JPH1045557A - Antimicrobial and low-irritant cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To enable the obtaining of a cosmetic, having antimicrobial actions and reduced in irritation and unpleasant feeling toward skin by including an N-long-chain acyl basic amino acid derivative and a crude drug therein. SOLUTION: This antimicrobial and low-irritant cosmetic comprises 0.001-0.5wt.% or more of an N-long-chain acyl basic amino acid represented by formulae I, II and III [RCO is a 6-20C fatty acid residue; X is NH2 , OCH3 , OC2 H5 , OC3 H7 , OC4 H9 or OCH2 C6 H5 ; (n) is 3 or 4] or its acid addition salt and 0.01-20wt.% of an extract or a pulverized substance of Sanguisorbae Radix which is a crude drug. The cosmetic is useful especially for a system containing a large amount of water or an oil-in-water type emulsion system in which the outer phases is the aqueous phase and can be prepared as a skin cosmetic, a makeup cosmetic, a cleaning cosmetic or a cosmetic for hair. Sufficient antimicrobial actions can be manifested at a low concentration by including the compound represented by formulae I, II and III and the irritation and sensitizing properties to the skin and an unpleasant feeling such as a sharply stabbing pain, a tingling pain or a prickling pain caused when using the cosmetic can remarkably be reduced by using the crude drug in combination.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition which has excellent antibacterial properties, is not contaminated by microorganisms such as bacteria and mold, is stable and has low skin irritation. More specifically, a low antibacterial activity obtained by using one or more of N-long-chain acyl-basic amino acid derivatives and acid addition salts thereof in combination with an extract or pulverized product of Jiyu, a kind of crude drug. Regarding stimulating cosmetics.

[0002]

2. Description of the Related Art Conventionally, water-containing cosmetics such as lotions, milky lotions and creams have various antiseptic and mildew-proofing agents in order to prevent deterioration due to contamination of microorganisms such as bacteria and molds during production and use. Agents have been used. Examples of such preservatives include phenols such as isopropylmethylphenol, paraoxybenzoate, phenoxyethanol and hinokitiol; benzoic acid and its salts; salicylic acid and its salts; dehydroacetic acid and its salts; sorbic acid and its salts; Quaternary ammoniums such as benzalkonium, benzethonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as alkylaminoethylglycine hydrochloride and sodium stearylhydroxyethylbetaine chloride, and photosensitizers are used.

However, many of the above-mentioned preservatives and fungicides have been reported to have primary irritation, sensitization or photosensitization to the skin, and the amount of the preservative and fungicide is regulated based on the standard of cosmetic raw materials from the viewpoint of safety. In many cases, it is not possible to add an amount that actually shows effective antibacterial activity. Furthermore, it is known that even if the skin does not show a stimulating or sensitizing reaction such as redness, rash, or edema, it may cause discomfort such as stinging, tingling or tingling when using the cosmetic. Have been. In addition, due to the interaction with the base of the cosmetic or other compounding components, there may be cases where sufficient antibacterial activity is not exhibited.

For example, isopropylmethylphenol,
When oil-soluble preservatives and fungicides such as paraoxybenzoate and sorbic acid are added to cosmetics containing a polymer thickener or powder, the antibacterial activity is reduced due to adsorption or the like. Also,
In cosmetics containing a surfactant, the antibacterial activity is also decreased due to incorporation into the surfactant micelle. On the other hand, if a large amount is blended in anticipation of sufficient antibacterial activity, problems such as crystal precipitation at low temperatures and the like arise in product stability.

[0005] Water-soluble preservatives and fungicides such as benzoate, salicylate and dehydroacetate are not effective unless the pH of the cosmetic is weakly acidic. As the acidity increases, the solubility in water decreases, and crystals may precipitate.

Further, regarding quaternary ammonium compounds and amphoteric surfactants, skin irritation and mucous membrane stimulation are observed, foaming tends to occur, and antibacterial activity decreases on the acidic side.
There are practical problems such as interaction with anionic substances. On the other hand, N-long chain acyl basic amino acid derivatives and acid addition salts thereof, which are commonly used as hydrophilic cationic surfactants, have long been known as bactericidal detergents (Japanese Patent Publication No. 51-5413). One of them is N-Cocoil-L
-Arginine ethyl ester-DL-pyrrolidone carboxylate is marketed under the trade name "CAE". However, in complex systems containing many types of raw materials such as cosmetics, the expected concentration of the compound is expected. Antibacterial effect is not obtained as expected,
When the amount was increased until a sufficient antibacterial action was exhibited, there was a problem that stability decreased.

[0007]

Accordingly, in the present invention, an effective antibacterial action is exhibited without deteriorating the antibacterial activity by the cosmetic base or other compounding components, and the antiseptic and fungicide is used as much as possible. The amount of the compound is reduced to obtain a cosmetic that not only shows no primary irritation or sensitization to the skin, but also does not cause discomfort such as stinging pain, tingling or tingling when using the cosmetic. It was intended.

[0008]

[Means for Solving the Problems] In order to solve the above problems, as a result of studying an antiseptic / fungal system having high stability and low irritation to the skin, N-long chain acyl basic amino acid derivative and its acid addition salt By combining one or more of the above with an extract or pulverized product of Jiyu, which is a kind of crude drug, not only synergistically improves antibacterial activity, but also increases irritation and discomfort to the skin Found a significant reduction,
The present invention has been completed.

The N-long-chain acyl basic amino acid derivatives and acid addition salts thereof are represented by the following general formulas (1) and (2)
And one or more selected from those represented by the general formula (3).

Embedded image

[Chemical 2]

(Wherein, in the general formulas (1) to (3), RC
O is a saturated or unsaturated fatty acid residue having 6 to 20 carbon atoms, and X is
_{-NH 2, -OCH 3, -OC 2} H 5, -OC 3 H 7, -OC 4 H 9
Or shows a -OCH ₂ C ₆ H _5, in general formula (2), n represents 3 or 4. )

For example, N-caproyl-L-arginine methyl ester hydrochloride, N-lauroyl-L-arginine ethyl ester-DL-pyrrolidonecarboxylate, N-palmitoyl
-L-arginine ethyl ester hydrochloride, N-cocoyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate,
N-caproyl-L-lysine methyl ester hydrochloride, N-lauroyl-L-lysine ethyl ester-DL-pyrrolidone carboxylate, N-myristoyl-L-lysine propyl ester hydrochloride, N-stearoyl-L-histidine methyl ester Hydrochloride, N-oleoyl-L-histidine ethyl ester-DL-
Examples thereof include pyrrolidone carboxylate.

One or more of these N-long chain acyl basic amino acid derivatives and acid addition salts thereof are usually added in an amount of 0.01
The antibacterial activity is exhibited at 0.5% by weight, but when added to a complex system such as a cosmetic, a sufficient antibacterial effect is often not observed. However, in the present invention, synergistic enhancement of antibacterial activity is recognized, and a sufficient concentration of antibacterial action is exhibited at a low concentration of about 0.001 to 0.2% by weight.

[0012] In the present invention, Ji, which is one of the crude drugs used in combination with the N-long-chain acyl basic amino acid derivative and its acid addition salt, is the Sanguisorba officinali.
s L., Sanguisorba tenuifolia Fisch et Link, Sangui
sorba applanata ( Sanguisorba alpina ) roots and rhizomes, which have long been used as hemostatic astringents. Waremokou has a hyaluronidase inactivating effect (Japanese Unexamined Patent Publication No.
1520) and antiplasmin effect (JP-A-1-6141)
5) is already known.

[0013] The ground may be used as it is, depending on the formulation of the cosmetic, but may be used as it is extracted with a solvent. As a solvent for obtaining these crude drugs and plant extracts, one or more selected from water, ethanol, 1,3-butylene glycol, propylene glycol, glycerin and diglycerin are preferable. The ratio of the soil and the solvent at the time of extraction is not particularly limited, but the solvent is preferably 2 to 1000 times by weight of the soil, especially 5 to 100 times by weight in view of the extraction operation and efficiency. Further, the extraction temperature is conveniently in the range of room temperature-normal pressure or lower than the boiling point of the solvent, and the extraction time is preferably in the range of 2 hours to 2 weeks, although it varies depending on the extraction temperature and the like.

In addition, the thus-obtained ground beetroot extract can be used as it is, or it is blended after deodorizing, refining and other operations within a range that does not impair the antiseptic / antifungal action. Alternatively, a fraction may be obtained using column chromatography or the like. Furthermore, these extracts, deodorized and purified products, and fractionated products can also be made into dried products by removing the solvent from them, and further provided in the form of being solubilized in a solvent such as alcohol or in the form of emulsion. can do. The blending amount is 0.01 to 2
0.0 wt% is suitable.

[0015]

The N-long-chain acyl basic amino acid derivative and its acid addition salt alone show antibacterial activity in the range of 0.01 to 0.5% by weight, but can be added to a complex mixture such as cosmetics. In many cases, the expected antibacterial effect is not obtained. However, in the present invention, synergistic enhancement of the antibacterial action is observed, so that one or more of the N-long-chain acyl-basic amino acid derivative and its acid addition salt is 0.001 to 0.2% by weight. Demonstrates sufficient antibacterial action even at low concentrations. In addition, the combined use of extract or pulverized product of Jiyu, a kind of crude drug, causes irritation to skin, sensitization, or stinging pain caused during use.
Discomfort such as burning and tingling can be greatly reduced.

[0016]

DETAILED DESCRIPTION OF THE INVENTION The invention according to the present invention is particularly useful for a system containing a large amount of water and an oil-in-water emulsification system in which the external phase is an aqueous phase. , Milky or creamy makeup base lotion, foundation, emulsion type eye color or cheek color, aqueous suspension or emulsion type eyeliner, makeup cosmetics such as mascara, cleansing lotion, cleansing gel, liquid soap, etc. Wash cosmetics,
It can be provided as hair cosmetics such as shampoo and hair rinse.

[0017]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples.

[Example 1] Lotion (1) Ethanol 7.0 (wt%) (2) 1,3-Butylene glycol 6.0 (3) Glycerin 2.0 (4) Polyoxyethylene hydrogenated castor oil 0 .6 (5) N-cocoyl-L-arginine ethyl ester 0.2 -DL-pyrrolidone carboxylate (6) 50% by weight aqueous solution of ethanol in ethanol 1.0 (7) Perfume 0.06 (8) Purification Water 83.14 Manufacturing method: Each component of (1) to (7) is sequentially added to (8) and mixed uniformly to prepare.

Example 2 Emulsion (1) Squalane 4.0 (% by weight) (2) Glyceryl tri-2-ethylhexanoate 2.0 (3) Cetyl 2-ethylhexanoate 3.0 (4) Cetanol 0.6 (5) Stearyl alcohol 0.4 (6) Sorbitan monostearate 1.2 (7) 1,3-Butylene glycol 6.0 (8) Glycerin 4.0 (9) Polyoxyethylene (20EO) Sorbitan 0.8 Monostearic acid ester (10) N-cocoyl-L-arginine methyl ester 0.1 -DL-pyrrolidone carboxylate (11) Purified water 72.8 (12) Chiyu 50% by weight 1,3- Butylene glycol extract 5.0 (13) Perfume 0.1 Manufacturing method: First, the oil phases (1) to (6) are mixed, heated and melted and kept at 75 ° C. On the other hand, the aqueous phases (7) to (11) are mixed and dissolved by heating to 75 ° C., and the oil phase is added thereto with stirring to emulsify. After cooling, add (12) and (13) at 40 ° C and mix.

Example 3 Cream (1) Stearyl alcohol 6.0 (% by weight) (2) Stearic acid 2.0 (3) Hydrogenated lanolin 4.0 (4) Squalane 9.0 (5) Octyldodeca Nol 10.0 (6) Polyoxyethylene (25EO) cetyl alcohol ether 3.0 (7) Glyceryl monostearate 2.0 (8) 1,3-butylene glycol 6.0 (9) N-cocoyl-L -Arginine propyl ester hydrochloride 0.2 (10) Purified water 56.2 (11) Ground peper 30% by weight propylene glycol extract 1.5 (12) Perfume 0.1 Production method: oil of (1) to (7) The phase components are mixed and heated to 75 ° C. On the other hand, the aqueous phase components (8) to (10) were mixed and heated to 7
The temperature was adjusted to 5 ° C., and the oil phase was added to the mixture and emulsified.
Add (11) and (12) at 0 ° C.

Example 4 Makeup Base Cream (1) Stearic acid 12.0 (% by weight) (2) Cetanol 2.0 (3) Self-emulsifying glyceryl monostearate 2.0 (4) Propylene glycol 10.0 (5) Potassium hydroxide 0.2 (6) N-lauroyl-L-lysine methyl ester hydrochloride 0.15 (7) Purified water 70.55 (8) Earthworm 70 wt% ethanol extract 1. 5 (9) Fragrance 0.1 (10) Titanium dioxide 1.0 (11) Bengala 0.1 (12) Yellow iron oxide 0.4 Production method: Knead (10) to (12) with (4) Is added to the aqueous phase of (5) to (7), mixed, and heated to 70 ° C. On the other hand, (1)-
The oil phase component of (3) is mixed and heated to 70 ° C., and this is added to the aqueous phase with stirring to emulsify. After emulsification, it is cooled and (8) and (9) are added at 40 ° C.

[Example 5] Milk liquid foundation (1) Stearic acid 2.4 (% by weight) (2) Propylene glycol monostearate 2.0 (3) Cetostearyl alcohol 0.2 (4) Liquid lanolin 2. 0 (5) Liquid paraffin 3.0 (6) Isopropyl myristate 8.5 (7) Sodium carboxymethylcellulose 0.2 (8) Bentonite 0.5 (9) Propylene glycol 4.0 (10) Triethanolamine 1. 1 (11) N-myristoyl-L-lysine ethyl ester hydrochloride 0.2 (12) Purified water 55.3 (13) Earthworm 50% by weight 1,3-butylene glycol extract 2.5 (14) Perfume 0 1.1 (15) Titanium oxide 8.0 (16) Talc 4.0 (17) Bengala 3.0 (18) Yellow iron oxide 2.5 (19) Black iron oxide 0.5 Manufacturing method: (15) to (19) After mixing the pigment of 1), it is ground with a grinder. (12) was heated to 70 ° C., (8) was added to swell well, to which was added (7) previously dispersed in (9), and (10) and (11) were added. Dissolve. (1) ~
The oil phases of (6) are mixed, heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring, and the mixture is heated to 75 ° C. through a colloid mill. The oil phase is added with stirring to emulsify. After cooling, (13) and (14) are added at 40 ° C.

[Example 6] Creamy foundation (1) Stearic acid 5.0 (wt%) (2) Lipophilic glyceryl monostearate 2.5 (3) Propylene glycol monolaurate 3.0 (4) Cetostearyl alcohol 1.0 (5) Liquid paraffin 7.0 (6) Isopropyl myristate 8.0 (7) Sorbitol 3.0 (8) Triethanolamine 1.2 (9) N-palmitoyl-L-lysineethyl Ester 0.2-DL-pyrrolidone carboxylate (10) Purified water 45.0 (11) Ground peper 50 wt% glycerin extract 3.0 (12) Perfume 0.1 (13) Titanium oxide 8.0 (14) ) Kaolin 5.0 (15) Talc 2.0 (16) Bentonite 1.0 (17) Bengala 2.6 (18) Yellow iron oxide 2.1 (19) Black iron oxide 0.3 Production method: (13) ~ After mixing the pigment of (19), it is ground with a grinder. Mix (7) to (10), dissolve, and heat. (1) ~
The oil phase of (6) is mixed and dissolved by heating to 80 ° C. The pigment is added to the aqueous phase with stirring, the temperature is raised to 75 ° C. through a colloid mill, the oil phase is added with stirring to emulsify, and after cooling, (11) and (12) are added at 40 ° C.

[Example 7] Emulsion type eye color (1) Stearic acid 8.0 (wt%) (2) White petrolatum 15.0 (3) Isopropyl palmitate 5.0 (4) Lanolin 5.0 (5) ) 1,3-butylene glycol 5.0 (6) triethanolamine 2.0 (7) N-stearoyl-L-lysine propyl ester 0.3-DL-pyrrolidone carboxylate (8) purified water 55.53 ( 9) Ground citrus purified water extract 1.25 (10) Lavender ethanol extract 1.25 (11) Perfume 0.15 (12) Red 221 0.02 (13) Ultramarine blue 1.50 Manufacturing method: (5) ~ The aqueous phase of (8) is mixed, dissolved and heated, and (12) and (13) previously mixed and pulverized are added to and dispersed therein, and the mixture is heated to 75 ° C. (1) to (4), which were previously mixed and heated to make it uniform, were added with stirring to emulsify, and after cooling, (9) to (11) were added and mixed.

[Example 8] Emulsion type cheek color (1) Beeswax 3.0 (wt%) (2) Stearic acid 2.0 (3) Cetanol 3.0 (4) Lanolin 3.0 (5) Liquid paraffin 15.0 (6) Isopropyl myristate 7.0 (7) Polyoxyethylene (20EO) sorbitan monostearate 4.2 (8) Sorbitan monostearate 1.8 (9) Glyceryl monostearate 2. 0 (10) Propylene glycol 5.0 (11) Triethanolamine 0.6 (12) N-caproyl-L-arginine ethyl ester hydrochloride 0.15 (13) Purified water 48.8 (14) Ground sand 50 weight % Dipropylene glycol extract 2.0 (15) Fragrance 0.15 (16) Red No. 202 0.05 (17) Yellow iron oxide 2.25 Production method: Mix and dissolve the aqueous phases of (10) to (13) And heat, mix and crush in advance (16), adding (17), dispersed and heated to 75 ° C.. The ingredients (1) to (9), which have been mixed and heated to homogenize in advance, are added thereto with stirring to emulsify, and after cooling (14) and (15) are added and mixed.

Example 9 Emulsion Type Eyeliner (1) Stearic acid 3.5 (% by weight) (2) Beeswax 2.0 (3) Carnauba wax 0.5 (4) Microcrystalline wax 5.0 (5) 1,3-butylene glycol 7.0 (6) Triethanolamine 1.5 (7) N-cocoyl-L-arginine ethyl ester 0.2-DL-pyrrolidone carboxylate (8) Purified water 40.2 (9 ) Earthworm purified water extract 10.0 (10) Perfume 0.1 (11) 3.0 wt% Bentonite extract 20.0 (12) Titanium oxide 8.0 (13) Carbon black 2.0 Manufacturing method: ( The oil phase components 1) to (4) are mixed and heated to dissolve. The aqueous phases (5) to (8) are mixed, heated, and added with stirring to emulsify. Then, to this emulsion (11) ~ (13)
, And dispersed by passing through a colloid mill, followed by cooling.
Add (9) and (10) at 0 ° C.

[Example 10] Aqueous suspension type mascara (1) 50% by weight of vinyl acetate emulsion 30.0 (% by weight) (2) Sodium carboxymethyl cellulose 1.0 (3) 1,3-butylene glycol 3.0 (4) N-oleoyl-L-histidine methyl ester hydrochloride 0.15 (5) Chiyu 1,3-butylene glycol extract 8.0 (6) Titanium oxide 8.0 (7) Carbon black 1.6 (8) Red iron oxide 0.4 (9) Purified water 47.85 Manufacturing method; (2) to (5) were added to and dissolved in (9), and then
Add (6) to (8) and disperse through a colloid mill. Add (1) to this and disperse evenly.

Example 11 Shampoo (1) Sodium alkyl ether sulfate 18.0 (% by weight) (2) Coconut oil fatty acid diethanolamide 2.0 (3) N-cocoyl-L-arginine amide hydrochloride 0.05 (4) Jiyu purified water extract 5.0 (5) Yellow 4 No. 1 1% by weight aqueous solution 0.1 (6) Fragrance 0.1 (7) Purified water 74.75 Production method; (1) to (6) Add to (7) sequentially and mix and dissolve uniformly.

[Example 12] Hair rinse (1) Cetanol 3.0 (% by weight) (2) Stearyltrimethylammonium chloride 0.7 (3) Glycerin 3.0 (4) N-stearoyl-L-lysine amide 0.1 -DL-pyrrolidone carboxylic acid (5) Green No. 3 1% by weight aqueous solution 0.2 (6) Earthworm 30% by weight 1,3-butylene glycol extract 3.0 (7) Perfume 0.1 (8) Purified water 89.9 Production method: (3) to (5) are added to (8), and the mixture is heated to 70 ° C. On the other hand, (1) and (2) are mixed, dissolved and heated to 70 ° C. This oil phase was gradually added to the previously prepared aqueous phase while stirring, and pre-emulsified, homogenized by adding a homomixer, and then cooled,
(6) and (7) are added at 40 ° C.

[Example 13] Face wash with scrub (1) Stearic acid 10.0 (wt%) (2) Palmitic acid 10.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) ) Oleyl alcohol 1.5 (6) Lanolin alcohol 1.0 (7) 2-phenoxyethanol 0.15 (8) Potassium hydroxide 6.0 (9) Purified water 53.45 (10) Fragrance 0.1 (11) Ground scrubbing scrub (average particle size 0.5 mm) 1.8 Manufacturing method: The oil phase of (1) to (6) and the aqueous phases of (8) and (9) were mixed and heated at 75 ° C., respectively, and then oiled. The aqueous phase is added to the phase and saponified. After cooling, (10) and (11) are added and mixed at 40 ° C.

Next, the above Examples 1 to 13 were evaluated for antibacterial activity, skin irritation and discomfort during use. At the same time, comparative examples shown in Table 1 were similarly evaluated.

[0032]

[Table 1]

(1) Evaluation of antibacterial activity As bacteria, Escherichia coli , Staphylococc
us aureus ), Pseudomonas aeruginosa , fungi as Candida albicans , black mold ( Asperg
illus niger ), using 10 ⁶ bacteria per 1 g of sample,
10 ⁵ fungi were inoculated and cultured at 37 ° C. and 25 ° C. respectively, and the viable cell count after 2 weeks was measured. Further, in Examples 11, 12 and Comparative Examples 11 and 12, Pseudomonas aeruginosa was used as a bacterium, and Candida albicans , Aspergillus niger and Pityrosporum were used as fungi . oval
e ) is used for Example 13 and Comparative Example 13, and the bacteria are Propionibacterium acnes and Proteus vulgaris, and Candida is the fungus.
( Candida albicans ) and black mold ( Aspergillus niger )
Was similarly tested. The antibacterial activity is judged to be sufficient after 2 weeks, when the bacteria were killed and when the viable count was 1/1000 for the fungi. The evaluation results are shown in Tables 2 to 4.

[0034]

[Table 2]

From Table 2, in Examples 1 to 10 of the present invention, sufficient antibacterial activity against both bacteria and fungi was observed. On the other hand, in the comparative example containing only one of the acid addition salt of N-long-chain acyl basic amino acid derivative and Jiju, sufficient antibacterial activity against both bacteria and fungi was observed. There was nothing.

[0036]

[Table 3]

From Table 3, it can be seen that both Example 11 and Example 12 of the present invention show good antibacterial activity against bacteria and fungi. Further, since it has an effective bactericidal effect against dandruff bacteria, it is shown that it also exhibits an anti-dandruff effect. On the other hand, in Comparative Example, sufficient antibacterial activity against both bacteria and fungi was not observed.

[0038]

[Table 4]

In Table 4 as well, it is recognized that Example 13 of the present invention exhibits sufficient antibacterial activity and exhibits a good bactericidal effect. Further, since it has a bactericidal effect against Acne bacteria, it is shown that it also exhibits an acne-preventing effect. On the other hand, Comparative Example 13 did not show sufficient antibacterial activity.

(2) Evaluation of skin irritation For each sample,
An obstruction sticking test was performed for 48 hours using 20 male panelists, and the evaluation was made according to the criteria shown in Table 5, and the average value of the skin irritation index of the 20 males was obtained. Examples 11 to 13 and Comparative Examples 11 to 13 were evaluated using 1.0% by weight aqueous solution.

[0041]

[Table 5]

(3) Evaluation of discomfort during use Twenty female panelists were grouped, and each group was allowed to use each sample.
Stinging pain felt between 30 seconds and 1 minute after application,
They were asked to evaluate discomfort such as tingling and tingling. The evaluation results were "very strong; 5 points", "somewhat strong; 4 points", "feeling; 3 points", "slightly feeling; 2 points", "subtle feeling; 1 point", and "not feeling". ; 0
The score was evaluated as “point”, and indicated by the average value of 20 persons. In addition,
Also in this evaluation, Examples 11 to 13 and Comparative Examples 11 to 13 were evaluated with a 1.0% by weight aqueous solution. The above results are summarized in Table 6.

[0043]

[Table 6]

In Table 6, in all of the examples of the present invention, neither skin irritation nor discomfort during use was recognized, and the panelists who felt the discomfort during use were subtle. there were. In Examples 1, 3 and 9 containing 0.2% by weight of the acid addition salt of the N-long-chain acyl basic amino acid derivative, the level was also extremely low. On the other hand, Comparative Example 1 containing 0.2% by weight of an acid addition salt of an N-long-chain acyl basic amino acid derivative and 7.0% by weight of ethanol, 0.15% by weight of the addition salt and 10. In Comparative Example 4 containing 0% by weight and Comparative Example 10 containing 015% by weight of the addition salt and the resin emulsion, slight erythema or edema was observed, and the skin irritation index was slightly increased.
In addition, panelists who felt discomfort in the group using these increased. Further, even in the group using Comparative Example 11 which is a shampoo containing 0.05% by weight of the addition salt,
A considerable number of panelists felt uncomfortable when using it. Further, Comparative Example 12 and Comparative Example 13 having a high surfactant content.
The skin irritation index and discomfort during use were high.

[0045]

As described in detail above, the antimicrobial action of the present invention is synergistically enhanced, and not only skin irritation but also almost no discomfort such as stinging, tingling and tingling when used. An unfeelable antibacterial cosmetic was obtained.

Claims (2)

[Claims] (1) one or more selected from N-long-chain acyl-basic amino acid derivatives represented by the general formulas (1), (2) and (3) and acid addition salts thereof: An antibacterial and hypoallergenic cosmetic, characterized by using an extract or ground product of Jiyu in combination. Embedded image Embedded image Embedded image (However, in the general formula (1) to the general formula (3), RCO is a saturated or unsaturated fatty acid residue having 6 to 20 carbon atoms, X is —NH ₂ ,
_{-OCH 3, -OC 2 H 5,} -OC 3 H 7, -OC 4 H 9 or -OC
It represents H ₂ C ₆ H ₅ , and in the general formula (2), n represents 3 or 4. ) 2. The amount of one or more N-long-chain acyl basic amino acid derivatives and acid addition salts thereof added is 0.001.
~ 0.5% by weight, blended amount of extract or pulverized product of Jiyu
It is 0.01 to 20.0% by weight, and the antibacterial hypoallergenic cosmetic composition according to claim 1.