JPWO2014077062A1 - Transparent gel skin disinfectant - Google Patents

Abstract

(A) a specific quaternary ammonium salt fungicide, (B) N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate, (C) a specific polyhydric alcohol, (D) ethanol, , (E) a carboxyvinyl polymer, the content of the component (B) is 0.01% by mass to 0.3% by mass, and the content of the component (D) is 15% by mass to 35%. The mass ratio of the total content of the component (A) and the component (B) to the total content of the component (C) and the component (D) [(C + D) / (A + B)] Is a transparent gel-like disinfectant for skin having a pH of 6.0 to 8.0 and a transparent appearance. [Selection figure] None

Description

  The present invention relates to a transparent gel-like skin disinfectant.

In recent years, a gel-like disinfectant has been used as a method for easily disinfecting skin such as fingers. As such a gel-like fungicide, a quaternary ammonium salt fungicide represented by benzalkonium chloride is widely used because it has a wide bactericidal spectrum and has an immediate effect. The quaternary ammonium salt disinfectant has a higher disinfecting power as the pH is higher, but the skin irritation becomes stronger.
Moreover, as a feeling of use of a gel-like disinfectant, the thing which does not sag when picked up and has good elongation is required, and a thickener is blended for this requirement.

  However, when the quaternary ammonium salt fungicide is used in combination with an anionic thickener such as carboxyvinyl polymer, it forms an anion-cation complex. Is greatly reduced, and the immediate effect is impaired.

Moreover, the gel-like disinfectant is also required to have quick drying as a characteristic, and ethanol is blended for this requirement (see, for example, Patent Document 1). The ethanol has an action of suppressing the formation of an anion-cation complex, and also has an action of clarifying the gel-like fungicide.
Since ethanol has skin irritation, it is desirable to suppress it to less than 40% by mass for the purpose of suppressing skin irritation during continuous use. However, at this concentration, the formation of an anion-cation complex is suppressed to make it transparent. There is a problem that can not be.

  Furthermore, in the gel-like fungicide containing the benzalkonium chloride, the ethanol, and the carboxyvinyl polymer, when the ethanol is less than 40% by mass and the pH is less than 8, further cloudiness occurs. There is a problem that the sterilizing power is greatly reduced.

  Therefore, a transparent gel-like skin disinfectant having a transparent appearance, an excellent bactericidal power with little skin irritation, an easy to stretch, a quick-drying property and no stickiness after drying. The current situation is that there is a strong demand for this.

JP 2011-153089 A

  An object of the present invention is to solve the above-described problems and achieve the following objects. That is, the present invention has a transparent gel-like appearance that is transparent in appearance, has excellent sterilizing power with little skin irritation, is easy to stretch, has quick drying properties, and has no stickiness after drying. An object is to provide a skin disinfectant.

  In order to solve the above-mentioned problems, the present inventors have made extensive studies and as a result, obtained the following findings. That is, in a transparent gel-like skin fungicide containing a quaternary ammonium salt fungicide, carboxyvinyl polymer, and 15% by mass to 35% by mass of ethanol, a specific amount of N-coconut oil fatty acid acyl L- Arginine ethyl DL-pyrrolidone carboxylate and a polyhydric alcohol, the total content of the polyhydric alcohol and the ethanol, the quaternary ammonium salt fungicide and the N-coconut oil fatty acid acyl L- By making the mass ratio with the total content of arginine ethyl DL-pyrrolidone carboxylate a specific mass ratio and adjusting the pH to 6.0 to 8.0, the appearance is made transparent, and the bactericidal power is low although there is little skin irritation. It is easy to stretch, has a quick drying property, and can give an excellent feeling of use that there is no stickiness after drying. And finding the door, leading to the completion of the present invention.

The present invention is based on the above findings by the present inventors, the transparent gel-like skin disinfectant of the present invention as a means for solving the above problems,
(A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride;
(B) N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate;
(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol;
(D) ethanol,
(E) a carboxyvinyl polymer;
The content of the component (B) is 0.01% by mass to 0.3% by mass, the content of the component (D) is 15% by mass to 35% by mass, and the component (A) The mass ratio [(C + D) / (A + B)] of the total content of the component and the component (B) to the total content of the component (C) and the component (D) is 100 to 400, pH 6. It is 0-8.0 and is a transparent gel-like skin disinfectant whose appearance is transparent.

  According to the present invention, the conventional problems can be solved, the object can be achieved, the appearance is transparent, the skin irritation is low, the sterilizing power is excellent, the stretch is easy, and the quick-drying property is achieved. It can provide a transparent gel-like skin disinfectant that has an excellent feeling of use, having no stickiness after drying.

(Transparent gel germicide)
The transparent gel-like skin disinfectant of the present invention comprises a quaternary ammonium salt disinfectant (hereinafter sometimes referred to as “component (A)”), N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carvone. An acid salt (hereinafter sometimes referred to as “component (B)”), a polyhydric alcohol (hereinafter sometimes referred to as “component (C)”), and ethanol (hereinafter referred to as “component (D)”) And a carboxyvinyl polymer (hereinafter sometimes referred to as “component (E)”), and further contains other components as necessary.

<(A) component: quaternary ammonium salt fungicide>
The quaternary ammonium salt fungicide as the component (A) is at least one selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride. The component (A) is a component having a high bactericidal power against bacteria such as E. coli.
Among these, benzalkonium chloride is preferable because it is excellent in sterilizing power, speed of drying, and non-stickiness after drying.

  The content of the component (A) in the transparent gel skin disinfectant is preferably 0.01% by mass to 0.3% by mass, and more preferably 0.02% by mass to 0.2% by mass. If the content of the component (A) is less than 0.01% by mass, the sterilizing power may be insufficient, and if it exceeds 0.3% by mass, white turbidity may occur and the sterilizing power is insufficient. May become difficult to stretch, slow to dry, may cause stickiness after drying, may cause skin irritation, and the like.

<(B) component: N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate>
By blending the N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate as the component (B) with the transparent gel skin disinfectant, it is advantageous in that the disinfecting power can be improved. It is.
A commercial item can be used for the said (B) component. Specific examples of the commercially available product include CAE (registered trademark) (cocoyl arginine ethyl PCA, manufactured by Ajinomoto Healthy Supply Co., Ltd.) under the trade name.

  Content of the said (B) component in the said germicidal agent for transparent gel-like skin is 0.01 mass%-0.3 mass% from the point which is excellent in transparency and bactericidal power, 0.05 mass%- 0.2 mass% is preferable. If the content of the component (B) is less than 0.01% by mass, the sterilizing power may be insufficient. If it exceeds 0.3% by mass, white turbidity may occur and the sterilizing power is insufficient. , Stickiness may occur after drying, and skin irritation may occur.

<(C) component: polyhydric alcohol>
The polyhydric alcohol as the component (C) is at least one selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol. The component (C) is advantageous in that it can improve the transparency of the transparent gel-like skin disinfectant.
Among these, hexylene glycol and 1,2-pentanediol are preferable from the viewpoint of excellent transparency and bactericidal activity.

  The content of the component (C) in the transparent gel skin disinfectant is preferably 5% by mass to 15% by mass and more preferably 8% by mass to 12% by mass from the viewpoint of excellent transparency. When the content of the component (C) is less than 5% by mass, white turbidity occurs, sterilizing power may be insufficient, may not be easily stretched, and when it exceeds 15% by mass, drying may be delayed. , Stickiness may occur after drying.

<(D) component: ethanol>
Blending ethanol as the component (D) in the transparent gel-like skin disinfectant is advantageous in that the transparency, bactericidal power, and drying speed can be improved.

  The content of the component (D) in the transparent gel-like skin disinfectant is excellent in transparency, bactericidal power, easiness of stretching, and speed of drying, and is less than 15% by mass from the point of less skin irritation. 35% by mass, preferably 20% by mass to 30% by mass. When the content of the component (D) is less than 15% by mass, white turbidity may occur, sterilizing power may be insufficient, it may be difficult to extend, and drying may be slow, and the content exceeds 35% by mass. If it is difficult to stretch, the skin may become rough during continuous use.

<(E) component: carboxyvinyl polymer>
By blending the carboxyvinyl polymer as the component (E) in the transparent gel-like skin disinfectant, it is possible to impart thickening to the transparent gel-like skin disinfectant, so that dripping from the skin is prevented. This is advantageous in that it can be prevented and the easiness of extension can be improved.

The viscosity of the component (E) is not particularly limited and may be appropriately selected depending on the intended purpose. An aqueous solution containing 0.2% by mass of the component (E) is neutralized with sodium hydroxide to adjust the pH. Of 2,000 mPa · s to 30,000 mPa · s from the point that the viscosity at 20 ° C. when the viscosity is 7.0 to 7.5 is excellent in transparency, speed of drying, and non-stickiness after drying Is preferable, and 3,000 mPa · s to 14,000 mPa · s is more preferable. If the viscosity is less than 2,000 mPa · s, the transparent gel-like skin disinfectant may not be thickened appropriately. If it exceeds 30,000 mPa · s, white turbidity may occur and drying may be slow. And stickiness after drying.
The said (E) component may be used individually by 1 type, and may use together 2 or more types from which the said viscosity differs.

The viscosity of the component (E) can be measured with a BL type viscometer or a BM type viscometer (manufactured by Tokyo Keiki Co., Ltd.).
In the case where the viscosity of the component (E) is 100 mPa · s or more and less than 10,000 mPa · s, no. 3 rotor or no. The measurement can be performed under the conditions of 1 rotor at 12 rpm and 20 minutes at 4 ° C. using 4 rotors.
When the viscosity of the component (E) is 10,000 mPa · s or more and less than 50,000 mPa · s, no. The measurement can be performed under the conditions of 1 rotor at 12 rpm and 20 minutes at 4 ° C. using 4 rotors.

A commercially available product can be used as the component (E). Specific examples of the commercially available products include trade names of Carbopol 981 (manufactured by Nihon Lubrizol Co., Ltd.), Carbopol ETD2050 (manufactured by Nihon Lubrizol Co., Ltd.), Hibiswako (registered trademark) 105 (Wako Pure Chemical Industries, Ltd.) The viscosity at 20 ° C. when the pH is adjusted to 7.0 to 7.5 is 3,000 mPa · s to 14,000 mPa · s. A 0.2% by mass aqueous solution such as Carbopol 980 (manufactured by Nippon Lubrizol Corporation), Hibiswaco (registered trademark) 104 (manufactured by Wako Pure Chemical Industries, Ltd.), etc. is neutralized with sodium hydroxide to adjust the pH to 7 Examples include those having a viscosity at 20 ° C of from 1 to 7.5 to 1 to 30,000 mPa · s. These may be used alone or in combination of two or more.
Among these, Carbopol 981 (0.2% by mass aqueous solution, pH 7.0 to 7.5, viscosity at 20 ° C .: 4 from the viewpoint of excellent transparency, speed of drying, and non-stickiness after drying. , 000 mPa · s to 7,500 mPa · s), Carbopol ETD2050 (0.2 mass% aqueous solution, pH 7.0 to 7.5, viscosity at 20 ° C .: 6,000 mPa · s to 14,000 mPa · s) Hibiswaco (registered trademark) 105 (0.2% by mass neutralized solution, viscosity at 20 ° C .: 7,000 mPa · s to 14,000 mPa · s) is preferable.

  The content of the component (E) in the transparent gel-like skin disinfectant is 0.1 because it is excellent in transparency, bactericidal power, ease of stretching, speed of drying, and non-stickiness after drying. % By mass to 0.5% by mass is preferable, and 0.3% by mass to 0.4% by mass is more preferable. When the content of the component (E) is less than 0.1% by mass, it tends to sag and difficult to extend to the skin, and when it exceeds 0.5% by mass, white turbidity occurs and the bactericidal power is poor. The feeling of use such as being sufficient, difficult to stretch, slowing drying, and stickiness after drying may be deteriorated.

<< mass ratio [(C + D) / (A + B)] >>
The mass ratio [(C + D) / (A + B)] of the total content of the component (A) and the component (B) and the total content of the component (C) and the component (D) is transparency, From the point which is excellent in the speed of drying and the non-stickiness after drying, it is 100-400, and 150-300 are preferable. If the mass ratio [(C + D) / (A + B)] is less than 100, white turbidity may occur and the sterilizing power may be insufficient. If it exceeds 400, the sterilizing power and the speed of drying and drying Later non-stickiness may be insufficient.

<Other ingredients>
The other components in the transparent gel skin disinfectant are not particularly limited as long as the effects of the present invention are not impaired, and can be appropriately selected according to the purpose. For example, a surfactant (anionic) Surfactants, cationic surfactants, amphoteric surfactants, etc.), polymer compounds other than the component (E), moisturizers, vitamins, amino acids, anti-inflammatory agents, ultraviolet absorbers, cooling agents, Antioxidant, sequestering agent, animal or plant extract or derivative thereof, colorant, fragrance, deodorant, preservative other than component (A), inclusion compound, solvent other than components (C) and (D) , PH adjusting agents and the like. These may be used alone or in combination of two or more.

  There is no restriction | limiting in particular as said pH adjuster, Although it can select suitably according to the objective, Triethanolamine, ethylenediamine-N, N, N ', N "-tetra-2-propanol (quadrol) is preferable. .

  There is no restriction | limiting in particular as content of the said other component in the said germicide for transparent gel skin, unless the effect of this invention is impaired, It can select suitably according to the objective.

<< Physical properties >>
-PH-
The pH of the transparent gel-like disinfectant for skin is 6.0 to 8.0 from the viewpoint of transparency, bactericidal ability, and non-stickiness after drying, and less skin irritation, and 6.5 to 7 .5 is preferred. If the pH is less than 6.0, white turbidity may occur, sterilizing power may be insufficient, it may be difficult to extend, and if it exceeds 8.0, drying may be slow and skin irritation may occur. It may occur.

  The pH of the transparent gel skin disinfectant can be determined by measuring the pH at 25 ° C. using a pH meter (manufactured by Toa DKK Co., Ltd.).

-Viscosity-
The viscosity of the transparent gel skin disinfectant is not particularly limited and may be appropriately selected depending on the intended purpose. The viscosity at 25 ° C. is preferably 300 mPa · s to 5,000 mPa · s. 000 mPa · s to 4,000 mPa · s is more preferable. If the viscosity of the transparent gel-like skin disinfectant is less than 300 mPa · s, it tends to sag, so it is difficult to stretch and it may be difficult to rub the skin evenly, and 5,000 mPa · s. If it exceeds, the viscosity of the transparent gel-like skin disinfectant is so high that it is difficult to extend when rubbed into the skin, and the usability may be deteriorated. Moreover, the malfunction that the discharge property from a container worsens may arise.
The viscosity of the transparent gel-like skin disinfectant can be adjusted by the component (E).

  The viscosity of the transparent gel skin disinfectant was measured using a BL type viscometer or a BM type viscometer (manufactured by Tokyo Keiki Co., Ltd.). 3 rotor or no. The measurement can be carried out under the conditions of 1 rotor at 30 rpm at 25 ° C. using 4 rotors.

-Transmissivity-
The transmittance (% T) of the transparent gel-like skin disinfectant is not particularly limited and may be appropriately selected depending on the intended purpose, but is preferably 80% T or more from the viewpoint of transparency and disinfecting power. 90% T or more is more preferable. If the transmittance is less than 80% T, white turbidity may occur, a good appearance may not be obtained, and sterilizing power may be reduced.
The transmittance (% T) of the transparent gel-like skin disinfectant can be determined by measuring the transmittance at 660 nm using an ultraviolet-visible spectrophotometer (manufactured by JASCO Corporation).

<< Manufacturing method >>
There is no restriction | limiting in particular as a manufacturing method of the said transparent gel-like skin disinfectant, Although it can select suitably according to the objective, The said (E) component is stirred at normal temperature (25 degreeC), stirring purified water. After the uniform dispersion, the component (A), the component (B), the component (C), and the component (D), and if necessary, the other components are added and stirred. It is preferable to dissolve the solution while adjusting the pH to a desired value by adding a pH adjuster.

<< Usage >>
The method for using the transparent gel skin disinfectant is not particularly limited and may be appropriately selected depending on the intended purpose. However, an appropriate amount (preferably about 1 g) is taken to a desired site such as a finger and the skin. A method of rubbing until the whole is dry is preferable. The transparent gel skin disinfectant is particularly preferably used for fingers. In the present invention, “finger” means the entire hand including the palm, the back of the hand, and the fingers of the hand.

  EXAMPLES The present invention will be specifically described below with reference to examples of the present invention, but the present invention is not limited to these examples. In the following examples and comparative examples, “%” represents “% by mass” unless otherwise specified.

(Examples 1-41 and Comparative Examples 1-14)
According to the composition and content shown in Tables 1 to 8 below, the component (E) was uniformly dispersed at 25 ° C. while stirring purified water with a three-one motor (BL-1200, manufactured by HEIDON). ) Component or (C ′) component and the component (D) are added and dissolved, then the component (A) and the component (B) are added and dissolved with stirring, and triethanol as a pH adjuster By adding amine and adjusting the pH to the values shown in Tables 1 to 8, a transparent gel-like skin disinfectant (transparent gel-like hand disinfectant) was prepared.

<Measurement of viscosity>
The viscosities of the transparent gel-like hand germicides of Examples 1-41 and Comparative Examples 1-14 were measured using a BL type viscometer (manufactured by Tokyo Keiki Co., Ltd.) 3 rotor or no. Using 4 rotors, the measurement was performed at 25 ° C. under the conditions of 1 rpm at a rotation speed of 30 rpm. The results are shown in Tables 1 to 8 below.

<Evaluation>
About the transparent gel-like hand germicide of Examples 1-41 and Comparative Examples 1-14, based on the following evaluation method, "transparency", "bactericidal power", "easiness to stretch", "speed of drying", " Evaluation was made on “no stickiness after drying” and “skin irritation”. The results are shown in Tables 1 to 8 below.

-Evaluation of transparency-
Using a UV-visible spectrophotometer (manufactured by JASCO Corporation), the transmittance (% T) at 660 nm of each of the transparent gel-like hand germicides of Examples and Comparative Examples was measured. Based on this measured value, it evaluated by the following evaluation criteria.
[Evaluation criteria]
◎: 90% T or more ○: 80% T or more and less than 90% T △: 70% T or more and less than 80% T ×: Less than 70% T

-Evaluation of bactericidal power-
E. coli ( Escherichia coli NBRC 3972, obtained from Independent Administrative Institution Product Evaluation Infrastructure) was used as a target bacterium, and evaluation was performed by a quantitative suspension method.
The Escherichia coli (E. Coli NBRC3972), using the SCD agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.), was 18 hours standing culture at 37 ℃ under aerobic conditions. An appropriate amount of colonies formed on the SCD agar medium was scraped, suspended in physiological saline (manufactured by Otsuka Pharmaceutical Co., Ltd.), adjusted to a bacterial concentration of 10 ⁸ cfu / mL, and used as a test bacterial solution. After injecting 0.005 mL of this test bacterial solution into 0.495 mL of each transparent gel-like hand germicide of Examples and Comparative Examples and bringing it into contact for 30 seconds, this mixed solution was immediately added to an SCDLP liquid medium (manufactured by Nippon Pharmaceutical Co., Ltd.). ) Was diluted 10 times and inactivated. The inactivated solution (hereinafter sometimes referred to as “inactivation solution”) was further diluted 100-fold, 1,000-fold, 10,000-fold, and 10-fold serial dilution with SCDLP medium. SCDLP agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.) (9 cm petri dish) was seeded with 1 mL each of the inactivated liquid diluted to each concentration (n = 3) and brought to 37 ° C. under aerobic conditions by the pour plate culture method. For 24 hours. After culture, the total number of colonies formed was counted and the number of remaining viable bacteria was measured. When no colony was observed, the detection limit was set to less than 10 cfu / mL. The measured number of remaining viable bacteria was determined according to the following score, and evaluated based on the following evaluation criteria based on the average value of the scores.
Note that cfu is a colony forming unit.
[Score]
5 points: remaining viable count is less than 10 cfu / mL (below detection limit)
4 points: remaining viable cell count of 10 cfu / mL or more and less than 100 cfu / mL 3 points: remaining viable cell count of 100 cfu / mL or more and less than 1,000 cfu / mL 2 points: remaining viable cell count of 1,000 cfu / mL or more 10, Less than 000 cfu / mL 1 point: The number of remaining viable bacteria is 10,000 cfu / mL or more [Evaluation criteria]
◎: 4.0 points or more ○: 3.0 points or more, less than 4.0 points Δ: 2.0 points or more, less than 3.0 points ×: Less than 2.0 points

-Evaluation of ease of extension-
10 expert panelists took 1 g of each of the transparent gel-like hand germicides of Examples and Comparative Examples in their hands in a 25 ° C. environment, and rubbed them into the palm and back of the hand. Sensory evaluation was performed based on the score, and the following evaluation criteria were used based on the average value of the scores.
[Score]
4 points: very easy to stretch 3 points: easy to stretch 2 points: difficult to stretch 1 point: very difficult to stretch [Evaluation Criteria]
◎: 4.0 points ○: 3.0 points or more and less than 4.0 points Δ: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

-Evaluation of the speed of drying-
10 expert panelists took 1 g of each of the transparent gel-like hand germicides of Examples and Comparative Examples in a 25 ° C. environment and rubbed into the palm and back of the hand while the transparent gel-like hand germicide dried. Was measured. Based on the average value of the measurement time of 10 people, the following evaluation criteria were used.
[Evaluation criteria]
◎: Less than 30 seconds ○: 30 seconds or more and less than 60 seconds △: 60 seconds or more and less than 90 seconds ×: 90 seconds or more

-Evaluation of non-stickiness after drying-
10 expert panelists took 1 g of each transparent gel-like hand disinfectant of Examples and Comparative Examples in a 25 ° C. environment, rubbed into the palm and back of the hand, and after the transparent gel-like hand disinfectant dried, Sensory evaluation was performed on the non-stickiness of the hands based on the following scores, and evaluation was performed based on the following evaluation criteria based on the average of the scores.
[Score]
4 points: Not sticky at all 3 points: Not sticky 2 points: Sticky 1 point: Very sticky [Evaluation criteria]
◎: 4.0 points ○: 3.0 points or more and less than 4.0 points Δ: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

-Evaluation of skin irritation-
Based on the following ratings, 10 expert panelists took 1 g of each of the transparent gel-like hand germicides of Examples and Comparative Examples in the hand at 25 ° C. and rubbed them into the palm and back of the hand. Sensory evaluation was performed, and evaluation was performed according to the following evaluation criteria based on the average value of the scores.
[Score]
4 points: I do not feel any stimulation 3 points: I do not feel stimulation 2 points: I feel stimulation 1 point: I feel very stimulation [Evaluation criteria]
◎: 4.0 points ○: 3.0 points or more and less than 4.0 points Δ: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

(Example 42)
In accordance with the composition and blending amount shown below, after stirring the purified water with a three-one motor (BL-1200, manufactured by HEIDON) at 25 ° C., the component (E) was uniformly dispersed, Add component (D) and dissolve, add component (A), component (B), and other additional components to dissolve with stirring, add pH adjuster to adjust pH to 7. By adjusting to 5, the transparent gel-like hand disinfectant of Example 42 was prepared.
About the transparent gel-like hand disinfectant of Example 42, “transparency”, “bactericidal power”, “easiness to stretch”, “speed of drying” in the same manner as in Examples 1-41 and Comparative Examples 1-14 ”,“ No stickiness after drying ”, and“ skin irritation ”.
[Composition and blending amount]
Benzalkonium chloride [component (A)] ・ ・ ・ 0.05%
N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate [component (B)] 0.1%
Hexylene glycol [component (C)] ... 10.0%
Ethanol [component (D)] 30.0%
Carboxy vinyl polymer (* 1) [(E) component] 0.3%
DL-pyrrolidonecarboxylate sodium (50% aqueous solution) (* 4) 0.2%
Fragrance ・ ・ ・ 0.2%
Ethylenediamine-N, N, N ′, N ″ -tetra-2-propanol (pH adjuster) ・ ・ ・ Suitable amount Purified water ・ ・ ・ Balance (added to be 100% in total)
Mass ratio [(C + D) / (A + B)]: 266.7
Viscosity: 3,850 mPa · s (25 ° C)
-PH: 7.5
[Evaluation results]
・ Transparency: ◎
・ Bactericidal power: ◎
・ Ease of extension: ◎
・ Dry speed: ◎
・ No stickiness after drying: ◎
・ Skin irritation: ◎

(Example 43)
In Example 42, the transparent gel-like hand germicide of Example 43 was prepared in the same manner as in Example 42, except that the composition and blending amount were changed to the composition and blending amount shown below.
About the transparent gel-like hand disinfectant of Example 43, “transparency”, “bactericidal power”, “easiness to stretch”, “speed of drying” in the same manner as in Examples 1-41 and Comparative Examples 1-14 And “no stickiness after drying”.
[Composition and blending amount]
Benzethonium chloride [component (A)] ... 0.05%
N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate [component (B)] 0.1%
Xylitol [component (C)] 10.0%
Ethanol [component (D)] 30.0%
Carboxyvinyl polymer (* 2) [(E) component] 0.3%
Ethylenediamine-N, N, N ′, N ″ -tetra-2-propanol (pH adjuster) ・ ・ ・ Suitable amount Dipotassium glycyrrhizinate (* 5) ・ ・ ・ 0.01%
Fragrance ・ ・ ・ 0.2%
Purified water: the remainder (added to be 100% in total)
Mass ratio [(C + D) / (A + B)]: 266.7
Viscosity: 4,500 mPa · s (25 ° C)
-PH: 7.5
[Evaluation results]
・ Transparency: ○
・ Bactericidal power: ○
・ Ease of extension: ○
・ Dry speed: ◎
・ No stickiness after drying: ◎
・ Skin irritation: ◎

  Each component used in Examples and Comparative Examples is as shown in Table 9 below.

Examples of the aspect of the present invention include the following.
<1> (A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride;
(B) N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate;
(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol;
(D) ethanol,
(E) a carboxyvinyl polymer;
Containing
The content of the component (B) is 0.01% by mass to 0.3% by mass, the content of the component (D) is 15% by mass to 35% by mass,
The mass ratio [(C + D) / (A + B)] of the total content of the component (A) and the component (B) and the total content of the component (C) and the component (D) is 100 to 400. Yes, it is a transparent gel-like skin disinfectant characterized by having a pH of 6.0 to 8.0 and a transparent appearance.
<2> The content of the component (A) is 0.01% by mass to 0.3% by mass, the content of the component (C) is 5% by mass to 15% by mass, and the content of the component (E) Is 0.1 to 0.5% by mass of the transparent gel-like skin disinfectant according to <1>.
<3> The mass ratio [(C + D) / (A + B)] of the total content of the components (A) and (B) and the total content of the components (C) and (D) is 150 to 300. The transparent gel-like skin disinfectant according to any one of <1> to <2>.
<4> The transparent gel-like skin disinfectant according to any one of <1> to <3>, wherein the component (C) is at least one of hexylene glycol and 1,2-pentanediol.
<5> The transparent gel-like skin disinfectant according to any one of <1> to <4>, wherein the pH is 6.5 to 7.5.

  The transparent gel-like skin disinfectant of the present invention has an excellent use in that the appearance is transparent, the skin irritation is excellent, the disinfecting power is excellent, it is easy to stretch, it has a quick drying property, and there is no stickiness after drying. As well as sterilizing the skin of fingers, etc. at home, employees in food-related industries such as meat and seafood processing, restaurant kitchens, doctors, nurses and caregivers in hospitals, health centers, etc. It can be suitably used for sterilization of the skin of fingers of patients and the like.

Claims (5)

(A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride;
(B) N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidone carboxylate;
(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol;
(D) ethanol,
(E) a carboxyvinyl polymer;
Containing
The content of the component (B) is 0.01% by mass to 0.3% by mass, the content of the component (D) is 15% by mass to 35% by mass,
The mass ratio [(C + D) / (A + B)] of the total content of the component (A) and the component (B) and the total content of the component (C) and the component (D) is 100 to 400. A transparent gel-like fungicide for skin having a pH of 6.0 to 8.0 and a transparent appearance.   The content of component (A) is 0.01% by mass to 0.3% by mass, the content of component (C) is 5% by mass to 15% by mass, and the content of component (E) is 0.00. It is 1 mass%-0.5 mass%, The germicide for transparent gel skin of Claim 1 characterized by the above-mentioned.   The mass ratio [(C + D) / (A + B)] of the total content of the component (A) and the component (B) and the total content of the component (C) and the component (D) is 150 to 300. The transparent gel-like skin disinfectant according to any one of 1 to 2.   The transparent gel skin disinfectant according to any one of claims 1 to 3, wherein the component (C) is at least one of hexylene glycol and 1,2-pentanediol.   The transparent gel-like skin disinfectant according to any one of claims 1 to 4, which has a pH of 6.5 to 7.5.