JP2010215570A - Skin sterilizing and cleaning composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin sterilizing and cleaning composition exhibiting sufficiently high sterilizing effect even by using for a short time and designed taking consideration of real hand-washing time in a busy site. <P>SOLUTION: The skin sterilizing and cleaning composition contains (a) at least one of sterilizing agent selected from the group consisting of triclosan, isopropylmethylphenol and p-chloro-m-xylenol, (b) a glyceryl ether having a 4-12C hydrocarbon group and (c) 0.5-15.0 wt.% of an anionic surfactant expressed by general formula (1) R-O-(CH<SB>2</SB>CH<SB>2</SB>O)<SB>n</SB>-SO<SB>3</SB>M, and pH of the composition is ≤5.5 at 25°C. <P>COPYRIGHT: (C)2010,JPO&INPIT

Description

  The present invention relates to a skin sterilizing and cleaning composition that exhibits a high bactericidal effect even when used for a short time.

  In recent years, hand washing has been promoted in hospitals, nursing homes, food processing sites, kitchens, and the like for the purpose of preventing pathogenic bacteria from being transmitted and transmitted through fingers. In such a field, various skin sterilization detergent compositions are used in order to more reliably sterilize and clean the skin. For example, there are compositions containing a large amount of a bactericidal agent in skin (hand) sterilizing detergent, and compositions containing a solvent having a high bactericidal effect such as ethanol.

  In Patent Document 1, a high bactericidal effect is obtained by the combined use of a specific anionic surfactant and triclosan, isopropylphenol and / or parachloroxylenol, and by containing glyceryl ether as a third component, foamability and low temperature stability are obtained. A liquid sterilizing detergent composition having excellent properties is proposed.

  Patent document 2 proposes to use a mixture containing glyceryl ether at a temperature of 25 ° C. or higher in order to sterilize the surface of the article.

JP 2008-138027 A JP 2004-315537 A

  In the above field, workers are often busy, and it is not practical to spend a long time washing hands. Accordingly, an object of the present invention is to provide a skin sterilizing and cleaning composition capable of exhibiting a sufficiently high degree of bactericidal properties even when used for a short time in consideration of the actual hand washing time in a busy site. It is.

  Accordingly, as a result of studying various factors relating to the skin sterilizing detergent composition, the present inventors have unexpectedly shortened the time by changing the pH of the skin sterilizing detergent composition from the neutral range to the acidic range. The present inventors have found that sufficient bactericidal properties can be exerted and completed the present invention.

That is, the gist of the present invention is as follows.
[1] (a) component: at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol, (b) component: glyceryl ether having a hydrocarbon group having 4 to 12 carbon atoms, And (c) component: the following general formula (1)
R—O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(Wherein R is an aliphatic group having 8 to 16 carbon atoms, n represents an average number of added moles, n = 0 to 3, and M is triethanolamine, ammonium or sodium). A skin sterilizing detergent composition containing 0.5 to 15.0% by weight of an anionic surfactant, wherein the composition (25 ° C.) has a pH of 5.5 or less. And [2] the skin sterilizing and cleaning composition according to [1], which is used for hand soap, body shampoo or hair shampoo.

  The skin sterilizing detergent composition of the present invention has an excellent effect of having a detergency effect and exhibiting a high bactericidal property even when used for a short time.

<(A) component>
The component (a) used in the present invention is at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol. 0.05-1.0 weight% is preferable and, as for content of (a) component in the skin disinfection cleaning composition of this invention, 0.1-0.6 weight% is more preferable. From the viewpoint of sufficiently exhibiting the bactericidal effect, the content is preferably 0.05% by weight or more, and from the viewpoint of ensuring the stability of the composition, the content is preferably 1.0% by weight or less.

  These fungicides are preferably used in combination of two from the viewpoint of bactericidal performance, and more preferably used in combination with triclosan and isopropylphenol from the viewpoint of raw material odor. In this case, triclosan / isopropylphenol = 5/1 to 1/1 (weight ratio) is preferable, and 4/1 to 1/1 (weight ratio) is more preferable.

<(B) component>
The component (b) used in the present invention is a glyceryl ether having a hydrocarbon group having 4 to 12 carbon atoms, preferably a linear or branched alkyl group or alkenyl group, and a linear chain having 8 to 12 carbon atoms. Or the monoalkyl body which has a branched alkyl group is preferable.

  Examples of the alkyl group include n-octyl group, 2-ethylhexyl group, n-nonyl group, n-decyl group, isodecyl group, n-undecyl group, and n-dodecyl group, and preferably 8 carbon atoms. To 12 alkyl groups, specifically, 2-ethylhexyl group and isodecyl group.

  Specific examples of glyceryl ether include 2-ethylhexyl glyceryl ether and isodecyl glyceryl ether. (B) The glyceryl ether of a component may be used individually by 1 type, or may be used in combination of 2 or more type.

  By blending the component (b) into the skin sterilizing detergent composition, the effect of further exerting the sterilizing effect against bacteria such as Escherichia coli can be achieved without reducing the cleaning effect of the detergent composition against fat and oil stains. The

  The content of the component (b) in the skin sterilizing and cleaning composition is preferably 0.25 to 7.5% by weight, and more preferably 1.0 to 5.0% by weight. The content is preferably 0.25% by weight or more from the viewpoint of exerting a bactericidal effect against bacteria such as Escherichia coli without deteriorating the cleaning effect on fat and oil stains, and from the viewpoint of product stability, the content is 7. 5% by weight or less is preferable.

<(C) component>
The component (c) in the skin sterilizing and cleaning composition of the present invention has the following general formula (1):
R—O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(In the formula, R represents an aliphatic group having 8 to 16 carbon atoms, preferably a saturated or unsaturated aliphatic group having 8 to 16 carbon atoms, n represents an average number of added moles, and n = 0 to 3; And M is triethanolamine, ammonium or sodium). As carbon number of R, 10-16 are preferable. As the average added mole number n, 0 to 3 are used, and 0 to 1 is preferable from the viewpoint of sterilization performance. The counter ion represented by M is triethanolamine, ammonium or sodium, and ammonium is preferable from the viewpoint of sterilization performance.

  Specific examples of the component (c) include polyoxyethylene (0) alkyl ether sulfate triethanolamine (alkyl sulfate triethanolamine), polyoxyethylene (0) alkyl ether ammonium sulfate (alkyl ammonium sulfate), and polyoxyethylene (0). Sodium alkyl ether sulfate (sodium alkyl sulfate), polyoxyethylene (1) alkyl ether triethanolamine sulfate, polyoxyethylene (1) ammonium alkyl ether sulfate, polyoxyethylene (2) ammonium alkyl ether sulfate, polyoxyethylene (2) alkyl Examples include sodium ether sulfate. From the viewpoints of foaming, bactericidal performance, and skin irritation, polyoxyethylene (1) alkyl ether sulfate triethanolamine and polyoxy Styrene (1) alkyl ether sulfate is preferable. In addition, in this specification, the numerical value in the parenthesis of these compounds means the average added mole number of ethylene oxide. As the component (c), one type of these compounds may be used alone, or a plurality of types may be used in combination.

  Content of (c) component in the skin disinfection cleaning composition of this invention is 0.5-15.0 weight%, and 3.0-10.0 weight% is preferable. The content is preferably 0.5% by weight or more from the viewpoint of sufficiently exhibiting foamability and detergency, and from the viewpoint of sufficiently exhibiting the bactericidal effect of the component (a), the content is 15.0% by weight. % Or less is preferable.

  The weight ratio of the component (c) to the component (b) is preferably (c) / (b) = 1/1 to 8/1, more preferably 1/1 to 5/1, and 1/1 to 4 / 1 is more preferable. The weight ratio is preferably 1/1 or more from the viewpoint of exerting a bactericidal effect on bacteria such as Escherichia coli without reducing the cleaning effect on fat and oil stains, and from the viewpoint of product stability, the weight ratio is 8/1 or less. Is preferred.

<(D) component>
In the present invention, the component (d) preferably further contains at least one compound selected from the group consisting of benzoate, sorbate, propionate, salicylate and dehydroacetate. As content of (d) component, 0.01-1.0 weight% of the skin disinfection cleaning composition of this invention is preferable from a viewpoint which aims at the further improvement of disinfection performance, 0.05-0.5 weight % Is more preferable, and 0.1 to 0.4% by weight is further preferable. As the salt, alkali metal salts such as sodium salt and potassium salt are preferable.

  (D) Although the mechanism about the point which the disinfection performance of the skin disinfection cleaning composition of this invention improves further by including a component is not clear, (D), so that pH of the composition of this invention becomes lower. It is considered that the proportion of non-dissociable molecules in the component increases, and when the pH of the composition of the present invention (25 ° C.) becomes 5.5 or less, this non-dissociable molecule is converted into component (a), It is estimated that it contributes to the sterilization performance by the component (b) and / or the component (c).

<Skin disinfectant cleaning composition>
The skin sterilizing and cleaning composition of the present invention is preferably in a liquid state using water as a medium. The amount of water can be appropriately set according to the amount of each component.

  The pH of the skin disinfectant cleaning composition (25 ° C.) of the present invention is 5.5 or less. pH can be calculated | required by measuring the undiluted | stock solution (25 degreeC) of the skin disinfection cleaning composition of this invention. Many conventional skin sterilizing and cleaning compositions have a neutral pH range (for example, 6 to 8) from the viewpoint of suppressing irritation to the skin. By reducing to 5 or less, the further improvement of the disinfection performance of a composition is aimed at. By making the skin sterilization detergent composition acidic, adverse effects on the skin (irritation, hand feeling, etc.) may occur, but since the skin sterilization detergent composition of the present invention is excellent in sterilization performance, By using the composition of the present invention for a short time, sufficient sterilization performance can be exhibited, and as a result, such adverse effects can be greatly relieved.

  The pH of the skin sterilizing and cleaning composition (25 ° C.) of the present invention is preferably 3.0 to 5.5, and preferably 3.5 to 5.2 from the viewpoint of achieving both improved bactericidal properties and low skin irritation. Is more preferable, and 4.0 to 5.0 is more preferable.

  Although the details of the mechanism of ensuring high bactericidal properties even when used for a short time by setting the pH of the skin sterilizing and cleaning composition (25 ° C.) of the present invention to 5.5 or less are not clear, When the fungicide component is adsorbed to the cell surface by the glyceryl ether in the system and acts, it is assumed that the pH has some influence on the penetration of the fungicide into the cell.

  Examples of the pH adjuster used for adjusting the pH of the skin sterilizing and cleaning composition of the present invention to a desired range include pH adjusters known in the technical field of the present invention, but citric acid, malic acid, Hydroxy acids such as tartaric acid are preferred.

  Furthermore, the skin sterilizing detergent composition of the present invention is a component used in a normal skin sterilizing detergent composition, for example, lower alcohols such as ethanol; glycerin, propylene glycol, 1,3-butylene glycol, dipropylene glycol, sorbitol. Polyhydric alcohols such as guar gum; plant-derived polysaccharides such as guar gum; microorganism-derived polysaccharides such as xanthan gum; celluloses such as hydroxypropyl cellulose and carboxymethyl cellulose; colorants such as dyes and pigments; sodium chloride and sodium sulfate Inorganic salts of: plant extracts; antiseptics; chelating agents; vitamins; fragrances; anti-inflammatory agents; antioxidants; moisturizers and the like may be contained within a range not impairing the effects of the present invention.

  The skin sterilizing and cleaning composition of the present invention can be used by filling it into a container that is usually used. However, by filling it into a former container, it has good foaming properties and good foam stability. Therefore, it is more preferable to fill the former container.

  The skin sterilizing and cleaning composition of the present invention can be produced according to a conventional method. For example, after the component (a) is dissolved in the component (b), the component (c), water, and the component (d) are added, and the pH of the skin disinfectant cleaning composition (25 ° C.) is 5. It can be manufactured to be 5 or less. As for the blending amount of each component, the description of the content of each component described above can be applied as it is as the description of the blending amount.

  Furthermore, the skin sterilization cleaning composition of the present invention is preferably used as a liquid sterilization cleaning agent for the body, for example, a hand cleaning agent such as a hand soap, a body shampoo, and a hair shampoo. It is more preferable to be used as a cleaning agent, and as an application site, it is further preferable to be used for a hospital, a nursing facility, or a kitchen.

  Hereinafter, an example is given and it demonstrates in detail. In addition, content of each component in a following example etc. was shown by weight% in Table 1 and Table 2 on the basis of an effective part. In addition, about the numerical value of the component ratio (c component / b component) in a table | surface, the denominator (/ 1) was abbreviate | omitted and described.

(C) component in each table | surface is as follows.
1: Ammonium lauryl sulfate 2: Triethanolamine lauryl sulfate 3: Polyoxyethylene (1) alkyl (C ₁₀ -C ₁₆ ) ether ammonium sulfate 4: Polyoxyethylene (1) alkyl (C ₁₀ -C ₁₆ ) ether triethanolamine sulfate 5: Polyoxyethylene (2) alkyl (C ₁₀ -C ₁₆ ) ether ammonium sulfate 6: Polyoxyethylene (2) alkyl (C ₁₀ -C ₁₆ ) sodium ether sulfate

(Test method and evaluation criteria for bactericidal effect)
As test bacteria, Escherichia coli NBRC3972 and Staphylococcus aureus NBRC13276 were used. A culture solution pre-cultured in an SCD medium [manufactured by Nippon Pharmaceutical Co., Ltd.] was prepared in advance. 2 mL of each composition diluted with 0.1 mL (10 ⁹ to 10 ¹⁰ cells / mL) of the culture solution to a predetermined concentration (composition dilution ratio × 1, × 3, × 10, × 40) with sterilized water. The diluted solution was inoculated. Every fixed time (15 seconds, 30 seconds), one platinum loop was taken from each diluted solution and inoculated into 1 mL of a growth medium (SCDLP medium [manufactured by Nippon Pharmaceutical Co., Ltd.]). After the growth liquid medium was cultured at 37 ° C. for 24 hours, the presence or absence of growth of the bacteria was observed.

  The presence or absence of fungal growth was determined visually. That is, when turbidity was observed in the cultured medium, it was determined that the bacteria had grown. Since the bactericidal effect was tested at four dilution concentrations and two contact times for one type of skin sterilizing detergent composition, visual judgment was performed on a total of eight growth media. The determination of the bactericidal effect was performed as follows according to the number of growth media in which the growth of bacteria was not observed. When no growth of bacteria was observed (that is, when no growth of bacteria was observed for all 8 growth media), the highest score (full score) was 8, and the total dilution concentration and total reaction time were The case where the growth of bacteria was observed in all of the growth media was set to 0 as the lowest score. That is, it means that the higher the value between 0 and 8, the higher the bactericidal effect of the skin sterilizing detergent composition. About a result, the test was done 3 times about one sample and the average value of the obtained value was shown as sterilization performance.

(Cleaning effect test method and evaluation criteria)
Samples 1 and 2 below were used as a model for oily and dirt stains.
0.5 mL of the oil / fat sample of Sample 1 was taken and applied uniformly to the palm. Hands were washed with 1 mL of each composition (washing and rinsing for 15 seconds each, water temperature of about 30 ° C., tap water, constant amount of water). Subsequently, Sample 2 was also evaluated in the same manner.
Sample 1: Squalane (deep sea bream liver extract oil), reagent, [manufactured by Tokyo Chemical Industry Co., Ltd.]
Sample 2: Cottonseed oil, reagent, [manufactured by Kanto Chemical Co., Ltd.]

  The cleaning effect was evaluated by five panelists. The panelists were instructed to perform the hand washing operation in the same manner for all the compositions, and did not inform which of the compositions was the product of the present invention and which was a comparative product. The case where fat and oil stains were completely removed was set to 5, and the case where no oily stains were removed was set to 1, and the cleaning effect was sensory evaluated with an integer between 1 and 5. It means that the higher the value, the higher the cleaning effect of the composition against oil stains. The numerical value was determined by the average value of Sample 1 and Sample 2.

Example 1 and Comparative Example 1
Compositions having the compositions shown in Tables 1 and 2 were prepared according to a conventional method, and a bactericidal effect test and a cleaning effect test were conducted. Tables 1 and 2 show the results of the bactericidal effect test. The cleaning effect was in the range of 4 to 5 in all of the products of the present invention and the comparative product, and it was shown that these compositions exhibited an excellent cleaning effect.

  Thus, it was found that the product of the present invention effectively killed Escherichia coli and Staphylococcus aureus by contact for an extremely short time (for example, within 15 seconds) assuming actual hand washing.

  On the other hand, if a comparative product is examined, even if the pH of the composition is in the acidic range, it is sufficient in a short time if at least one of the components (a), (b) and (c) is missing. It was found that bactericidal properties could not be exhibited (Comparative products 1, 2, 4, 5 and 7). Furthermore, in the case where the pH is in a neutral range, sufficient bactericidal properties cannot be exhibited in a short time (Comparative products 3 and 6), and in addition, (a) component, (b) component and (c) component are contained. However, it was found that if the pH was outside the predetermined range, sufficient bactericidal properties could not be exhibited in a short time (Comparative Product 6). Thus, it was found that a skin sterilizing and cleaning composition that exhibits a sufficient sterilizing effect in a short time can be provided only by completely satisfying the configuration of the present invention.

Example 2 (hand soap)
A hand soap having the following composition was produced by a conventional method. The pH of the obtained hand soap solution (25 ° C.) was 5.0 (25 ° C.), and was excellent in detergency and high in bactericidal effect. In addition, five panelists replied that they did not experience irritation or touch when they cleaned their fingers for normal use over two weeks.

Polyoxyethylene (1) alkyl (C ₁₀ -C ₁₆₎ ether sulfate: 5.0 (wt%)
2-ethylhexyl glyceryl ether: 2.0 (% by weight)
・ Triclosan: 0.3 (% by weight)
・ Isopropylmethylphenol: 0.1 (% by weight)
Propylene glycol: 5.0 (% by weight)
・ Sodium benzoate: 0.3 (% by weight)
-PH adjuster (citric acid): appropriate amount (amount that makes hand soap pH 5.0)
・ Purified water: Balance ・ Total: 100 (% by weight)

  The skin sterilizing and cleaning composition of the present invention has a high sterilizing effect in a short use time without increasing the amount of the sterilizing agent, and is therefore suitable for use in hospitals, nursing homes, food processing sites, kitchens and other sites. Applicable to.

Claims (5)

(A) Component: at least one fungicide selected from the group consisting of triclosan, isopropylmethylphenol and parachlorometaxylenol, (b) component: glyceryl ether having a hydrocarbon group having 4 to 12 carbon atoms, and (c ) Component: the following general formula (1)
R—O— (CH ₂ CH ₂ O) _n —SO ₃ M (1)
(Wherein R is an aliphatic group having 8 to 16 carbon atoms, n represents an average number of added moles, n = 0 to 3, and M is triethanolamine, ammonium or sodium). A skin sterilizing detergent composition containing 0.5 to 15.0% by weight of an anionic surfactant, which has a pH at 25 ° C. of 5.5 or less.   (D) component: The skin disinfection cleaning composition of Claim 1 which further contains the at least 1 sort (s) of compound chosen from the group which consists of a benzoate, a sorbate, a propionate, a salicylate, and a dehydroacetate. object.   The skin sterilization cleaning composition according to claim 1 or 2, wherein the weight ratio of the component (c) to the component (b) is (c) / (b) = 1/1 to 8/1.   The skin disinfection cleaning composition of any one of Claims 1-3 whose pH of this composition (25 degreeC) is 3.0-5.5.   The skin sterilizing and cleaning composition according to any one of claims 1 to 4, which is used for hand soap, body shampoo or hair shampoo.