JP2023120388A - external composition - Google Patents

Abstract

To provide a preparation technique for an external composition, where the external composition contains a phosphocholine group-containing polymer and hydroxypropyl methylcellulose, prevents the occurrence of floating material and precipitate, and has a good appearance.SOLUTION: An external composition contains a phosphocholine group-containing polymer and hydroxypropyl methylcellulose, with a heparin analog. The external composition prevents the occurrence of floating material and precipitate during its storage, and has a good appearance.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to a composition for external use that contains a phosphocholine group-containing polymer and hydroxypropylmethyl cellulose, yet is capable of suppressing the generation of floating matter and sediment, and has excellent appearance properties.

Conventionally, phosphocholine group-containing polymers such as 2-methacryloyloxyethylphosphorylcholine and butyl methacrylate copolymer penetrate the stratum corneum, prevent evaporation of moisture, support the skin barrier function, and protect against various stimuli. It is known to have the effect of protecting the skin from toxins, and is attracting attention as a compounding ingredient of external compositions. Therefore, various studies have been made on the formulation of an external composition containing a phosphocholine group-containing polymer. For example, in Patent Document 1, a skin care composition containing a phosphocholine group-containing polymer having a specific average molecular weight and a specific structure, and polyethylene glycol and/or polyoxyethylene methyl glucoside having a specific average molecular weight is applied to the skin. It has been reported that it has excellent slipperiness when applied and has a good feeling in use.

In addition, it is known that when hydroxypropylmethylcellulose is blended into a composition for external use, properties such as viscosity and retention on the skin are improved.

In recent years, the demand for the feel of use and functionality of topical compositions has been increasing, and if we can provide topical compositions that combine the action of a phosphocholine group-containing polymer and the action of hydroxypropylmethyl cellulose, we will increase consumer satisfaction with skin care. expected to increase.

On the other hand, in order to put a composition for external use into practical use, it is necessary to give sufficient consideration not only to its functionality but also to its excellent appearance. At present, the external appearance properties of compositions for external use containing are not sufficiently studied.

Japanese Unexamined Patent Application Publication No. 2010-43018

The inventors of the present invention conducted studies to put a composition for external use containing a phosphocholine group-containing polymer and hydroxypropylmethylcellulose into practical use. In addition, we faced a new problem that cloudiness and precipitation due to floating matter occurred, and it was not possible to provide appearance properties that could withstand practical use.

Accordingly, an object of the present invention is to provide a formulation technology capable of suppressing the generation of suspended solids and precipitates and providing excellent appearance properties in an external composition containing a phosphocholine group-containing polymer and hydroxypropylmethylcellulose. .

The present inventors conducted intensive studies to solve the above-mentioned problems, and found that an external composition containing a heparin-like substance together with a phosphocholine group-containing polymer and hydroxypropylmethyl cellulose produced suspended solids and sediments even after storage. It was found that the occurrence of can be suppressed and excellent appearance properties can be provided.

That is, the present invention provides inventions in the following aspects.
Section 1. A composition for external use comprising (A) a phosphocholine group-containing polymer, (B) hydroxypropylmethylcellulose, and (C) a heparinoid.
Section 2. Item 2. The composition for external use according to Item 1, wherein the (A) phosphocholine group-containing polymer is a 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer.
Item 3. Item 3. The composition for external use according to Item 1 or 2, containing 0.01 to 5% by weight of (C) the heparinoid.
Section 4. Item 4. The composition for external use according to any one of Items 1 to 3, further comprising (D) a polyhydric alcohol.
Item 5. A method for suppressing the generation of floating matter and/or sediment in an external composition containing a phosphocholine group-containing polymer and hydroxypropylmethylcellulose,
(A) a phosphocholine group-containing polymer and (B) hydroxypropylmethylcellulose, and (C) a heparin analogue are blended into the composition for external use;
A method for suppressing the generation of floating matter and/or sediments of the composition for external use.

The composition for external use of the present invention can suppress the generation of floating matter and sediment, and can have excellent appearance properties, even though it contains a phosphocholine group-containing polymer and hydroxypropylmethylcellulose.

1. Composition for external use The composition for external use of the present invention comprises a phosphocholine group-containing polymer (sometimes referred to as component (A)), hydroxypropylmethylcellulose (sometimes referred to as component (B)), and a heparin analogue ( (C) It is characterized by containing component. The composition for external use of the present invention is described in detail below.

(A) Phosphocholine group-containing polymer A phosphocholine group-containing polymer is a polymer obtained by polymerizing a monomer containing a phosphocholine group (hereinafter sometimes referred to as "phosphocholine group-containing monomer"), and has a moisturizing effect. , is a known component having a barrier function for the stratum corneum.

In the phosphocholine group-containing polymer used in the present invention, the type of the phosphocholine group-containing monomer is not particularly limited, but examples thereof include monomers having a phosphocholine group and a vinyl group. More specific examples of the phosphocholine group-containing monomer include 2-methacryloyloxyethylphosphorylcholine, 2-methacryloyloxyethylphosphorylethanolamine, and the like. In the phosphocholine group-containing polymer, the phosphocholine group-containing monomer may be contained singly or in combination of two or more. Among these phosphocholine group-containing monomers, 2-methacryloyloxyethylphosphorylcholine is preferred from the viewpoint of more effectively suppressing the generation of suspended solids and precipitates.

The phosphocholine group-containing polymer used in the present invention may be a homopolymer consisting of one type of phosphocholine group-containing monomer, or a copolymer consisting of two or more types of monomers. good.

When the phosphocholine group-containing polymer is a copolymer, it may be a copolymer composed of two or more phosphocholine group-containing monomers, or at least one phosphocholine group-containing monomer and at least one A copolymer composed of a monomer other than the phosphocholine group-containing monomer may also be used.

Regarding the type of monomer other than the phosphocholine group-containing monomer contained in the phosphocholine group-containing polymer, it is particularly limited to being pharmaceutically acceptable and capable of being radically polymerized with the phosphocholine group-containing monomer. Examples include, but are not limited to, monomers having a vinyl group. Specific examples of monomers other than the phosphocholine group-containing monomer include methyl (meth) acrylate, ethyl (meth) acrylate, butyl (meth) acrylate, lauryl (meth) acrylate, stearyl (meth) acrylate, 2- Alkyl (meth)acrylates such as ethylhexyl (meth)acrylate; benzyl (meth)acrylate, phenoxyethyl (meth)acrylate, cyclohexyl (meth)acrylate, polypropylene glycol mono(meth)acrylate, polytetramethylene glycol mono(meth)acrylate, polypropylene glycol di(meth)acrylate, polytetramethylene glycol mono(meth)acrylate, polypropylene glycol polyethylene glycol mono(meth)acrylate, sodium methacrylate, 2-hydroxy-3-methacryloyloxypropyltrimethylammonium and the like. In the phosphocholine group-containing polymer, monomers other than the phosphocholine group-containing monomer may be contained singly or in combination of two or more. Among the monomers other than these phosphocholine group-containing monomers, alkyl (meth)acrylates and 2-hydroxy-3-methacryloyl are preferred from the viewpoint of more effectively suppressing the generation of suspended solids and precipitates. Oxypropyltrimethylammonium, more preferably alkyl (meth)acrylate having 1 to 18 carbon atoms in the alkyl group, more preferably alkyl (meth)acrylate having 3 to 5 carbon atoms in the alkyl group, particularly preferably butyl (meth) Acrylates are mentioned. In addition, in this specification, "(meth)acrylate" shows a methacrylate and/or an acrylate.

Specific examples of the phosphocholine group-containing polymer used in the present invention include polymethacryloyloxyethylphosphorylcholine homopolymer, 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer (polyquaternium-51), 2-methacryloyloxy Ethylene Phosphorylcholine/Butyl Methacrylate/Sodium Methacrylate Copolymer (Polyquaternium-65), 2-Methacryloyloxyethyl Phosphorylcholine/2-Hydroxy-3-Methacryloyloxypropyltrimethylammonium Copolymer (Polyquaternium-64), 2-Methacryloyloxy ethylphosphorylcholine/stearyl methacrylate copolymer (polyquaternium-61); Incidentally, in the above notation regarding the phosphocholine group-containing polymer, the name in parentheses indicates the display name of the cosmetic component.

In the composition for external use of the present invention, the phosphocholine group-containing polymer may be used singly or in combination of two or more.

Among these phosphocholine group-containing polymers, 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer and polymethacryloyloxyethyl are preferred from the viewpoint of more effectively suppressing the generation of suspended solids and precipitates. phosphorylcholine homopolymer, 2-methacryloyloxyethyl phosphorylcholine/2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer; more preferably 2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer, 2-methacryloyloxyethyl phosphorylcholine/2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer; particularly preferred is 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer.

In the composition for external use of the present invention, the content of the component (A) is not particularly limited, and may be appropriately set according to the action to be imparted. . From the viewpoint of more effectively suppressing the generation of suspended solids and sediments, the content of component (A) is preferably 0.05 to 0.5% by weight, more preferably 0.1 to 0.3%. % by weight.

(B) Hydroxypropylmethylcellulose Hydroxypropylmethylcellulose is a cellulose derivative and a compound also called hypromellose.

The substitution degree type of hydroxypropylmethylcellulose used in the present invention is not particularly limited, and may be any of 1828, 2208, 2906, and 2910, from the viewpoint of more effectively suppressing phase separation. , preferably of the 2208, 2906 and 2910 degree of substitution types.

The viscosity of the hydroxypropylmethyl cellulose used in the present invention is not particularly limited. mentioned. Here, the viscosity is measured using a rotor: M3 (rotation speed: 20 rpm, time: 1 min, unit: mPa s) in a B-type viscometer "TOKI SANGYO VISCOMETER TVB-10" (manufactured by Toki Sangyo Co., Ltd.). It is the value measured by

A commercially available hydroxypropylmethylcellulose can be used in the composition for external use of the present invention. Specific examples of commercial products of hydroxypropyl methylcellulose include Shin-Etsu Chemical Co., Ltd. "Metolose 90SH-100SR", "Metolose 90SH-4000SR", "Metolose 90SH-15000SR", "Metolose 90SH-100000SR", "Metolose 90SH-100000SR", METOLOSE 65SH-50", "METOLOSE 65SH-400", "METOLOSE 65SH-1500", "METOLOSE 65SH-4000", "METOLOSE 60SH-50", "METOLOSE 60SH-4000", "METOLOSE 60SH-10000", "METOLOSE TC-5E, METOLOSE 90SH-100SR, METOLOSE 90SH-4000SR, METOLOSE 90SH-15000SR, METOLOSE 90SH-100000SR, METOLOSE TC-5M, METOLOSE TC-5R, METOLOSE TC -5S", "Methocel SB-4"; "Methocel E4M", "Methocel E4M", "Methocel 40-100", "Methocel 40-101", "Methocel 40-202" manufactured by Dow Chemical Japan; "Marporose 60MP-4000" manufactured by Matsumoto Yushi Seiyaku Co., Ltd., and the like.

In the composition for external use of the present invention, hydroxypropylmethylcellulose may be used singly or in combination of two or more.

In the composition for external use of the present invention, the content of the component (B) is not particularly limited, and may be appropriately set according to the viscosity to be imparted to the composition for external use and the feeling of use. ~5% by weight. From the viewpoint of more effectively suppressing the generation of suspended solids and sediments, the content of component (B) is preferably 0.1 to 3% by weight, more preferably 0.3 to 2% by weight, particularly 0.3 to 1% by weight is preferred.

In the composition for external use of the present invention, the ratio of component (B) to component (A) is determined according to the respective contents of component (A) and component (B). 50 to 3,000 parts by weight of the component (B) may be used per unit. The ratio of component (B) to component (A) is preferably 100 parts by weight of component (B) per 100 parts by weight of component (A) from the viewpoint of more effectively suppressing the generation of suspended solids and sediments. Up to 2500 parts by weight, more preferably 300 to 2000 parts by weight.

(C) Heparin-like substances Heparin-like substances are polysulfated mucopolysaccharides such as chondroitin polysulfate, and are known drugs known to have moisturizing, anti-inflammatory, and blood circulation promoting effects. In the composition for external use of the present invention, by containing a heparin analogous substance, it is possible to suppress the generation of floating matter and sediment that occur in the coexistence of the phosphocholine group-containing polymer and hydroxypropylmethyl cellulose, and to have excellent appearance properties. It has become.

The origin of the heparin-like substance used in the present invention is not particularly limited, but examples include those obtained by polysulfating mucopolysaccharides, tissues of edible animals (e.g., tracheal cartilage of bovine, porcine, etc.). (including lungs), and the like. In the composition for external use of the present invention, as the heparinoid substance, a heparinoid substance included in the Japanese Pharmaceutical Standards outside the Pharmacopoeia is preferably used.

The content of component (C) in the topical composition of the present invention is not particularly limited, but may be, for example, 0.01 to 5% by weight. From the viewpoint of more effectively suppressing the generation of suspended solids and sediments, the content of component (C) is preferably 0.05 to 3% by weight, more preferably 0.1 to 1% by weight, and particularly 0.3 to 1% by weight is preferred.

In the composition for external use of the present invention, the ratio of component (C) to component (A) is determined according to the respective contents of component (A) and component (B). 100 to 2,000 parts by weight of component (C) per unit. The ratio of component (C) to component (A) is preferably 200 parts by weight per 100 parts by weight of component (A) from the viewpoint of more effectively suppressing the generation of suspended solids and sediments. Up to 1500 parts by weight, more preferably 300 to 1000 parts by weight.

(D) Polyhydric alcohol The composition for external use of the present invention contains a polyhydric alcohol (sometimes referred to as (D)) in addition to the above components (A) to (C). may By containing a polyhydric alcohol, excellent appearance properties can be provided more effectively, and the moisturizing action of the component (A) can be enhanced.

Polyhydric alcohols are not particularly limited as long as they are pharmaceutically or cosmetically acceptable. Examples include 1,3-butylene glycol, ethylene glycol, propylene glycol, isoprene glycol, diethylene glycol, dipropylene glycol, polyethylene glycol, glycerin, and the like. Among these polyhydric alcohols, 1,3-butylene glycol and propylene glycol are preferred.

These polyhydric alcohols may be used singly or in combination of two or more.

When the composition for external use of the present invention contains component (D), the content thereof may be appropriately set according to the type of polyhydric alcohol used. to 20% by weight, more preferably 3 to 20% by weight.

Water The topical composition of the present invention is prepared as an aqueous composition containing water. In the composition for external use of the present invention, the content of water may be appropriately set according to the form of the formulation, and is, for example, 5 to 95% by weight, preferably 5 to 90% by weight, more preferably 10 to 90% by weight. is mentioned.

Other Ingredients The composition for external use of the present invention may contain other pharmacological ingredients in addition to the ingredients described above, if necessary. Such pharmacological ingredients include, for example, antihistamines (diphenhydramine, diphenhydramine hydrochloride, etc.), local anesthetics (procaine, tetracaine, bupipacaine, mepipacaine, chloroprocaine, proparacaine, meprilcaine or salts thereof, orthocaine, oxethazein, oxypolyethoxylate). Decane, Rohto extract, percamimpase, tecit decithin, etc.), anti-inflammatory agents (dipotassium glycyrrhizinate, glycyrrhetinic acid, indomethacin, felbinac, diclofenac sodium, loxoprofen sodium, etc.), skin protective agents (collodion, castor oil, etc.), blood circulation promoting ingredients ( nonylic acid vanillylamide, benzyl nicotinate, capsaicin, red pepper extract, etc.), cooling agents (menthol, camphor, etc.), vitamins (vitamin A, etc.), mucopolysaccharides (sodium chondroitin sulfate, glucosamine, etc.).

In addition, the composition for external use of the present invention may, if necessary, contain base materials and additives other than the components described above in order to obtain a desired formulation form. Such bases and additives are not particularly limited as long as they are pharmaceutically acceptable. , cottonseed oil, peanut oil, lard, squalane, fish oil, etc.), mineral oil (liquid paraffin, paraffin, gelling hydrocarbon, petrolatum, etc.), waxes and waxes (beeswax, carnauba wax, candelilla wax, ceresin, rice wax, microcrystalline wax, etc.), ester oils (isopropyl myristate, isopropyl adipate, diethyl sebacate, isopropyl sebacate, isopropyl palmitate, cetyl palmitate, ethyl oleate, etc.), fatty acid alkyl esters, fatty acids (stearic acid, oleic acid) , palmitic acid, behenic acid, linoleic acid, lanolin, etc.), fatty acid esters (cetyl palmitate, isopropyl palmitate, ethyl linoleate, etc.), lower alcohols (ethanol, propanol, isopropanol, butanol, isobutanol, etc.), higher alcohols ( stearyl alcohol, cetanol, behenyl alcohol, myristyl alcohol, oleyl alcohol, hexadecyl alcohol, lanolin alcohol, etc.), cholesterol, glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, silicone oil (dimethylpolysiloxane, cyclic silicone, etc.) Oil base such as POE (10-50 mol) phytosterol ether, POE (10-50 mol) dihydrocholesterol ether, POE (10-50 mol) 2-octyldodecyl ether, POE (10-50 mol) decyltetradecyl Ether, POE (10-50 mol) oleyl ether, POE (2-50 mol) cetyl ether, POE (5-50 mol) behenyl ether, POE (5-30 mol) polyoxypropylene (5-30 mol) 2- Polyoxyethylene alkyl ethers such as decyltetradecyl ether, POE (10-50 mol) polyoxypropylene (2-30 mol) cetyl ether, their phosphoric acid/phosphate (POE cetyl ether sodium phosphate, etc.), POE (20-60 mol) sorbitan monooleate, POE (10-60 mol) sorbitan monoisostearate, POE (10-80 mol) glyceryl monoisostearate, POE (10-30 mol) glyceryl monostearate, POE ( 20 to 100 mol)-polyoxypropylene-modified silicone, POE-alkyl-modified silicone, polyethylene glycol monolaurate, polyethylene glycol monopalmitate, polyethylene glycol monostearate, polyethylene glycol dilaurate, polyethylene glycol dipalmitate, polyethylene glycol distearate , polyethylene glycol dioleate, polyethylene glycol diricinoleate, polyoxyethylene hydrogenated castor oil (5-100), polysorbate (20-85), glycerin fatty acid ester (glyceryl monostearate, etc.), hydrogenated soybean phospholipid, hydrogenation Surfactants such as lanolin alcohol; cooling agents (menthol, camphor, borneol, peppermint water, peppermint oil, etc.), preservatives (methylparaben, propylparaben, benzoic acid, sodium benzoate, sorbic acid, etc.), flavoring agents ( citral, 1,8-cioneal, citronellal, farnesol, etc.), coloring agents (tar pigments (brown No. 201, blue No. 201, yellow No. 4, yellow No. 403, etc.), cacao pigments, chlorophyll, aluminum oxide, etc.), viscous Agents (carboxyvinyl polymer, polyvinylpyrrolidone, sodium alginate, ethylcellulose, sodium carboxymethylcellulose, xanthan gum, carrageenan, etc.), pH adjusters (phosphoric acid, hydrochloric acid, citric acid, sodium citrate, succinic acid, tartaric acid, sodium hydroxide, water potassium oxide, triethanolamine, triisopropanolamine, etc.), wetting agents (sodium dl-pyrrolidonecarboxylate solution, D-sorbitol solution, macrogol, etc.), stabilizers (dibutylhydroxytoluene, butylhydroxyanisole, sodium edetate, sodium metaphosphate, L-arginine, L-aspartic acid, DL-alanine, glycine, sodium erythorbate, propyl gallate, sodium sulfite, sulfur dioxide, chlorogenic acid, catechin, rosemary extract, etc.), antioxidants, ultraviolet rays Additives such as absorbents, chelating agents, adhesives, buffers, solubilizers, solubilizers, and preservatives are included.

pH
The pH of the composition for external use of the present invention is not particularly limited, and may be appropriately set in consideration of skin irritation and the like.

Formulation Form The form of the preventive or therapeutic agent of the present invention is not particularly limited as long as it is a dosage form that can be applied transdermally, and may be liquid or semi-solid (gel, paste). good.

The composition for external use of the present invention may be in any formulation form, such as an external skin drug (including quasi-drugs), a cosmetic, or a skin cleanser, as long as it is applied to the skin. Specific formulations of the external composition of the present invention include gels, creams, lotions, milky lotions, liquids, patches, aerosols, ointments, skin external medicines such as packs; gels and creams. , cosmetics such as milky lotions, lotions, lotions and packs; skin cleansers such as body shampoos, hair shampoos and rinses. Among these formulation forms, skin preparations for external use are preferred, and gels, lotions, and liquids are more preferred.

The composition for external use of the present invention can exhibit moisturizing action, stratum corneum barrier function, etc. based on the component (A) it contains, and can exhibit moisturizing action, anti-inflammatory action, blood circulation promoting action, etc. based on the component (C) it further contains. Therefore, it is preferably used for purposes such as moisturizing, improving rough skin, preventing or treating dry skin diseases, and preventing or treating inflammatory skin diseases.

2. A method for suppressing the generation of suspended solids and/or precipitates in a composition for external use The present invention further provides suspended solids and/or precipitates in a composition for external use containing (A) a phosphocholine group-containing polymer and (B) hydroxypropylmethylcellulose. A method for suppressing the generation of suspended solids and/or sediments in the composition for external use, which comprises blending (C) a heparin-like substance in the composition for external use. .

In the method, the type and content of (A) to (C) used, the type and content of other ingredients to be blended, the form of formulation of the composition for external use, etc. are as described in "1. Composition for external use" above. It is the same as the case.

EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these.
Test example
1. Preparation of composition for external use A gel composition for external use having the composition shown in Table 1 was prepared. Specifically, a predetermined amount of hydroxypropylmethylcellulose, a heparin-like substance, and propylene glycol are added to purified water, uniformly dispersed and dissolved, and then a predetermined amount of 2-methacryloyloxyethylphosphocholine/butyl methacrylate is added. A gel composition for external use was obtained by adding and mixing the polymer.

2. Evaluation of Appearance Properties The appearance of each external composition obtained immediately after production was visually confirmed to evaluate the appearance properties. In addition, after storing each of the obtained compositions for external use at 20° C. under light-shielding conditions for 1 hour, the external appearance was visually observed to evaluate the appearance properties. Appearance properties were evaluated according to the following criteria.
<Evaluation Criteria for Appearance Properties>
(Suppression of precipitation)
A: No precipitate was observed immediately after preparation and after storage.
◯: A slight precipitate was generated immediately after preparation, but the precipitate disappeared after storage.
Δ: A slight precipitate was generated immediately after preparation, and the precipitate remained as it was even after storage.
x: Significant precipitates were generated immediately after preparation, and the precipitates remained as they were even after storage.
(Suppression of floating matter)
⊚: Immediately after preparation and after storage, no suspended matter was observed, and cloudiness was not observed at all.
◯: Immediately after preparation, a slight amount of suspended matter was generated and a slight cloudiness was observed, but after storage, the suspended matter disappeared and no cloudiness was observed.
Δ: Immediately after preparation, a slight amount of suspended matter was generated and a slight cloudiness was observed, and even after storage, the suspended matter remained as it was and remained cloudy.
x: Immediately after preparation, significant cloudiness was observed due to the generation of significant floating matter.

3. Results Table 1 shows the results obtained. When hydroxypropylmethylcellulose was contained alone (Reference Example 1), no floating matter or precipitate occurred, but when 2-methacryloyloxyethylphosphocholine-butyl methacrylate copolymer and hydroxypropylmethylcellulose were used in combination, In (Comparative Examples 1 and 2), significant floating matter and sedimentation were observed. On the other hand, when the heparin analogue is contained together with the 2-methacryloyloxyethylphosphocholine/butyl methacrylate copolymer and hydroxypropyl methylcellulose (Examples 1 to 8), the generation of suspended solids and precipitates is sufficiently suppressed. It was ready.

Formulation Examples External compositions (liquid formulations) shown in Table 2, external compositions (lotions) shown in Table 3, and external compositions (gels) shown in Table 4 were prepared. When the appearance properties of the obtained compositions for external use were evaluated in the same manner as in the above test examples, the generation of suspended matter and sedimentation could be sufficiently suppressed in all cases.

Claims (5)

A composition for external use comprising (A) a phosphocholine group-containing polymer, (B) hydroxypropylmethylcellulose, and (C) a heparinoid. 2. The composition for external use according to claim 1, wherein the (A) phosphocholine group-containing polymer is a 2-methacryloyloxyethylphosphorylcholine/butyl methacrylate copolymer. 3. The composition for external use according to claim 1, containing 0.01 to 5% by weight of (C) the heparinoid. 4. The composition for external use according to any one of claims 1 to 3, further comprising (D) a polyhydric alcohol. A method for suppressing the generation of floating matter and/or sediment in an external composition containing a phosphocholine group-containing polymer and hydroxypropylmethylcellulose,
(A) a phosphocholine group-containing polymer and (B) hydroxypropylmethylcellulose, and (C) a heparin analogue are blended into the composition for external use;
A method for suppressing the generation of floating matter and/or sediments of the composition for external use.