone carboxylate. Table 1 Item how RESULTS Acute toxicity mouse oral LD _50: 10.75g / kg primary skin irritation guinea Draize method 8% Mild Skin sensitization guinea 4% anionic ocular mucosal irritation Rabbit Draize Method 1 percent light Degree Mutagenicity Salmonella Negative ─────────────────────────────────── Clear from the results shown in Table 1. As described above, the drug used in the present invention, N-coconut oil fatty acid acyl-L-arginine ethyl-
The amount of DL-pyrrolidone carboxylate used is 0.0
Since it is 1 to 0.05% by weight, it can be said that it is safe for the human body.

[0006]

Example Each cosmetic product of the present invention was obtained with the following composition (weight basis). The drug A is N-coconut oil fatty acid acyl-L-arginine ethyl-DL-pyrrolidone carboxylate. Toner lotion placenta extract 3% Hyaluronic acid 0.2% Collagen 0.1% Herbal extract 5% Ethanol 3% Drug A 0.025% Hinokitiol 0.02% Purified water balance 100% Emulsion Glycerin monostearate 4% carboxyvinyl 0.2% polymer 1% herbal extract 4% hyaluronic acid 1: 3GB 5% drug A 0.025% hinokitiol 0.02% purified water balance total 100% 8% cream glycerol monostearate carboxyvinyl polymers 1% Caustic potassium 0.3% Squalane 5% Polyoxyethylene stearyl ether 0.2% Placenta extract 3% Hyaluronic acid 0.1% Butylene glycol 4% Drug A 0.025% Hinokitiol 0.02% Purified water balance meter 100% Gel Jo essence mosquitoes Bo carboxyvinyl polymer 1% potassium hydroxide 0.3% Plastic Center extract 50% hyaluronic acid 0.1% herbal extract 10% drug A 0.025% hinokitiol 0.002% Purified water Balance Total 100% Hair shampoo cationized cellulose 2 0.5% nonionic surfactant 10% anionic surfactant 13% placenta extract 2% chitosan solution 3% drug A 0.025% hinokitiol 0.002% purified water balance 100% hair treatment cationized cellulose 3.2% Glycerin monostearate 0.25% Polyoxyethylene stearyl ether 0.3% Hydrolyzed keratin powder 0.2% Polysiloxane 2% Squalane 2% Chitosan solution 3% Hydrolyzed collagen 4% Ethanol 3% Drug A 0.025% Hinokichio Le 0.02% Purified water balance 100% Herbal extract 12% Cepharanthin 0.01% Keratin 3% Collagen 0.2% Placenta extract 3% Ethanol 7% Drug A 0.025% Hinokitiol 0.03% Purified water Balance 100% Hap agent Polyvinyl alcohol 7% Polyvinylpyrrolidone 6% Ethanol 7% DNA 2% Chitin chitosan 2% Collagen 0.1% Herbal extract 3% Drug A 0.025% Hinokitiol 0.02% Purified water Balance 100 %

100 g of each of the above cosmetic compositions 2
A set of samples was prepared and the storage stability was evaluated by the following method. Evaluation of storage stability 1 Switch is on for 9 hours from 8 am to 5 pm
And the switch is off from 5 pm to 8 am the next day
When each sample of the first set prepared above was stored in a constant temperature bath (set temperature of 45 ° C) operated by a timer for 60 consecutive days, no abnormality was found in the appearance and quality of each sample. . Further, even when the set temperature of the constant temperature bath was raised to 50 ° C. and the same storage test was conducted for 30 days, no abnormality was found in appearance and quality. Evaluation of storage stability 2 Each sample of the second set was tested from September 2, 1993 to August 1, 1994.
It was stored at room temperature for up to 7 days for about 350 days, and the appearance and quality were inspected every 10 days, but no abnormality was found. Since cosmetics containing no antioxidant or preservative usually deteriorate after storage for 10 to 20 days, the drug A used in the present invention, namely, N-coconut oil fatty acid acyl-L-arginine ethyl-DL- It can be seen that pyrrolidone carboxylate and hinokitiol are extremely effective in preventing the deterioration and deterioration of cosmetics.

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Claims (1)

[Claims] 1. N-coconut oil fatty acid acyl-L-arginine ethyl-dl-pyrrolidone carboxylate is added in an amount of 0.01-.
0.05 wt%, hinokitiol 0.001-0.1
Cosmetics containing 50% by weight and free of antioxidants and preservatives specified by the Pharmaceutical Affairs Law.