JP3001121B2 - External preparation for skin - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a novel external preparation for skin, and more particularly, to an effect of activating skin metabolism, increasing skin elasticity, protecting skin and retaining moisture. The present invention relates to an external preparation for skin which gives moisture and is also excellent in improving skin roughness.

[0002]

2. Description of the Related Art Urea is present in living organisms and alters the protein polybesotide, thereby increasing its possibility. It also has an antibacterial action, a protein dissolving and altering action, a reduction in hydration, that is, an action of enhancing the water retention ability. Has a chemically important pharmacological effect,
It is used as a therapeutic agent for keratosis, and when it is incorporated into cosmetics, it acts as a protective agent for retaining amino acids that are suitable for the skin, as well as its moisturizing, cell activating and wound healing effects. Etc. are expected.

[0003]

SUMMARY OF THE INVENTION However, in the case of a single formulation of urea into an external preparation for skin,
The expected effects and effects are not yet sufficient, and therefore, if the amount is increased, the stability of the external preparation for skin is adversely affected, and stickiness is caused.

An object our invention has been made in view of the above circumstances, intensive research and as a result, the urea, tranexamic acid or its salts, or skin external preparation containing a combination of its induction pair retention of moisture It has been found that they increase synergistically, make the skin smooth, give moderate “moistening” and “abrasion”, and have an effect of improving skin roughness. Based on these findings, the present invention has been completed.

[0005]

That is, the present invention provides a skin external preparation for improving rough skin, characterized by comprising urea and tranexamic acid, a salt thereof, or a derivative thereof, or a mixture thereof.

Hereinafter, the configuration of the present invention will be described in detail. The urea used in the present invention may be a commercially available urea.

The compounding amount is generally 0.1 to 30% by weight, preferably 1 to 10% by weight, based on the total amount of the external preparation for skin. If the amount is less than 0.1% by weight, the effect of the present invention cannot be sufficiently exhibited. If the amount exceeds 30% by weight, urea crystal is likely to be precipitated, and the effect cannot be substantially increased.

[0008] Tranexamic acid, its salts or derivatives thereof used in the present invention are generally used as antiplasmin agents, and are known as components characterized by high safety in cosmetics applications. (Japanese Patent Application No. 42
-36980) is disclosed in Japanese Patent No. 2406611.
, Patents 242664, 480411 and 488168.

Tranexamic acid has a melting point of 262 ° -267 ° C.
White crystals or powder, no smell, bitter taste. Tranexamic acid salts are commonly used salts such as Na, Mg,
There are metal salts such as Ca and K, sulfates, and the like. Derivatives include vitamin esters such as vitamin A acid ester, vitamin A ester, vitamin E ester, vitamin C ester, vitamin D ester, phenyl esters, N,
N-maleylamino tranexamic acid and the like,
It is not limited to these.

In the present invention, one or more of the above-mentioned tranexamic acids or salts or derivatives thereof are arbitrarily selected and used.
It is 0.1 to 30% by weight, preferably 6 to 20% by weight, based on the total amount of the external preparation for skin. If the amount is less than 0.1% by weight, the effect of the present invention is not sufficiently exhibited, and even if the amount exceeds 30% by weight, the effect cannot be substantially increased.

[0011] In addition to the above essential components, the skin external preparation of the present invention may further contain other components which are usually used in the pharmaceutical and cosmetic fields, such as edetic acid, 2, 3, or 4 sodium, and sodium sodium citrate. Acid sequestrants of sodium sodium phosphate, sodium sodium phosphate, sodium butylhydroxytoluene (BHT), propyl gallate, dl-α-tocopherol, etc.
Surfactants, ultraviolet absorbers, fragrances, water, alcohols such as ethanol, isopropanol, thickeners, coloring agents, powders, drugs, organic acids such as citric acid and malic acid, and inorganic acids such as phosphoric acid. It can be used within a range that does not impair the effects of the invention.

The dosage form of the external preparation for skin of the present invention is optional.
Any dosage form such as a solution type, a solubilizing type, an emulsifying type, a powder dispersing type, a water-oil two-layer type water-oil-powder three-layer type may be used.

The use of the external preparation for skin of the present invention is also optional, and it can be used for facials such as lotions, emulsions, creams and packs, or external preparations for the body, or for hair such as hair tonics, hair creams, shampoos and hair rinses. It can be used for skin external preparations.

[0014]

EFFECTS OF THE INVENTION Since the skin external preparation of the present invention contains tranexamic acid, a salt thereof and a derivative thereof in urea, it activates skin metabolism, increases skin elasticity, protects skin and retains moisture. It is an external preparation for skin that gives excellent moisture, moderate moisture and firmness of the skin, and also has an excellent effect of improving rough skin.

[0015]

Next, the present invention will be described in detail with reference to examples. The present invention is not limited by this. The compounding amount is% by weight.

[0016]

[Actual use test] Eighty women were divided into four groups to make panels. The following Examples 1 to 3 and Comparative Examples 1 to 1 as samples
3 was used.

The first group contains the lotions of Example 1 and Comparative Example 1, the second group contains the creams of Example 2 and Comparative Example 2, and the third group contains the creams of Example 3 and Comparative Example 3. Tested using water.

After the face was washed twice a day, in the morning and at night, an appropriate amount of the cosmetic of the example was applied to the left side of the face and the cosmetic of the comparative example was applied to the right side of the face for two weeks. In the evaluation, the effectiveness was determined for the following four items. Table 1 shows the results.
It is shown in Table 6.

Example 1 Lotion% by weight Ethanol 8.0 2-Pyrrolidone-5-2.0 Sodium carboxylate Polyoxyethylene (20 mol) 1.8 Oleyl alcohol ether Tranexamic acid 0.1 Urea 0.5 Pullulan 0 .05 Jojoba oil 0.5 Caustic potash 0.015 EDTA-3Na 0.01 Fragrance 0.1 Ion-exchanged water Remaining method A lotion was produced by an ordinary method.

Comparative Example 1 Chemical Water Weight% Ethanol 8.0 2-Pyrrolidone-5-2.0 Sodium Carboxylate Polyoxyethylene (20 mol) 1.8 Oleyl Alcohol Ether Urea 0.5 Pullulan 0.05 Jojoba Oil 0.5 Caustic potash 0.015 EDTA-3Na 0.01 Fragrance 0.1 Deionized water remaining amount Production method A lotion was produced by an ordinary method.

Example 2 Cream Weight% 1,3-butylene glycol 5.0 Polyethylene glycol 4000 1.0 Glycerin 2.0 Squalane 20.0 Vaseline 5.0 Cetostearyl alcohol 3.0 Polyoxyethylene (20 mol) 1 5.5 Oleyl alcohol ether glyceryl monostearate 1.5 Na salt of tranexamic acid 0.1 Urea 0.5 Sodium lactate 2.0 Xanthan gum (Celtrol brand name) 0.05 Methyl paraben 0.1 Ethyl paraben 0.2 EDTA- 3Na 0.01 Flavor 0.2 Ion-exchanged water Remaining method A cream was produced by an ordinary method.

Comparative Example 2 Cream Weight% 1,3-butylene glycol 5.0 Polyaethylene glycol 4000 1.0 Glycerin 2.0 Squalane 20.0 Cetostearyl alcohol 3.0 Polyoxyethylene (20 mol) 1.5 Oleyl Alcohol ether Glyceryl monostearate 1.5 Urea 0.5 Sodium lactate 2.0 Xanthan gum (Keltrol brand name) 0.05 Methyl paraben 0.1 Ethyl paraben 0.2 EDTA-3Na 0.01 Fragrance 0.2 Ion exchange Water remaining amount Production method A cream was produced by an ordinary method.

Example 3 Emulsion Weight% Glycerin 2.0 Squalane 5.0 Vaseline 1.0 Cetostearyl Alcohol 0.3 Polyoxyethylene (20 mol) 1.5 Oleyl Alcohol Ether Glyceryl Monooleate 1.5 Tranexamic Acid Potassium salt 0.1 Sodium polyacrylate 0.03 Ethyl paraben 0.2 Urea 0.5 Caustic potash 0.1 EDTA-3Na 0.03 Fragrance 0.2 Deionized water Remaining amount Production method Emulsion by a usual method I got

Comparative Example 3 Emulsion Weight% Glycerin 2.0 Squalane 5.0 Vaseline 1.0 Cetostearyl Alcohol 0.3 Polyoxyethylene (20 mol) 1.5 Oleyl Alcohol Ether Glyceryl Monooleate 1.5 Polyacrylic Acid Sodium 0.03 Ethylparaben 0.2 Urea 0.5 Caustic potash 0.1 EDTA-3Na 0.03 Fragrance 0.2 Deionized water Remaining method Emulsion was obtained by an ordinary method.

[0025]

[Table 1]

[0026]

[Table 2]

[0027]

[Table 3]

[0028]

[Table 4]

[0029]

[Table 5]

[0030]

[Table 6]

As is clear from the results shown in Tables 1 to 6, the cosmetic of the present invention was extremely excellent in the moisture of the skin, the firmness of the skin, and the moisture of the next morning as compared with the conventional product. Furthermore, it was also excellent in skin roughness improvement effect.

Example 4 Pack% by weight Propylene glycol 2.0 Polyethylene glycol 4000 3.0 Glycerin 15.0 Ethanol 10.0 Vitamin A ester of tranexamic acid 10.0 Polyvinyl alcohol 10.0 Olive oil 3.0 Lactic acid 1.0 Urea 5.0 Carboxymethylcellulose 0.07 Methylparaben 0.1 Ethylparaben 0.1 Caustic potash 0.02 EDTA-3Na 0.01 Fragrance 0.1 Deionized water Remaining method Production A pack was obtained by an ordinary method. The pack of the present invention activated skin metabolism, increased skin viscoelasticity, was excellent in skin protection and moisture retention, provided moderate moisture and firmness of skin, and was also excellent in the effect of improving skin roughness. .

Example 5 Hair Cream Weight% Beeswax 3.0 Vaseline 15.0 Liquid paraffin 42.0 Polyoxyethylene (5 mol) 3.0 Stearic acid ester Polyoxyethylene (6 mol) 2.0 Oleyl alcohol ether Poly Oxyethylene (6 mol) 1.0 Cetyl alcohol ether Vitamin C ester of tranexamic acid 15.0 Urea 5.0 Purified water Residual perfume Appropriate preservative Appropriate Production Method A hair cream was obtained by an ordinary method.

Example 6 Cream% by weight 1,3-butylene glycol 5.0 Polyethylene glycol 4000 1.0 Glycerin 2.0 Squalane 20.0 Vaseline 5.0 Cetostearyl alcohol 3.0 Polyoxyethylene (20 mol) 1 5.5 Oleyl alcohol ether glyceryl monostearate 1.5 Sodium salt of tranexamic acid 0.1 Urea 0.5 Lactate sorter 2.0 Xanthan gum (Celtrol brand name) 0.05 Methyl paraben 0.1 Ethyl paraben 0.2 EDTA -3Na 0.01 Flavor 0.2 Ion-exchanged water Remaining method A cream was produced by an ordinary method. The cream of the present invention activates skin metabolism, increases skin viscoelasticity, is excellent in skin protection and moisture retention, provides moderate moisture, gives skin firmness, and has an excellent effect of improving rough skin. .

Example 7 Emulsion weight% glycerin 2.0 squalane 5.0 petrolatum 1.0 cetostearyl alcohol 0.3 polyoxyethylene (20 mol) 1.5 oleyl alcohol ether glyceryl monooleate 1.5 tranexam Acid potassium salt 15.0 Sodium polyacrylate 0.03 Ethyl paraben 0.2 Urea 1.5 Caustic potash 0.1 EDTA-3Na 0.03 Fragrance 0.2 Ion exchange water Remaining method An emulsion was obtained. All the emulsions of the present invention activate skin metabolism, increase skin viscoelasticity, have excellent skin protection and moisture retention,
It gave moderate moisture and firmness of the skin, and was also excellent in the effect of improving skin roughness.

Claims (1)

(57) [Claims] 1. An external preparation for improving rough skin , comprising urea and tranexamic acid, or a salt thereof, or a derivative thereof, or a mixture thereof.