KR20110087663A - Gel form hand fungicide - Google Patents

Abstract

PURPOSE: A gel phase resin disinfectant is provided to prevent leakage from a container and to ensure less skin irritation. CONSTITUTION: A gel phase resin disinfectant contains: 50-80 mass% of alcohol of 1-3 carbon atoms; 0.1-1.0 mass% of carboxy vinyl polymer and/or acrylic acid-methacrylic acid alkyl copolymer; alkanol amine; and oligosaccharides. The oligosaccharides are malto oligosaccharides. The disinfectant further contains cylic silicon. The disinfectant is a skin therapeutic agent.

Description

Gel Resin Fungicide {Gel form hand fungicide}

The present invention relates to a gel-type resin sterilizing agent having excellent sterilizing and disinfecting effect by rubbing on a resin.

Lower alcohol has a strong bactericidal power and is widely used as a bactericide. However, when used for resin, since the viscosity is low, there exists an unreasonable flow from a container, and in order to eliminate this, the research which makes it into a gel form using hydroxy propyl cellulose as a thickener is performed (for example, patent document 1). : Japanese Patent Application Laid-Open No. 62-106012) It is also proposed to use a hypoallergenic gel-like external preparation using carboxyvinyl polymer and a neutralizing substance which is a neutralizing agent in ethanol of 10% by mass or less as a thickener (for example, Patent Document 2: Japanese Patent Application Laid-Open No. 2003-119129).

[Patent Document]

(Patent Document 1) Japanese Unexamined Patent Publication No. 62-106012

(Patent Document 2) Japanese Unexamined Patent Publication No. 2003-119129

While lower alcohol has a high bactericidal power, it penetrates the skin and impairs the skin barrier function, and also dehydrates the moisture on the surface of the skin, thereby lowering the moisturizing function of the skin and causing rough skin. If hydroxypropyl cellulose is used as a thickening agent in a gel external preparation, a moisturizing effect is obtained, but stickiness occurs and a feeling is bad, and when a carboxy vinyl polymer and an organic amine are used, there is little stickiness after use, but a moisturizing effect is enough. Not. This invention is made | formed in view of the said situation, It is good in appearance, without precipitation, it is easy to spread in resin, without falling out from a container, it is quick to dry after use, there is no stickiness, there is a moist feeling, and skin irritation An object of this invention is to provide a less gelling resin fungicide.

MEANS TO SOLVE THE PROBLEM The present inventors earnestly researched and studied in order to achieve the said objective, (A) 50-80 mass% of C1-C3 alcohols, and (B) carboxy vinyl polymer and / or the acrylic acid methacrylate alkyl copolymer 0.1. To (1.0)% by mass and (C) alkanol amine, and (D) oligosaccharide is blended with a gel-like resin sterilizing agent having a pH (25 ° C) of 5.5 to 9.0. The present invention has been accomplished by confirming that there is no dropping, easy to spread to the hands, quick drying after use, no stickiness, moist feeling, and low skin irritation.

Therefore, this invention provides the following gel resin sterilizer.

[One]. (A) 50 to 80 mass% of alcohol having 1 to 3 carbon atoms,

(B) 0.1-1.0 mass% of carboxy vinyl polymer and / or acrylic acid methacrylate alkyl copolymer,

(C) alkanol amines and

(D) A gel-like resin sterilizing agent containing oligosaccharide and whose pH (25 degreeC) is 5.5-9.0.

[2]. (D) The gel resin sterilizing agent as described in [1] whose component is malto oligosaccharide.

[3]. Moreover, the gel resin sterilizer as described in [1] or [2] containing (E) cyclic silicone.

[4]. The gel resin sterilizing agent in any one of [1]-[3] which is a moisturizing agent.

[5]. The gel resin sterilizing agent in any one of [1]-[3] which is a rough skin improvement agent.

[6]. The gel resin sterilizing agent in any one of [1]-[3] which is an itch inhibitor.

According to the present invention, there is no precipitation or the like, the appearance is good, there is no falling off from the container, it is easy to spread on the resin, the drying after use is fast, there is no stickiness, there is a moist feeling, and the skin resin germicide with little skin irritation Can provide.

Hereinafter, the present invention will be described in detail. The gel resin sterilizing agent of this invention (A) 50-80 mass% of C1-C3 alcohols, (B) carboxy vinyl polymer and / or 0.1-1.0 mass% of acrylic acid methacrylate alkyl copolymer, (C ) Alkanol amine and (D) oligosaccharide, and pH (25 degreeC) are 5.5-9.0.

(A) alcohols having 1 to 3 carbon atoms

By mix | blending (A) component, sterilization power and drying improve. As (A) component, ethanol, isopropanol, etc. are mentioned, It can be used individually by 1 type or in combination of 2 or more types. Especially, ethanol is preferable at the point which smells good.

The compounding quantity of (A) component is 50-80 mass% in a gel-type resin sterilizing agent, and 55-65 mass% is more preferable at the point of sterilization power. If the amount of the component (A) is less than 50% by mass, the sterilizing power is insufficient, and the drying after rubbing on the resin is delayed. If the content of the component (A) exceeds 80% by mass, the sterilizing power is lowered. The viscosity becomes low and it is easy to flow out of a container at the time of use.

(B) By mix | blending a carboxy vinyl polymer and / or an acrylic acid methacrylate alkyl copolymer (B) component, a formulation increases viscosity, it prevents it from falling out from a container, and it is easy to spread on resin. (B) A component can be used individually by 1 type or in combination of 2 or more types. As for the component (B) of the present invention, the viscosity at 20 ° C when the 0.2 mass% aqueous solution is neutralized with sodium hydroxide and the pH is set to 7.0 to 7.5 is preferably 14000 to 32000 mPa · s. Do. In addition, the viscosity is measured for one minute at a rotation speed of 12 rpm using a No. 4 rotor with a BL-type viscometer (manufactured by a Tokyo-based machine).

Specific examples of the carboxy vinyl polymer include Carbopol 980 (trade name: Ruburisol and Hibiswako 103 (trade name: Wako Pure Chemical Industries) as the carboxyvinyl polymer. As a coalescence, an acriretz / alkyl acrylate (C10-30) cross polymer (the display name is also the same) can be enumerated, More specifically, as a brand name, Carbopol ETD2020 (brand name: ruburizol, carbopol 1382 (brand name) : Ruburizol) etc. can be mentioned.

As for the compounding quantity of (B) component, 0.1-1.0 mass% is preferable in a gel-type resin sterilizing agent. If it is less than 0.1 mass%, it will fall from a container, and it will become difficult to unfold on resin, and if it exceeds 1.0 mass%, it will be slippery when rubbed on resin, and stickiness after drying. Moreover, usability (degree which is easy to take out from a container and extent which it is easy to unfold in resin) is good. In order to acquire the viscosity (5000-25000 mPa * s) of a gel-type resin sterilizer, 0.2-0.6 mass% is more preferable.

(C) alkanol amines

Alkanol amine neutralizes the said (B) component, thickens the gel resin sterilizer in a gel resin sterilizer, and adjusts the pH of a gel resin sterilizer to 5.5-9.0. Examples of the alkanol amine include triethanolamine, 2-amino-2-methyl-1-propanol, and giisopuranolamine, and can be used alone or in combination of two or more thereof. The compounding quantity of (C) component is an amount which neutralizes (B) component and becomes a gel resin sterilizing agent 5.5-9.0.

(D) oligosaccharides

The oligosaccharide of the present invention is a compound in which 2 to 10 single sugars are bound by glycosidic bonds. By blending oligosaccharides, it is possible to impart a moist feeling after drying without losing the speed of drying, exhibit a moisturizing effect, improve rough skin, and suppress itching. There is no restriction | limiting in particular as an oligosaccharide, Although it can select suitably according to the objective, Specifically, it is scros, lactose, maltose, trehalose, tranos, serobiose, raffinose, merezitose, maltotriose, malto Tetraose, maltopentaose, acarbose, starchiose, glucosyl trehalose, maltosyl trehalose, maltotoriosyl tore halos and the like. Among these, malto oligosaccharides of 4 to 5 sugars, such as maltotetraose and maltopentaose, are more preferable in terms of moist feeling after drying, itch suppression, and rough skin recovery, and maltotetraose is more preferable. These can be used individually by 1 type or in combination of 2 or more types.

(D) As oligosaccharides, for example, trehalose from Hayashibara Biochemistry Research Institute, Raffinose from Japanese Beet Sugar Agent, Torreha of Trehalose from Hayashibara Biochemistry Research Institute, Maltotetra from Hayashibara Biochemistry Research Institute Osinptoterap H, maltotriose, maltotetraose, maltopentaose and the like manufactured by Wako Pure Chemical Industries can be used.

As for the compounding quantity of (D) component, 0.1-10 mass% is preferable in a gel resin sterilizing agent, and 0.5-4 mass% is preferable. By setting it as 0.1 mass% or more, the moist feeling, rough skin improvement, and itching suppression after drying can be obtained more, and if it exceeds 10 mass%, stickiness will generate | occur | produce.

It is preferable to mix | blend (E) cyclic silicone with the gel resin sterilizing agent of this invention. By mix | blending (E) cyclic silicone, the feeling of stickiness after drying is suppressed more, and the soft feeling improves more. (E) It does not specifically limit as cyclic silicone, It can be used individually by 1 type or in combination of 2 or more types. Especially, 4-6 hexamer is preferable at the point of stickiness suppression. Specifically, as cyclopentasiloxane which is a pentamer, it is SF-Cyclomechicone 5-NF (brand name) as SH245 Fluid (brand name: Dore Dow Corning), KF-995 (brand name: Shin-Etsu Silicone), decamethyl cyclopentasiloxane. : Dore Dow Corning) can be enumerated. Examples of the hexacyclohexyl hexasiloxane include DC246 Fluid (brand name: Dore Dow Corning), and DSC345 Fluid (brand name: Dore Dow Corning) as a mixture of cyclopentasiloxane and cyclohexasiloxane. Among them, cyclopentasiloxane, cyclohexasiloxane, and decamethylcyclopentasiloxane are preferable.

0.1-2 mass% is preferable in a gel resin sterilizing agent, and, as for the compounding quantity of (E) component, 0.3-1.0 mass% is more preferable. By setting it as 0.1 mass% or more, the effect enough to suppress stickiness after drying and the improvement of a smooth feeling can be acquired, and even if it mixes exceeding 2 mass%, an effect will not rise further.

The gel-type resin sterilizing agent of this invention can mix | blend an appropriate amount individually by 1 type individually or in combination of 2 or more types of arbitrary components in the range which does not impair the effect of this invention. As the optional component, for example, surfactants such as anionic surfactants, cationic surfactants and amphoteric surfactants, water-insoluble powders such as inorganic powders and organic powders, high molecular compounds such as polyethylene glycol, moisturizers, vitamins, amino acids, etc. And anti-inflammatory agents, ultraviolet absorbers, cold sensitizers, antioxidants, colorants, paints, deodorants, preservatives, inclusion compounds, water, solvents, polyhydric alcohols, and the like.

PH (25 degreeC) of a gel resin sterilizer is 5.5-9.0, and pH 6.0-7.5 are more preferable. If the pH of the gel-type resin sterilizer is less than 5.5, sufficient product viscosity cannot be obtained, so it is likely to flow out of the container, causing precipitation and deteriorating appearance. On the other hand, if the pH exceeds 9.0, it is not preferable in terms of skin personality. In addition, pH is measured at 25 degreeC of undiluted | stock solution using the pH meter.

5000-25000 mPa * s is preferable and, as for the viscosity (25 degreeC) of a gel resin sterilizer, 10000-15000 mPa * s is more preferable. If it is less than 5000 mPa · s, it may easily flow out of a container such as a tube, and if it exceeds 25000 mPa · s, it may be difficult to come out of a container such as a tube, such that it is difficult to unfold when rubbed with a resin, and drying after use is delayed. There is concern. In addition, the measurement of a viscosity is measured by rotation speed 12rpm and time 1 minute using a No.4 rotor for a BL-type viscometer. In addition, it is preferable that the gel resin sterilizing agent of the present invention is transparent and uniform without any deposit or the like.

The gel resin sterilizing agent of this invention can be prepared based on a conventional method, For example, the following method is mentioned, It is not specifically limited. (A) component, (C) component, (D) component, (E) component (when mix | blending (E) component) and purified water are mixed uniformly at normal temperature using a paddle type stirrer. While continuing stirring, the component (B) is slowly added thereto and uniformly dispersed. Subsequently, the aqueous solution of (C) component is added gradually and adjusted to pH 5.5-8.0.

The gel resin sterilizing agent of the present invention is used by applying an appropriate amount (for example, about 1 g) to a hand and rubbing it over the entire resin until it dries. Since the gel resin sterilizing agent of the present invention has an excellent bactericidal effect, it is possible to sterilize food poisoning causative bacteria such as Escherichia coli and Staphylococcus aureus, and viruses such as influenza, and is effective for such prevention.

By mix | blending (D) oligosaccharide of this invention, since it has the outstanding moisturizing effect, rough skin improvement effect, and itching suppression effect, it can be used also as a moisturizer, rough skin improver, and an itch inhibitor. In addition, the moisturizing effect is "each layer moisture support effect", the rough skin improvement effect is the "each layer moisture content support effect, transdermal water evaporation inhibitory effect" of the Example mentioned later, and the itching inhibitory effect by the "pruritic action inhibitory effect" You can check it.

(Example)

Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not limited to the following Example. In addition, in the following example, when there is no specific description, "%" of a composition shows the mass%.

[Examples 1 to 23 and Comparative Examples 1 to 8]

 The alcohol of (A) component, (D) component (or glycerin), (E) component (when mix | blended) and purified water were mixed uniformly at normal temperature using the paddle type stirrer. While continuing stirring, the component (B) was slowly added thereto and uniformly dispersed. Next, the aqueous solution of (C) component (or the triethanolamine of a comparative example) was added gradually, pH was adjusted to the range described in the table, and the composition of the composition shown in following Tables 1-4 was obtained. About the obtained composition (sample), pH and a viscosity were measured by the following method, and the following evaluation was performed. The results are written together in the table.

[pH]

The pH was measured at 25 degreeC of the sample stock solution using the pH meter (made by Dong-A radio wave).

[Viscosity]

The viscosity was measured at a rotation speed of 12 rpm for 1 minute using a No. 4 rotor for a BL-type viscometer (manufactured by a Tokyo-based machine).

[Exterior]

A 45 mlL sample was filled in a hard transparent glass bottle (50 mlL), the external appearance was observed at 25 degreeC, and the following judgment criteria were shown.

<Criteria>

◎: Transparent, uniform state

○: The state that is uniform by haze

×: Sediment is generated or separated

[No dropping down]

50 g of the sample is filled into an 80 ml volume tube (8 mm inside diameter of the inlet of the tube), and the cap is removed, and the tube is tilted from the horizontal state, the tube inlet is lowered, and the tube is not dropped from the container when it is upright. Is shown by the following criteria.

<Criteria>

(Double-circle): A sample does not flow even if a tube is shaken vertically once.

○: The sample does not flow when the tube is upright, but the sample flows when the tube is shaken vertically once.

(Triangle | delta): A sample flows when the tube is tilted 45 degrees below horizontally.

X: A sample flows until it tilts a tube to 45 degree | times from horizontal.

[Degree of expansion]

1 g of a sample at 25 ° C. was taken under a 25 ° C. environment, and ease of spreading to the entire resin was evaluated. The result was sensory evaluation of 5 professional panels, and the following criteria were shown based on the average value of the rating.

<grade>

Five points: It is easy to open up considerably

Four points: It is easy to spread

Three points: Slightly easy to spread

2 points: It is hard to spread

One point: It is hard to spread considerably

<Criteria>

◎: It is less than 5.0 points more than 4.5 points

◎-○: 4.0 points or more and less than 4.5 points

○: It is less than 4.0 points more than 3.0 points

△: It is less than 3.0 points more than 2.0 points

×: Less than 2.0 points

[Fastness of drying]

1 g of a sample at 25 ° C. was placed on the hand under an environment of 25 ° C., and the time until the liquid dries while rubbing on the palm and the back of the hand was measured. The result was measured about five specialized panels and was shown by the following criteria based on the average value of the time.

<Criteria>

◎: Less than 30 seconds

○: It is less than 60 seconds more than 30 seconds

△: It is less than 90 seconds more than 60 seconds

× ： 90 seconds or more

[Moist feeling after drying]

1 g of a sample at 25 ° C. was placed on the hand under a 25 ° C. environment, rubbed into the palms and the back of the hand, and the moisture feeling of the hand was evaluated after the liquid dries. The result was sensory evaluation of five professional panels, and the following criteria were shown based on the average value of the rating.

<grade>

5 points: Quite moist

Four points: Moist

3 points: Almost moist

2 points: Slightly moist

1 point: It is not moist

<Criteria>

◎: It is less than 5.0 points more than 4.5 points

◎-○: 4.0 points or more and less than 4.5 points

○: It is less than 4.0 points more than 3.0 points

△: It is less than 3.0 points more than 2.0 points

×: Less than 2.0 points

[No stickiness after drying]

1 g of a sample at 25 ° C. was placed on the hand under a 25 ° C. environment, rubbed into the palms and the back of the hand, and the degree to which the hand was not sticky after the liquid was dried was evaluated. The result was sensory evaluation of five professional panels, and the following criteria were shown based on the average value of the rating.

<grade>

Five points: I do not feel stickiness

Four points: I feel some stickiness (I hardly feel it)

Three points: I feel a little sticky

2 points: I feel stickiness

One point: I feel sticky quite

<Criteria>

◎: 4.5 or more and 5.0 or less

◎-○: 4.0 points or more and less than 4.5 points

○: It is less than 4.0 points more than 3.0 points

△: It is less than 3.0 points more than 2.0 points

×: Less than 2.0 points

[Evaluation of Skin Irritation]

20 microliters of the sample was dripped at the filter paper (7.5 mm diameter) in a fin chamber (Daisho Pharmaceutical Co., Ltd.), and it attached to the back part (integrity part) of five adult men who feel that they are sensitive skin. The patch was removed 48 hours after adhesion, and evaluation was performed in accordance with the following <Decision Criteria: Tawara Kawamura, Japanese Skin Society, 80, 301, 1970> shown below after 24 hours. The results are expressed as the mean score of five people.

<Criteria>

0: no reaction

1: light erythema

2: erythema

3: erythema + edema

4: erythema + edema + papules, serous papules, small blisters

5: large blisters

The raw material used in the said table | surface is shown below.

* 1: Carbopol ETD2020 (ruburizole)

* 2: Carbopol 980 (Ruburisol)

* 3: Tetorab H (Hayashibara Institute of Biochemistry)

* 4: Raffinose (Japanese Beet Sugar)

* 5: Torreharoose (Hayashibara Institute of Biochemistry)

* 6: SH245 Fluid (Dore Dow Corning)

* 7: DC246 Fluid (Dore Dow Corning)

In addition, the quantity in a table | surface shows the quantity (purity) of the described component.

Test Example 1: bactericidal effect

In addition, since the composition of this invention has 50-80 mass% of alcohols of 1-3 carbon atoms, since it has a bactericidal effect, the bactericidal effect of the composition of Example 1 was evaluated by the following method.

Sample inoculum of Escherichia coli or Staphylococcus aureus in 9mL (bacterial count: 10 ⁶ to 10 ⁸ / mL) to a 1mL was added, and mixed with the test solution and allowed to act at 25 ℃ 30 seconds. After 30 seconds, after diluting 10 times by adding SCDLP liquid medium (manufactured by Nippon Pharmaceutical Co., Ltd.), the viable cell count in the test solution was measured by mixed plate culture method using SCDLP agar medium (manufactured by Nippon Pharmaceutical Co., Ltd.). As a result, after 30 seconds of action time, the bactericidal effect of E. coli and Staphylococcus aureus was less than the detection limit (<10 / mL), and the bactericidal effect was confirmed. Similarly, the bactericidal effect was confirmed in other examples.

[Test Example 2: effect of maintaining the moisture content of each layer, Test Example 3: inhibitory effect of transdermal water transpiration, Test Example 4: inhibiting yang behavior behavior]

(Preliminary breeding method)

As a test animal, female 10-week-old female mouse (HOS: HR-1, Japan SL Co., Ltd.) was purchased, and 12 animals per group were used as a test subject. SPF (Specific Pathogen Free) in which the subject had a temperature of 23 ± 1 ° C., a humidity of 60 ± 10%, and a contrast cycle of (7:00 to 19:00 (bright)-> 19:00 to 7:00 (dark)). : Aseptic special environment), preliminary breeding was conducted for one week with free intake of feed (manufactured by Nippon Agricultural Co., Ltd., trade name "HRAD") and water. In addition, the feed is to be used as a feed causing the behavior.

After completion of the preliminary breeding, anesthetize both feet of the subject using Somunopentyl (Public Pharmaceutical Co., Ltd.), and insert a piece of magnet (diameter 1 mm, length 3 mm, manufactured by NeuroScience Inc.) under the skin of both feet. Provided in.

After the preliminary breeding, the number of cultivation was measured by the following method before the start of sample application. Then, the sample was apply | coated to the back part once a day and 70 ml / time for 6 weeks continuously. After 4 and 6 weeks of sample application, the number of samples was measured, and 6 weeks after the sample application, the surface conductance and the amount of transdermal water evaporation (TEWL) were measured.

[Subsurface Conductance (Effect of Maintaining Water Content in Each Layer)]

As an indicator of the moisturizing effect, the moisture content of each layer was measured by the surface conductance measurement correlated with the moisture content of each layer by comparing Comparative Example 1 with respect to the compositions of Example 1 and Comparative Example 8 by the following method. The target conductance was measured using a commercially available device (Skicon-200: manufactured by I.P. S), and the moisture content retention rate (%) of each layer was determined by the following formula. The results are shown in Table 5. In Example 1, a remarkable effect of maintaining the moisture content of each layer was confirmed.

Moisture content retention rate (%) of each layer = (the surface conductance of Example 1 or the comparative example 8 / surface conductance of the comparative example 1) * 100

Moisture content retention rate of each layer (%) Example 1 275 Comparative Example 1 100 Comparative Example 8 213

[Termal moisture evaporation (TEWL) (inhibitory effect of transdermal water evaporation)]

As an indicator of the rough skin recovery effect, Comparative Example 1 was compared with respect to the compositions of Example 1 and Comparative Example 8 by the following method, and the amount of transdermal water evaporation (TEWL) correlated with the skin barrier function was measured. Percutaneous water evaporation inhibition rate (%) was calculated | required. The results are shown in Table 6. In Example 1, the effect of inhibiting transdermal water transpiration was confirmed.

Percutaneous moisture evaporation inhibition rate (%) = (transdermal moisture evaporation amount of Comparative Example 1-transdermal water evaporation amount of Example 1 or Comparative Example 8) / expense water evaporation amount of Comparative Example 1) × 100

Percutaneous water evaporation inhibition rate (%) Example 1 36 Comparative Example 1 - Comparative Example 8 17

 [Suppressive behavior inhibitory effect]

As an index of the itch inhibitory effect, the number of times of prism, which is a practicable action, of the compositions of Example 1, Comparative Example 1 and Comparative Example 8 was measured. Cultivation behavior was automatically measured for one period of cultivation using a MicroAct device (Nurocyens). Table 7 shows the results of the percent reduction in the amount of litter recovery by the following formula. In Example 1, a significant anti-itch effect was confirmed.

Retention rate reduction rate (%) = (the number of the number of the cultivation after the start of application / number of the total number of the cultivation before application of the start) * 100

Reduction rate of cultivation (%) After 4 weeks After 6 weeks Example 1 75 72 Comparative Example 1 110 92 Comparative Example 8 98 110

Example 24

According to the following composition, the gel resin sterilizer was prepared by a conventional method.

Furtherance %

Ethanol 60

Acrylets / Alkyl acrylate (C10-30) cross polymer * 1 0.3

Amount adjusted to 2-amino-2-methyl-1-propanol pH6.5

Maltotetraos * 2 1.0

Benzalkonium chloride (50% aqueous solution) * 3 0.1

Polyethylene powder (average particle size 100㎛) 0.3

Spices 0.1

Purified water Remainder

100.0 total

* 1 Carbopol EDT2020 (Luprisol)

* 2 Tetorab H (Hayashibara Institute of Biochemistry)

* 3 Nissan Kacion F2-50E (Japan)

[Example 25]

According to the following composition, a gelled resin fungicide was prepared by a conventional method.

Furtherance %

Ethanol 60

Acrylets / Alkyl acrylate (C10-30) cross polymer * 1 0.3

Amount adjusted to 2-amino-2-methyl-1-propanol pH6.5

Maltotetraos * 2 1.0

Benzalkonium chloride (50% aqueous solution) * 3 0.1

Decamethylcyclopentasiloxane / Cyclo Hexasiloxane Mixture * 4 0.5

Polyethylene powder (average particle size 100㎛) 0.3

Spices 0.1

Purified water Remainder

100.0 total

* 1 Carbopol EDT2020 (Luprisol)

* 2 Tetorab H (Hayashibara Institute of Biochemistry)

* 3 Nissan Kacion F2-50E (Japan)

* 4 DSC345 Fluid (Dore Dow Corning): 60% or more of cyclohexahexanic acid

Claims (6)

(A) 50 to 80 mass% of alcohol having 1 to 3 carbon atoms,
(B) 0.1-1.0 mass% of carboxy vinyl polymer and / or acrylic acid methacrylate alkyl copolymer,
(C) alkanol amines and
(D) a gel-like resin sterilizing agent containing oligosaccharides, and having a pH (25 ° C) of 5.5 to 9.0, The method of claim 1,
(D) the component is a malto oligosaccharide, a gel resin sterilizing agent, 3. The method according to claim 1 or 2,
(E) a gel-type resin sterilizer which further contains cyclic silicone, The germicide of any one of Claims 1-3 is a moisturizing agent, The gel resin sterilizer characterized by the above-mentioned, Gel-type resin fungicide, characterized in that the fungicide according to any one of claims 1 to 3 is a rough skin improver, The gelling resin fungicide according to any one of claims 1 to 3, which is an anti-itch agent.