KR20150085807A - Transparent gel-like skin-sterilizing agent - Google Patents

Abstract

(A) a specific quaternary ammonium salt disinfectant, (B) N-coconut fatty acid acyl L-arginine ethyl DL-pyrrolidonecarboxylate, (C) a specific polyhydric alcohol, (D) Wherein the content of the component (B) is from 0.01 mass% to 0.3 mass%, the content of the component (D) is from 15 mass% to 35 mass%, the content of the component (A) (C + D) / (A + B)] between the total content of the components (C) and (D) is 100 to 400, Is a transparent, transparent gel-type skin-fungicide.

Description

[0001] TRANSPARENT GEL-LIKE SKIN-STERILIZING AGENT [0002]

The present invention relates to a transparent gel type skin fungicide.

Recently, as a method for disinfecting skin such as a finger easily, a gel fungicide has been used. Since such a gel fungicide has a broad sterilizing spectrum and has an effective effect, a quaternary ammonium salt fungicide represented by benzalkonium chloride is widely used. The sterilizing power of the quaternary ammonium salt bactericide is increased as the pH is higher, but since the skin irritation becomes stronger, it is necessary to make the quaternary ammonium salt sterilizing agent a neutral region having a pH of 8 or less.

In addition, as a feeling of use of the germicidal bactericide, it is required that it does not fall off when it is taken by hand and that spreading is good, and a thickening agent is mixed with this demand.

However, when the quaternary ammonium salt bactericide is used in combination with an anionic thickener such as a carboxyvinyl polymer, since the anion-cation complex is formed, white turbidity is formed to deteriorate the appearance and also significantly reduce the sterilizing power, There is a problem that it is damaged.

In addition, the gel type bactericide is required to have fast drying property as its characteristic. Ethanol is mixed with this requirement (see, for example, Patent Document 1). The ethanol has an action to inhibit the formation of the anion-cation complex, and also has the action of making the gel fungicide transparent.

Since ethanol has skin irritation, it is preferable to suppress the ethanolic content to less than 40% by mass for the purpose of suppressing skin irritation at the time of continuous use (continuous use), and this concentration is preferably such that the formation of the anion-cationic complex There is a problem that it can not be suppressed and made transparent.

Further, in the case of a gel fungicide in which the benzalkonium chloride, the ethanol, and the carboxyvinyl polymer are blended, if the pH is less than 8, ethanol becomes less than 40 mass%, cloudiness is further produced, There is a problem that it is largely deteriorated.

Therefore, there is a strong demand for a transparent gel-type skin fungicide having a clear appearance, less skin irritation, excellent sterilizing power, easy spreading, quick-drying property, and excellent feeling of use without stickiness after drying.

Japanese Patent Laid-Open Publication No. 2011-153089

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned conventional problems (problems) and to achieve the following objects. That is, the object of the present invention is to provide a transparent gel-type skin disinfectant having an excellent appearance that is transparent in appearance, less irritating to the skin, has an excellent disinfecting power, spreads easily, has quick drying property and is free from stickiness after drying do.

In order to solve the above problems, the inventors of the present invention have made extensive studies and obtained the following findings. That is, in the case of a transparent gel type skin fungicide containing quaternary ammonium salt disinfectant, carboxyvinyl polymer and 15 mass% to 35 mass% ethanol, a further specified amount of N-coconut oil fatty acid acyl L-arginine ethyl DL- Wherein the polyvalent alcohol and the ethanol are contained in an amount of 1 to 50% by weight based on the total amount of the polyhydric alcohol and the ethanol, and the content of the quaternary ammonium salt disinfecting agent and the N-coconut fatty acid acyl L-arginine ethyl DL-pyrrolidonecarboxylate It is possible to make the appearance transparent and to improve the sterilizing power while minimizing the skin irritation and also to make the skin easy to spread and quick drying and to be sticky after drying And that the present invention has been completed.

The present invention is based on the above finding by the inventors of the present invention. The transparent gel-type skin fungicide of the present invention as a means for solving the above-

(A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride,

(B) N-coconut fatty acid acyl L-arginine ethyl DL-pyrrolidonecarboxylate,

(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol,

(D) ethanol,

(E) a carboxyvinyl polymer

, And the content of the component (B) is from 0.01 mass% to 0.3 mass%, the content of the component (D) is from 15 mass% to 35 mass%, and the total amount of the component (A) (C + D) / (A + B)] between the content of the component (C) and the total content of the component (D) It is a disinfectant for shape skin.

According to the present invention, there is provided a cosmetic composition which solves the above-mentioned problems in the prior art, achieves the above objects, is transparent in appearance, has less skin irritation and excellent disinfecting power, is spreadable, has quick drying property, It is possible to provide a transparent gel-type skin-fungicide having an excellent feeling of use that is free from discoloration.

(Transparent gel type disinfectant for skin)

The transparent gel type skin fungicide of the present invention can be obtained by mixing a quaternary ammonium salt disinfectant (hereinafter may be referred to as "component (A)") and N-coconut oil fatty acid acyl L-arginine ethyl DL-pyrrolidonecarboxylate (Hereinafter may be referred to as "component (B)"), polyvalent alcohol (hereinafter, may be referred to as "component (C)") and ethanol ) And a carboxyvinyl polymer (hereinafter may be referred to as " component (E) "), and if necessary, contains other components.

<Component (A): Quaternary ammonium salt disinfectant>

The quaternary ammonium salt bactericide as the component (A) is at least one selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride. The component (A) is a component having a high sterilizing power against bacteria such as Escherichia coli.

Among them, benzalkonium chloride is preferable because it is excellent in sterilizing power, fast drying and no stickiness after drying.

The content of the component (A) in the above-mentioned transparent gel-type skin fungicide is preferably 0.01% by mass to 0.3% by mass, more preferably 0.02% by mass to 0.2% by mass. If the content of the component (A) is less than 0.01% by mass, the sterilizing power may be insufficient. If the content is more than 0.3% by mass, clouding may occur, the sterilizing power may become insufficient, Delayed drying, stickiness after drying, skin irritation, and the like.

<Component (B): N-coconut fatty acid acyl L-arginine ethyl DL-pyrrolidonecarboxylate>

The blending of the N-coconut fatty acid acyl L-arginine ethyl DL-pyrrolidonecarboxylate as the component (B) in the above-mentioned transparent gel type skin fungicide is advantageous in that the sterilizing power can be improved.

As the component (B), a commercially available product can be used. Specific examples of the commercially available products include trade names of CAE (registered trademark) (cocoyl arginine ether PCA, manufactured by Ajinomoto Healthcare Co., Ltd.) and the like.

The content of the component (B) in the above-mentioned transparent gel type skin fungicide is preferably from 0.01% by mass to 0.3% by mass, and more preferably from 0.05% by mass to 0.2% by mass, from the viewpoint of transparency and sterilizing power. If the content of the component (B) is less than 0.01% by mass, the sterilizing power may be insufficient. When the content of the component (B) exceeds 0.3% by mass, cloudiness may occur and the sterilizing power may become insufficient, And skin irritation may occur.

&Lt; Component (C): polyhydric alcohol >

The polyhydric alcohol as the component (C) is at least one selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol. The component (C) is advantageous in that the transparency of the above-mentioned transparent gel type skin fungicide can be improved.

Of these, hexylene glycol and 1,2-pentanediol are preferable because they are excellent in transparency and sterilizing power.

The content of the component (C) in the transparent gel-type skin fungicide is preferably 5% by mass to 15% by mass, and more preferably 8% by mass to 12% by mass, from the viewpoint of excellent transparency. If the content of the component (C) is less than 5% by mass, clouding may occur, the sterilizing power may become insufficient, and it may become difficult to spread. When the content exceeds 15% by mass, drying may be delayed, And the like.

&Lt; Component (D): Ethanol >

It is advantageous in that transparency, sterilizing power and quick drying can be improved by adding ethanol as the component (D) to the above-mentioned transparent gel type skin fungicide.

The content of the component (D) in the above-mentioned transparent gel-type skin fungicide is 15% by mass to 35% by mass and 20% by mass or less in view of transparency, sterilizing power, ease of spreading and quick drying, By mass to 30% by mass. When the content of the component (D) is less than 15% by mass, clouding occurs, the sterilizing power becomes insufficient, spreading becomes difficult, drying becomes delayed, and when it exceeds 35% by mass, And the skin becomes rough during continuous use.

&Lt; Component (E): Carboxyvinyl polymer >

By mixing the above-mentioned carboxyvinyl polymer as the component (E) with the above-mentioned transparent gel type skin fungicide, the transparent gel type skin fungicide can be given a thickening property, so that it can be prevented from flowing out from the skin, It is advantageous in that it can be improved.

The viscosity of the component (E) is not particularly limited and can be appropriately selected in accordance with the purpose. It is preferable that the viscosity of the component (E) is adjusted such that the aqueous solution containing 0.2 mass% of the component (E) is neutralized with sodium hydroxide, The viscosity at 20 占 폚 is preferably from 2,000 mPa 占 퐏 to 30,000 mPa 占 퐏, and more preferably from 3,000 mPa 占 퐏 to 14,000 mPa 占 퐏, in view of being excellent in transparency, fast drying and no stickiness after drying. s is more preferable. When the viscosity is less than 2,000 mPa s, the transparent gel-type skin fungicide may not be properly thickened. When the viscosity exceeds 30,000 mPa · s, clouding occurs, drying is delayed, drying And later stickiness.

The component (E) may be used singly or in combination of two or more species having different viscosities.

The viscosity of the component (E) can be measured with a BL-type viscometer or a BM-type viscometer (manufactured by TOKYO KAGAKU CO., LTD.).

When the viscosity of the component (E) is 100 mPa s or more and less than 10,000 mPa-s, 3 rotor or No. 4 rotors at 20 DEG C and 12 rpm for 1 minute.

When the viscosity of the component (E) is 10,000 mPa s or more and less than 50,000 mPa-s, 4 rotor at 20 DEG C and at a revolution of 12 rpm for 1 minute.

As the component (E), a commercially available product can be used. Specific examples of the above commercial products include Carbopol 981 (made by Nippon Rubori Co., Ltd.), Carbopol ETD2050 (made by Nippon Ruburizon Co., Ltd.), Hibiswako (registered trademark) 105 (made by Wako Pure Chemical Industries, Ltd.) Or the like is neutralized with sodium hydroxide to have a viscosity of 3,000 mPa · s to 14,000 mPa · s at 20 ° C when the pH is adjusted to 7.0 to 7.5; A 0.2 mass% aqueous solution of Carbopol 980 (manufactured by Nippon Rubel Co., Ltd.) and Hibiswako (registered trademark) 104 (manufactured by Wako Pure Chemical Industries, Ltd.) was neutralized with sodium hydroxide to adjust the pH to 7.0 to 7.5 And those having a viscosity at 20 캜 of 15,000 mPa s to 30,000 mPa 등. These may be used alone, or two or more kinds may be used in combination.

Of these, Carbopol 981 (0.2 mass% aqueous solution, pH 7.0 to 7.5, viscosity at 20 占 폚: 4,000 mPa 占 퐏 -7 to 7 占 퐉) is preferable from the viewpoint of transparency, fast drying and no stickiness after drying. (Viscosity at 20 ° C: 6,000 mPa · s to 14,000 mPa · s), carbopore ETD2050 (0.2 mass% aqueous solution, pH 7.0 to 7.5, 105 (0.2 mass% neutralized liquid, viscosity at 20 캜: 7,000 mPa s s to 14,000 mPa 가).

The content of the component (E) in the above-mentioned transparent gel-type skin fungicide is preferably from 0.1% by mass to 0.5% by mass from the viewpoint of transparency, sterilizing power, ease of spreading, fast drying and no stickiness after drying, And more preferably 0.3% by mass to 0.4% by mass. If the content of the component (E) is less than 0.1% by mass, it tends to flow easily, and it may become difficult to spread on the skin. If the content exceeds 0.5% by mass, cloudiness may occur and the sterilizing power becomes insufficient, A feeling of feeling such as a delay in drying, stickiness after drying, etc. may be deteriorated.

«Mass ratio [(C + D) / (A + B)]»

The mass ratio [(C + D) / (A + B)] of the total content of the components (A) and (B) to the total content of the components (C) and (D) It is preferably from 100 to 400, more preferably from 150 to 300, from the standpoint of the fastness of drying and the absence of stickiness after drying. If the mass ratio [(C + D) / (A + B)] is less than 100, clouding may occur and the sterilizing power may become insufficient. On the other hand, when the mass ratio exceeds 400, the sterilizing power and drying speed, There is a case that the point of no play is insufficient.

&Lt; Other components >

The other components of the above-mentioned transparent gel-type skin fungicide may be appropriately selected in accordance with the purpose without any particular limitation as long as the effect of the present invention is not impaired. Examples thereof include surfactants (anionic surfactants, A surfactant, an amphoteric surfactant, etc.), a polymer compound other than the component (E), a moisturizing agent, a vitamin, an amino acid, an anti-inflammatory agent, an ultraviolet absorber, a cold sensation agent, an antioxidant, A preservative other than the above component (A), an inclusion compound, a solvent other than the above components (C) and (D), and a pH adjuster. These may be used alone, or two or more kinds may be used in combination.

The pH adjuster is not particularly limited and can be appropriately selected in accordance with the purpose. Preferred is triethanolamine, ethylenediamine-N, N, N ', N "-tetra-2-propanol (quadrore).

The content of the other components in the above-mentioned transparent gel-type skin fungicide is not particularly limited as long as the effect of the present invention is not impaired and can be suitably selected in accordance with the purpose.

«Property»

-pH-

The pH of the above-mentioned transparent gel type skin fungicide is preferably 6.0 to 8.0, and more preferably 6.5 to 7.5 in terms of transparency, sterilizing power, and no stickiness after drying. When the pH is less than 6.0, clouding occurs, the sterilizing power becomes insufficient, and spreading becomes difficult. When the pH is more than 8.0, drying is delayed and skin irritation occurs.

The pH of the above-mentioned transparent gel type skin fungicide can be determined by measuring the pH at 25 캜 using a pH meter (manufactured by Doadiketake Co., Ltd.).

-Viscosity-

The viscosity of the above-mentioned transparent gel type skin fungicide is not particularly limited and can be appropriately selected in accordance with the purpose. The viscosity at 25 ° C is preferably 300 mPa · s to 5,000 mPa · s, More preferably 4,000 mPa · s. If the viscosity of the above-mentioned transparent gel-type skin fungicide is less than 300 mPa s, it tends to flow down easily, which makes it difficult to spread and rubbing without rubbing on the skin. When it exceeds 5,000 mPa · s, The viscosity of the above-mentioned transparent gel type skin fungicide is too high, which makes it difficult to spread when rubbed against the skin, resulting in poor usability. In addition, it may be incompatible that the dischargeability from the container is deteriorated.

The viscosity of the transparent gel-type skin fungicide can be adjusted by the component (E).

The viscosity of the transparent gel-like skin fungicide was measured using a BL-type viscometer or a BM-type viscometer (manufactured by TOKYO KAGAKU CO., LTD.). 3 rotor or No. 4 rotor at 25 DEG C and at a rotation speed of 30 rpm for 1 minute.

- Transmittance -

The transmittance (% T) of the above-mentioned transparent gel-type skin fungicide is not particularly limited and can be appropriately selected in accordance with the purpose. From the viewpoint of transparency and sterilizing power, 80% T or more is preferable, and 90% . If the transmittance is less than 80% T, cloudiness may occur, a satisfactory appearance may not be obtained, and the sterilizing power may be lowered.

The transmittance (% T) of the above-mentioned transparent gel-type skin fungicide can be determined by measuring the transmittance at 660 nm using an ultraviolet visible spectrophotometer (manufactured by Nihon Spectroscope KK).

«Manufacturing method»

The method for producing the transparent gel-like skin fungicide is not particularly limited and may be appropriately selected in accordance with the purpose. The component (E) is uniformly dispersed at room temperature (25 캜) while stirring the purified water, (A), the component (B), the component (C), and the component (D), if necessary, and the other components are added and dissolved while stirring and the pH is adjusted to the desired value Value is preferable.

«How to use»

The method for using the above-mentioned transparent gel-type skin fungicide is not particularly limited and can be appropriately selected in accordance with the purpose. It is preferable that an appropriate amount (preferably about 1 g) is taken at a desired site of a finger or the like, The application method is preferable. The above-mentioned transparent gel type skin fungicide is suitably used for fingers in particular. In the present invention, the term &quot; finger &quot; means the entire hand including the palm, the back of the hand, and the finger.

Example

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail by way of examples of the present invention, but the present invention is not limited at all by these examples. In the following examples and comparative examples, &quot;% &quot; indicates &quot; mass% &quot; unless otherwise specified.

(Examples 1 to 41, Comparative Examples 1 to 14)

Depending on the composition and content shown in Tables 1 to 8 below,

(E) is uniformly dispersed while stirring with a three-one circular motor (BL-1200, manufactured by HEIDON), and then the component (C) or the component (C ') and the component (D) (A) and the component (B) were dissolved and dissolved with stirring, and triethanolamine as a pH adjuster was added to adjust the pH to the values shown in Tables 1 to 8 to obtain a transparent gel type skin fungicide ) Was prepared.

&Lt; Measurement of viscosity &

The viscosities of the transparent gel fingernail agents of Examples 1 to 41 and Comparative Examples 1 to 14 were measured using a BL type viscometer (manufactured by TOKYO KAGAKU KOGYO CO., LTD.). 3 rotor or No. 4 rotor at 25 DEG C and a rotation speed of 30 rpm for 1 minute. The results are shown in Tables 1 to 8 below.

<Evaluation>

Transparency "," disinfecting power "," spreadability "," fast drying "," stickiness after drying ", and" transparency "were evaluated for the transparent gel fingernail agents of Examples 1 to 41 and Comparative Examples 1 to 14, No fogging &quot;, and &quot; skin irritation &quot;. The results are shown in Tables 1 to 8 below.

- Evaluation of transparency -

Using a ultraviolet visible spectrophotometer (manufactured by Nihon Spectroscope, Ltd.), the transmittance (% T) of each of the transparent gel fingernail sterilizing agents of Examples and Comparative Examples at 660 nm was measured. Based on these measurements, the following evaluation criteria were used.

[Evaluation standard]

◎: 90% T or more

○: 80% T or more and less than 90% T

?: Less than 70% T and less than 80% T

×: less than 70% T

- Evaluation of sterilization power -

Escherichia coli NBRC3972 (obtained from the Independent Administrative Product Evaluation Agency) was used as the target bacteria and evaluated by quantitative suspension method.

The Escherichia coli ( E. coli NBRC3972) was cultured for 18 hours at 37 ° C under aerobic conditions using SCD agar medium (manufactured by Nihon Pharmaceutical Co., Ltd.). The colonies formed on the SCD agar medium were thoroughly agitated, suspended in physiological saline (manufactured by Otsuka Pharmaceutical Co., Ltd.) and adjusted to a concentration of 10 ⁸ cfu / ml. 0.005 ml of this test solution was added to 0.495 ml of each of the transparent gel type finger sterilizing agents of Examples and Comparative Examples and contacted for 30 seconds. The mixed solution was immediately diluted 10-fold with SCDLP liquid medium (manufactured by Nihon Pharmaceutical Co., Ltd.) Inactivated. The inactivated solution (hereinafter, also referred to as &quot; inactivated solution &quot;) was diluted 100-fold in the SCDLP medium, diluted 1,000-fold and diluted 10-fold in 10,000-fold dilution. (N = 3), respectively, in an SCDLP agar medium (manufactured by Nihon Pharmaceutical Co., Ltd.) (9 cm chalet) diluted with each concentration, and the cells were cultured under aerobic conditions at 37 캜 for 24 hours Lt; / RTI &gt; After the culture, the total number of colonies formed was counted, and the number of viable cells remaining was counted. When no colonies were observed, the detection limit was set at less than 10 cfu / ml. The number of viable cells remaining after the measurement was determined as the following rating, and based on the average value of the rating, the following evaluation criteria were used.

Also, cfu is a colony forming unit.

[grade]

5 points: the number of remaining viable cells was less than 10 cfu / ml (less than the detection limit)

4 points: the number of remaining viable cells was 10 cfu / ml or more and less than 100 cfu / ml

3 points: the remaining viable cell count is 100 cfu / ml or more and less than 1,000 cfu / ml

2 points: the number of remaining viable cells was 1,000 cfu / ml or more and less than 10,000 cfu / ml

1 point: the number of remaining viable cells was 10,000 cfu / ml or more

[Evaluation standard]

◎: 4.0 points or more

○: 3.0 points or more, less than 4.0 points

?: 2.0 points or more and less than 3.0 points

×: less than 2.0 points

- Evaluation of spreadability -

Ten professional panelists took 1 g of each transparent gel fingicide of the examples and comparative examples under the environment of 25 캜 and rubbed it on the palm and the back of the hand while evaluating the easiness of spreading over the entire finger The sensory evaluation was carried out on the basis of the average value of the evaluations, and the evaluation was made according to the following evaluation criteria.

[grade]

4 points: Very easy to spread

3 points: easy to spread

2 points: It is difficult to spread

1 point: very difficult to spread

[Evaluation standard]

◎: 4.0 points

○: 3.0 points or more and less than 4.0 points

△: 2.0 points or more and less than 3.0 points

×: less than 2.0 points

- Evaluation of fast drying -

10 professional panelists took 1 g of each transparent gel fingicide of the examples and comparative examples under the environment of 25 캜 and rubbed it on the palms and hands to measure the time until the transparent gel fingicide dissolves Respectively. Based on the average value of the measurement times of 10 persons, evaluation was made by the following evaluation criteria.

[Evaluation standard]

◎: Less than 30 seconds

○: Less than 60 seconds for more than 30 seconds

DELTA: less than 60 seconds and less than 90 seconds

×: 90 seconds or more

- Evaluation of no stickiness after drying -

10 professional panelists took 1 g of each transparent gel fingicide of the examples and comparative examples under the environment of 25 캜 and rubbed on the palms and back of the hands and dried the transparent gel fingicide after the hands were sticky , The sensory evaluation was carried out on the basis of the following rating, and the evaluation was carried out on the basis of the average value of the ratings.

[grade]

4 points: It is not sticky at all

3 points: not sticky

2 points: Sticky.

1 point: Very sticky.

[Evaluation standard]

◎: 4.0 points

○: 3.0 points or more and less than 4.0 points

△: 2.0 points or more and less than 3.0 points

×: less than 2.0 points

- Assessment of skin irritation -

Ten professional panelists each took 1 g of each of the transparent gel fingicide of Examples and Comparative Examples under the environment of 25 캜 and rubbed on the palms and back of the hands, , And the sensory evaluation was carried out. Based on the average value of the scores, evaluation was made by the following evaluation criteria.

[grade]

4 points: No stimulation at all

3 points: I do not feel stimulation

2 points: I feel irritation

1 point: Very irritating

[Evaluation standard]

◎: 4.0 points

○: 3.0 points or more and less than 4.0 points

△: 2.0 points or more and less than 3.0 points

×: less than 2.0 points

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5]

[Table 6]

[Table 7]

[Table 8]

(Example 42)

(E) was uniformly dispersed while stirring the purified water with a three-round motor (BL-1200, manufactured by HEIDON) at 25 캜 according to the composition and blending amount shown below, (A), the component (B), and other additives were added and dissolved while stirring, and the pH was adjusted to 7.5 by adding a pH adjuster to obtain a transparent Gel finger fungicide.

Transparency "," disinfecting power "," ease of spreading "," fast drying "," post-drying ", and" post-drying "were carried out in the same manner as in Examples 1 to 41 and Comparative Examples 1 to 14 with respect to the transparent gel fingernail of Example 42 No stickiness &quot;, and &quot; skin irritation &quot;.

[Composition and compounding amount]

Benzalkonium chloride [component (A)] 0.05%

N-coconut fatty acid acyl L-arginine ethyl · DL-pyrrolidonecarboxylate [Component (B)] 0.1%

Hexylene glycol [Component (C)] 10.0%

Ethanol [component (D)] ... 30.0%

Carboxyvinyl polymer (* 1) [Component (E)] 0.3%

DL-pyrrolidonecarboxylic acid sodium (50% aqueous solution) (* 4) ... 0.2%

Spices … 0.2%

Ethylenediamine-N, N, N ', N "-tetra-2-propanol (pH adjusting agent)

Purified water … The remainder (added so that the total is 100%)

Mass ratio [(C + D) / (A + B)]: 266.7

· Viscosity: 3,850 mPa · s (25 ° C)

PH: 7.5

[Evaluation results]

· Transparency: ◎

· Sterility: ◎

· Easy to spread: ◎

· Fast drying: ◎

· No stickiness after drying: ◎

· Skin irritation: ◎

(Example 43)

In Example 42, a transparent gel fingernail sterilizer of Example 43 was prepared in the same manner as in Example 42 except that the composition and blending amount were changed to the compositions and blending amounts shown below.

The transparency, the sterilizing power, the ease of spreading, the speed of drying, and the drying time of the transparent gel fingernail of Example 43 were measured in the same manner as in Examples 1 to 41 and Comparative Examples 1 to 14, No stickiness after ".

[Composition and compounding amount]

Benzethonium chloride [Component (A)] 0.05%

N-coconut fatty acid acyl L-arginine ethyl · DL-pyrrolidonecarboxylate [Component (B)] 0.1%

Xylitol [Component (C)] ... 10.0%

Ethanol [component (D)] ... 30.0%

Carboxyvinyl polymer (* 2) [Component (E)] 0.3%

Ethylenediamine-N, N, N ', N "-tetra-2-propanol (pH adjusting agent)

Dipotassium glycyrrhizinate (* 5) ... 0.01%

Spices … 0.2%

Purified water … The remainder (added so that the total is 100%)

Mass ratio [(C + D) / (A + B)]: 266.7

· Viscosity: 4,500 mPa · s (25 ° C)

PH: 7.5

[Evaluation results]

Transparency: Yes

· Sterility: ○

· Easy to spread: ○

· Fast drying: ◎

· No stickiness after drying: ◎

· Skin irritation: ◎

The components used in Examples and Comparative Examples are shown in Table 9 below.

[Table 9]

Examples of the embodiment of the present invention include the following.

&Lt; 1 > A cleaning composition comprising (A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride,

(B) N-coconut fatty acid acyl L-arginine ethyl DL-pyrrolidonecarboxylate,

(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol,

(D) ethanol,

(E) a carboxyvinyl polymer,

Wherein the content of the component (B) is 0.01 mass% to 0.3 mass%, the content of the component (D) is 15 mass% to 35 mass%

(C + D) / (A + B)] of the total content of the components (A) and (B) to the total content of the components (C) and , A pH of 6.0 to 8.0, and a transparent appearance.

(2) The positive resist composition as described in the item (1) or (2), wherein the content of the component (A) is 0.01 mass% to 0.3 mass%, the content of the component (C) is 5 mass% to 15 mass%, and the content of the component The transparent gel-type skin fungicide according to <1> above.

<3> The mass ratio [(C + D) / (A + B)] of the total content of the components (A) and (B) to the total content of the components (C) and Is a transparent gel type skin fungicide according to any one of < 1 > to < 2 >.

<4> The transparent gel-type skin fungicide according to any one of <1> to <3>, wherein the component (C) is at least one of hexylene glycol and 1,2-pentanediol.

<5> The transparent gel-type skin fungicide according to any one of <1> to <4>, wherein the pH is 6.5 to 7.5.

[Industrial applicability]

INDUSTRIAL APPLICABILITY Since the transparent gel type skin fungicide of the present invention has an excellent feeling of being transparent in appearance, less irritating to the skin, having excellent germicidal power, easy spreading, quick-drying property and no stickiness after drying, It is suitable for disinfection of skin such as fingers of doctors, nurses, nurses, patients and the like in employees of hospitals and public health centers such as food processing industry such as processing of meat and fishery products, It is possible.

Claims (5)

(A) at least one quaternary ammonium salt fungicide selected from benzalkonium chloride, benzethonium chloride, and cetylpyridinium chloride,
(B) N-coconut fatty acid acyl L-arginine ethyl DL-pyrrolidonecarboxylate,
(C) at least one polyhydric alcohol selected from hexylene glycol, 1,2-pentanediol, 1,6-hexanediol, propylene glycol, sorbitol, and xylitol,
(D) ethanol,
(E) a carboxyvinyl polymer,
Wherein the content of the component (B) is 0.01 mass% to 0.3 mass%, the content of the component (D) is 15 mass% to 35 mass%
(C + D) / (A + B)] of the total content of the components (A) and (B) to the total content of the components (C) and , A pH of 6.0 to 8.0, and a transparent appearance. The method according to claim 1,
, The content of the component (A) is from 0.01 to 0.3 mass%, the content of the component (C) is from 5 to 15 mass%, and the content of the component (E) is from 0.1 to 0.5 mass% A transparent gel-type disinfectant for skin. 3. The method according to claim 1 or 2,
(C + D) / (A + B)] of the total content of the component (A) and the component (B) to the total content of the components (C) and (D) And a sterilizing agent for transparent gel-type skin. 4. The method according to any one of claims 1 to 3,
Wherein the component (C) is at least one of hexylene glycol and 1,2-pentane diol. 5. The method according to any one of claims 1 to 4,
wherein the pH is 6.5 to 7.5.