JPH1045563A - Antimicrobial and low-irritant cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a cosmetic having synergistically enhanced antimicrobial actions without not only manifesting primary irritation or sensitizing properties to the skin but also imparting an unpleasant feeling such as a sharply stabbing pain, a tingling pain or a prickling pain thereto when using the cosmetic. SOLUTION: This antimicrobial and low-irritant cosmetic comprises one or more of antimicrobial metal-supporting ceramics and one or more selected from the group consisting of p-hydroxybenzoic esters, phenoxyethanol, Kankohso 101 [Photosensitizer 101 (platonin)], a Kankohso 201 [Photosensitizer 201 (pionin)], Kankohso 401 [Photosensitizer 401 (luminex)], hinokitiol, an N-long- chain acyl basic amino acid derivative and its acid addition salt and zinc oxide used in combination. Silver, copper and zinc are preferred as the antimicrobial metal to be supported. A calcium compound, zinc oxide, zirconium oxide, titanium oxide, magnesium oxide, aluminum oxide, silicon oxide, talc and zeolite are preferred as the ceramics.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition which has excellent antibacterial properties, is not contaminated by microorganisms such as bacteria and fungi, is stable and has low skin irritation. More specifically, 1 of antibacterial metal-supported ceramics
TECHNICAL FIELD The present invention relates to a hypoallergenic cosmetic having high antibacterial properties, which comprises one or two or more kinds and one or more kinds of substances having an antibacterial activity such as paraoxybenzoic acid esters.

[0002]

2. Description of the Related Art Conventionally, water-containing cosmetics such as lotions, milky lotions, and creams have various antiseptic and fungicidal properties in order to prevent deterioration due to the contamination of microorganisms such as bacteria and mold during production and use. Agents have been used. Examples of such preservatives include phenols such as isopropylmethylphenol, paraoxybenzoate, phenoxyethanol and hinokitiol; benzoic acid and its salts; salicylic acid and its salts; dehydroacetic acid and its salts; sorbic acid and its salts; Quaternary ammoniums such as benzalkonium, benzethonium chloride and alkyltrimethylammonium chloride, amphoteric surfactants such as alkylaminoethylglycine hydrochloride and sodium stearylhydroxyethylbetaine chloride, and photosensitizers are used.

However, many of the above-mentioned preservatives and fungicides have been reported to have primary irritation, sensitization or photosensitization to the skin, and the amount of the preservative and fungicide is regulated based on the standard of cosmetic raw materials from the viewpoint of safety. In many cases, it is not possible to add an amount that actually shows effective antibacterial activity. Furthermore, it is known that even if the skin does not show a stimulating or sensitizing reaction such as redness, rash, or edema, it may cause discomfort such as stinging, tingling or tingling when using the cosmetic. Have been. In addition, there are cases in which sufficient antibacterial activity is not exhibited due to the interaction with the base of cosmetics and other ingredients.

[0004] For example, oil-soluble preservatives and fungicides such as isopropylmethylphenol, paraoxybenzoate, and sorbic acid, when incorporated into cosmetics containing polymer thickeners and powders, have reduced antibacterial activity due to adsorption and the like. To do. Also,
In cosmetics containing a surfactant, the antibacterial activity is also decreased due to incorporation into the surfactant micelle. On the other hand, if a large amount is blended in anticipation of a sufficient antibacterial activity, problems such as crystal precipitation at low temperatures will occur in the stability of the product.

[0005] Water-soluble preservatives and fungicides such as benzoate, salicylate and dehydroacetate are not effective unless the pH of the cosmetic is weakly acidic. As the acidity increases, the solubility in water decreases, and crystals may precipitate.

Further, regarding quaternary ammonium compounds and amphoteric surfactants, skin irritation and eye mucous membrane irritation are recognized, foaming is likely to occur, and antibacterial activity decreases on the acidic side.
There is a problem in practical use such as interaction with an anionic substance.

In addition to the above-mentioned organic antibacterial agents, ceramics carrying an antibacterial metal have been studied as inorganic antibacterial compositions, and their application to oral compositions such as toothpastes and mouthwashes has been studied. It has been made for a long time, and its application to treatment of atopic dermatitis (JP-A-6-285131) and antibacterial cosmetics containing it (JP-A-7-101821) have been disclosed. However, the antibacterial metal-supporting ceramics alone could not obtain a sufficient antibacterial and antifungal action even in an amount of about 10% by weight in a complicated formulation system.

[0008]

Therefore, in the present invention, the cosmetic base and other components show an effective antibacterial action without lowering the antibacterial activity, and the antiseptic and fungicide is incorporated as much as possible. To obtain a cosmetic that reduces the amount and does not cause primary irritation or sensitization to the skin, and does not cause discomfort such as stinging, tingling, or tingling when using the cosmetic. Aimed at.

[0009]

In order to solve the above problems, an antiseptic / antifungal system having high stability and low irritation to the skin was examined. As a result, one or more antibacterial metal-supported ceramics were obtained. Not only synergistically improving the antibacterial activity but also significantly reducing the irritation and discomfort to the skin by including one or more substances having an antibacterial action such as paraoxybenzoates in combination. As a result, they have completed the present invention.

As the antibacterial metal-supported ceramics used in the present invention, one or more kinds of silver, copper and zinc are calcium compounds, zinc oxide, zirconium oxide, titanium oxide, magnesium oxide, aluminum oxide, silicon oxide, Those supported on ceramics such as talc and zeolite are preferred, and those supported on calcium compounds such as calcium phosphate, hydroxyapatite and calcium carbonate are particularly preferred. These can be obtained by supporting a ceramic with a salt of an antibacterial metal selected from silver, copper, and zinc, and then firing at a temperature equal to or higher than the melting point of the antibacterial metal. A low concentration of about 0.1 to 10.0% by weight is sufficient as the amount to be added to cosmetics.

In the present invention, the substance having an antibacterial action used in combination with the antibacterial metal-supporting ceramics includes paraoxybenzoic acid esters, phenoxyethanol, photosensitizer No. 101 (platonin), photosensitizer No. 201 (pionin), photosensitizer 401 No. (LUMINEX), hinokitiol, N-long-chain acyl basic amino acid derivatives and acid addition salts thereof, and zinc oxide. One or more of these are selected and blended.

The paraoxybenzoic esters include:
Examples include methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate. In the present invention, since a synergistic improvement in antibacterial activity is recognized by the combined use with the antibacterial metal-supported ceramics, the amount of these compounds is 0.01 to
About 0.2% by weight is sufficient.

In the present invention, sufficient antibacterial activity of phenoxyethanol can be obtained by adding about 0.05 to 0.3% by weight. In addition, each of photosensitive element 101 (platonin), photosensitive element 201 (pionine), and photosensitive element 401 (luminex) is 0.00.
A blending amount of about 01 to 0.002% by weight is sufficient. For hinokitiol, a blending ratio of 0.0001 to 0.1% by weight is appropriate.

The N-long-chain acyl basic amino acid derivatives and acid addition salts thereof are represented by the following general formulas (1) and (2)
And those represented by the general formula (3) are preferable, and one kind or two or more kinds are selected from these and used.

Embedded image

[Chemical 2]

(Wherein, in the general formulas (1) to (3), RC
O is a saturated or unsaturated fatty acid residue having 6 to 20 carbon atoms, X
It is _{-NH 2, -OCH 3, -OC 2} H 5, -OC 3 H 7, -OC 4 H
₉ or —OCH ₂ C ₆ H ₅ , and in the general formula (2), n is 3
Or 4 is shown. )

For example, N-caproyl-L-arginine methyl ester hydrochloride, N-lauroyl-L-arginine ethyl ester-DL-pyrrolidone carboxylate, N-palmitoyl-L-arginine ethyl ester hydrochloride, N-cocoyl- L-
Arginine ethyl ester-DL-pyrrolidone carboxylate, N-caproyl-L-lysine methyl ester hydrochloride, N-
Lauroyl-L-lysine ethyl ester-DL-pyrrolidone carboxylate, N-myristoyl-L-lysine propyl ester hydrochloride, N-cocoyl-L-lysine methyl ester-DL-pyrrolidone carboxylate, N-stearoyl-L- Examples thereof include histidine methyl ester hydrochloride, N-oleoyl-L-histidine ethyl ester-DL-pyrrolidone carboxylate and the like. A suitable amount is about 0.001 to 0.5% by weight.

Zinc oxide is used as a white pigment in powder cosmetics. The blending amount in the present invention may be the amount usually blended with cosmetics, but 0.1 to 30.0 wt%
The degree is appropriate.

[0017]

When the antibacterial metal-supporting ceramics alone is incorporated into the cosmetic composition, even if 10.0% by weight cannot be incorporated, sufficient antibacterial activity cannot be obtained. However, in the present invention, a synergistic antibacterial effect is observed when used in combination with an antibacterial substance such as paraoxybenzoic acid esters. A sufficient antibacterial and antifungal action can be obtained. Further, in the present invention, since a small amount of antibacterial metal-supported ceramics and an antibacterial substance exhibit antibacterial activity, irritation and discomfort to the skin and eyes can be alleviated.

[0018]

The invention according to the present invention is particularly useful for a system containing a large amount of water or an O / W type emulsification system in which the external phase is an aqueous phase. Cosmetics,
Makeup cosmetics such as makeup base lotion or cream, emulsion or creamy foundation, emulsified eye color or cheek color, aqueous suspension eye liner, emulsified eye liner or mascara, cleansing lotion, cleansing gel, It can be provided as cleaning cosmetics such as liquid soap, and hair cosmetics such as shampoo and hair rinse. In addition, it can be satisfactorily carried out even for cosmetics containing a large amount of powder that is difficult to sterilize.

[0019]

EXAMPLES Further, the features of the present invention will be described in detail with reference to examples. First, the formulations of Examples 1 to 3 are shown in Table 1 as the lotion according to the present invention. These are shown in Table 1.
Add each of the components (1) to (7) in order to (8), mix uniformly,
Disperse and prepare.

[Table 1]

Then, as an emulsion according to the present invention, Example 4
Table 2 shows the formulations of Examples to 6. These are prepared as follows. First, the oil phase components (1) to (6) in Table 2 are mixed, heated and melted, and kept at 75 ° C. On the other hand, the aqueous phase components (7) to (11) are mixed, heated and dissolved, and then (12) is dispersed to 75 ° C., and the above oil phase is added thereto with stirring to emulsify.
After cooling, add (13) at 40 ° C. and mix.

[Table 2]

Next, the formulations of Examples 7 to 9 which are creams according to the present invention are shown in Table 3. These are prepared as follows. The oil phase components (1) to (7) are mixed and heated to 75 ° C. On the other hand, the water phase components (8) to (11) are mixed and heated, and (12) is dispersed to 75 ° C. The oil phase is added to this to emulsify, and after cooling, (13) is added at 40 ° C.

[Table 3]

Example 10 Makeup Base Cream (1) Stearic acid 12.00 (% by weight) (2) Cetanol 2.00 (3) Self-emulsifying glyceryl monostearate 2.00 (4) Paraoxybenzoate Propyl acid 0.01 (5) Propylene glycol 10.00 (6) Potassium hydroxide 0.30 (7) Purified water 66.09 (8) Fragrance 0.10 (9) Zinc-loaded hydroxyapatite 6.00 (10) Titanium dioxide 1.00 (11) Red iron oxide 0.10 (12) Yellow iron oxide 0.40 Manufacturing method: (9) to (12) are kneaded with (5), and this is the water phase component of (6) and (7). , Mixed and heated to 70 ° C. On the other hand, (1) ~ (4)
The oil phase component is mixed and heated to 70 ° C., and this is added to the aqueous phase while stirring to emulsify. Cool after emulsification 4
Add (8) at 0 ° C.

Example 11 Emulsion Foundation (1) Stearic acid 2.4 (% by weight) (2) Propylene glycol monostearate 2.0 (3) Cetostearyl alcohol 0.2 (4) Liquid lanolin 0 (5) Liquid paraffin 3.0 (6) Isopropyl myristate 8.5 (7) Sodium carboxymethyl cellulose 0.2 (8) Bentonite 0.5 (9) Propylene glycol 4.0 (10) Triethanolamine 1. 1 (11) N-myristoyl-L-lysine ethyl ester hydrochloride 0.1 (12) Purified water 57.7 (13) Fragrance 0.1 (14) Silver-supported titanium oxide 4.5 (15) Titanium oxide 7 (16) Talc 4.0 (17) Bengala 3.0 (18) Yellow iron oxide 2.5 (19) Black iron oxide 0.5 Production method: After mixing pigments of (14) to (19), pulverizer And pulverize. (12) was heated to 70 ° C., (8) was added to swell well, to which was added (7) previously dispersed in (9), and (10) and (11) were further added. Dissolve. (1) ~ (6)
Are mixed, heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring, the mixture is passed through a colloid mill to 75 ° C., the oil phase is added with stirring to emulsify,
After cooling, add (13) at 40 ° C.

[Example 12] Creamy foundation (1) Stearic acid 5.00 (% by weight) (2) Lipophilic glyceryl monostearate 2.50 (3) Propylene glycol monolaurate 3.00 (4) Cetostearyl alcohol 1.00 (5) Liquid paraffin 7.00 (6) Isopropyl myristate 8.00 (7) Butyl paraoxybenzoate 0.01 (8) Sorbitol 3.00 (9) Triethanolamine 1.20 ( 10) Purified water 45.69 (11) Perfume 0.10 (12) Copper-supported zinc oxide 2.50 (13) Titanium oxide 8.00 (14) Kaolin 5.00 (15) Talc 2.00 (16) Bentonite 1.00 (17) Bengala 2.60 (18) Yellow iron oxide 2.10 (19) Black iron oxide 0.30 Production method: After mixing the pigments of (12) to (19), pulverize with a pulverizer. Mix and dissolve (8) to (10) and heat. (1)-(6)
The oil phase components are mixed, heated and melted to 80 ° C. The pigment is added to the aqueous phase with stirring, brought to 75 ° C. through a colloid mill, and the oil phase is added with stirring and emulsified,
After cooling, (11) is added at 40 ° C.

[Example 13] Emulsion type eye color (1) Stearic acid 8.00 (% by weight) (2) White petrolatum 15.00 (3) Isopropyl palmitate 5.00 (4) Lanolin 5.00 (5 1.) 1,3-butylene glycol 5.00 (6) Triethanolamine 2.00 (7) Phenoxyethanol 0.15 (8) Purified water 56.18 (9) Fragrance 0.15 (10) Zirconium oxide supported on zinc 2. 00 (11) Red No. 221 0.02 (12) Gunjo 1.50 Manufacturing method: Mixing and dissolving the water phase components of (5) to (8), and mixing and pulverizing them in advance (10) to Add (12), disperse and heat to 75 ° C. Add (1) to (4), which was mixed and heated to make it uniform, with stirring to emulsify,
After cooling, add (9) and mix.

Example 14 Powder Foundation (1) Talc 33.85 (% by weight) (2) Mica 20.00 (3) Nylon powder 15.00 (4) Titanium oxide 10.00 (5) Zinc oxide 2 .50 (6) Zinc talc 2.50 (7) Red iron oxide 3.00 (8) Yellow iron oxide 2.50 (9) Black iron oxide 0.50 (10) Squalane 5.00 (11) Octyldodecyl myristate 2.50 (12) Macadamian nut oil 2.50 (13) Fragrance 0.15 Production method: (1) to (9) are mixed and pulverized through a pulverizer. This is transferred to a high-speed blender, and (10) to (13) are added and mixed to make it uniform. This is processed by a pulverizer, passed through a sieve to make the particle size uniform, and then filled in a gold plate and compression molded.

[Example 15] Emulsion type eyeliner (1) Stearic acid 3.50 (% by weight) (2) Beeswax 2.00 (3) Carnauba wax 0.50 (4) Microcrystalline wax 5.00 (5) Butyl paraoxybenzoate 0.01 (6) 1,3-butylene glycol 7.00 (7) Triethanolamine 1.50 (8) Methyl paraoxybenzoate 0.10 (9) Purified water 48.79 (10) Fragrance 0.10 (11) 3.0% by weight bentonite dispersion 20.00 (12) Silver-supported silicon oxide 1.50 (13) Copper-supported titanium oxide 1.50 (14) Titanium oxide 6.50 (15) Carbon black 2.00 Production method: The oil phase components (1) to (5) are mixed and heated to dissolve. The aqueous phase components (6) to (9) are mixed, heated, and added with stirring to emulsify. Then, (11) ~ (1
5) was added, dispersed through a colloid mill and then cooled,
Add (10) at 40 ° C.

Example 16 Emulsion resin type mascara (1) 50.0% by weight vinyl acetate emulsion 30.0 (% by weight) (2) Sodium carboxymethylcellulose 1.0 (3) 1,3-butylene glycol 0 (4) Phenoxyethanol 0.1 (5) Methyl paraoxybenzoate 0.1 (6) Magnesium oxide 0.5 supported on silver 0.5 (7) Aluminum oxide 0.5 supported on zinc 0.5 (8) Hydroxyapatite supported on copper 1.0 (9 ) Titanium oxide 8.0 (10) Carbon black 1.6 (11) Bengala 0.4 (12) Purified water 53.8 Production method: (2) to (5) are added to (12) and dissolved, (6)
Add ~ (11) and disperse through colloid mill. Add (1) to this and disperse uniformly.

[Example 17] Shampoo (1) Sodium alkyl ether sulfate 18.000 (% by weight) (2) Coconut oil fatty acid diethanolamide 2.000 (3) N-stearoyl-L-lysine propyl ester 0.050- DL-pyrrolidone carboxylate (4) Yellow No. 4 0.001 (5) Silver-supported zeolite 2.500 (6) Perfume 0.200 (7) Purified water 77.249 Production method: (1) to (6) in order. Add to (7), mix uniformly, dissolve and disperse.

Example 18 Hair rinse (1) Cetanol 2.00 (% by weight) (2) Stearyltrimethylammonium chloride 2.00 (3) Silicone oil 3.00 (4) Polyoxyethylene (10E.O. ) Oleyl 1.00 ether (5) Glycerin 3.00 (6) Hinokitiol 0.02 (7) Zinc-supported calcium phosphate 1.00 (8) Fragrance 0.15 (9) Purified water 87.83 Production method: (9) Add (5) to (7) and heat to 70 ° C. On the other hand, (1) to (4) are mixed and dissolved and heated to 70 ° C. This oil phase was gradually added to the previously prepared aqueous phase while stirring, and pre-emulsified. The mixture was homogenized with a homomixer and cooled.
Add (8) at 0 ° C.

Example 19 Cleansing Gel (1) Glycerin 15.000 (% by weight) (2) 1,3-butylene glycol 10.000 (3) Silicic anhydride 7.000 (4) Polyoxyethylene (20E .O.) Lauryl ether 5.000 (5) Polyoxyethylene (50E.O.) hydrogenated castor oil 2.500 (6) Hydroxyapatite supporting silver and zinc 5.000 (7) Carboxyvinyl polymer 0.500 (8) ) Potassium hydroxide 0.450 (9) Photosensitizer No. 201 0.001 (10) Perfume 0.100 (11) Purified water 54.449 Manufacturing method: (3), (7) are added to (11) to be uniform After dispersing (6), dissolve (4) and (5) in (1) and (2) and add
Heat to 0 ° C. to dissolve uniformly. Then cool down to 40
Add (9) and (10) at ℃, and finally add (8) to neutralize.

Next, the above examples were evaluated for antibacterial activity, skin irritation and discomfort during use. As samples, Examples 1, 4 and 7 and Examples 10 to 1 were used.
9 was used. At the same time, the comparative examples shown in Table 4 were similarly evaluated.

[Table 4]

(1) Evaluation of antibacterial activity As bacteria, Escherichia coli , Staphylococc
us aureus ), Pseudomonas aeruginosa , and acne ( Propionibacterium acnes ) as fungi, Candida albicans , and black mold ( Aspergillus ).
s niger ) and dandruff fungus ( Pityrosporum ovale ),
Samples 1g per bacterium 10 ^6, fungus was inoculated 10 ^5, were cultured respectively at 37 ° C. and 25 ° C., the viable cell count after two weeks was measured, when killed for bacteria, the fungi Determined that the antibacterial activity was sufficient when the viable cell count was 1/1000 or less. The evaluation results are shown in Table 5 as ◯ when sufficient antibacterial activity was observed, and as X when not observed.

[Table 5]

As apparent from Table 5, in Examples of the present invention, sufficient antibacterial activity against both bacteria and fungi was observed. In contrast, Comparative Examples 2, 3, and 5 containing only the antibacterial metal-supported ceramics
In Nos. And 8, no antibacterial activity was observed for most test bacteria. Comparative Examples 1 and 4 containing a considerable amount of an antibacterial substance such as methyl parahydroxybenzoate.
No. 6, 7, 9 and 10 did not meet the acceptance criteria for some test bacteria.

(2) Evaluation of skin irritation For each sample,
A 48-hour occlusion patch test was performed using 30 male panelists, and evaluated according to the criteria shown in Table 6 to obtain the average value of the skin irritation index of 30 persons. In Examples 17 to 19 and Comparative Examples 8 to 10, 1.0% by weight was used.
The aqueous solution was used for the test.

[Table 6]

(3) Evaluation of discomfort during use Twenty female panelists were divided into one group, and each group was allowed to use each sample.
Stinging pain felt between 30 seconds and 1 minute after application,
They were asked to evaluate discomfort such as tingling and tingling. The evaluation results were "very strong; 5 points", "somewhat strong; 4 points", "feeling; 3 points", "slightly feeling; 2 points", "subtle feeling; 1 point", and "not feeling". ; 0
The score was evaluated as “point”, and indicated by the average value of 20 persons. Also at this time, Examples 17 to 19 and Comparative Examples 8 to 1
For 0, the test was performed with a 1.0% by weight aqueous solution. The above results are summarized in Table 7.

[0037]

[Table 7] In Table 7, the skin irritation was not observed in any of the examples of the present invention, and the discomfort during use was only slightly felt. On the other hand, Comparative Example 4 containing 0.2% by weight of methyl paraoxybenzoate,
Considerable discomfort was observed in Comparative Example 6 containing 0.05% by weight of butyl paraoxybenzoate and Comparative Example 7 containing 0.5% by weight of phenoxyethanol. In Comparative Examples 6 and 7, some skin irritation was observed.

[0038]

As described in detail above, the antimicrobial action of the present invention is synergistically enhanced, and not only skin irritation but also almost no discomfort such as stinging, tingling and tingling when used. An unfeelable antibacterial cosmetic was obtained.

Claims (6)

[Claims] 1. One or more antibacterial metal-supporting ceramics, paraoxybenzoic acid esters, phenoxyethanol, Photosensitizer No. 101 (Platonin), Photosensitizer No. 201 (Pionine), Photosensitizer No. 401 (Luminex). , Hinokitiol, N-long-chain acyl basic amino acid derivatives and acid addition salts thereof, and one or more kinds selected from the group consisting of zinc oxide, which is an antibacterial hypoallergenic cosmetic composition. 2. The antimicrobial metal-carrying ceramic is silver,
The antibacterial anti-irritant cosmetic according to claim 1, wherein one or more selected from copper and zinc are carried. 3. The ceramic material is one or more selected from a calcium compound, zinc oxide, zirconium oxide, titanium oxide, magnesium oxide, aluminum oxide, silicon oxide, talc and zeolite. The antibacterial hypoallergenic cosmetic composition according to claim 1 or 2. 4. The method according to claim 1, wherein the calcium compound is calcium phosphate,
4. A material selected from one or more selected from hydroxyapatite and calcium carbonate.
2. The antibacterial and hypoallergenic cosmetic according to item 1. 5. The N-long-chain acyl basic amino acid derivative and an acid addition salt thereof are represented by the following general formulas (1), (2) and (3): The antibacterial hypoallergenic cosmetics according to claim 1. Embedded image Embedded image Embedded image (However, in the general formulas (1) to (3), RCO is a saturated or unsaturated fatty acid residue having 6 to 20 carbon atoms, and X is -N.
H ₂ , —OCH ₃ , —OC ₂ H ₅ , —OC ₃ H ₇ , —OC ₄ H ₉ or
-OCH ₂ C ₆ H ₅ is shown, and n is 3 or 4 in the general formula (2).
Is shown. ) 6. An antimicrobial metal-carrying ceramic having a compounding amount of 0.1 to 10.0% by weight, paraoxybenzoic acid esters, phenoxyethanol, photosensitizer No. 101 (platonin), photosensitizer No. 201 (pionin), photosensitizer 401 (Luminex), hinokitiol, N-long chain acyl basic amino acid derivative and its acid addition salt, and zinc oxide in an amount of 0.01 to 0.2% by weight and 0.05 to 0.
3% by weight, 0.0001 to 0.002% by weight, 0.00
01-0.002% by weight, 0.0001-0.002% by weight, 0.0001-0.1% by weight, 0.001-0.
The antibacterial hypoallergenic cosmetics according to claims 1 to 5, characterized in that they are 5% by weight and 0.1 to 30.0% by weight, respectively.