JP2011153089A - Gel-like finger disinfectant - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a gel-like finger disinfectant that does not have precipitation, has excellent appearance, does not cause sagging and dropping from a container, is easily spread to the fingers, quickly dried after use, has no stickiness and has moist feeling and slight skin irritation. <P>SOLUTION: The gel-like finger disinfectant comprises (A) 50-80 mass% of a 1-3C alcohol, (B) 0.1-1.0 mass% of a carboxy vinyl polymer and/or acrylic acid-alkyl methacrylate copolymer, (C) an alkanolamine and (D) an oligosaccharide and has a pH (25°C) of 5.5-9.0. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a gel-like hand disinfectant having an excellent sterilizing / disinfecting effect by being rubbed into a finger.

  Lower alcohols are widely used as bactericides because of their strong bactericidal activity. However, when it is used for fingers, there is a problem of dripping from the container because the viscosity is low, and in order to solve this, a device is made to form a gel using hydroxypropylcellulose as a thickener (for example, patents) Reference 1: Japanese Patent Application Laid-Open No. 62-106012). In addition, it has been proposed to use a carboxyvinyl polymer as a thickener and a basic substance as a neutralizing agent in 10% by mass or less of ethanol as a hypoallergenic gel external preparation (for example, Patent Documents). 2: JP 2003-119129 A).

Japanese Patent Laid-Open No. 62-106012 JP 2003-119129 A

  Lower alcohol has high bactericidal activity, but penetrates into the skin and impairs the skin barrier function. Furthermore, it lowers the skin's moisturizing function due to the removal of moisture from the skin surface during volatilization, and also causes rough skin. When hydroxypropylcellulose is used as a thickening agent in gelled external preparations, a moisturizing effect can be obtained, but stickiness occurs and the feeling of use is poor, and when carboxyvinyl polymer and organic amine are used, stickiness after use is lost. Although it is small, the moisturizing effect is not sufficient. The present invention was made in view of the above circumstances, has no appearance such as precipitation, has good appearance, does not sag from the container, is easy to extend to the fingers, does not dry easily after use, has a moist feeling, An object of the present invention is to provide a gel-like hand disinfectant with less skin irritation.

  As a result of intensive studies to achieve the above object, the present inventors have found that (A) 50 to 80% by mass of an alcohol having 1 to 3 carbon atoms, (B) a carboxyvinyl polymer and / or an acrylic acid / alkyl methacrylate copolymer. A gel-like hand germicide containing 0.1 to 1.0% by mass of a polymer and (C) an alkanolamine and having a pH (25 ° C.) of 5.5 to 9.0, and (D) an oligosaccharide By blending, the appearance is good with no precipitation, etc., no dripping from the container, easy to extend to fingers, fast drying after use, no stickiness, moist feeling, less skin irritation It has been found and the present invention has been made.

Accordingly, the present invention provides the following gel-like hand germicide.
[1]. (A) 50 to 80% by mass of an alcohol having 1 to 3 carbon atoms;
(B) 0.1 to 1.0% by mass of carboxyvinyl polymer and / or acrylic acid / alkyl methacrylate copolymer;
(C) an alkanolamine,
(D) A gel-like hand germicide containing an oligosaccharide and having a pH (25 ° C.) of 5.5 to 9.0.
[2]. (D) The gel-like hand germicide according to [1], wherein the component is maltooligosaccharide.
[3]. The gel-like finger disinfectant according to [1] or [2], which is a humectant.
[4]. The gel-like finger disinfectant according to [1] or [2], which is a rough skin improving agent.
[5]. The gel-like finger disinfectant according to [1] or [2], which is an itching inhibitor.

  According to the present invention, there is no precipitation, etc., good appearance, no dripping from the container, easy to extend to fingers, fast drying after use, no stickiness, moist feeling, less gel irritation Finger disinfectants can be provided.

  Hereinafter, the present invention will be described in detail. The gel-like hand germicide of the present invention comprises (A) 50 to 80% by mass of an alcohol having 1 to 3 carbon atoms, and (B) a carboxyvinyl polymer and / or an acrylic acid / alkyl methacrylate copolymer 0.1 to 1. It contains 0.0 mass%, (C) an alkanolamine, and (D) an oligosaccharide, and has a pH (25 ° C) of 5.5 to 9.0.

(A) Alcohol having 1 to 3 carbon atoms (A) By blending the component, bactericidal power and ease of drying are improved. Examples of the component (A) include ethanol, isopropanol and the like, which can be used alone or in combination of two or more. Of these, ethanol is preferable from the viewpoint of good odor.

  (A) The compounding quantity of a component is 50-80 mass% in a gel-like hand germicide, and 55-65 mass% is more preferable from the point of bactericidal power. When the blending amount of the component (A) is less than 50% by mass, the sterilizing power is insufficient, and further, drying after rubbing on the finger is slow, and when it exceeds 80% by mass, the sterilizing power is reduced and further precipitation occurs. When it is used, it tends to sag from the container.

(B) Carboxyvinyl polymer and / or acrylic acid / alkyl methacrylate copolymer The blending of the component (B) increases the viscosity of the preparation, prevents dripping from the container, and easily extends to fingers. (B) A component can be used individually by 1 type or in combination of 2 or more types. The component (B) of the present invention has a viscosity of 14,000 at 20 ° C. when neutralizing a 0.2% by mass aqueous solution with sodium hydroxide to adjust the pH to 7.0 to 7.5. The thing of 32000 mPa * s is preferable. The viscosity was measured with a BL type viscometer (manufactured by Tokyo Keiki). Using a 4 rotor, measurement is performed for 1 minute at 12 rpm.

  Specific examples of carboxyvinyl polymers that fall within the above viscosity range include Carbopol 980 (trade name: Lubrizol) and Hibiswaco 103 (trade name: Wako Pure Chemical Industries). Examples of the acrylic acid / alkyl methacrylate copolymer include acrylates / alkyl acrylate (C10-30) cross-polymer (the display name is the same). More specifically, as a trade name, Carbopol ETD2020 (trade name: Lubrizol), Carbopol 1382 (trade name: Lubrizol), and the like.

  (B) As for the compounding quantity of a component, 0.1-1.0 mass% is preferable in a gel-like hand germicide. If it is less than 0.1% by mass, it will sag from the container and it will be difficult to extend to the fingers, and if it exceeds 1.0% by mass, it will become sticky when rubbing on the fingers and sticky after drying. Furthermore, in order to obtain the viscosity (5000 to 25000 mPa · s) of the gel-like hand disinfectant with good usability (easy to take out from the container, easy to extend to fingers), 0.2 to 0.6% by mass is More preferred.

(C) Alkanolamine The alkanolamine neutralizes the component (B), thickens the gel-like hand germicide in the gel-like hand germicide, and adjusts the pH of the gel-like hand germicide to 5.5-9. Adjust to zero. Examples of the alkanolamine include triethanolamine, 2-amino-2-methyl-1-propanol, diisopropanolamine, and the like, which can be used singly or in appropriate combination of two or more. (C) The compounding quantity of a component is the quantity which neutralizes (B) component and a gel-like hand germicide becomes 5.5-9.0.

(D) Oligosaccharide The oligosaccharide of the present invention is a compound in which 2 to 10 monosaccharides are bound by a glycosidic bond. By blending the oligosaccharide, a moist feeling after drying can be imparted without impairing the speed of drying, a moisturizing effect can be exhibited, rough skin can be improved, and itching can be suppressed. The oligosaccharide is not particularly limited and may be appropriately selected depending on the intended purpose.Specific examples include sucrose, lactose, maltose, trehalose, turanose, cellobiose, raffinose, melezitose, maltotriose, maltotetraose. , Maltopentaose, acarbose, stachyose, glucosyl trehalose, maltosyl trehalose, maltotriosyl trehalose and the like. Among these, 4-5 sugar maltooligosaccharides such as maltotetraose and maltopentaose are more preferable in terms of moist feeling after drying, suppression of itchiness, and recovery from rough skin, and maltotetraose is more preferable. These can be used individually by 1 type or in combination of 2 or more types.

  (D) As the oligosaccharide, for example, Trehalose manufactured by Hayashibara Biochemical Research Institute, Raffinose manufactured by Nippon Sugar Sugar, Trehalose Trehalose manufactured by Hayashibara Biochemical Research Institute, Tetrap H, a maltotetraose manufactured by Hayashibara Biochemical Research Institute Further, maltotriose, maltotetraose, maltopentaose, etc. manufactured by Wako Pure Chemical Industries, Ltd. can be used.

  (D) As for the compounding quantity of a component, 0.1-10 mass% is preferable in a gel-like hand germicide, and 0.5-4 mass% is preferable. By setting it as 0.1 mass% or more, a moist feeling after drying, improvement of rough skin, and suppression of itching can be obtained more, and stickiness will be produced when it exceeds 10 mass%.

  In the gel-like hand germicide of the present invention, an appropriate amount can be blended, as long as it does not impair the effects of the present invention, as a single optional component or in combination of two or more. Optional components include, for example, anionic surfactants, cationic surfactants, surfactants such as zwitterionic surfactants, water-insoluble powders such as inorganic powders and organic powders, and polymers such as polyethylene glycol. Compounds, moisturizers, vitamins, amino acids, anti-inflammatory agents, UV absorbers, cooling agents, antioxidants, colorants, fragrances, deodorants, preservatives, inclusion compounds, water, solvents, polyvalent Alcohol etc. are mentioned.

  The pH of the gel-like hand germicide (25 ° C.) is 5.5 to 9.0, more preferably 6.0 to 7.5. If the pH of the gel-like hand germicide is less than 5.5, a sufficient product viscosity cannot be obtained. On the other hand, if the pH exceeds 9.0, it is not preferable in terms of skin irritation. The pH is measured by using a pH meter to measure the pH of the stock solution at 25 ° C.

  The viscosity (25 ° C.) of the gel-like hand germicide is preferably 5000 to 25000 mPa · s, and more preferably 10,000 to 15000 mPa · s. If it is less than 5000 mPa · s, it may be easily dropped from a container such as a tube, and if it exceeds 25000 mPa · s, it will be difficult to take out from the container such as a tube, and it will be difficult to extend when rubbing on a finger, resulting in slow drying after use. There is a risk. The viscosity was measured using a BL type viscometer, No. Using a 4-rotor, measurement is performed at 12 rpm for 1 minute. Moreover, the gel-like hand disinfectant of the present invention is preferably transparent and uniform with no precipitate or the like.

  The gel-like hand germicide of the present invention can be prepared based on a conventional method, and examples thereof include the following methods, and are not particularly limited. The component (A), the component (C), the component (D), and purified water are mixed uniformly at room temperature using a paddle type stirrer. While continuing to stir, component (B) is gradually added thereto and dispersed uniformly. Next, an aqueous solution of the component (C) is gradually added to adjust the pH to 5.5 to 8.0.

  The gel-like hand disinfectant of the present invention is used by taking an appropriate amount (for example, about 1 g) and rubbing the entire finger until it is dry. Since the gel-like hand disinfectant of the present invention has an excellent disinfecting effect, it can disinfect food poisoning bacteria such as Escherichia coli and Staphylococcus aureus, and viruses such as influenza, and is effective in preventing these.

  By blending the oligosaccharide (D) of the present invention, it has an excellent moisturizing effect, skin roughening effect, and itching suppression effect, so it can also be used as a moisturizing agent, skin roughening agent, and itching inhibitor. In addition, the moisturizing effect is “the stratum corneum moisture retention effect”, the rough skin improvement effect is “the stratum corneum moisture retention effect, the transdermal moisture transpiration inhibiting effect” in the examples described later, and the itching inhibiting effect is the “itching behavior inhibiting effect” Can be confirmed.

  EXAMPLES Hereinafter, although an Example and a comparative example are shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, unless otherwise specified, “%” in the composition represents mass%.

[Examples 1-20, Comparative Examples 1-8]
The (A) component alcohol, the (D) component (or glycerin), and purified water were uniformly mixed at room temperature using a paddle type stirrer. While continuing the stirring, the component (B) was gradually added thereto and dispersed uniformly. Next, an aqueous solution of component (C) (or triethanolamine of Comparative Example) was gradually added to adjust the pH to the range described in the table, and compositions having the compositions shown in Tables 1 to 4 below were obtained. About the obtained composition (sample), pH and a viscosity were measured with the following method, and the following evaluation was performed. The results are also shown in the table.

[PH]
The pH of the sample stock solution at 25 ° C. was measured using a pH meter (manufactured by Toa Denpa).
[viscosity]
The viscosity was measured using a BL type viscometer (manufactured by Tokyo Keiki). Using 4 rotors, the measurement was performed at a rotation speed of 12 rpm and a time of 1 minute.

[appearance]
A hard transparent glass bottle (volume: 50 mL) was filled with 45 mL of sample, the appearance at 25 ° C. was observed, and the following criteria were used.
<Criteria>
◎: Transparent and uniform state ○: Slightly turbid, uniform state ×: Precipitate is generated or separated

[No dripping]
Fill an 80 mL capacity tube (tube inner diameter of 8 mm) with 50 g of sample, remove the cap, tilt the tube from the horizontal state, with the tube port down, and from the container when standing upright. The absence of dripping was shown by the following criteria.
<Criteria>
A: Even if the tube is shaken once vertically, the sample does not sag.
○: The sample does not sag when the tube is set up vertically, but the sample sags when the tube is shaken once vertically.
Δ: When the tube is tilted 45 degrees below the horizontal, the sample drips.
X: The sample drips before the tube is tilted 45 degrees from the horizontal.

[Ease of extension]
A 1 g sample at 25 ° C. was taken in a 25 ° C. environment and evaluated for ease of extension to the entire finger. The results were sensory-evaluated by five specialist panels, and based on the average value of the scores, the results were shown in the following criteria.
<Score>
5 points: very easy to extend 4 points: easy to extend 3 points: slightly easy to extend 2 points: difficult to extend 1 point: very difficult to extend <Criteria>
◎: 4.5 points or more and 5.0 points or less ◎ to ○: 4.0 points or more and less than 4.5 points ○: 3.0 points or more and less than 4.0 points Δ: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

[Speed of drying]
A sample of 1 g at 25 ° C. was taken in an environment at 25 ° C., and the time until the liquid dried was measured while being rubbed into the palm and back of the hand. The results were measured for 5 specialized panels and based on the average value of the time, the following criteria were used.
<Criteria>
◎: Less than 30 seconds ○: 30 seconds or more and less than 60 seconds Δ: 60 seconds or more and less than 90 seconds ×: 90 seconds or more

[Moist feeling after drying]
A 1 g sample at 25 ° C. was taken in a 25 ° C. environment and rubbed into the palm and back of the hand, and the moist feeling of the hand was evaluated after the liquid had dried. The results were sensory-evaluated by 5 specialist panels and based on the average value of the scores, and the following criteria were used.
<Score>
5 points: very moist 4 points: moist 3 points: slightly moist 2 points: slightly moist 1 point: not moist <Criteria>
◎: 4.5 points or more and 5.0 points or less ◎ to ○: 4.0 points or more and less than 4.5 points ○: 3.0 points or more and less than 4.0 points Δ: 2.0 points or more and less than 3.0 points ×: Less than 2.0 points

[No stickiness after drying]
A sample of 1 g at 25 ° C. was taken in a 25 ° C. environment, rubbed into the palm and back of the hand, and the non-stickiness of the hand was evaluated after the liquid had dried. The results were sensory-evaluated by 5 specialist panels and based on the average value of the scores, and the following criteria were used.
<Score>
5 points: no stickiness 4 points: slightly sticky (almost no stickiness)
3 points: feels slightly sticky 2 points: feels sticky 1 point: feels very sticky <Criteria>
◎: 4.5 or more and 5.0 or less ◎ ~ ○: 4.0 or more and less than 4.5 ○: 3.0 or more and less than 4.0 △: 2.0 or more and less than 3.0 ×: Less than 2.0 points

[Evaluation of skin irritation]
20 μL of a sample was dropped onto a filter paper (diameter 7.5 mm) in a fin chamber (Taisho Pharmaceutical Co., Ltd.) and attached to the backs (non-eruption parts) of five adult men who felt they were sensitive skin. The patch was removed 48 hours after pasting, and evaluation was performed according to the following <Criteria: Taro Kawamura, Jichikai, 80, 301, 1970) shown below when 24 hours passed. The results are shown as the average score of the five people.
<Criteria>
0: No response 1: Mild erythema 2: Erythema 3: Erythema + edema 4: Erythema + edema + papules, serous papules, small blisters 5: Large blisters

The raw materials used in the above table are shown below.
* 1: Carbopol ETD2020 (Lubrisol)
* 2: Carbopol 980 (Lubrisol)
* 3: Tetrap H (Hayashibara Biochemical Research Institute)
* 4: Raffinose (Japanese sugar beet sugar)
* 5: Trehalose (Hayashibara Institute of Science)
In addition, the quantity in a table | surface shows the quantity (pure part) of the described component.

[Test Example 1: Bactericidal effect]
In addition, although the composition of this invention has 50-80 mass% of (A) C1-C3 alcohol, it has a bactericidal effect, About the composition of Example 1, it sterilizes with the following method. The effect was evaluated.
1 mL of Escherichia coli or Staphylococcus aureus bacterial solution (the number of bacteria: 10 ⁶ to 10 ⁸ / mL) was added to 9 mL of the sample and mixed to obtain a test solution, which was allowed to act at 25 ° C. for 30 seconds. After 30 seconds, SCDLP liquid medium (Nippon Pharmaceutical Co., Ltd.) was added and diluted 10-fold, and the number of viable bacteria in the test solution was measured by the pour plate culture method using SCDLP agar medium (Nippon Pharmaceutical Co., Ltd.). did. As a result, after 30 seconds of action time, the number of remaining bacteria of both Escherichia coli and Staphylococcus aureus was below the detection limit (<10 / mL), and a bactericidal effect was observed. Similarly, the bactericidal effect was confirmed in other examples.

[Test Example 2: stratum corneum moisture retention effect, Test Example 3: transdermal moisture transpiration suppression effect, Test Example 4: pruritus behavior suppression effect]
(Preliminary breeding method)
A 10-week-old female hairless mouse (HOS: HR-1, Nippon SLC Co., Ltd.) was purchased as a test animal, and 12 animals per group were used as subjects. The subject is SPF (Specific Pathogen Free) with a temperature of 23 ± 1 ° C., a humidity of 60 ± 10%, and a light / dark cycle of (7: 00 to 19:00 (bright) → 19: 00 to 7:00 (dark)). : Aseptic special environment), food (manufactured by Nippon Nosan Kogyo Co., Ltd., trade name “HRAD”) and water were freely ingested, and preliminary breeding for 1 week was performed. The bait is used as a bait that causes pruritus behavior.
After completing the above-described preliminary breeding, both legs of the subject were anesthetized using Somnopentyl (Kyoritsu Pharmaceutical Co., Ltd.), and magnet pieces (diameter 1 mm, length 3 mm, manufactured by Neuroscience) were inserted subcutaneously into both legs. It was used for.
After the preliminary breeding, the number of pruritus was measured by the following method before starting the sample application. Thereafter, the sample was applied to the back at 70 μL / time once a day for 6 weeks continuously. The number of pruritus was measured 4 and 6 weeks after the application of the sample, and the skin conductance and transdermal water transpiration (TEWL) were measured 6 weeks after the application of the sample.

[Skin surface conductance (horny layer moisture retention effect)]
As an index of the moisturizing effect, the stratum corneum moisture content was measured by the skin conductance measurement correlated with the moisture content of the stratum corneum, using Comparative Example 1 as a control for the compositions of Example 1 and Comparative Example 8 by the following method. . The skin conductance was measured using a commercially available device (Skicon-200: manufactured by IBS), and the stratum corneum moisture content retention rate (%) was determined according to the following formula. The results are shown in Table 5. In Example 1, a remarkable stratum corneum moisture retention effect was observed.
Moisture retention rate of stratum corneum (%) = (skin conductance of Example 1 or Comparative Example 8 / skin conductance of Comparative Example 1) × 100

[Transcutaneous moisture transpiration (TEWL) (Inhibition effect on transdermal moisture transpiration)]
As an index of the rough skin recovery effect, the composition of Example 1 and Comparative Example 8 was measured by the following method, using Comparative Example 1 as a control, and measuring the transdermal water transpiration (TEWL) correlated with the skin barrier function. The transdermal moisture transpiration suppression rate (%) was determined. The results are shown in Table 6. In Example 1, a remarkable transdermal moisture transpiration suppressing effect was observed.
Percutaneous water transpiration suppression rate (%) = (transdermal water transpiration amount of Comparative Example 1−transdermal water transpiration amount of Example 1 or Comparative Example 8) / transdermal water transpiration amount of Comparative Example 1) × 100

[Itching effect suppression effect]
As an index of the effect of suppressing itching, the number of pruritus, which is an itching action, was measured for the compositions of Example 1, Comparative Example 1 and Comparative Example 8 by the following method. For pruritus behavior, the number of pruritus for 1 hour was automatically measured using a MicroAct device (Neuroscience). Table 7 shows the results of the reduction rate (%) of pruritus frequency according to the following formula. In Example 1, a significant stagnation suppression effect was observed.
Reduction rate of pruritus frequency (%) = (total number of pruritus after starting application / total number of pruritus before starting application) × 100

[Example 21]
A gel-like hand germicide was prepared by a conventional method according to the following composition.
Composition%
Ethanol 60
Acrylates / alkyl acrylate (C10-30) crosspolymer * 1
0.3
2-Amino-2-methyl-1-propanol Amount adjusted to pH 6.5 Maltotetraose * 2 1.0
Benzalkonium chloride (50% aqueous solution) * 3 0.1
Polyethylene powder (average particle size 100 μm) 0.3
Fragrance 0.1
Purified water balance
Total 100.0
* 1 Carbopol ETD2020 (Lubrisol)
* 2 Tetrap H (Hayashibara Biochemical Research Institute)
* 3 Nissan Cation F2-50E (NOF)

Claims (5)

(A) 50 to 80% by mass of an alcohol having 1 to 3 carbon atoms;
(B) 0.1 to 1.0% by mass of carboxyvinyl polymer and / or acrylic acid / alkyl methacrylate copolymer;
(C) an alkanolamine,
(D) A gel-like hand germicide containing an oligosaccharide and having a pH (25 ° C.) of 5.5 to 9.0.   The gel-like hand germicide according to claim 1, wherein the component (D) is maltooligosaccharide.   The gel-like hand disinfectant according to claim 1 or 2, which is a humectant.   The gel-like finger disinfectant according to claim 1 or 2, which is a rough skin improving agent.   The gel-like hand disinfectant according to claim 1 or 2, which is an itching inhibitor.